Colloids And Surfaces. B, Biointerfaces[JOURNAL]
Sun
200 papers
Janus nanofiber membrane integrates exudate management and immunomodulation for enhanced diabetic wound healing.
Ren Q, Gong C, Zhang S … +3 more , Song X, Wang D, Le W
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42235200 · Publisher ↗
Diabetic foot ulcers (DFUs) often experience delayed healing due to factors such as excessive exudate, neuropathy, immune dysregulation, along with ongoing infection, creating substantial hurdles for clinical treatment....
Diabetic foot ulcers (DFUs) often experience delayed healing due to factors such as excessive exudate, neuropathy, immune dysregulation, along with ongoing infection, creating substantial hurdles for clinical treatment. Currently, therapeutic protocols for DFUs are mainly directed at mitigating inflammation reactions or fostering angiogenesis, whereas comparatively limited focus has been given to promoting nerve regeneration. To address this gap, we propose a Janus-structured nanofiber membrane (PCL/PAN-xCur) that not only enables automatic exudate management but also exhibits light-enhanced antibacterial properties. Additionally, the loaded curcumin (Cur) can modulate the immune microenvironment by reestablishing macrophage phenotype and eliminating excess reactive oxygen species. In the infected diabetic mice models, application of this nanofiber membrane effectively facilitates nerve regeneration and enhances the immune microenvironment, thus accelerating wound healing. Overall, this multifunctional nanofiber membrane demonstrates significant therapeutic potential for tissue repair by precisely regulating the neuro-immune microenvironment.
Hierarchical polymer-drug nanoplatform with polydopamine shell and folate targeting for synergistic cancer therapy.
Nita LE, Serban AM, Ghilan A … +4 more , Rusu AG, Nacu I, Verestiuc L, Chiriac AP
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42235199 · Publisher ↗
The clinical performance of paclitaxel (PTX) remains limited by poor tumor selectivity, systemic toxicity, and rapid clearance. In this study, we report the development of multifunctional polymeric nanoemulsions based on...
The clinical performance of paclitaxel (PTX) remains limited by poor tumor selectivity, systemic toxicity, and rapid clearance. In this study, we report the development of multifunctional polymeric nanoemulsions based on poly(ethylene brassylate-co-squaric acid) (PEBSA_Brij) designed for targeted and controlled anticancer delivery. The copolymer matrix integrates hydrophobic domains for PTX encapsulation and polar squaric acid moieties to enhance intermolecular interactions and structural tunability. Surface functionalization with polydopamine (PDA) enabled subsequent folic acid (FA) conjugation, aiming to promote receptor-mediated uptake in folate receptor-overexpressing breast cancer cells. Nanoemulsions with controlled size (170-181 nm), low polydispersity, and good colloidal stability were successfully obtained. Spectroscopic analyses confirmed polymer-drug interactions and surface modification. Antioxidant evaluation demonstrated radical scavenging capacity associated with the PDA layer, while loading of PTX enabled therapeutic potential. Biological evaluation on MCF-7 cells revealed enhanced cytotoxicity for FA-functionalized PTX-loaded nanoemulsions compared to non-targeted formulations, suggesting improved cellular internalization. At 24 h, PEBSA/PDA/FA/PTX (25/75) demonstrated the most rapid onset of cytotoxicity, with cell viability decreasing to approximately 90% at 5 mg/mL. The developed platform combines structural versatility, targeting capability, and dual-drug loading potential, highlighting PEBSA-based nanoemulsions as promising candidates for advanced breast cancer nanotherapy.
Multifunctional self-assembled nanoparticles loaded into immunomodulatory microneedles for synergistic therapy of psoriasis.
Zhang Y, Qu J, Zhang C … +5 more , Wang J, Zhang Y, XianyiSha, Feng N, Guo T
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42235198 · Publisher ↗
Psoriasis is an immune-mediated inflammatory skin disease that currently lacks safe and effective transdermal therapies capable of multi-target action. In this study, hyaluronic acid (HA) and glycyrrhetinic acid (GA) wer...
Psoriasis is an immune-mediated inflammatory skin disease that currently lacks safe and effective transdermal therapies capable of multi-target action. In this study, hyaluronic acid (HA) and glycyrrhetinic acid (GA) were separately conjugated to D-alpha tocopherol acid polyethylene glycol succinate (TPGS), which subsequently self-assembled into nanoparticles (HA/GA-NPs). Bletilla striata polysaccharide (BSP) and HA were employed as the microneedle matrix to fabricate soluble microneedles incorporating the nanoparticles (HA/GA-NPs-MNs). This strategy combined the CD44-targeting capability and anti-inflammatory activity of the nanoparticles with the immunomodulatory function and efficient penetration-enhancing ability of the BSP-based microneedles, thereby achieving synergistic therapeutic effects against psoriasis. In vitro studies demonstrated that the CD44-targeting capability of HA/GA-NPs enhanced cellular uptake, reduced intracellular ROS expression, and suppressed the inflammatory proliferation of HaCaT cells. Concurrently, BSP and HA/GA-NPs synergistically promote M2 polarization in RAW264.7 cells while suppressing the production of NO and proinflammatory factors IL-6, TNF-α, and IL-1β. Furthermore, HA/GA-NPs-MNs enhanced drug accumulation and skin penetration, enabling efficient delivery into the deeper skin layers. During in vivo studies, the system was observed to significantly enhance immune regulation and demonstrated the strongest efficacy in suppressing psoriatic inflammatory infiltration. The primary therapeutic mechanism of HA/GA-NPs-MNs against psoriasis involved the blockade of STAT3 phosphorylation to inhibit IL-23 signaling and downstream IL-17 release. The biosafety assessment confirmed high dermal and hemocompatibility of the system. This work presented a novel integrated platform of multifunctional self-assembled nanoparticles and immunomodulatory microneedles for the topical treatment of psoriasis.
Multifunctional copper complex-mediated self-blocking plasmid delivery of PD-L1 for tumor chemoimmunotherapy.
Xu J, Huang X, Fang Z … +4 more , Li S, Song M, Zhang M, Liu K
Colloids Surf B Biointerfaces · 2026 May · PMID 42235197 · Publisher ↗
Copper-based therapeutics can induce the immunogenic death of tumor cells and promote activation of the tumor immune microenvironment, thereby exerting a synergistic effect with PD-1/PD-L1 blockade and enhancing the anti...
Copper-based therapeutics can induce the immunogenic death of tumor cells and promote activation of the tumor immune microenvironment, thereby exerting a synergistic effect with PD-1/PD-L1 blockade and enhancing the antitumor immune response. However, adaptive DNA damage repair and inefficient tumor-specific delivery remain major obstacles limiting their therapeutic efficacy. Herein, we developed a homologous tumor cell membrane-camouflaged biomimetic nanoplatform, in which polyethyleneimine (PEI) and Olaparib (Ola) were assembled to construct the nanoparticle framework, enabling Cu²⁺ coordination and pPD-L1 trap plasmid condensation, while conjugation of R15 peptides facilitated nuclear-targeted delivery. The biomimetic nanoplatform utilized homologous tumor cell membrane camouflage to achieve prolonged blood circulation and tumor-targeted delivery in vivo, followed by R15 peptide-guided nuclear translocation, while intracellular Cu²⁺ ions and Ola functioned as Fenton-like reaction inducers and DNA damage aggravators, respectively, thereby enhancing tumor immunogenicity, remodeling the immunosuppressive tumor microenvironment, and synergizing with PD-L1 trap proteins to amplify antitumor immune responses. Collectively, this biomimetic drug delivery system achieved targeted co-delivery of three therapeutic components, effectively exerted their synergistic antitumor effects, and provided a promising strategy for combined chemotherapy and immunotherapy against tumors.
Ultraelastic adaptive Bletilla striata polysaccharide hydrogel bandage for rapid sealing, hemostasis and infection-resistant healing.
Qiao Y, Zhu X, Liu C … +9 more , Cheng Y, Zhu Y, Li Z, Zhang C, Shao B, Guo H, Xu D, Ge S, Yang N
Colloids Surf B Biointerfaces · 2026 May · PMID 42229333 · Publisher ↗
Uncontrolled bleeding and unstable sealing of irregular, dynamic wounds remain a major clinical challenge, particularly in emergency trauma, surgery, and organ injuries. Herein, this work incorporated the active substanc...
Uncontrolled bleeding and unstable sealing of irregular, dynamic wounds remain a major clinical challenge, particularly in emergency trauma, surgery, and organ injuries. Herein, this work incorporated the active substance Bletilla striata polysaccharide (BSP) into a multi-network system composed of polyethyleneimine (PEI), carboxymethyl chitosan (CMCS), and polyacrylamide (PAAm) to construct a self-sealing living hydrogel bandage (CAP@BSP-H). Benefiting from the electrostatic-hydrophobic synergy and a dynamic hydrogen-bond network, the hydrogel exhibits strong wet adhesion (94.55 kPa) and ultrahigh stretchability (>2000%), enabling the hydrogel bandage to achieve rapid self-sealing (approximately 10 s) and synchronous deformation with the wound surface. It features a unique dual hemostatic mechanism, combining physical sealing with BSP-mediated biological coagulation, which achieved a ∼94.8% reduction in blood loss (1.67 mg) and a ∼96.3% shortening of hemostasis time (3.5 s) in a mouse liver hemorrhage model. Furthermore, CAP@BSP-H demonstrates potent antibacterial and antioxidant activities, promotes angiogenesis, and achieved a 98.57% wound closure rate within 14 days in a rat infected wound model. In summary, this CAP@BSP-H bandage achieves autonomous self-sealing, synchronized deformation, and rapid hemostasis on dynamically moving wound surfaces, which shows great potential for clinical applications in emergency hemostasis, complex trauma, and infected wound care.
3D-printed skeletal tissue analogues using bone decellularized extracellular Matrix with PCL-bioglass composite: A biomimetic approach.
Das S, Rahaman SH, Saha B … +7 more , Vaidya PV, Dogra N, Panda K, Bagde A, Fulzele P, Zahiruddin Q, Dhara S
Colloids Surf B Biointerfaces · 2026 May · PMID 42229332 · Publisher ↗
Skeletal tissue injuries and defects remain a major clinical challenge due to the limited regenerative capacity of bone with critical-sized defects and limitations in current grafting methods. Bone-derived decellularized...
Skeletal tissue injuries and defects remain a major clinical challenge due to the limited regenerative capacity of bone with critical-sized defects and limitations in current grafting methods. Bone-derived decellularized matrix (dECM) offers a bioactive composition with growth factors that closely replicate the native tissue analogues. dECM functions as bioactive scaffold that can replicate the native extracellular matrix for promoting effective tissue repair. In this study, dECM was processed into a printable bioink along with PCL and bioglass to fabricate a three-dimensional scaffold using extrusion-based printing. The scaffold showed a well-connected porous structure, good structural stability, and mechanical strength, appropriate for applications in skeletal tissue engineering. In vitro evaluation demonstrated favorable cell adhesion, proliferation, and osteogenic differentiation, while in vivo implantation indicated enhanced tissue integration. Thereby, CT data-guided 3D printing of personalized scaffolds could be an interesting approach with promise of advanced therapeutic alternatives by reverse engineering tools.
Mn-based redox homeostasis disruptor for photothermal-enhanced chemodynamic synergistic therapy.
Wu X, Qiu M, Liu X … +3 more , Xu Q, Zhang L, Chen S
Colloids Surf B Biointerfaces · 2026 May · PMID 42229331 · Publisher ↗
Breaking the redox homeostasis of tumor microenvironment (TME) and reshaping it sustainably remain major challenges in chemodynamic therapy (CDT) of tumors. The low concentration of HO and metal ions (Fe, Mn, Co, Cu), in...
Breaking the redox homeostasis of tumor microenvironment (TME) and reshaping it sustainably remain major challenges in chemodynamic therapy (CDT) of tumors. The low concentration of HO and metal ions (Fe, Mn, Co, Cu), insufficient tumor acidity, and overexpressed glutathione (GSH) in the tumor region severely limit the CDT effect. Herein, a Mn-doped mesoporous polydopamine nanoparticle modified with glucose oxidase (GOx) and hyaluronic acid (HA) (Mn-PDA-GOx@HA, MDGH) was constructed. Under near-infrared (NIR) light irradiation, the excellent photothermal conversion efficiency (55.2%) of MDGH was utilized to induce a rapid increase in temperature of the tumor site, resulting in the highly efficiency Mn-mediated Fenton-like reaction and the generation of reactive oxygen species (ROS). Besides, the overexpressed GSH could be consumed by high-valence Mn ions, enhancing the damage of ROS to tumor cells, and ultimately achieving superior anti-tumor PTT-CDT effects (95.95% tumor inhibition rate). The MDGH exhibited superior H T-weighted magnetic resonance imaging (MRI) enhancement with a longitudinal relaxivity (r) value of 7.01 mM s at 9.4 T, which is 1.7 times that of the commercial Gd-DTPA. In vivoH T-weighted MRI results showed 43.8% enhancement of tumor signal intensity post i.v. injection of MDGH. This platform enhances the therapeutic efficacy of synergistic CDT-PTT by the release of Mn ions, self-supplying HO, and blocking nutrition supplies, providing a significant and promising strategy to develop more effective and practical treatment for tumors.
P-SElectin-targeting Fucoidan Nanoparticles Enable Combined NAC delivery and neutrophil recruitment blockade in acetaminophen-induced liver injury.
Luo H, Ling X, Guan X … +9 more , Hu Y, Liu T, Ma L, Dong Z, Li J, Li M, Guo R, Liu J, He Q
Colloids Surf B Biointerfaces · 2026 May · PMID 42229330 · Publisher ↗
N-Acetylcysteine (NAC) is the only approved antidote for acetaminophen-induced liver injury (AILI), but its clinical benefit is largely restricted to the early stage of disease. In delayed-treatment AILI, massive neutrop...
N-Acetylcysteine (NAC) is the only approved antidote for acetaminophen-induced liver injury (AILI), but its clinical benefit is largely restricted to the early stage of disease. In delayed-treatment AILI, massive neutrophil infiltration further aggravates liver damage, highlighting the need for therapeutic strategies that not only scavenge oxidative stress but also regulate inflammatory cell recruitment. Herein, we developed fucoidan-based NAC-loaded nanoparticles (NAC-FD NPs) to target P-selectin overexpressed on inflamed vascular endothelial cells. Through fucoidan-P-selectin interactions at the inflammatory vascular biointerface, NAC-FD NPs selectively accumulated at injured hepatic sites and enabled localized NAC delivery. More importantly, occupation of P-selectin binding sites competitively disrupted the PSGL-1/P-selectin-mediated adhesion cascade, thereby inhibiting neutrophil adhesion to endothelial cells and subsequent transendothelial migration. In a murine model of delayed-treatment AILI, NAC-FD NPs markedly reduced neutrophil accumulation in injured liver tissue and achieved significant therapeutic efficacy. By integrating the antioxidant activity of NAC with biointerface-mediated blockade of neutrophil recruitment, this nanoplatform simultaneously suppressed pathogenic events involved in both the early and late stages of AILI progression. These findings provide a promising biointerface-oriented strategy for the treatment of delayed-treatment AILI and broaden the therapeutic potential of targeted nanomedicine for inflammatory liver injury.
Gelatin methacryloyl hydrogel with post-injection magnetic alignment: Structural modulation and protein-cell interactions.
Bae G, Muthuramalingam K, Lee HJ … +1 more , Koh WG
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42229329 · Publisher ↗
Gelatin methacryloyl (GelMA), a photocrosslinkable derivative of collagen-derived gelatin, retains inherent bioactive motifs including RGD sequences for cell adhesion and matrix metalloproteinase-sensitive domains for en...
Gelatin methacryloyl (GelMA), a photocrosslinkable derivative of collagen-derived gelatin, retains inherent bioactive motifs including RGD sequences for cell adhesion and matrix metalloproteinase-sensitive domains for enzymatic remodeling. However, conventional GelMA hydrogels exhibit isotropic architectures that fail to recapitulate the anisotropic organization of native tissues. Here, we report a strategy to introduce controlled fibril alignment and structural organization into injectable GelMA hydrogels through post-injection magnetic alignment of embedded polycaprolactone (PCL) microfibrils containing magnetic nanoparticles (MNPs). This approach enables fibril orientation within 30 s under external magnetic field, followed by UV crosslinking to preserve the aligned architecture without compromising the protein-based matrix integrity. Aligned architectures exhibited enhanced compressive modulus (∼11 kPa at 0.1% fibril content) comparable to random configurations with tenfold higher loadings, demonstrating that structural organization outweighs material quantity in determining bulk stiffness. In C2C12 myoblast cultures within the GelMA matrix, fibril alignment promoted cell elongation and moderate directional organization, though responses remained heterogeneous. Interestingly, while mechanical reinforcement was evident at the lowest fibril content, significant upregulation of MyoD occurred only at ≥ 0.5%, suggesting that cellular responses to the protein-based matrix depend on cell-fibril contact frequency rather than bulk mechanics alone. These findings suggest that structural modulation of gelatin-based biopolymer hydrogels can influence bulk compressive stiffness and early protein-cell interactions, providing insights into structure-function relationships in aligned biopolymer systems.
Electrospinning preparation of poly (L-lactic acid)/collagen/nano-hydroxyapatite nanocomposite fibrous membrane for hemostatic application.
Long X, Zhang L, Liu J … +2 more , Wei X, Han Y
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42229328 · Publisher ↗
Uncontrolled hemorrhage remains a main reason of mortality in trauma. The safe and effective hemostatic materials are therefore crucial for rapid blood loss control. Herein, an organic-inorganic nanocomposite fibrous mem...
Uncontrolled hemorrhage remains a main reason of mortality in trauma. The safe and effective hemostatic materials are therefore crucial for rapid blood loss control. Herein, an organic-inorganic nanocomposite fibrous membrane composed of poly (L-lactic acid) (PLLA), collagen (Col), and nano-hydroxyapatite (n-HAP) was fabricated via electrospinning for hemostatic applications. PLLA acted as mechanical support, and Col and n-HAP were incorporated as active hemostatic agents. The PLLA100/Col40/n-HAP30 (PC40H30, W:W:W=100:40:30) hemostatic membrane exhibited excellent properties in hydrophilicity (wetting within 0.5 s) and water absorption capacity (1056 ± 19% within 5 min), enabling rapid blood absorption and concentration of coagulation factors from blood to accelerate hemostasis. The PC40H30 membrane exhibited a blood clotting index, hemostasis time, and blood loss of 4.2 ± 0.3%, 36.3 ± 3.5 s, and 112.0 ± 8.7 mg, respectively, which were significantly lower than those of medical gauze (68.3 ± 3.2%, 100.0 ± 8.2 s, 598.9 ± 24.5 mg) and collagen sponge (37.4 ± 1.2%, 52.0 ± 3.0 s, 194.7 ± 16.0 mg). The adhesion of red blood cells and platelets was significantly promoted on nanocomposite fibrous membrane; moreover, Col played a role in activating platelet, and the released Ca from n-HAP could activate the coagulation cascade. Hence, owing to its superior properties, the nanocomposite fibrous membrane holds high potential for clinical hemostatic applications.
Co-dispersion-mediated stabilization of a poorly soluble palmitoylation inhibitor within an alginate hydrogel for localized ferroptosis therapy.
Shen L, Zhang H, Li Y … +9 more , Duan J, Tang B, Qu Y, Zhou S, Huang Z, Luo Z, Chen M, Dong X, Li K
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42229327 · Publisher ↗
Stabilizing high-loadings of hydrophobic small molecules in aqueous systems remains challenging due to crystallization and phase separation, which limit their therapeutic application. Here, we report a co-dispersion-medi...
Stabilizing high-loadings of hydrophobic small molecules in aqueous systems remains challenging due to crystallization and phase separation, which limit their therapeutic application. Here, we report a co-dispersion-mediated interfacial stabilization strategy that enables high-loading delivery of the poorly soluble palmitoylation inhibitor 2-bromopalmitic acid (2-BP) within an injectable alginate hydrogel system. Through high-shear co-dispersion with Fe₃O₄ nanoparticles, 2-BP undergoes amorphization and is stabilized in a uniformly dispersed state via interfacial interactions and spatial confinement within the hydrogel network, effectively suppressing crystallization and supporting stable dispersed loading under high-concentration conditions. The resulting hydrogel exhibits pH-responsive and coordinated release of 2-BP and Fe²⁺ under mildly acidic tumor conditions, supporting sustained local drug exposure. Functionally, the co-delivery system significantly enhances oxidative stress and tumor suppression both in vitro and in vivo. Mechanistically, these effects are associated with disruption of redox homeostasis and downregulation of the SLC7A11-GPX4 antioxidant axis, thereby promoting ferroptosis. Collectively, this work establishes a co-dispersion-based formulation strategy for achieving high-loading and stable delivery of poorly soluble small-molecule drugs, providing a generalizable strategy for stabilizing poorly soluble hydrophobic drugs under high-loading conditions.
Colon-targeted mucin/cyclosporine A co-loaded microspheres synergistically ameliorate ulcerative colitis via immunosuppression and mucosal barrier repair.
Qian L, Wang Y, Yang Y … +7 more , Fan W, Gao X, Han Q, Zhang W, Lv X, Tian Y, Zhang J
Colloids Surf B Biointerfaces · 2026 May · PMID 42224972 · Publisher ↗
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum, associated with epithelial barrier defects and dysregulated immune responses. Here, we developed Eudragit S100-coated mucin/CyA co-loaded...
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum, associated with epithelial barrier defects and dysregulated immune responses. Here, we developed Eudragit S100-coated mucin/CyA co-loaded calcium alginate microspheres (E-CMAMs) for synergistic UC therapy via immunosuppression and mucosal barrier repair. E-CMAMs were prepared by a high-voltage electrostatic method and an emulsification-solvent evaporation method. Their characteristics were analyzed by inverted optical microscope, SEM, FTIR, and DSC. E-CMAMs exhibited excellent pH-responsive behavior, as they remained stable in acidic gastric fluid, swelled moderately in neutral intestinal fluid, and rapidly disintegrated in the alkaline colonic environment, which enabled the colon-specific release of CyA. Moreover, E-CMAMs effectively protected CyA from degradation by gastric acid and proteolytic enzymes. In vivo gastrointestinal fate and distribution study showed that E-CMAMs maintained structural integrity in the upper gastrointestinal tract and released fluorescent dye upon reaching the colon. In DSS-induced UC mice, E-CMAMs significantly alleviated colitis symptoms, suppressed inflammatory responses (MPO, TNF-α, IL-1β, and IL-6 reduced), and restored intestinal barrier integrity by reconstructing the mucus layer and upregulating tight junction proteins (Occludin and ZO-1). Finally, E-CMAMs demonstrated excellent biosafety, with no detectable toxicity in major organs. The combination of CyA-mediated immunosuppression and mucin-mediated mucosal repair achieved superior efficacy, with excellent biosafety. This colon-targeted co-delivery strategy offers a promising approach for more effective and safer UC therapy.
Corrigendum "Folic Acid navigated Silver Selenide nanoparticles for photo-thermal ablation of cancer cells" [Colloids Surf. B: Biointerfaces, 159 (2017) 564-570].
Khan MS, Talib A, Pandey S … +3 more , Bhaisare ML, Gedda G, Wu HF
Colloids Surf B Biointerfaces · 2026 Sep · PMID 42219854 · Publisher ↗
Abstract loading — click title to view on PubMed.
Cuproptosis: An emerging strategy for nanomaterial for the treatment of cancer.
Che X, Cao S, Shao Q … +3 more , Duan W, Cai Y, Yang Z
Colloids Surf B Biointerfaces · 2026 May · PMID 42217853 · Publisher ↗
Cuproptosis is a recently identified form of programmed cell death dependent on copper ions. Its mechanism primarily involves the abnormal accumulation of intracellular copper, which directly binds to and disrupts the me...
Cuproptosis is a recently identified form of programmed cell death dependent on copper ions. Its mechanism primarily involves the abnormal accumulation of intracellular copper, which directly binds to and disrupts the metabolic function of lipoylated proteins in the tricarboxylic acid cycle, leading to protein aggregation, toxic stress responses, and ultimately cell death. In recent years, it has emerged as a potential direction for cancer therapy. Nanomedicine-based cuproptosis therapy has achieved significant progress, garnering widespread attention and leading to the development of various novel therapeutic strategies. This review systematically elaborates on the concept and mechanism of cuproptosis, nano-delivery systems for copper ions, the interplay between cuproptosis and other cell death pathways, as well as combination therapies involving cuproptosis. Furthermore, it provides an in-depth analysis of the latest research advances in nanomedicine-mediated cuproptosis. Finally, the review outlines future directions and challenges, emphasizing that ongoing research will continue to elucidate the molecular details of cuproptosis and develop precise, efficient cuproptosis-targeted anti-tumor strategies.
Injectable thiol-yne-crosslinked γ-PGA/alginate hydrogels with chlorogenic acid-loaded nanoparticles for antibacterial and antioxidant activity.
Wang J, Bao Y, Zhang S … +4 more , Shao Y, Zhao T, Cao W, Qiao C
Colloids Surf B Biointerfaces · 2026 May · PMID 42217852 · Publisher ↗
Injectable hydrogels capable of addressing both bacterial contamination and oxidative stress are attractive for local biomedical applications, yet integrating controllable network formation with sustained bioactivity rem...
Injectable hydrogels capable of addressing both bacterial contamination and oxidative stress are attractive for local biomedical applications, yet integrating controllable network formation with sustained bioactivity remains challenging. Herein, an injectable γ-poly(glutamic acid)/alginate (γ-PGA/Alg) hydrogel was constructed via thiol-yne photoclick crosslinking between alkynylated γ-PGA and thiolated alginate, and further functionalized with chlorogenic acid-loaded chitooligosaccharide/tripolyphosphate nanoparticles (NP-CA). The hydrogel contained ∼98 wt% water and formed a dual crosslinked network comprising stable thioether linkages and dynamic disulfide bonds, whose respective roles in structural integrity and recovery behavior were clarified by reduction experiments. NP-CA exhibited an average hydrodynamic diameter of 239.9 nm, an encapsulation efficiency of 85.9%, and a loading content of 5.35%. The incorporation of NP-CA decreased the equilibrium swelling ratio, improved water retention, and reduced mass loss during degradation. Zeta potential, FT-IR, and microstructural analyses suggest that NP-CA is integrated into the hydrogel network through electrostatic interactions, hydrogen bonding, and physical confinement. In addition, the system exhibited a sustained release behavior of CA, with the release rate decreasing as nanoparticle loading increased. The hydrogels showed shear-thinning behavior and rapid modulus recovery under cyclic strain. NP-CA loading enhanced radical-scavenging activity, with the highest-loading group reaching 89.81 ± 2.74% for DPPH and 92.52 ± 3.23% for ABTS⁺ scavenging. NP-CA-loaded hydrogels inhibited both Escherichia coli and Staphylococcus aureus, while control experiments indicated that blank nanoparticles did not significantly contribute under the present conditions. All formulations showed hemolysis below 1% and no evident cytotoxicity toward L929 fibroblasts. These results indicate that thiol-yne-crosslinked γ-PGA/Alg hydrogels combined with nanoparticle incorporation provide a practical approach for constructing multifunctional injectable biomaterials with sustained bioactivity.
Photothermal-immunotherapy of colon carcinoma by carbon nanoparticle-Fe(II) complex with immunoadjuvant.
Xie P, Qu T, Huang Y … +11 more , Yuan H, Zhao Y, Xin Q, Gou Z, Tang K, Zeng G, Yang J, Huang H, Wu X, Yang ST, Tang X
Colloids Surf B Biointerfaces · 2026 May · PMID 42217851 · Publisher ↗
Ferroptosis is a regulated necrotic cell death pathway, which demonstrates significant anticancer potential. As the only ferroptosis-based nanomedicine under clinical trial evaluation, carbon nanoparticle-Fe (II) complex...
Ferroptosis is a regulated necrotic cell death pathway, which demonstrates significant anticancer potential. As the only ferroptosis-based nanomedicine under clinical trial evaluation, carbon nanoparticle-Fe (II) complex (CNSI-Fe) not only induces ferroptosis in tumor cells, but also serves as photothermal conversion agents for tumor photothermal therapy. In this study, we combined the treatments of CNSI-Fe, NIR irradiation and immunoadjuvant glycated chitosan (GC) to extend the use of CNSI-Fe from partial treatment to systemic therapy by arousing cancer immune response. In the established bilateral CT26.WT mouse models, CNSI-Fe + NIR (52 °C) + GC treatments triggered abscopal effects to induce systemic tumor regression. The inhibition rate was 96.10% for the primary tumor and 44.28% for the distant tumor. The supplement of GC largely enhanced the abscopal effects of CNSI-Fe photothermal therapy, where only the CNSI-Fe + NIR(52 °C) showed the inhibition rate of 16.68% for the distant tumor without GC. In addition to the ferroptosis induced by CNSI-Fe in the primary tumor, CNSI-Fe induced the release of tissue factors from primary tumors under NIR irradiation. GC captured these autologous cancer vaccines to initiate a systemic immune response. The long-term immune memory after the combination treatments was evidenced by the suppression of rechallenged tumors. The combination treatments showed acceptable toxicity during in vivo evaluations. Our study offered a translatable strategy for next-generation ISV and would hopefully benefit the patients in near future.
Nanogel-coated nanozymes for ulcerative colitis targeted treatment by restoring redox homeostasis and anti-inflammatory activity.
Wang J, Wang Y, Zhu M … +9 more , Ye R, Shen W, Wang Z, Wang Y, Lai X, Qiu X, Yu C, Zhang Q, Fu T
Colloids Surf B Biointerfaces · 2026 May · PMID 42217850 · Publisher ↗
Excessive accumulation of reactive oxygen species (ROS) and overloaded immune system are key pathological features of ulcerative colitis (UC), but conventional treatments (such as aminosalicylates and immunosuppressants)...
Excessive accumulation of reactive oxygen species (ROS) and overloaded immune system are key pathological features of ulcerative colitis (UC), but conventional treatments (such as aminosalicylates and immunosuppressants) often prove inadequate and have significant side effects. Here, an orally administrable PSGI utilized inulin (IN) as an outer shell and hollow mesoporous Prussian blue (HMPB) nanoparticles loaded with the aminosalicylate drug salazosulfapyridine (SASP) (PS) was developed to treat UC by scavenging ROS, reducing pro-inflammatory factors. After oral administration, IN can protect the drug-loaded nanoparticles from degradation by the enzymes of the upper gastrointestinal tract, easily penetrate into the lower gastrointestinal tract and reach the colon, where the IN shell could be degraded under the action of the colon-specific enzyme inulinase, to achieve the specific release of drugs that act like a "band-aid", adhering the inflamed colon through a combination of enzymatic degradation and electrostatic adsorption, thereby prolonging drug retention at the site of inflammation, providing an improved synergistic therapy for UC. PSGI demonstrated a significant preventive effect in the mouse dextran sodium sulfate (DSS)-induced colitis model, with no obvious damage to major organs. This is because the ROS clearance effect of prussian blue (PB) itself enhances and complements the anti-inflammatory effect of SASP, thereby reducing the dosage of SASP and lowering the risk of potential side effects. Overall, PSGI has demonstrated good anti-inflammatory activity and biosafety in both in vivo and in vitro studies. We hope that this oral targeted nanoplatform for the treatment of UC can address key challenges such as targeted drug delivery, improved efficacy, and reduced side effects in the treatment of colitis.
Triamcinolone :acetonide-controlled release urinary catheter: Localized delivery with anti-fibrotic and anti-inflammatory effects for preventing urethral stricture.
Gong Z, Kan L, Chen J … +4 more , Xu R, Zhao Z, Liu W, Liu Z
Colloids Surf B Biointerfaces · 2026 May · PMID 42214952 · Publisher ↗
Urethral stricture remains a challenging urological condition due to its high recurrence rate and limited therapeutic efficacy. Triamcinolone acetonide (TA) has been shown to inhibit scar formation in the management of u...
Urethral stricture remains a challenging urological condition due to its high recurrence rate and limited therapeutic efficacy. Triamcinolone acetonide (TA) has been shown to inhibit scar formation in the management of urethral stricture. However, current administration strategies, including local injection and topical catheter application, are limited by suboptimal drug stability and insufficient duration of efficacy. Therefore, we developed a controlled drug-release system by incorporating TA into polyether polyurethane (PEUR) and integrated it onto a urinary catheter to achieve sustained local drug delivery. Continuous TA release during the critical phase of wound healing was designed to suppress excessive scar formation and thereby reduce stricture recurrence. This novel catheter exhibited favorable material properties, including a smoother surface, enhanced hydrophilicity, and improved mechanical performance. In vitro release studies demonstrated an initial burst release of TA within the first week, followed by sustained drug release for up to 7 weeks. Both in vitro experiments and a rabbit urethral injury model demonstrated that TA can reduce the formation of fibroblasts in the injured urethra by suppressing the TGF-β/Smad2 signaling pathway and decreasing the secretion of pro-inflammatory cytokines, such as IL-6 and TNF-α, thereby inhibiting the formation of urethral scars. This novel catheter with a controlled-release function can significantly reduce the incidence of urethral stricture and exhibits promising potential for clinical translation.
Dual-modal breath-bioimpedance flexible sensing coupled with causal ensemble learning for non-invasive monitoring of fish physiological stress.
Zhang L, Li Y, Wang Y … +3 more , Bakarić MB, Hu J, Zhang X
Colloids Surf B Biointerfaces · 2026 May · PMID 42214951 · Publisher ↗
Real-time monitoring of fish physiological stress during green waterless low-temperature transportation remains a key technical challenge for aquatic food quality and safety. Such conditions induce complex multi-scale ph...
Real-time monitoring of fish physiological stress during green waterless low-temperature transportation remains a key technical challenge for aquatic food quality and safety. Such conditions induce complex multi-scale physiological responses, leading to high mortality and quality deterioration of aquatic products. In this study, we report an additively manufactured flexible dual-modal biosensing system based on biointerface engineering, which integrates breath peak (BrP) and bioimpedance (BI) detection modules and is tailored for non-invasive, continuous evaluation of fish stress in practical aquatic food cold-chain scenarios. A key interfacial optimization, validated through systematic electric field simulations, demonstrates that a two-electrode BI configuration generates a more uniform electric field distribution at the sensor-tissue interface, which markedly enhances signal stability and reproducibility for long-term cold-chain biosensing applications. We further establish a hierarchical multi-level information fusion framework. Firstly, Granger causality analysis verifies the bidirectional temporal causality between BrP and BI signals, laying a mechanistic foundation for effective biological data fusion. Secondly, a stacking ensemble model with GRU and SVM as base models was built to achieve multi-level information fusion for accurate stress assessment. Experimental results show the proposed dual-modal biosensing system reaches a stress evaluation accuracy of 0.9669, markedly outperforming single-modal BrP (0.9256) and BI (0.8182). The data-driven non-invasive biosensing method delivers superior performance for target fish under waterless low-temperature cold-chain conditions, with great potential for broader application. It is poised to facilitate aquatic food monitoring, underpin sustainable high-quality cold-chain management for aquatic products, and reduce post-harvest losses while safeguarding aquatic food quality in green logistics.
Layered double hydroxide-nanoengineered injectable hydrogel based on oxidised pectin/carboxymethyl chitosan for sustained enoxaparin release in deep vein thrombosis.
Nguyen TN, Luu CH, Vo TN … +7 more , Le KT, Le VD, Tran DA, Huynh QL, Nguyen NH, Nguyen KT, Phan GVH
Colloids Surf B Biointerfaces · 2026 May · PMID 42214950 · Publisher ↗
Deep vein thrombosis prophylaxis with enoxaparin (ENO) requires frequent subcutaneous injections, posing treatment burden and compliance challenges. However, the sustained delivery of ENO remains challenging due to its h...
Deep vein thrombosis prophylaxis with enoxaparin (ENO) requires frequent subcutaneous injections, posing treatment burden and compliance challenges. However, the sustained delivery of ENO remains challenging due to its highly anionic nature and rapid diffusion from conventional delivery matrices. Here, we developed an injectable hydrogel incorporating ENO-loaded layered double hydroxide (LDH) nanocarriers within an oxidised pectin/carboxymethyl chitosan (OP/CMCs) matrix to enable prolonged release. The hydrogel forms via Schiff base chemistry, yielding rapid gelation (∼7 min), self-healing properties, and strong tissue adhesion suitable for minimally invasive administration. The LDH nanocarriers provided dual-mechanism retention through electrostatic interactions and tortuous diffusion pathways. The optimised formulation containing 6.0 wt% CMCs and 0.1 wt% OP with a 1:0.5 LDH:ENO mass ratio demonstrated minimal burst release (∼5.3% at day 1) and sustained delivery over 13 days with ∼40.1% cumulative release. In vitro, in ovo, and in vivo studies confirmed good biocompatibility and stable subcutaneous depot formation. Crucially, the prolonged thrombin time demonstrated the capability to regulate blood coagulation. Consequently, the sustained-release ENO hydrogel system exhibited the potential to significantly reduce injection frequency compared to standard regimens, thereby improving patient compliance and quality of life.
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