Polski Merkuriusz Lekarski[JOURNAL]
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200 papers
Study of ophthalmologists' opinions on the influence of current conditions in Ukraine on the organization of medical care for glaucoma patients.
Melnyk VO, Bobkovych KO, Pavlovska MO … +1 more , Palamar BI
Pol Merkur Lekarski · 2025 · PMID 41075241 · Publisher ↗
OBJECTIVE: Aim: To investigate the professional opinions of ophthalmologists who provide medical care to glaucoma patients in current conditions in Ukraine, particularly regarding the impact of Russia's full-scale invasi...
OBJECTIVE: Aim: To investigate the professional opinions of ophthalmologists who provide medical care to glaucoma patients in current conditions in Ukraine, particularly regarding the impact of Russia's full-scale invasion of Ukraine on the organization, quality, and timeliness of medical care for these patients. PATIENTS AND METHODS: Materials and Methods: The research materials were data from a voluntary anonymous questionnaire survey of 322 ophthalmologists from various regions of Ukraine who work in public and private medical institutions. Data from the Kyiv City Information and Analytical Center of Medical Statistics were also analyzed. RESULTS: Results: According to the ophthalmologists, the proportion of patients with secondary glaucoma (62,9±3,5%) and open-angle glaucoma (34,4±3,5%) has increased, as well as the proportion of patients with stage III glaucoma (61,6±3,4%). Since the onset of the full-scale invasion, the number of glaucoma patients seeking ophthalmological help late (74,8±2,4%) or irregularly (83,5±2,1%) has increased. A total of 62,7±2,7% of ophthalmologists report that glaucoma patients are effectively refusing surgical treatment, mostly due to a lack of financial resources to undergo the operation (82,7±2,7%). CONCLUSION: Conclusions: The war has had a negative impact on the ability to provide quality ophthalmologic care, particularly to patients with open-angle glaucoma. The findings may be used to identify opportunities and strategies for improving the quality of ophthalmologic care.
Hospital stay duration prediction score system for covid-19 patients: Evaluation of proposed practical models.
Kurakh AV, Hechko MM, Hechko KA … +1 more , Ploskina YMV
Pol Merkur Lekarski · 2025 · PMID 41075240 · Publisher ↗
OBJECTIVE: Aim: Evaluate the prognostic value of the proposed scale on determining hospital stay duration of patients with COVID-19. Establish baseline values of the scale for further implementation into primary care. PA...
OBJECTIVE: Aim: Evaluate the prognostic value of the proposed scale on determining hospital stay duration of patients with COVID-19. Establish baseline values of the scale for further implementation into primary care. PATIENTS AND METHODS: Materials and Methods: We gathered and analyzed data of 140 hospitalized patients who underwent treatment in Uzhhorod CMCH and had a positive COVID-19 test from the start of the pandemic and until January of 2022. 4 models were proposed, each patient was analyzed based on a point system determined by the model, to compare the number of accumulated points with hospital stay duration. RESULTS: Results: Linear regression results showed that models I and IV provide a low practical usage as per R2. Models II and III are most promising showing a high prognostic value (R2 are 0.0703 and 0.111 respectively). Models II and III showed a statistically significant increase in hospital stay for scores 2 and 5 compared with 0. The accumulated data shows that scores 2 and 5 show a significant increase in hospital stays, while 1, 3 and 4 did not show any significant increase for practical usage. CONCLUSION: Conclusions: Overall, this analysis showed that middle scores and maximum scores showed significance compared to hospital stays, while Models II and III showed the highest practical usage coefficients in COVID-19 scenarios. Despite the fact that the number of asthma and COPD patients was low, these models may prove useful for practical usage in triage scenarios and primary care.
Detection and prevention of gambling disorder among Ukrainian law enforcement personnel under high operational stress: Institutional experience and comparative analysis.
Kozeratska OA, Pogoretskyi MA, Serhiieva DB … +2 more , Starenkyi OS, Denysenko GV
Pol Merkur Lekarski · 2025 · PMID 41075239 · Publisher ↗
OBJECTIVE: Aim: To conduct a comparative institutional analysis of existing practices for detecting and preventing gambling disorder among Ukrainian law enforcement personnel under conditions of high operational stress....
OBJECTIVE: Aim: To conduct a comparative institutional analysis of existing practices for detecting and preventing gambling disorder among Ukrainian law enforcement personnel under conditions of high operational stress. PATIENTS AND METHODS: Materials and Methods: The study involved 342 employees (average age 34,1±5,2 years; 86,5% males and 13,5% females) from four Ukrainian law enforcement agencies, performing investigative, operational-search, counterintelligence, analytical, and administrative-control functions. The study was conducted during 2023-2025 and employed the Problem Gambling Severity Index (PGSI) and Gambling Disorder Identification Test (GDIT) screening tools, an anonymous survey, structured psychological interviews, behavioural observation, and digital monitoring. RESULTS: Results: According to the PGSI, 7,1% of respondents demonstrated pathological gambling behaviour. The use of the GDIT revealed an elevated score (≥15) in 40 (11,7%) respondents, with 19 of them (5,6%) exhibiting clinically relevant symptoms. Respondents with a GDIT score ≥15 (vs. <15 score group) showed 1,3 times higher anxiety levels (by HADS-A score), 3,4 times greater frequency of disciplinary incidents, and systematic interaction with gambling platforms during off-duty hours. Significant correlations were found between elevated gambling risk levels (by PGSI and GDIT) and symptoms of anxiety (HADS-A), impulsive financial decisions, and increased disciplinary infractions. CONCLUSION: Conclusions: The implementation of a comprehensive system for the prevention of gambling disorder, integrating psychometric, behavioural, and digital indicators, is advisable to enhance psychological resilience and prevent a decline in operational reliability among Ukrainian law enforcement personnel under high operational stress.
Emotional burnout, anxiety, and depression in patients with chronic pain undergoing rehabilitation during the war in Ukraine: A clinical-psychological study.
Butska LV, Varina HB, Falko NM
Pol Merkur Lekarski · 2025 · PMID 41075238 · Publisher ↗
OBJECTIVE: Aim: To evaluate emotional burnout, anxiety, and depression in men with chronic pain undergoing rehabilitation during wartime in Ukraine, with attention to age and pain duration. PATIENTS AND METHODS: Material...
OBJECTIVE: Aim: To evaluate emotional burnout, anxiety, and depression in men with chronic pain undergoing rehabilitation during wartime in Ukraine, with attention to age and pain duration. PATIENTS AND METHODS: Materials and Methods: The study included 35 male military personnel aged 25-60 years, undergoing inpatient rehabilitation at the State Institution «Veteran Mental Health and Rehabilitation Center «Forest Glade» Ministry of Health of Ukraine (Kyiv, Ukraine) (January-May 2025). The mean age was 43±10 years; average pain duration was 23±17 months. Data were collected via structured questionnaires and clinical interviews. Standardized instruments included the Maslach Burnout Inventory (MBI), State-Trait Anxiety Inventory (STAI), and Hospital Anxiety and Depression Scale (HADS). RESULTS: Results: Most participants exhibited moderate-to-high levels of emotional exhaustion (88,6%), depersonalization (80%), and reduced personal accomplishment (85,7%) (by MBI). More than 70% showed moderate-to-high levels of both state and trait anxiety (by STAI). Сlose to half of patients (48,6%) demonstrated borderline or abnormal depression patterns. Participants with pain lasting over 12 months showed significantly higher anxiety score, with 78,9% experiencing clinically relevant anxiety versus 37,5% in the short-term (3-12 months) group (p=0,018). Strong (or close to strong) correlations were identified between burnout, anxiety, and depression subscales (ρ=0,68-0,89; p<0,001 [n=35]). CONCLUSION: Conclusions: Chronic pain in wartime conditions is linked to severe psychological distress. Extended pain duration increases anxiety. The strong interplay between burnout and affective symptoms underscores the need for integrative, multidisciplinary rehabilitation tailored to psychological needs.
Analysis of the men's sexual dysfunctions impact on different aspects of their quality of life.
Trishch VI, Detsyk OZ, Solomchak DB … +1 more , Antoniv RR
Pol Merkur Lekarski · 2025 · PMID 41075237 · Publisher ↗
OBJECTIVE: Aim: To study different aspects of quality of life depending on the type and severity of sexual disorders in men. PATIENTS AND METHODS: Materials and Methods: An observed case-control study was carried out dur...
OBJECTIVE: Aim: To study different aspects of quality of life depending on the type and severity of sexual disorders in men. PATIENTS AND METHODS: Materials and Methods: An observed case-control study was carried out during 2023-2024, at three private-funded out-patient health care facilities of the Ivano-Frankivsk region of Ukraine. A survey of the quality of life of 402 men with sexual dysfunctions and 200 men without ones was carried out. The control group included men who visited the health care facilities for the check-up and were recognized as practically healthy. The study data were analyzed using Microsoft Excel data analysis and the Statistica10.0 software packages. Statistical processing of qualitative data was carried out by calculating their prevalence per 100 respondents, and the reliability of their differences in different observation groups was assessed by calculating the chi-square (χ2) test. The research design and programs were reviewed and approved by the Ethics Commission of the Ivano-Frankivsk National Medical University (protocol No. 133/23 dated March 29, 2023). RESULTS: Results: The quality-of-life integral index in sexual dysfunctions was (64.9±7.14) % of the maximum possible 100% vs (92.4±3.52) % in the control group. The progression of erectile dysfunction was accompanied by a decrease of the quality-of-life integral index from -25.2% in mild to -33.3% in moderate and -41.6% in severe, and the presence of premature ejaculation reduces the quality of life by 38.6%, hypoactive sexual desire disorder by 38.0%, orgasmic dysfunction by 39.8%. The greatest impact on the men`s quality-of-life reduction in sexual dysfunctions was the dissatisfaction with sexual drive, interest and/ or performance (on average 2.1 points on a 5-point scale, compared to 4.9 points in the control group), especially expressed in hypoactive sexual desire disorder (1.6 points, respectively), orgasmic dysfunction (1.7) and severe erectile dysfunction (1.5). Respondents with sexual dysfunctions were the least satisfied with the psychological components of the quality-of-life, in particular in case of severe erectile dysfunction (3.0 points), premature ejaculation (2.9), hypoactive sexual desire disorder (3.0) and orgasmic dysfunction (3.0). CONCLUSION: Conclusions: Male sexual dysfunctions negatively affect the psychological component of the quality of life without significant impact on the physical and socio-economic. The complex of treatment measures for men`s sexual dysfunctions must necessarily include psychological interventions.
The effect of melatonin on antioxidant defense indicators in the blood of rats with insulin resistance.
Kushnir OY, Yaremii I, Pantsiuk K … +4 more , Vivsyannuk V, Buzdugan I, Bukach O, Prodanchuk G
Pol Merkur Lekarski · 2025 · PMID 41075236 · Publisher ↗
OBJECTIVE: Aim: To determine the effect of melatonin on the activities of glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase and the content of reduced glutathione, glucose and insulin level...
OBJECTIVE: Aim: To determine the effect of melatonin on the activities of glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase and the content of reduced glutathione, glucose and insulin levels in the blood of rats with insulin resistance. PATIENTS AND METHODS: Materials and Methods: Research performed in compliance with the Rules of the work using experimental animals (1977) and the Council of Europe Convention on the Protection of Vertebrate Animals used in experiments (Strasbourg, 1986). Sexually mature 18-month-old outbred white male rats were divided into groups: 1) control, 2) insulin resistant rats (dexamethasone at a dose of 0.125 mg/kg for 13 days daily), 3) insulin resistant rats ingested with metformin (200 mg/kg) daily, 4) insulin resistant rats were orally administered melatonin at a dose of 10 mg/kg daily. Measurement of fasting glucose content in the blood from the tail vein (One Touch, USA) and insulin in the blood serum (immunochemiluminescent analyzer Snibe Co., Ltd, the Maglumi test kit, China) was performer on the 14th day. Blood was taken to determine the parameters of glutathione system by using standard methods. Statistical processing was performed using the IBM SPSS Statistics 21 program. Differences were considered statistically significant at p≤0.05. RESULTS: Results: Melatonin ingestion as well as metformin were helpful in normalization of insulin level on the background of glucose level restoration and antioxidant system activation. CONCLUSION: Conclusions: We have established the hypoglycemic and antioxidant effects of melatonin on the background of dexamethasone-induced insulin resistance.
Evaluation of fructosamine as a new biomarker in the diagnosis of diabetes mellitus.
Jallod IMS, Jabbar SS, Shubar SNA … +1 more , Al-Fahham AA
Pol Merkur Lekarski · 2025 · PMID 41075235 · Publisher ↗
OBJECTIVE: Aim: To evaluate the using of fructosamine as a new biomarker in the diagnosis of diabetes mellitus. PATIENTS AND METHODS: Materials and Methods: This is a cross-sectional case-control study that was conducted...
OBJECTIVE: Aim: To evaluate the using of fructosamine as a new biomarker in the diagnosis of diabetes mellitus. PATIENTS AND METHODS: Materials and Methods: This is a cross-sectional case-control study that was conducted at The Medical City, Baghdad/Iraq, from January to May 2024. In this study, 60 diabetic patients were compared with 60 apparently healthy controls. Information was collected from the hospital records and serum fructosamine was measured manually using the nitroblue tetrazolium colorimetric method. RESULTS: Results: Serum fructosamine levels were significantly higher in diabetic patients (mean=367 μmol/l, SD=12.7) than in the controls (mean=242 μmol/l, SD=22.8), p<0.0001. Logistic regression found that high fructosamine levels were associated with a significantly increased risk of developing diabetes mellitus (odds ratio=1.45; 95% CI: 1.12-1.86; p-value <0.046). Diagnostic performance analysis yielded a sensitivity of 79% and specificity of 73% (p-value=0.033). CONCLUSION: Conclusions: Its high levels in the sera of diabetic patients, association with disease risk, and moderate diagnostic accuracy speak for the probable usefulness of this test in clinical practice, these results need confirmation in larger studies.
The impact of judo training on the morphofunctional state and physical fitness of healthy adolescents.
Griban GP, Dmytrenko SM, Salnykova SV … +4 more , Brezdeniuk OY, Khurtenko OV, Holovkina VV, Liakhova N
Pol Merkur Lekarski · 2025 · PMID 41075234 · Publisher ↗
OBJECTIVE: Aim: The aim is to investigate the impact of an experimental judo training program on the morphofunctional state and physical fitness of healthy adolescents. PATIENTS AND METHODS: Materials and Methods: The st...
OBJECTIVE: Aim: The aim is to investigate the impact of an experimental judo training program on the morphofunctional state and physical fitness of healthy adolescents. PATIENTS AND METHODS: Materials and Methods: The study involved 54 male adolescents aged 16-17, who were divided into an experimental group (EG, n=27) and a control group (CG, n=27). The morphofunctional state of the students was evaluated based on the indicators of muscular, cardiovascular, and respiratory system activities, while physical fitness was assessed using physical education tests. RESULTS: Results: It was found that during the experiment, adolescents' morphofunctional state and physical fitness indicators improved in both groups. However, in the EG, the difference between the initial and final data was significant (p 0.05). Moreover, at the end of the experiment, all the studied indicators in the EG were significantly better than in the CG. The most pronounced impact of judo training was observed on the strength index, Ruffier index, Stange index, Genchi index, Robinson index, and the results in the long jump, pull-ups, push-ups, and trunk lifts. CONCLUSION: Conclusions: It was proven that extracurricular judo training sessions, provided that adolescents consciously choose the sport and are motivated to participate, as well as the rational planning of training sessions, are more effective compared to traditional physical education lessons in high school for improving the morphofunctional state and physical fitness of healthy adolescents. The high level of the studied indicators in adolescents will enhance their health and improve their future educational and professional activities.
Depression, PTSD and psychological distress among Ukrainian youth: The impact of war on mental health.
Fedchyshyn NO, Shulhai AH, Hantimurova NI … +4 more , Klishch HI, Hnatyshyn SI, Bilavych HV, Fedoniuk LY
Pol Merkur Lekarski · 2025 · PMID 41075233 · Publisher ↗
OBJECTIVE: Aim: To determine the prevalence of traumatization, depression, stress, and anxiety during the war in the rear western region of Ukraine. PATIENTS AND METHODS: Materials and Methods: For the study of the war's...
OBJECTIVE: Aim: To determine the prevalence of traumatization, depression, stress, and anxiety during the war in the rear western region of Ukraine. PATIENTS AND METHODS: Materials and Methods: For the study of the war's impact on the psychological state of medical students to be successful, it is essential to analyze various influencing factors and explore possible ways of supporting students in difficult situations duringmilitary conflict. The 1 to 6-year students of the Medical Faculty of I. Horbachevsky Ternopil National Medical University, who voluntarily completed the DASS-21 survey scale, participated in our research on students' mental health. The statistical sample was 716 students. RESULTS: Results: To compare the degree of the emotional state of depression, anxiety, and stress in medical students, we have used a survey conducted among the students (716 people). Horbachevsky Ternopil National Medical University in 2019 and 2024. In 2019, the degree of depression severity among the students was determined to be 50.9%, anxiety - 48.9%, and stress - 50.7%. After two years of the war, in 2024, this indicator is already 65.8%, 65.9 %, and 74.7%, respectively, which is 1.3 times higher than the degree of depression and anxiety severity and 1.5 times higher than the degree of stress severity in 2019. Withinan extensivesurvey of I. Horbachevsky Ternopil National Medical Universitystudents, 98% said they had been affected by the war in some way, 86% suffered from war-related nightmares, 49% experienced symptoms of insomnia, and 27% had symptoms of post-traumatic stress disorder. However, the mental health of young people who were close to the combat zone or directly participated in hostilities was significantly worse. At the same time, another study on the mental state of students in Ukraine revealed that symptoms of psychological disorder were observed in 52.7% of respondents, with anxiety being characteristic of the majority of participants - 54.1%. Almost half of the young respondents reported experiencing depression - 46.8%. The conducted studies established a connection between mental health disorders among young Ukrainians and factors such as gender, place of residence (urban or rural area), whether they lived in territory occupied by Russian forces, as well as the presence of their own family or elderly relatives. CONCLUSION: Conclussions: As the trauma of war can persist for years after its end, there is a need to monitor the psychological state and well-being of students systematically. It is equally important to study the aspects of strengthening psychological health and the resources that may be needed for this. Maintaining students' mental health in martial law requires all types of resources (personal, physical, informational, and other), psychological competence, social support, cognitive training, and simulation modeling methods.
The profile of the resistance of Staphylococcus aureus against selected antibiotics in Najaf.
Kadhim S, Ismaeel GL, Abdul-Hussein AH … +2 more , Najaf HN, Oleiwi ZK
Pol Merkur Lekarski · 2025 · PMID 41075232 · Publisher ↗
OBJECTIVE: Aim: In this study, we examine and discuss about the resistance of Staphylococcus aureus to common antibiotic classes in Najaf. PATIENTS AND METHODS: Materials and methods: Information on Staphylococcus aureus...
OBJECTIVE: Aim: In this study, we examine and discuss about the resistance of Staphylococcus aureus to common antibiotic classes in Najaf. PATIENTS AND METHODS: Materials and methods: Information on Staphylococcus aureus's resistance to drugs was collected from the directorate of health and analyzed. RESULTS: Results: It was found that Staphylococcus aureus exhibited resistance to cephalosporins that was comparable to that of penicillin. On the other hand, significant resistance to cefoxitine, ceftazidim, and penicillin was seen, further studies are required to evaluate the mechanism of antibiotic resistance responsible for such resistance. CONCLUSION: Conclusions: the profile of resistance of Staphylococcus aureus is variable across antibiotic families. Inter-member differences have been noticed within the group, a pattern that more likely indicates resistance at the level of intracellular concentration of antibiotic rather than the mechanism of action. In addition, it has been noticed that the development of resistance is directly proportional to the frequency of use of antibiotics. Further studies are required to investigate the molecular mechanism of resistance.
The effect of the phytotherapeutic agent Desolis on the cytokine profile in the secretion of paraurethral glands in the complex treatment of women with chronic urethritis.
Tsiporenko SY, Babinets LS, Doroshenko MM … +1 more , Gudzenko AV
Pol Merkur Lekarski · 2025 · PMID 41075231 · Publisher ↗
OBJECTIVE: Aim: To investigate the effect of the phytotherapeutic agent Desolis on cytokine profiles in the secretion of paraurethral glands as part of combination therapy in women with chronic urethritis. PATIENTS AND M...
OBJECTIVE: Aim: To investigate the effect of the phytotherapeutic agent Desolis on cytokine profiles in the secretion of paraurethral glands as part of combination therapy in women with chronic urethritis. PATIENTS AND METHODS: Materials and Methods: A total of 79 women with chronic urethritis were examined and divided into two groups. The main group (n=40) received standard etiological therapy in accordance with CDC guidelines along with Desolis (administered orally twice daily for 10 days). The control group (n=39) received standard treatment only. Cytokine concentrations in the secretion of the paraurethral glands were determined before and after treatment using ELISA. RESULTS: Results: Women with chronic urethritis demonstrated significantly elevated levels of pro-inflammatory cytokines (IL-8, IFN-γ, IP-10) and reduced concentrations of IL-2, IL-1β, RANTES, and Fractalkine. The addition of Desolis to treatment led to normalization of these markers, which did not differ significantly from reference values (p>0.05), unlike the control group. Furthermore, patients in the Desolis group experienced a shorter duration of clinical symptoms and significantly higher pathogen elimination rates (87.5% vs. 56.4%, p<0.05). CONCLUSION: Conclusions: The use of Desolis in combination therapy contributes to the normalization of the local cytokine profile, improves clinical outcomes, and increases treatment efficacy in women with chronic urethritis.
Effect of winter swimming on the cardiovascular system: adaptive mechanisms and potential hazards.
Jurczak P, Saied A, Sztaba K … +4 more , Zdzieborska P, Zubik K, Osowiecka K, Gromadziński L
Pol Merkur Lekarski · 2025 · PMID 41075230 · Publisher ↗
OBJECTIVE: Aim: To investigate the impact of winter swimming on the cardiovascular system. PATIENTS AND METHODS: Material and methods: A group of 30 adult subjects underwent an ECG Holter examination twice (during the wi...
OBJECTIVE: Aim: To investigate the impact of winter swimming on the cardiovascular system. PATIENTS AND METHODS: Material and methods: A group of 30 adult subjects underwent an ECG Holter examination twice (during the winter swimming season and after its end). The following parameters available in the results of the ECG Holter examination were analysed: HR, VE and SVE beats, QT and heart rate variability parameters: SDNN, SDANN, pNN50, RMSSD and Tiangular index. RESULTS: Results: In subjects over 45 years of age, higher values of the SDNN and SDANN parameters during the winter period may suggest a positive impact of winter swimming on the cardiovascular system. The QTc max parameter showed higher values in males during the winter study, whereas higher values were recorded in females during the summer study. As the frequency of winter swimming episodes increased, higher HR min values and lower SDNN and SDANN values were observed. CONCLUSION: Conclusions: In healthy subjects under 45 years of age, winter swimming appears to have no significant impact on the heart rate variability parameters, whereas in individuals over 45 years of age, it shows a statistically significant positive impact. Winter swimming practised more frequently than once a week may reduce the autonomous reserve and increase cardiovascular risk. Further research with a larger sample size is necessary to better understand the effects of winter swimming on the cardiovascular system.
Building a child-centred, multilayered MHPSS eco-system for conflict-affected children (Ukraine).
Vus V, Nalyvaiko O, Zotova L … +3 more , Kostruba N, Fradelos E, Papathanasiou IV
Pol Merkur Lekarski · 2025 · PMID 41075229 · Publisher ↗
OBJECTIVE: Aim: This article aims to propose a multilayered, child-centred Mental Health and Psychosocial Support (MHPSS) ecosystem model tailored for conflict-affected children (on example of Ukraine). The model integra...
OBJECTIVE: Aim: This article aims to propose a multilayered, child-centred Mental Health and Psychosocial Support (MHPSS) ecosystem model tailored for conflict-affected children (on example of Ukraine). The model integrates evidence-based interventions, multisectoral collaboration, and cultural adaptation to address acute psychosocial distress and foster long-term resilience, offering a replicable blueprint for humanitarian contexts. PATIENTS AND METHODS: Materials and Methods: The development of the MHPSS ecosystem model was informed by a comprehensive review of theoretical frameworks, peerreviewed literature, international reports, and successful MHPSS interventions in humanitarian settings. The model synthesizes the Inter-Agency Standing Committee (IASC) pyramid of psychosocial intervention and Bronfenbrenner's ecological systems theory, contextualized through analysis of UNICEF and WHO reports, Ukraine's National the Action Plan for 2024-2026 and Target Model of the MHPSS System, and global best practices. An 11-stage implementation plan was formulated, incorporating adaptation, governance, capacity building, database/certification, supervision, quality assurance, and policy integration, guided by implementation science frameworks. RESULTS: Results: The proposed model operationalizes a coordinated, scalable MHPSS ecosystem centred on children, layered across family, school, service infrastructure, and policy. Through localization, community-driven delivery, and multisectoral governance, the model enhances cultural fit, professionalizes the MHPSS workforce, and embeds continuous quality improvement. Integration with Community Resilience Centres (CRCs) strengthens local service delivery and sustainability. The staged implementation plan provides a universal roadmap for bridging immediate psychosocial needs and long-term systemic resilience. CONCLUSION: Conclusions: The multilayered MHPSS ecosystem represents a paradigm shift in addressing the psychosocial impact of conflict on children. By embedding evidence-based, contextually adapted supports within a sustainable multisectoral framework, the model offers significant potential to mitigate distress and promote resilience, serving as a foundation for future research and global replication.
Effect of short duration vitamin E supplementation on some reproductive hormones in infertile women.
Assi MA, Shamran SG, Mahdi KA … +1 more , Al-Fahham AA
Pol Merkur Lekarski · 2025 · PMID 41075228 · Publisher ↗
OBJECTIVE: Aim: To study the effects of short duration vitamin E supplementation (100 mg/day) on reproductive hormones disturbance estrogen, follicle stimulating hormone, luteinizing hormone, and prolactin. PATIENTS AND...
OBJECTIVE: Aim: To study the effects of short duration vitamin E supplementation (100 mg/day) on reproductive hormones disturbance estrogen, follicle stimulating hormone, luteinizing hormone, and prolactin. PATIENTS AND METHODS: Materials and Methods: The study included 40 women with ages ranged between 18-35 years; they were treated from infertility at Al-Zahraa Teaching Hospital in Al-Najaf City in Iraq between June 2023 and May 2024. Women participated in the study were divided into two groups: Group (A): was given vitamin E supplementation (100 mg/day) starting at the 4th day of menstruation; Group (B): was given vitamin E supplementation (100 mg/day) starting at the mid of menstruation (expected ovulation time). The hormonal measurements for (Follicle Stimulating Hormone, Luteinizing Hormone, estradiol and prolactin) were conducted by immunoassay (Cobas E 411). RESULTS: Results: The results revealed that there was a significant increase in blood level of E after treatment compared to their levels before treatment. The results also indicated that the levels of estradiol and Luteinizing Hormone have been elevated after intervention as compared to that before intervention. CONCLUSION: Conclusions: It was concluded the complementation of vitamin E supplementation (100 mg/day) has a positive impact in the enhancement of female hormonal indicators (especially estradiol and Luteinizing Hormone) which may increase the efficiency of the therapeutic approaches of infertility. Early-cycle supplementation also resulted in higher estradiol (P=0.04) and luteinizing hormone levels (P=0.02) compared with mid-cycle supplementation, indicating increased hormonal activity.
Structural features of the endocardium, arteries, prostatę and adrenal glands under the conditions of iodine deficiency.
Sobol LV, Kuibida IS, Harhaun OT … +1 more , Popadynets OH
Pol Merkur Lekarski · 2025 · PMID 41075227 · Publisher ↗
OBJECTIVE: Aim: To indicate the morphofunctional changes in the endocardium, wall of the arteries of various types, prostate gland, and adrenal glands in the dynamics of iodine deficiency during postnatal ontogenesis. PA...
OBJECTIVE: Aim: To indicate the morphofunctional changes in the endocardium, wall of the arteries of various types, prostate gland, and adrenal glands in the dynamics of iodine deficiency during postnatal ontogenesis. PATIENTS AND METHODS: Materials and Methods: The experiment involved 50 male Wistar rats (25 immature, aged 3-5 months, and 25 mature, aged 6-8 months). Group 1 (control) included 11 animals of both age groups, while Groups 2 and 3 (with iodine deficiency) consisted of 14 animals each, with material sampling on days 60 and 90 of the experiment, respectively. Morphological (light and electron microscopy), morphometric, biochemical studies, and statistical data processing were conducted. RESULTS: Results: Key components of thyroid signaling were found in the prostate gland, indicating a possible direct effect of thyroid hormones on this organ. Edematous changes in the epithelium of terminal secretory parts result from ischemia caused by edema in vascular walls and connective tissue elements of the prostate. Structural changes found in endocrine cells of the glomerular, fascicular, and reticular zones of the adrenal glands, along with the dynamic increase in cortical thickness during the experiment, suggest trophic disturbances, as edema was detected in vessel walls and stromal components. CONCLUSION: Conclusions: Thus, on both day 60 and day 90 of iodine deficiency, edematous changes occur in all organs in connective tissue components, wall of blood vessels, and epithelial tissues. Altered thyroid status triggers systemic interrelated changes in the organism.
Ultrasound assessment of optic nerve sheath diameter during surgery in the Trendelenburg position.
Skladzien T, Kurdziel E, Przydacz M … +3 more , Czogala M, Terlecki M, Wordliczek J
Pol Merkur Lekarski · 2025 · PMID 41075226 · Publisher ↗
OBJECTIVE: Aim: To determine whether the Trendelenburg position during laparoscopic urological surgery changed the ONSD and whether changes correlated with postoperative complications. PATIENTS AND METHODS: Materials and...
OBJECTIVE: Aim: To determine whether the Trendelenburg position during laparoscopic urological surgery changed the ONSD and whether changes correlated with postoperative complications. PATIENTS AND METHODS: Materials and Methods: In this prospective study, we measured ONSD before patients were placed in the Trendelenburg position. Then the Trendelenburg position was established by tilting the operating table to 20-25 degrees. After surgery, the patients were placed in a horizontal position, and the second measurement of ONSD was obtained. RESULTS: Results: The study included 69 patients. The average preoperative ONSD in the right eye was 5.8±0.7 mm and 5.8±0.8 mm in the left eye. The average postoperative ONSD in the right eye was 6.6±0.8 mm and 6.6±0.7 mm in the left eye. The differences between postoperative and preoperative values in the right and left eyes were statistically significant (p<0.000001). ONSD increases above the norm did not correlate with the incidence of postoperative nausea (p=0.94), delirium (p=0.81), or the time to patient awakening (p=0.29). CONCLUSION: Conclusions: ONSD increased in patients who underwent surgical procedures performed in the Trendelenburg position, but the increase did not correlate with postoperative complications.
Experimental and morphological rationale for applying a synthetic bone graft containing Hydroxyapatite and β-tricalcium phosphate in combination with a collagen sponge with polydeoxyribonucleotide in the treatment of mandibular bone defects.
Malanchuk VO, Hryniuk OI, Myroshnychenko MS … +4 more , Mykhailyk TV, Mazuryk YM, Prokuda OV, Brodetskyi IS
Pol Merkur Lekarski · 2025 · PMID 41075225 · Publisher ↗
OBJECTIVE: Aim: To evaluate the effectiveness of the simultaneous use of a synthetic bone graft containing hydroxyapatite and β-tricalcium phosphate in combination with a collagen sponge impregnated with polydeoxyribonuc...
OBJECTIVE: Aim: To evaluate the effectiveness of the simultaneous use of a synthetic bone graft containing hydroxyapatite and β-tricalcium phosphate in combination with a collagen sponge impregnated with polydeoxyribonucleotide for the treatment of mandibular bone tissue defects through comprehensive morphological analysis of experimental material. PATIENTS AND METHODS: Materials and Methods: In this study, an experiment was conducted on 96 male rats of the WAG population aged 6 to 8 months. All animals were randomly divided into four groups. Group 1 included 24 rats in which a perforated defect was modeled in the region of the mandibular angle. Group 2 included 24 rats in which a perforated defect similar to that in group 1 was modeled in the region of the mandibular angle. The defect was filled with the synthetic bone graft «Biomin GT» (RAPID, Ukraine), which is composed of hydroxyapatite and β-tricalcium phosphate. Group 3 included 24 rats with a mandibular defect similar to those in groups 1 and 2. The defect was filled with a collagen sponge (DSI Dental Solutions Ltd., Israel) impregnated with polydeoxyribonucleotide (BNC Korea, Korea). Group 4 included 24 rats with a mandibular defect similar to those in the previous groups. The defect was simultaneously filled with the synthetic bone graft «Biomin GT» (RAPID, Ukraine) and a collagen sponge impregnated with polydeoxyribonucleotide. In groups 1 to 4, six rats from each group were sacrificed on days 3, 7, 14, and 28. Fragments of the mandible from the area of the modeled defect were used as material for morphological analysis. Histological, morphometric and statistical research methods were used. RESULTS: Results: The authors' comprehensive morphological analysis of experimental material demonstrated an activation of reparative osteogenesis in the mandible in cases where the perforated defect was filled either with the synthetic bone graft «Biomin GT», containing hydroxyapatite and β-tricalcium phosphate, or with a collagen sponge containing polydeoxyribonucleotide. The therapeutic effect was more pronounced in the group treated with the collagen sponge impregnated with polydeoxyribonucleotide. However, neither of these treatment strategies led to the formation of fully mature bone regenerate by day 28 of the experiment. In contrast, the simultaneous application of the synthetic bone graft «Biomin GT» and the collagen sponge with polydeoxyribonucleotide resulted in a more active stimulation of reparative osteogenesis and contributed to the formation of a structurally complete bone regenerate by day 28. CONCLUSION: Conclusions: Simultaneous filling of a bone defect in the mandible modeled in rats with the synthetic bone graft «Biomin GT», containing hydroxyapatite and β-tricalcium phosphate, and a collagen sponge with polydeoxyribonucleotide stimulates reparative osteogenesis and leads to the formation of a complete bone regenerate by day 28 of the experiment. The therapeutic effect is due to the rapid clearance of the defect cavity from blood fragments and alteratively changed tissues; active production and replacement within the regenerate of granulation, connective, and osteogenic fibroreticular tissues with the formation of lamellar bone tissue characterized by the presence of hematopoietic foci; decrease in the severity of inflammatory infiltration and hemodynamic disturbances in the tissues of the regenerate area.
Iodine deficiency and iodine supplementation in pregnancy and lactation. A literature review.
Józefowicz W, Stawińska-Dudek J, Machaj D … +6 more , Dudek J, Brzoza M, Orzeł M, Orzeł B, Aboud A, Buras B
Pol Merkur Lekarski · 2025 · PMID 40929548 · Publisher ↗
OBJECTIVE: Aim: Iodine is an essential nutrient for the synthesis of thyroid hormones. It has a huge impact on the normal brain development of the foetus and the health of the pregnant woman. During pregnancy and lactati...
OBJECTIVE: Aim: Iodine is an essential nutrient for the synthesis of thyroid hormones. It has a huge impact on the normal brain development of the foetus and the health of the pregnant woman. During pregnancy and lactation, the need for iodine increases significantly. This review aims to summarize the role of iodine supplementation in addressing these elevated demands and preventing associated health risks.. PATIENTS AND METHODS: Materials and Methods: The review is based on the thorough analysis of the materials selected from "PubMed" and "Google Scholar" scientific databases using the following key words: iodine; pregnant; lactation; supplementation. These key words were chosen based on their relevance to the matter of the article. CONCLUSION: Conclusions: Iodine supplementation is essential for optimal maternal and foetal health. However, comprehensive strategies are needed to address iodine deficiency, including public education on iodine-rich diets, policy initiatives on salt iodisation and minimising exposure to harmful chemicals in the environment. These measures can affect the health of pregnant and lactating women and their children. Moreover, the paper discusses the potential implications of excessive iodine intake, which may lead to thyroid dysfunction. This review underlines the crucial role of interdisciplinary collaboration in ensuring optimal maternal and neonatal health outcomes.
Human papillomavirus: problems and prospects for women's reproductive health (systematic review).
Hrynevych OY
Pol Merkur Lekarski · 2025 · PMID 40929547 · Publisher ↗
OBJECTIVE: Aim: To consider the specific activity of drops and suppositories of PROTEFLAZID® at the stage of preclinical study, to assess the effectiveness and safety of use in clinical practice in papillomavirus-associa...
OBJECTIVE: Aim: To consider the specific activity of drops and suppositories of PROTEFLAZID® at the stage of preclinical study, to assess the effectiveness and safety of use in clinical practice in papillomavirus-associated diseases of the female reproductive system.. PATIENTS AND METHODS: Materials and Methods: Analysis of scientific publications on the treatment of palilomavirus infection with PROTEFLAZID® in women over the past decade. RESULTS: Results: Medicines have a direct antiviral effect on papillomaviruses. Clinical trials have shown that the drugs are safe and effective agents for the treatment of papillomavirus-associated CIN1 and CIN2 in the mode of simultaneous systemic and topical use. The proposed scheme is a promising method of treating class I-II neoplasias in women of reproductive age, as it avoids cervical damage, early and late complications and preserves female reproductive function. CONCLUSION: Conclusions: PROTEFLAZID® (drops and suppositories) are safe and effective etiopathogenetic drugs for the systemic and topical treatment of papillomavirusassociated diseases in women. Medicines demonstrate the potential for the prevention of cervical cancer, as they allow organ-preserving treatment in women of reproductive age as a guarantee of future motherhood.
Edwards syndrome: Neurocognitive and linguistic profile, diagnosis, overlaps and treatment.
Katsarou DV, Argyriadis A, Sofologi M … +5 more , Argyriadi A, Kougioumtzis GA, Megari K, Mantsos E, Theodoratou M
Pol Merkur Lekarski · 2025 · PMID 40929546 · Publisher ↗
OBJECTIVE: Aim: To provide a comprehensive understanding of the profound developmental and medical challenges associated with this condition.. PATIENTS AND METHODS: Materials and Methods: Τhis study employed a narrative...
OBJECTIVE: Aim: To provide a comprehensive understanding of the profound developmental and medical challenges associated with this condition.. PATIENTS AND METHODS: Materials and Methods: Τhis study employed a narrative review methodology, drawing upon a wide range of peer-reviewed scientific literature, clinical guidelines, and case studies. The reviewed materials were selected based on their relevance to the neurocognitive, linguistic, diagnostic, and therapeutic aspects of Edwards syndrome. Databases such as PubMed, Scopus, and Google Scholar were used, with key terms including "Edwards syndrome," "trisomy 18," "developmental delays," "prenatal diagnosis," and "palliative care." Comparative analysis was conducted to explore clinical overlaps with related syndromes such as trisomy 13 and Turner syndrome. CONCLUSION: Conclusions: Edwards syndrome presents significant challenges, requiring early diagnosis and multidisciplinary care to improve quality of life. Comprehensive understanding and tailored interventions can foster better outcomes and enhance family support systems.
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