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Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal Of Applied Physiology[JOURNAL]
Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal Of Applied Physiology[JOURNAL]
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200 papers
Unlocking the Potential of Alpelisib in Breast Cancer: A Comprehensive Review.
Chandak SM, Kumbhare MR, Patole VP
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2025 May · PMID 40350259 · Publisher ↗
Alpelisib is a cancer therapy drug that has shown significant promise in the treatment of certain types of cancer. Its pharmacokinetics and pharmacodynamics indicate that it is absorbed better orally and has a prolong ha...
Alpelisib is a cancer therapy drug that has shown significant promise in the treatment of certain types of cancer. Its pharmacokinetics and pharmacodynamics indicate that it is absorbed better orally and has a prolong half-life, allowing for once-every day dosing. Currently, its mechanism of action is established to be the suppression of phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), which is the pivotal enzyme of PI3K pathway, which is abnomal in most cancers. The chemistry of alpelisib involves its selective inhibition of PI3K, targeting specifically HR-positive, HER2-negative breast cancer with PIK3CA mutations. The common side effects associated with alpelisib include fever, peripheral edema, fatigue, headache, skin rash, alopecia, pruritis, hyperglycemia, increased gamma-glutamyl transferase, decreased serum calcium, weight loss, diarrhea, nausea, increased serum lipase, decreased appetite, stomatitis, vomiting, dysgeusia, lymphocytopenia, prolonged PTT, and increased serum creatinine. The use of alpelisib in cancer therapy is being extensively studied through various clinical trials, aiming to determine the optimal patient populations for treatment and explore alternative tumor indications and drug combine regimens.
A Mini-review on Immunoblotting Technique in Vaccine Development: Current Innovations.
Dubey RK
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2025 May · PMID 40340799 · Publisher ↗
Immunoblotting, commonly known as Western blotting, remains a pivotal technique in the identification and quantification of specific proteins, offering critical insights into antigen-antibody interactions essential for v...
Immunoblotting, commonly known as Western blotting, remains a pivotal technique in the identification and quantification of specific proteins, offering critical insights into antigen-antibody interactions essential for vaccine development. This mini-review highlights the evolving role of immunoblotting in modern vaccinology, focusing on its application in evaluating immune responses, verifying antigen expression, and screening candidate vaccine components. Current innovations, including enhanced detection systems, high-throughput formats, and integration with proteomics, have significantly improved the sensitivity and specificity of this method. Moreover, advancements in automation and data analysis are streamlining workflows, enabling faster and more reliable vaccine research. This review underscores the continued relevance of immunoblotting in the post-genomic era, particularly as new vaccine platforms, such as mRNA and vector-based vaccines, demand precise immunological validation.
Preclinical Evaluation on Rabbit of Lakshadi Anjana Drops: Physico-Chemical, Histopathological, and Anti-Inflammatory Insights for Ocular Therapeutic Applications.
Nair PP, Keskar MP
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2025 Feb · PMID 39971321 · Publisher ↗
INTRODUCTION: Lakshadi Anjana Drops, a traditional Ayurvedic ocular formulation, is designed to alleviate eye-related conditions. Composed of herbal ingredients with therapeutic properties, this study aimed to evaluate t...
INTRODUCTION: Lakshadi Anjana Drops, a traditional Ayurvedic ocular formulation, is designed to alleviate eye-related conditions. Composed of herbal ingredients with therapeutic properties, this study aimed to evaluate the formulation's quality, safety, and efficacy through physico-chemical, microbiological, and preclinical analysis. METHODS: Formulation was analyzed for physico-chemical parameters such as pH, refractive index, peroxide value, saponification value, and iodine value. Preclinical testing was conducted using New Zealand white rabbits, where the Draize test was used to evaluate ocular safety and carrageenan-induced ocular inflammation model was employed to assess anti-inflammatory efficacy. Histopathological analysis of ocular tissues was performed to assess potential tissue damage. RESULTS: pH of Lakshadi Anjana Drops was found to be 7.82, confirming its suitability for ocular use. Physico-chemical parameters, including refractive index (1.4542), peroxide value (2.18 meq/kg), saponification value (210), and iodine value (38.49), were within acceptable limits, ensuring stability. Preclinical results indicated minimal ocular irritation and significant anti-inflammatory activity, comparable to a marketed formulation. Histopathological analysis showed minimal epithelial thickening, with no significant tissue damage. CONCLUSION: Lakshadi Anjana Drops exhibited strong physico-chemical stability, and biocompatibility, supporting its therapeutic potential for ocular applications. The combination of traditional Ayurvedic ingredients with modern scientific validation highlights its promise for clinical use in ocular therapeutics.
Innovations in Drug Delivery Systems for Biologics: Enhancing Stability and Targeted Delivery for Next-Generation Therapeutics.
Kumar P, Goel A, Dash B … +5 more , Rishishwar P, S J, Suryawanshi MV, Rishishwar S, Asokan N
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2025 Jan · PMID 39748757 · Publisher ↗
The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generatio...
The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generation therapeutics. The most recent developments in a variety of DDS, such as nanoparticles, microneedles, hydrogels, and biodegradable polymers, were examined in depth. Information from peer-audited diaries, clinical preliminaries, and mechanical reports were blended to survey the presentation of these frameworks concerning dependability, designated conveyance, patient consistence, and controlled discharge. A radar chart was used in a comparative analysis to show the advantages and disadvantages of each DDS. Utilizing cutting-edge DDS, our analysis revealed significant improvements in the stability and targeted delivery of biologics. Nanoparticles exhibited the most elevated precision in designated conveyance at 92% and showed a 85% improvement in soundness. With an 88% satisfaction rate and moderate improvements in other criteria, microneedles achieved the highest level of patient compliance. Biodegradable polymers provided a balanced enhancement across all criteria, with 88% improvements in stability, 87% improvements in targeted delivery, and 89% improvements in controlled release for hydrogels. Nanoparticles lost only 6% of their stability, microneedles lost 10% of their controlled release, hydrogels lost 7% of their stability, and biodegradable polymers lost 5% of their patient compliance across all of these systems. The stability and precise delivery of biologics have been significantly improved by advancements in drug delivery systems. Hydrogels and microneedles, on the other hand, provide advantages in controlled release and patient compliance. Biodegradable polymers and nanoparticles are promising for maintaining drug integrity and targeting particular sites. In order to overcome the limitations that exist currently and enhance the therapeutic outcomes of biologics, future research ought to concentrate on hybrid strategies that combine the advantages of multiple DDS.
Harnessing Pharmacogenomics for Personalized Medicine: Tailoring Drug Therapy to Genetic Profiles.
Kumar P, Goel A, Malik P … +3 more , Sirswal S, Rishishwar P, Rishishwar S
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Dec · PMID 39647853 · Publisher ↗
This study means to investigate the capability of pharmacogenetics which can customize drug treatment through altered treatment of male genetic profiles. We finished hereditary profiling utilizing cutting edge sequencing...
This study means to investigate the capability of pharmacogenetics which can customize drug treatment through altered treatment of male genetic profiles. We finished hereditary profiling utilizing cutting edge sequencing (NGS) to figure out the key hereditary varieties that impact the medications metabolic adequacy and security. Patients were checked for a very long time to evaluate clinical results including ADRs and general wellness. Hereditary assessment uncovered variations in enormous qualities, for example, CYP2C9 CYP2D6 ABCB1 VKORC1 and SLCO1B1 which assume significant parts in drug digestion and transport. These hereditary markers are related with clinical realities to evaluate their effect on drug reactions and unfriendly impacts. The outcomes recommend that customized treatment dependent exclusively upon hereditary profiles could prompt better treatment results. For instance, patients with VKORC1 changes answer better to anticoagulants and drain less while patients with SLCO1B1 transformations have statin-incited myopathy which is more expensive and requires portion changes. This mirrors the useful effect of altered treatment on wellness results. Pharmacogenomics gives a useful asset to customized medication to tailor drug medicines dependent exclusively upon a person's genetic profile.
Breakthrough Biomarkers in Lung Cancer: Pioneering Early Detection and Precision Treatment Strategies.
Tiwari R
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Nov · PMID 39566916 · Publisher ↗
There are several biological, genetic, and environmental variables that contribute to lung cancer, which is one of the main causes of cancer-related death globally. In addition to exposure to radon gas, air pollution, an...
There are several biological, genetic, and environmental variables that contribute to lung cancer, which is one of the main causes of cancer-related death globally. In addition to exposure to radon gas, air pollution, and occupational dangers like asbestos, smoking is a major risk factor because it releases carcinogens like nitrosamines and polycyclic aromatic hydrocarbons (PAHs) into the lungs. The risk of developing lung cancer is also influenced by genetic predispositions, such as variations in genes like EGFR, KRAS, and TP53. Additionally, new research emphasises how epigenetic changes, such as DNA methylation and histone acetylation, affect the expression of genes connected to the development of cancer. In determining risk and spotting early indicators of lung cancer, biomarkers have become important instruments. Cell-free DNA (cfDNA), circulating tumour cells (CTCs), and certain microRNAs (miRNAs) in blood are non-invasive biomarkers that indicate tumour heterogeneity and load. Molecular indicators include anaplastic lymphoma kinase (ALK) rearrangements, epidermal growth factor receptor (EGFR) mutations, and programmed death-ligand 1 (PD-L1) expression have proved very important in tailoring the therapy of lung cancer. Inflammatory indicators such as interleukins and C-reactive protein (CRP) are also linked to the prognosis of lung cancer. Finding and confirming these biomarkers is essential for improving early detection, tracking the course of the disease, and directing focused treatments. As research progresses, combining molecular, genetic, and environmental insights might improve lung cancer care, prevention, and early diagnosis, thereby lowering the disease's worldwide burden.
Exploring Computational Advancements in ADME: Essential Insights for Drug Disposition.
Johnson DB, Singh G, Sharma D … +6 more , Natarajan V, Lakshmi KC, Dhakar RC, Shahi SR, Velayutham S, Tiwari R
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Nov · PMID 39496312 · Publisher ↗
The physicochemical properties of the physiological makeup and the chemical componentof the system make this challenging throughout strenuous procedure. The current review concentrated on in silico modelling of drug disp...
The physicochemical properties of the physiological makeup and the chemical componentof the system make this challenging throughout strenuous procedure. The current review concentrated on in silico modelling of drug disposition, involving absorption process, distribution process, and excretion process and includes thorough knowledge of various database expeditions, the development of a pharmacophore model, molecular docking studies, homology modelling supported sequence similarity and quantitative structure-activity relationships (QSAR)/ quantitative structure-property relationships (QSPR) evaluation along with all information about drug movement and related computational tools for understanding potential chemical and pathophysiological changes. The primary development in ADMET modeling in current times has been the clarification of the function and effective modeling of various transporters. In ADMET modelling, there is still work to be done on including the impact of these transporters into existing models. The present state of modelling different elements of drug disposal at the systemic level will then be discussed, along with recent developments in modelling a wide range of active transporters and their effects on drug pharmacokinetic profiles. A more thorough knowledge of the underlying processes governing different aspects of drug disposition should also lead to an increase in mechanism-based modelling methods that are simple to grasp and put into practice. These developments will hasten the transition of model construction from computational to experimental scientists.
Oncogenetics: Unraveling the Genetic Underpinnings of Cancer for Improved Immunotherapeutic Outcomes.
Dwivedi S, R P, Sivakumar T … +3 more , Posa MK, Dhakar RC, Tiwari R
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Oct · PMID 39467652 · Publisher ↗
In this review article we will highlight the evidences that how oncogenes are formed due to the physical genetic variations in proto-oncogenes and tumor suppressor genes and various planned immunotherapies which will inc...
In this review article we will highlight the evidences that how oncogenes are formed due to the physical genetic variations in proto-oncogenes and tumor suppressor genes and various planned immunotherapies which will include- The immune checkpoint inhibitor-opposing antibodies, adoptive cell treatments, and biologic modifiers (cytokines and vaccines). We will make an effort to provide guidance and potential fixes for these issues, along with pertinent sources for foundational research. For suitable studies, a literature search was undertaken from various database sources such as PubMed, EMBASE, and Google Scholar. One type of gene known as an oncogene-a cellular gene that becomes dysfunctional owing to mutation and overexpression-is the cause of cancer. Certain oncogenes seem to inhibit the homeostatic mechanism by limiting the single cell lineage of leukemia stem cells. According to the clonal theory of oncogenes, tumors are thought to begin in a single cell, Moreover, the growth of tumors is closely linked to the prevention of apoptosis, or programmed cell death. These activities of oncogene can be minimized by some immunological therapies.
Recent Innovations and Future Perspectives in Transferosomes for Transdermal Drug Delivery in Therapeutic and Pharmacological Applications.
Patel S, Ismail Y, Singh S … +7 more , Rathi S, Shakya S, Patil SS, Bumrela S, Jain PC, Goswami P, Singh S
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Oct · PMID 39442957 · Publisher ↗
There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfor...
There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it can prevent untargeted drug delivery to tissues not intended for the treatment and buildup of localized drug concentrations. Transdermal delivery is hampered by a number of physicochemical characteristics of the skin, which have led to a great deal of research into ways to get over these barriers. The majority of transdermal medicines that have proved effective do so by using smaller lipophilic compounds, which have a molecular weight of a few 100 Daltons. Transferosomes have proven to be an effective method for transdermal distribution of a range of therapies, including hydrophilic actives, bigger molecules, peptides, proteins, and nucleic acids, in order to get around the medications' size and lipophilicity limits. Because of their flexible form and increased surface hydrophilicity, transferosomes are essential for the delivery of medicines and other solutes through and into the skin by exploiting hydration gradients a source of energy. As a result, the medication is released into the skin layers under regulated conditions and has improved overall penetration. In this section we outline the development of transferosomes from liposomes and solid lipid nanoparticles, as well as their subsequent advancements as commercially available dosage forms, physical-chemical characteristics, and cutaneous kinetics.
Antipsychotic Activity of Ethanolic Extracts of Crinum asiaticum and Crinum defixum in Animal Models.
Mishra P, Senapati AK, Swain SR … +2 more , Dash S, Kar S
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Oct · PMID 39428354 · Publisher ↗
The current study examined the antipsychotic properties of ethanolic extracts of Crinum asiaticum (EECA) and Crinum defixum (EECD). The effects of the extracts on rodents' ketamine-induced hyperactivity, amphetamine-indu...
The current study examined the antipsychotic properties of ethanolic extracts of Crinum asiaticum (EECA) and Crinum defixum (EECD). The effects of the extracts on rodents' ketamine-induced hyperactivity, amphetamine-induced stereotypy, forced swim test, conditioned avoidance response, and catalepsy were assessed. According to the findings, EECA and EECD both significantly outperformed typical antipsychotic medications in antipsychotic-like behaviours across a variety of behavioural paradigms. The extracts exhibited a 50-75% reduction in ketamine-induced hyperactivity, indicating a possible impact on glutamatergic signalling. Additionally, they greatly reduced amphetamine-induced stereotypy, suggesting a potential antagonistic interaction with the dopamine D2 receptor. Similar to haloperidol, EECD at 400 mg/kg dramatically decreased avoidance behaviour in the conditioned avoidance response test. Though less so than with haloperidol, both extracts caused catalepsy in rodents. The reversal of ketamine's effect in the forced swim test suggests that it may be effective in preventing psychosis's negative symptoms. Given that oxidative stress is a contributing factor to psychotic disorders, the antipsychotic effect of these extracts may be associated with their anti-inflammatory and antioxidant characteristics. These results bolster the long-standing usage of Crinum species in the treatment of mental illnesses and imply that they could be rich sources of new antipsychotic chemicals. To determine the active ingredients, clarify the mechanisms of action, and assess the safety and effectiveness of clinical trials, more study is necessary.
A Comparative Analysis of Generic Drug Assessment and Regulatory Approval in the USA, Europe and India.
Patel BD, Suthar SP, Mansuri AM … +1 more , Joshi VD
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Oct · PMID 39384543 · Publisher ↗
The Abbreviated New Drug Application (ANDA) is used for the regulatory submission of generic drugs, which are pharmaceutical equivalents to brand-name drugs and distributed without patent protection. Different countries...
The Abbreviated New Drug Application (ANDA) is used for the regulatory submission of generic drugs, which are pharmaceutical equivalents to brand-name drugs and distributed without patent protection. Different countries have their own regulatory requirements for the approval of generic drugs, enforced by authorities such as the CDSCO in India, EDQM in Europe, and USFDA in the United States. This review aims to compare the regulatory processes and requirements for generic drug approval in India, Europe, and the US, highlighting key differences and challenges. The involvement of regulatory authorities in the drug development process is crucial for expediting approval and addressing queries, helping to minimize delays. The Common Technical Document (CTD) format is employed across regions to harmonize submission requirements. This study underscores the differences in dossier submission for generics across the three regions, illustrating India's position in the global generic drug approval landscape. By comparing approval requirements, this work provides insight into the hurdles India must overcome to streamline its approval process. The ANDA allows generic manufacturers to submit bioequivalence studies, using the original innovator's safety and efficacy data. However, obtaining approval simultaneously from multiple regulatory authorities remains a challenging task. Careful review of regulatory documents by skilled personnel can reduce regulatory queries, ultimately accelerating the market launch of generic drugs. This review provides a comprehensive overview of the generic drug approval process, emphasizing the need for harmonization and improved efficiency in India's regulatory framework.
Mechanistic Insights into Tau Protein-Mediated Regulation of Oxidative Stress.
Sethi P, C RD, Borra R … +5 more , Vahora S, Vashi A, Mukherjee RK, Pavani B, Tiwari G
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Oct · PMID 39379150 · Publisher ↗
Abnormal hyperphosphorylation and microtubule-associated protein tau aggregation development in the brain are characteristics of neurodegenerative diseases referred to as tauopathies, which include Alzheimer's disease (A...
Abnormal hyperphosphorylation and microtubule-associated protein tau aggregation development in the brain are characteristics of neurodegenerative diseases referred to as tauopathies, which include Alzheimer's disease (AD). The current review summarizes the complex relationships that exist between oxidative stress and tau illness, with particular attention to the roles played by the tau protein, reactive oxygen species and their consequences, and tau phosphorylation and oxidative stress. Two key elements of detrimental cycle that are critical in neurodegenerative tauopathies are tau hyperphosphorylation and oxidative stress. When tau and microtubules are not connected properly, microtubule instability, issues with microtubule transport, and ultimately neuronal death result. While the causes of the more prevalent sporadic late-onset variants and the connections between tau hyperphosphorylation and neurodegeneration remain largely unknown, mutations in the microtubule-associated protein tau (MAPT) gene have been identified in familial cases of early-onset tauopathies. Another detrimental feature of tauopathies is oxidative stress, but the exact role it plays in the development of the disease is unclear. The source of reactive oxygen species (ROS), which lead to oxidative stress within neural tissue, remains an unresolved topic. Although mitochondria have historically been thought to be a primary source of oxidative stress, microglial cells have recently been discovered to create reactive oxygen species in tauopathies. In conclusion, enhancing our comprehension of the impact of oxidative stress on various diseases could facilitate the identification of new disease markers and lead to the formulation of treatment strategies aimed at halting, reversing, or mitigating disease progression.
In Vitro Cytotoxicity and Pharmacokinetic Study for Bosutinib Solid Lipid Nanoparticles.
Nagaiah B, Nirmala S
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Sep · PMID 39341725 · Publisher ↗
OBJECTIVE: Bosutinib (BST) is a Biopharmaceutics Classification System Class II drug having very low solubility and high permeability. Low aqueous solubility and poor dissolution of BST lead to poor bioavailability, Thus...
OBJECTIVE: Bosutinib (BST) is a Biopharmaceutics Classification System Class II drug having very low solubility and high permeability. Low aqueous solubility and poor dissolution of BST lead to poor bioavailability, Thus, limited aqueous solubility is the bottleneck for the therapeutic outcome of BST. Animal data suggest that the absolute bioavailability of BST is about 14-34% due to an extensive first-pass effect. To overcome hepatic first-pass metabolism and to enhance oral bioavailability, lipid-based drug delivery systems such as solid lipid nanoparticles (SLNs) can be used. METHODS: SLNs are submicron colloidal carriers having a size range of 50-1000 nm. These are prepared with physiological lipid and dispersed in water or aqueous surfactant solution. BST can be conveniently loaded into SLNs to improve the oral bioavailability by exploiting the intestinal lymphatic transport. An optimal system was evaluated for bioavailability study in rats compared with that of BST suspension (SUS). RESULTS: An in vitro cytotoxicity study was done by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay method through ATCC cell lines; the percent inhibition was more in SLN when compared with SUS. The pharmacokinetics of BST-SLNs after oral administration in male Wistar rats was studied. The bioavailability of BST was increased by 2.28 fold when compared with that of a BST SUS. CONCLUSION: The results are indicative of SLNs as suitable lipid-based carrier system for improving the oral bioavailability of BST.
Unveiling the Therapeutic Potential and Conservation Strategies for Rare and Endangered Medicinal Plants in Traditional Chinese Medicine: A Comprehensive Review.
Rastogi S, Verma R, Raju R … +5 more , Narayanan V, Mundada PA, Maheshwari R, Pandhare Y, Tiwari R
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Sep · PMID 39245564 · Publisher ↗
INTRODUCTION: Incorporating rare and threatened healing plants from Traditional Chinese Medicine (TCM) into modern medicine is a hopeful way to expand treatment choices and encourage the long-term use of plant resources....
INTRODUCTION: Incorporating rare and threatened healing plants from Traditional Chinese Medicine (TCM) into modern medicine is a hopeful way to expand treatment choices and encourage the long-term use of plant resources. These plants have been used in Traditional Chinese Medicine for a long time. They have powerful healing properties, including the ability to reduce inflammation and fight cancer. They also protect nerves and the heart. METHOD: A thorough study of all the scientific studies, clinical trials, ethnobotanical surveys, and conservation reports that were found were all looked at in relation to rare and threatened medical plants used in TCM. We looked through databases like PubMed, Scopus, and Web of Science for relevant pieces. Studies published in peer-reviewed journals, reports from reputable conservation organisations, and written down traditional knowledge were all considered to be relevant. RESULTS: Key results show that plants like Dendrobium, Panax notoginseng, Taxus chinensis, and Cistanche deserticola can be used as medicines and that there are good ways to protect them. Some of the conservation methods that have been named are agroforestry, community-based management, current breeding techniques, and sustainable gathering. Collaboration in research, clinical trials, personalised medicine, regulatory harmonisation, and public education programs are all part of the integration with modern medicine. These programs try to solve problems like scientific proof, protection, and cultural integration. CONCLUSION: When rare and threatened medical plants from Traditional Chinese Medicine (TCM) are used in modern medicine, it can improve health and help protect wildlife. Using both old information and new science discoveries together can lead to new treatments and long-term uses for these plant materials. Large-scale clinical studies, new ways of growing plants, and looking into how TCM herbs and regular drugs can work together should be the main topics of future study. For global healthcare to improve and for these important plant resources to be used in the long term, academics, healthcare workers, lawmakers, and local communities must work together.
Design and Development of Propranolol HCl Fast Dissolving Tablets by Using Isolated Mucilage of Salvia Hispanica for the Treatment of Hypertension by Using DoE tools.
J N, Anandhi B, Patnaik SS … +6 more , Shirole RL, Mourya ND, Siddiqui N, Mathew J, Ravikkumar VR, Karthikeyan E
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39210543 · Publisher ↗
The main issue with Hypertension therapy is quick commencement of effect. The creation of suitable dose forms may help address the issue of medications having a delayed beginning of effect. Oral Antihypertensive medicati...
The main issue with Hypertension therapy is quick commencement of effect. The creation of suitable dose forms may help address the issue of medications having a delayed beginning of effect. Oral Antihypertensive medication treatment is best suited for and has seen a rise in popularity with fast-disintegrating tablets. In terms of patient compliance, quick start of action, precise dosage, strong chemical stability, ease of self-administration, and compactness, they are superior to other traditional methods. As a popular hypertension medication, Propranolol HCl is a strong candidate for development into Fast Dissolving Tablets (FDTs). Because to first pass metabolism, it has a limited bioavailability. Therefore, the primary goal of the research was to create Propranolol HCl fast-dissolving tablets in order to increase the drug's bioavailability and dissolution rate. Microcrystalline cellulose used to make fast-dissolving Propranolol HCl tablets, together with varying concentrations of super disintegrates such as Chia Seed mucilage and sodium starch glycolate. Each batch was made by compressing it directly. Three formulation variables were combined, and the combined impact was examined using a 23 Full Factorial design. Here, the disintegration time is examined as a dependent parameter and the concentrations of chia seed mucilage, Sodium Starch Glycolate, and Microcrystalline Cellulose were considered as independent variables, X1, X2, and X3, respectively. The program Design Expert is used to depict the data.
Preparation of Allium Cepa Peel Extract-mediated Silver Nanoparticles: A Hair Dye Formulation.
Rama B, K S, Sudhamani K … +4 more , Dhule SM, Rani LJ, Rajkamal B, Nagalaxmi V
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39191638 · Publisher ↗
The burgeoning field of nanotechnology has ushered in innovative Novel drug delivery systems (NDDS) that enhance the efficacy, safety, and patient compliance of pharmaceutical treatments. This study explores the synthesi...
The burgeoning field of nanotechnology has ushered in innovative Novel drug delivery systems (NDDS) that enhance the efficacy, safety, and patient compliance of pharmaceutical treatments. This study explores the synthesis and application of silver nanoparticles (AgNPs) using green chemistry approaches, specifically leveraging plant extracts as reducing agents. AgNPs, known for their unique physical and chemical properties, including antimicrobial capabilities, offer significant potential in modern drug delivery. This study investigates the potential of using Allium cepa peel waste for the green synthesis of silver nanoparticles. This study also revealed the resultant formation of silver nanoparticles through microscopy and UV spectroscopy, which were further analyzed by Scanning Electron Microscopy. This green synthesis method not only aligns with environmentally friendly practices but also provides a cost-effective and scalable approach to nanoparticle production. We formulated a hair dye incorporating these AgNPs and evaluated its physicochemical parameters, demonstrating enhanced performance compared to control formulations without nanoparticles. This work underscores the promise of green-synthesized nanoparticles in developing advanced drug delivery systems, offering insights into future applications in anticancer and antimicrobial treatments. Our findings advocate for the broader adoption of sustainable nanotechnology in pharmaceutical sciences, potentially revolutionizing the treatment landscape with safer and more effective therapeutic options.
Design and Characterization of Fast-Dissolving Oral Film of Apixaban.
Sagili SP, Deepika PP, Pavuluri E … +4 more , Bai NJL, Priyadarshini KS, Kumar MS, Ramu B
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39191637 · Publisher ↗
BACKGROUND: Following the COVID-19 pandemic, microvascular and macrovascular thrombotic problems emerged that required anticoagulants. Apixaban (RN) is a factor Xa inhibitor that treats deep vein thrombosis and the two f...
BACKGROUND: Following the COVID-19 pandemic, microvascular and macrovascular thrombotic problems emerged that required anticoagulants. Apixaban (RN) is a factor Xa inhibitor that treats deep vein thrombosis and the two forms of artery diseases (coronary artery disease and peripheral artery disease). MATERIALS AND METHODS: The study objective was to create fast-disintegrating Apixaban Oral Thin Films (OTF) with the help of various super disintegrants to shorten disintegration time and enhance drug release in order to assist patients who have difficulty in swallowing conventional dosage forms and increase bioavailability. OTF was created using the solvent casting method. A 22 factorial design was employed in Design-Expert® software to develop an ideal formula. RESULTS: The optimized film formula pH, drug content, disintegration time, folding endurance, and dissolution rate were estimated, and the film was subjected to a short-term stability study. The optimized formula exhibited a cumulative drug release of 93.47% in 60 sec. CONCLUSION: The drug's in vitro release pattern shows first-order kinetics and fickian diffusion was the mechanism of drug release. These findings supported that Apixaban OTFs offer a quick release of the medication from the administration site into the systemic circulation.
Evaluation of Antidepresant Activity and Phytochemical Screening of Plant Cordia Dichotoma.
Sudan P, Jallepalli VR, Ramu B … +4 more , Bhongiri B, Kumar SDS, Kumar MS, Kumar VR
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39187399 · Publisher ↗
INTRODUCTION: The traditional medicinal system of India, Ayurveda, has mentioned Cordia Dichotoma as a potential treatment for various ailments. In the current research, the extracts of Cordia Dichotoma was examined to e...
INTRODUCTION: The traditional medicinal system of India, Ayurveda, has mentioned Cordia Dichotoma as a potential treatment for various ailments. In the current research, the extracts of Cordia Dichotoma was examined to evaluate their antidepressant potential. MATERIALS AND METHODS: Here, green leaves of Cordia Dichotoma were used to prepare chloroform, ethanol, and aqueous extracts (referred to as CdCe, CdEe, and CdAe respectively). The research focused on investigating the antidepressant effects of these extracts using behavioral models in experimental animals. Additionally, locomotor activity was assessed as part of the evaluation process. RESULTS: Immobility time was reduced with CdEe Cordia Dichotoma rFST & mTST when at 200 mg/kg and 400 mg/kg body weight. The CdAe showed reduction in immobility time in the repeated rFST) at 400 mg/kg, while in the mTST, significant effects were observed at 200 and 400 mg/kg. Regarding the chloroform extract, it only exhibited a significant reduction in immobility time in the modified Tail Suspension Test (mTST) at a low dose of 200 mg/kg. However, no noticeable change in motor dysfunction was observed with CCl4 and aqueous extracts at doses of 200 and 400 mg/kg. It is worth noting that the chloroform extract (CdCe) did lead to a significant decrease in locomotor activity at the same dosage level. Taken together, these findings suggest that extracts obtained from Cordia Dichotoma leaves may possess antidepressant properties.
Method Development and Validation of Lorlatinib by RP-HPLC.
Illendula S, Sharma S
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39160080 · Publisher ↗
A simple, Accurate, precise method was developed for the estimation of the Lorlatinib in API form and Marketed pharmaceutical dosage form by RP-HPLC. Chromatogram was run through Hypersil C18 (4.6mm×150mm, 5µm) Particle...
A simple, Accurate, precise method was developed for the estimation of the Lorlatinib in API form and Marketed pharmaceutical dosage form by RP-HPLC. Chromatogram was run through Hypersil C18 (4.6mm×150mm, 5µm) Particle size Column and Mobile phase containing Methanol and Water taken in the ratio of 25: 75% v/v was pumped through column at a flow rate of 1.0 ml/min. Temperature was maintained at 38ºC. Optimized wavelength selected was 310 nm. Retention times of Lorlatinib were found to be 3.513 minutes respectively. The %RSD for the Repeatability and Intermediate Precision of the Lorlatinib were found to be within limits. %Recovery was obtained 98.96% and it was found to be within the limits for Lorlatinib respectively. The LOD, LOQ values obtained from regression equations of Lorlatinib were 0.332µg/ml and 1.0078 µg/ml respectively. Regression equation of Lorlatinib was found to be y = 39948x + 16821 respectively. The Retention times was decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
Statistical Design Approach for the Formulation And Optimization of Nanosponges Using Poorly Water-soluble Candidate.
Verma R, Sethi P, Rastogi S … +5 more , Mundhe VS, Ks R, Mishra S, Bhurat MR, Samathoti P
Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2024 Aug · PMID 39147577 · Publisher ↗
BACKGROUND AND OBJECTIVES: Nanosponges are one of the most innovative ways to use the newest developments in nanodrugs delivery. Nanosponges can catch drugs that dissolve in water or ones that don't. This work uses stati...
BACKGROUND AND OBJECTIVES: Nanosponges are one of the most innovative ways to use the newest developments in nanodrugs delivery. Nanosponges can catch drugs that dissolve in water or ones that don't. This work uses statistical design to find the best nanosponges for drugs that don't dissolve easily and make them. MATERIAL AND METHODS: It was looked into how to statistically make the most of the effects of independent factors. The ethyl cellulose ratio and stirring rate were chosen based on how they affected the dependent variables, such as particle size and how well they were trapped. FTIR, SEM, zeta potential, entrapment efficiency, and particle size data were used to test the nanosponges that were made. Using carbopol, the best lot of nanosponges was added to the gel. RESULTS: Using ethyl cellulose and polyvinyl alcohol as stabilizers in the emulsion liquid diffusion method, it was possible to make drug-loaded nanosponges. It was possible to make the nanosponges composition work better by using Central Composite Design. It has been seen that making drug-filled nanosponges improves stability. CONCLUSION: The study showcased the enhanced capacity of a formulation with decreased particle size and high entrapment efficiency to disseminate effectively.
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