Endocrine Research[JOURNAL]
Sun
200 papers
Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study.
Wang Z, Hu Y, Wei Y … +6 more , Xue C, Hu Y, Wang Y, Wu C, Jiang F, Wang F
Endocr Res · 2025 Nov · PMID 40920026 · Publisher ↗
BACKGROUND: This Mendelian Randomization (MR) study investigates the causal relationships between mitochondrial proteins and Diabetic polyneuropathy (DPN). METHODS: Using a two-sample MR design with data from FINNGEN (10...
BACKGROUND: This Mendelian Randomization (MR) study investigates the causal relationships between mitochondrial proteins and Diabetic polyneuropathy (DPN). METHODS: Using a two-sample MR design with data from FINNGEN (1048 DPN cases, 374,434 controls) and 63 mitochondrial proteins from GWAS datasets. Analyses used the Inverse Variance Weighted (IVW) method, MR-Egger regression, and weighted medians, with extensive sensitivity tests for robustness. RESULTS: Elevated COA3 levels (OR = 0.5774, 95% CI: 0.4466-0.7465, < 0.01) decreased DPN risk, while elevated NFU1 (OR: 1.3992, 95% CI: 1.0935-1.7904, = 0.0075) and SARS2 (OR: 1.3660, 95% CI: 1.0651-1.7520, = 0.0140) increased risk. CONCLUSION: COA3, NFU1, and SARS2 significantly affect DPN risk, with COA3 lowering and NFU1 and SARS2 increasing risk. These findings highlight potential targets for DPN prevention and treatment, suggesting the importance of mitochondrial proteins in DPN pathogenesis, and providing new insights for future therapeutic strategies to effectively combat this debilitating condition.
Blood metabolome of cardiovascular disease, diabetic kidney disease, and diabetic retinopathy in type 2 diabetes patients: A systematic review and meta-analysis.
Kuo S, Li D, Wargny M … +2 more , Yoshida T, Yoshida Y
Endocr Res · 2025 Nov · PMID 40835231 · Full text
METHODS: MEDLINE (PubMed), Embase, Web of Science, and Cochrane Library were searched for relevant articles published before August 1, 2023. Studies assessing the association between circulating metabolites and CVD, incl...
METHODS: MEDLINE (PubMed), Embase, Web of Science, and Cochrane Library were searched for relevant articles published before August 1, 2023. Studies assessing the association between circulating metabolites and CVD, including coronary heart disease, strokes, heart failure, CV death, DKD, and DR in T2D were eligible for review. We performed meta-analyses for metabolites with ≥2 estimates and reported adjusted odds ratios (ORs) of outcome per SD increase of metabolite. tests were used to assess the study heterogeneity. RESULTS: We identified 74 total studies ( = 48 cross-sectional and = 26 cohort; 33 exclusively for CVD, 21 exclusively for DKD, and 20 exclusively for DR, 19 for more than one outcome; a total of 49,866 T2D patients, mean age 60 years, 55% male) describing metabolism of Trimethylamine N-oxide (TMAO), amino acids, fatty acids, sugars, sphingolipids, phospholipids, organic compounds, bacteria, and enzymes. Eleven metabolites were included in meta-analyses for their association with CVD. These include TMAO (OR 1.1, 95% confidence interval (CI) 0.91-1.3) and derivatives (choline: 0.95, 0.76-1.18, carnitine: 1.08, 0.86-1.36, betaine: 1.00, 0.91-1.11), branched-chain amino acids (leucine: 1.12, 0.05-25.5, valine: 1.14, 0.09-14.2, isoleucine: 1.02, 0.76-1.35), other amino acids (glutamine: 1.02, 0.35-2.9, alanine: 0.99, 0.87-1.13), and metabolites for energy metabolism (lactate: 1.11, 0.81-1.52, glycerol: 1.05, 0.61-1.81). I for all studies >30%. CONCLUSIONS: In this review, TMAO and amino acids are the most studied circulating metabolites for diabetic complications. TMAO was marginally associated with the CVD risk among people with T2D. However, the studies were subject to high heterogeneity and the findings are inconclusive. Our review indicates limited evidence linking circulating metabolites to the prediction of vascular complications in T2D. To strengthen the evidence in this field, large prospective studies are required.
Genetic insights and biochemical profiles in hyperlipidemia: a cohort study from Eastern Anatolia.
Yarali O, Bayrak M, Ogutlu OBG … +4 more , Kurnaz E, Arslan S, Sebin E, Guler MC
Endocr Res · 2025 Nov · PMID 40730230 · Publisher ↗
This study investigates the genetic and clinical characteristics of hyperlipidemia in patients from Eastern Anatolia. A retrospective cohort of 205 patients (aged 3-71) underwent next-generation sequencing (NGS) to ident...
This study investigates the genetic and clinical characteristics of hyperlipidemia in patients from Eastern Anatolia. A retrospective cohort of 205 patients (aged 3-71) underwent next-generation sequencing (NGS) to identify genetic variations in lipid metabolism genes (LDLR, APOB and LPL), which were then correlated with the patients' clinical data. Patients with obesity or chronic diseases were excluded. The LDLR c.1729T > C variant was detected in 12 patients. Severe hypertriglyceridemia was observed in patients with homozygous variants in GPIHBP1 and LPL. Elevated triglyceride levels have also been observed to be associated with variants such as APOA5 c.70C > T, thus highlighting their role in lipid metabolism. Phenotypic variation was observed based on the type of genetic variant and its zygosity. The study emphasizes the intricate relationship between lipid metabolism and genetic abnormalities, underscoring potential ramifications for personalized treatment strategies. The report calls for the incorporation of genetic screening into clinical practice with a view to improving diagnostics and outcomes, and it emphasizes the necessity for further research to achieve a full understanding of variants of uncertain significance (VUS) and their associated phenotypes.
The Cardiorenal Protective Effects of Finerenone in Patients with Diabetes and Heart Failure: A Meta-Analysis.
Shang C, Ma J, Liang H … +2 more , Zhang Y, Sui Y
Endocr Res · 2025 Nov · PMID 40667759 · Publisher ↗
INTRODUCTION: To evaluate the cardiorenal protective effects of finerenone in patients with diabetes and heart failure through a meta-analysis of randomized controlled trials (RCTs). METHODS: This meta-analysis included...
INTRODUCTION: To evaluate the cardiorenal protective effects of finerenone in patients with diabetes and heart failure through a meta-analysis of randomized controlled trials (RCTs). METHODS: This meta-analysis included 12 RCTs (total = 65,226) assessing finerenone versus placebo. Primary outcomes included cardiovascular composite endpoints (major adverse cardiovascular events [MACE]) and kidney composite outcomes (sustained eGFR decline, end-stage kidney disease, or renal mortality). Secondary outcomes encompassed total worsening heart failure events and cardiovascular mortality. Random-effects models were applied to pool hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity was quantified using Cochran's Q and I² statistics. Sensitivity analyses and publication bias assessments (Egger's/Begg's tests, funnel plots) were performed. RESULTS: Finerenone significantly reduced major adverse cardiovascular events (9 RCTs, = 21,542; hazard ratio [HR] 0.858, 95% CI: 0.786-0.937; = 0.001) and kidney composite outcomes ( = 23,109; HR 0.827, 95% CI: 0.760-0.901; < 0.001), despite substantial heterogeneity (I² = 78.2% and 64.4%, respectively). Sensitivity analyses confirmed robustness, with consistent effects after sequential trial exclusion. Finerenone also reduced worsening heart failure events ( = 12,874; HR 0.790, 95% CI: 0.700-0.891; < 0.001; I² = 4.7%), though cardiovascular mortality reduction was nonsignificant (HR 0.914, 95% CI: 0.831-1.005; = 0.063). No publication bias was detected for primary outcomes. CONCLUSION: Finerenone demonstrates consistent cardiorenal protection in patients with diabetes and heart failure, significantly reducing cardiovascular and kidney complications.
Interaction between interleukin 10 () gene polymorphisms and obesity on susceptibility to polycystic ovary syndrome in Chinese women.
Ding N, Chen YR, Jia RJ … +4 more , Lu XZ, Xie SL, Shang HL, Shuai JG
Endocr Res · 2025 Nov · PMID 40562065 · Publisher ↗
OBJECTIVES: The pathogenesis of polycystic ovary syndrome (PCOS) was complex, and the incident PCOS involves both genetic and environmental factors. However, no study focused on the synergistic effect between interleukin...
OBJECTIVES: The pathogenesis of polycystic ovary syndrome (PCOS) was complex, and the incident PCOS involves both genetic and environmental factors. However, no study focused on the synergistic effect between interleukin 10 (IL-10) gene and obesity on PCOS risk yet. This study aimed to evaluate the correlation between IL-10 gene single nucleotide polymorphisms (SNPs) and PCOS susceptibility and impact of the interaction between IL-10 gene and obesity on PCOS risk. METHODS: A total of 540 participants consisted of 180 PCOS patients and 360 normal controls were enrolled in this study. Logistic regression model was employed to evaluate the association between IL-10 gene polymorphisms and PCOS susceptibility, odds ratios (ORs) and 95% confidence interval (CI) were calculated. Generalized multifactor dimensionality reduction (GMDR) was employed to screen the IL-10 gene-obesity interaction. RESULTS: Logistic regression also indicated that rs1800896-G allele was statistically significant correlated with increased risk of PCOS, the ORs (rs (95%CI) for AG, GG and AG+GG genotype was 1.75 (1.21-2.33), 1.93 (1.17-2.72) and 1.79 (1.26-2.35), respectively. However, no significant difference was observed on the distribution of genotypes and alleles within rs1800890, rs1800871, rs1800872 between PCOS patients and normal controls (all values > 0.05). GMDR model found a significant interaction combination (two-locus model with = 0.001) between rs1800896 and obesity, the cross-validation consistency was 10/10 and the prediction error was 0.641. Compared with those non-obese participants with rs1800896-AA genotype, OR (95% CI) was 1.62 (1.14-2.12), 1.46 (1.02-1.95) for non-obese participants with rs1800896-AG or GG genotype, obese participants with rs1800896-AA genotype, and obese participants with rs1800896-AG or GG genotype have the highest PCOS risk, OR (95% CI) = 3.58 (1.81-5.41), after covariates adjusting. CONCLUSIONS: We found that rs1800896-G allele, gene-environment interaction between rs1800896 and obesity were all correlated with increased PCOS risk.
Microbiota and Neuropeptides in Dysbiosis-Driven Inflammation: Emerging Therapeutic Perspectives.
Singh P, Mohanty B
Endocr Res · 2025 Nov · PMID 40551481 · Publisher ↗
BACKGROUND: The gut microbiota (GM) comprises diverse microorganisms that inhabit the gastrointestinal tract (GIT) and play crucial roles in maintaining the host's health. The fascinating interrelations between the GM an...
BACKGROUND: The gut microbiota (GM) comprises diverse microorganisms that inhabit the gastrointestinal tract (GIT) and play crucial roles in maintaining the host's health. The fascinating interrelations between the GM and various organs lead to establishing the "gut-organ" axis, including the gut-thyroid axis, an emerging research area that requires exploration. Changes in diversity and functionality of GM (dysbiosis) may impact the gut locally and significantly affect other organs, raising concerns about potential systemic effects. METHOD: We performed a literature search on PubMed/Google-Scholar using the keywords GM and: autoimmune-diseases/inflammation/dietary-supplements/neuropeptides. The search included original studies/reviews/meta-analyses. DISCUSSION/CONCLUSION: Dysbiosis is correlated with many diseases, where alterations in gut-associated neuropeptide levels have been detected. Gut-neuropeptides, secreted by entero-endocrine-cells, are potent neuro-immune modulators, regulate GM homeostasis through antimicrobial and inflammation-modulating properties, and serve as a communication intermediary between GM and host. This review offers a concise overview of the association between GM and neuropeptides, and the roles of microbial metabolites and GIT-neuropeptides during inflammation and stress.
Acute Transient Thyroid Cracking: A Proposal of a New Disease Entity as a Mild Form of Acute Transient Thyroid Swelling.
Nagayama Y, Shindo H, Tachibana S … +7 more , Fukuda T, Katsuyama K, Tatsushima D, Mori Y, Takahashi H, Sato S, Yamashita H
Endocr Res · 2025 Aug · PMID 40455888 · Publisher ↗
This study aims to investigate the clinical and ultrasonographic features of thyroid swelling following fine-needle aspiration biopsy (FNAB), and to distinguish between symptomatic and asymptomatic forms. We retrospectiv...
This study aims to investigate the clinical and ultrasonographic features of thyroid swelling following fine-needle aspiration biopsy (FNAB), and to distinguish between symptomatic and asymptomatic forms. We retrospectively reviewed 872 patients who underwent thyroid ultrasonography before and after FNAB between January and November 2024. Patients showing new hypoechoic cracking after FNAB were identified. Clinical symptoms, degree of thyroid swelling, and outcomes were evaluated. Hypoechoic cracking developed in 18 patients (2.1%), appearing immediately in 17 and at 4 hours in one. Three patients (17%) experienced symptoms such as pain or compression, all with thyroid swelling exceeding 1.8-fold the original size. The remaining 15 patients were asymptomatic, with swelling less than 1.5-fold. No clinical characteristics were significantly associated with the development of symptoms. All patients recovered spontaneously; two symptomatic cases received steroid treatment. Post-FNAB thyroid swelling can be classified into two entities: typical, symptomatic acute transient thyroid swelling (ATTS) and a newly proposed asymptomatic form, acute transient thyroid cracking (ATTC). Recognizing ATTC as a mild, self-limiting condition is important for avoiding unnecessary treatment and alleviating patient concern.
The effect of hyperprolactinemia and its treatment on oxidative stress.
Keti DB, Mammadov M, Goksuluk MB … +4 more , Hacioglu A, Okcesiz I, Karaca Z, Unluhizarci K
Endocr Res · 2025 Aug · PMID 40432284 · Publisher ↗
INTRODUCTION: There are few studies investigating oxidative stress in hyperprolactinemia. We aimed to analyze the associations between hyperprolactinemia, its treatment, and oxidative stress parameters. METHODS: Twenty p...
INTRODUCTION: There are few studies investigating oxidative stress in hyperprolactinemia. We aimed to analyze the associations between hyperprolactinemia, its treatment, and oxidative stress parameters. METHODS: Twenty patients who had hyperprolactinemia secondary to a prolactin-secreting pituitary tumor, and 20 age- and BMI-matched healthy controls were prospectively included. Patients were studied at recruitment and six months post-treatment. Markers indicating protein oxidation and antioxidant system were analyzed. RESULTS: Serum prolactin level in the patient group (13 female, 7 male) was significantly higher than controls. Myeloperoxidase (MPO) activity and advanced oxidation protein product (AOPP) levels were comparable between the groups, while pyrrolized protein, and protein carbonyl compound (PCC) levels were significantly higher, and thiol levels lower in the patients at baseline. A decrease in prolactin levels along with improvements in estradiol (in females) and testosterone (in males) levels were observed following treatment. After treatment of hyperprolactinemia a significant decrease in AOPP, PCC, pyrrolized protein, and an increase in thiol levels were observed. MPO activity remained stable. DISCUSSION: In addition to reproductive dysfunctions and altered sex hormones, hyperprolactinemia is associated with oxidative stress, which improves four to six months after cabergoline treatment.
Predictive Value of LncRNA LINC01184 in Papillary Thyroid Cancer Development and Prognosis and Its Regulatory Effect on Cellular Processes.
Sun Y, Hu W, Huang J … +1 more , Liu Z
Endocr Res · 2025 Aug · PMID 40421523 · Publisher ↗
INTRODUCTION: This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis and its regulatory mechanism in PTC cellular processes, aiming to explore a novel biomarker for PTC. METHODS...
INTRODUCTION: This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis and its regulatory mechanism in PTC cellular processes, aiming to explore a novel biomarker for PTC. METHODS: The study enrolled 111 PTC patients and collected paired tissue samples. Using PCR, the expression of LINC01184 was analyzed, and its association with patients' clinicopathological features and prognosis was evaluated. The regulatory effects of LINC01184 on cell growth and metastasis were assessed by CCK8 and Transwell assays. RESULTS: LINC01184 was significantly downregulated in PTC, which was closely correlated with poor differentiation, advanced TNM stage, the occurrence of lymph node metastasis, and poor overall survival. In PTC cells, LINC01184 negatively regulated miR-296-3p, and its overexpression suppressed cell growth and metastasis of PTC, which was reversed by overexpressing miR-296-3p. CONCLUSION: Downregulated LINC01184 served as a biomarker for PTC. Overexpressing LINC01184 suppressed PTC cell progression via suppressing miR-296-3p.
Validation of a Lenvatinib Assay: A Pilot Study.
Majumder M, Ding LE, Wood C … +6 more , Hodgkins C, White E, Robinson BG, Clifton-Bligh RJ, Bonnitcha P, Gild ML
Endocr Res · 2025 Aug · PMID 40405339 · Publisher ↗
OBJECTIVES: Lenvatinib has demonstrated efficacy in improving progression-free and overall survival in patients with radioiodine refractory thyroid cancer. However, treatment-related adverse events (TRAEs) frequently cau...
OBJECTIVES: Lenvatinib has demonstrated efficacy in improving progression-free and overall survival in patients with radioiodine refractory thyroid cancer. However, treatment-related adverse events (TRAEs) frequently cause dose interruptions and suboptimal dosing, underscoring the importance of monitoring of lenvatinib levels. Currently, there is no validated lenvatinib assay for clinical use. We describe the development of a mass spectrometry assay for accurate quantification of lenvatinib, along with a pilot study reporting peak and trough levels. DESIGN, PATIENTS AND MEASUREMENTS: A pilot prospective single-center study was conducted at Royal North Shore Hospital, to develop and validate an in-house high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for measuring plasma lenvatinib levels in patients with radioiodine refractory thyroid cancer. Patient data including dosage, TRAEs, and disease progression were recorded. RESULTS: Lenvatinib doses ranged between 4 mg to 14 mg daily. Trough and peak levels were measured in nine and eight patients respectively. Duration of treatment ranged from 7 to 63 months (mean 29 months), with treatment duration at the time of testing ranging from 1 to 14 months. Trough levels ranged from 4.60 to 30.53 µg/L (median 21.74 µg/L). Peak levels for patients receiving 10 mg ( = 3) ranged from 78.50 to 237.72 µg/L (median 129.56 µg/L), while those receiving 14 mg ( = 4) ranged from 65.10 to 263.64 µg/L (median 185.23 µg/L). CONCLUSIONS: Our study describes the successful development of a novel LC-MS/MS assay for quantifying plasma lenvatinib levels. Despite consistent dosing, we observed considerable variability in levels in this group. Further research is required to examine the utility of lenvatinib drug monitoring in the setting of thyroid cancer.
The Role of Blood Cell-Derived Parameters in the Differential Diagnosis of Subacute Thyroiditis and Graves' Disease and Long-Term Outcomes in Subacute Thyroiditis.
Soyer AK, Cuhaci Seyrek FN, Demirel KD … +4 more , Tam AA, Topaloglu O, Ersoy R, Cakir B
Endocr Res · 2025 Aug · PMID 40372793 · Publisher ↗
PURPOSE: To assess the utility of blood cell-derived parameters in differentiating subacute thyroiditis (SAT) from Graves' disease (GD) and their association with recurrence and the development of permanent hypothyroidis...
PURPOSE: To assess the utility of blood cell-derived parameters in differentiating subacute thyroiditis (SAT) from Graves' disease (GD) and their association with recurrence and the development of permanent hypothyroidism in the patients with SAT. METHODS: The study involved 414 patients with SAT, 415 patients with GD, and 92 healthy controls. Pre-treatment hematological parameters were retrospectively compared, especially in cases where differentiation is challenging, including painless SAT, acute phase reactants negative SAT, and TSI, TRAB (Thyroid Stimulating Immunoglobulin, TSH-receptor-antibodies) negative GD. Factors influencing recurrence and permanent hypothyroidism were also analyzed in SAT group. RESULTS: When compared with the GD group, ratios of neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), systemic inflammatory response index (SIRI), systemic immune inflammatory index (SII) and pan immune inflammation value (PIV) were significantly higher, while large unstained cell percentage (LUC%) and the ratios of eosinophil/monocyte (EMR), eosinophil/lymphocyte (ELR), eosinophil/neutrophil (ENR), eosinophil/platelet (EPR), mean platelet volume/neutrophil (MPV/NEU), MPV/monocyte and MPV/platelets were significantly lower in the SAT group. SII demonstrated the highest diagnostic value, with an optimal cutoff of 652,784. No significant association was observed between these parameters and recurrence or permanent hypothyroidism. CONCLUSION: Differentiation between SAT and GD can be reliably achieved using blood cell-derived parameters, and that these markers are also applicable in groups where differentiation is challenging. To the best of our knowledge, this is the first study to investigate the LUC%, ELR, ENR, EPR, MPV/NEU, and MPV/monocyte ratios and revealed that they are significantly different between these two diseases.
Thyroglobulin (TG) gene variants in cases with congenital goiter.
Cevizoglu M, Erkal O, Turkkahraman D
Endocr Res · 2025 Aug · PMID 40346829 · Publisher ↗
OBJECTIVE: To evaluate TG gene variants and their effects on the clinical course of the disease in children with congenital hypothyroidism (CH) who are suspected to have thyroglobulin synthesis defect. METHODS: The study...
OBJECTIVE: To evaluate TG gene variants and their effects on the clinical course of the disease in children with congenital hypothyroidism (CH) who are suspected to have thyroglobulin synthesis defect. METHODS: The study was carried out in patients who were suspected to have thyroglobulin synthesis defect due to low serum thyroglobulin level and goiter at the time of diagnosis of CH. Peripheral blood samples were taken and hypothyroidism gene panel including 344 genes was amplified by PCR and sequenced using next-generation DNA sequencing (NGS) method. RESULTS: A total of four eligible cases were identified for genetic analysis, and variants were detected in all of them. In case 1, a previously reported homozygous c.638 + 5 G>A splice site variant was detected. In case 2, compound heterozygous variants including a previously reported nonsense variant c.7111 C>T, (p.Arg2371Ter) on the first allele and a novel nonsense variant c.5748 C>A, (p.Tyr1916Ter) on the second allele were detected. In case 3, a previously reported homozygous nonsense variant c.1888 C>T, (p.Gln630Ter) was detected. In case 4, a novel homozygous intronic variant c.6200-25T>G was detected. CONCLUSION: The distinctive phenotypic features of TG gene variants, which are one of the rare causes of dyshormonogenesis, provide an advantage in diagnosis. Therefore, we recommend genetic analysis in cases with low thyroglobulin levels and goiter. Our findings support that TG variants show a heterogeneous distribution over the whole gene. Since the relationship between TG gene variants and thyroid cancer, we suggest that clarification of TG gene variants is important in terms of early diagnosis of thyroid nodule and malignancy.
Isolated Adrenocorticotropic Hormone Deficiency Associated with Sintilimab in the Treatment of Lung Adenocarcinoma: A Case Report and Literature Review.
Liu Z, Ma Q, Ma S … +4 more , Yang M, Zhang H, Zhu W, Han R
Endocr Res · 2025 Aug · PMID 40257860 · Publisher ↗
Isolated adrenocorticotropic hormone (ACTH) deficiency, a rare condition associated with immune checkpoint inhibitors, can manifest with symptoms such as fatigue, poor appetite, dizziness, hypotension, and hyponatremia....
Isolated adrenocorticotropic hormone (ACTH) deficiency, a rare condition associated with immune checkpoint inhibitors, can manifest with symptoms such as fatigue, poor appetite, dizziness, hypotension, and hyponatremia. We present a case of a 52-year-old Chinese woman with stage IB lung adenocarcinoma who developed these symptoms after 8 months of treatment with sintilimab. Laboratory tests revealed hyponatremia, low ACTH and cortisol levels, and thyrotoxicosis. Imaging studies showed a Rathke's cleft cyst in the pituitary gland but normal adrenal glands. The patient was diagnosed with isolated ACTH deficiency and thyroid dysfunction and prescribed prednisone as replacement therapy, which improved her symptoms despite persistently low ACTH levels. This case highlights the importance of early diagnosis and treatment of immune checkpoint inhibitor-related endocrine disorders and provides insights into their management to enhance clinical practice and outcomes.
Menopause and diabetes: Interconnected associations of risk.
Rodriguez CP, Michos ED
Endocr Res · 2025 Aug · PMID 40255094 · Publisher ↗
Menopause is an important transition in a women's life that has been associated with a worsening cardiometabolic risk profile. Diabetes is a well-known risk factor for cardiovascular disease risk in women. Recent studies...
Menopause is an important transition in a women's life that has been associated with a worsening cardiometabolic risk profile. Diabetes is a well-known risk factor for cardiovascular disease risk in women. Recent studies have improved the understanding of the hormonal and metabolic changes that occur during menopause, which have provided an opportunity to intervene with preventive efforts. Despite this, menopause's role and its direct (independent) relationship with cardiovascular risk factors, such as diabetes, remain largely unknown. This review highlights the inter-relationships between menopause, vasomotor symptoms, and menopausal hormone therapy with the risk of developing diabetes and outlines further knowledge gaps.
Effects of Moderate-Intensity Aerobic Exercise on Estrogen Levels and Bone Mineral Density in Ovariectomized Rats.
Bai Y
Endocr Res · 2025 May · PMID 40162777 · Publisher ↗
OBJECTIVE: This study aimed to explore the effects of moderate-intensity aerobic exercise on estrogen levels and bone density density (BMD) in ovariectomized rats. METHODS: The sham-operated (SHAM), ovariectomized sedent...
OBJECTIVE: This study aimed to explore the effects of moderate-intensity aerobic exercise on estrogen levels and bone density density (BMD) in ovariectomized rats. METHODS: The sham-operated (SHAM), ovariectomized sedentary (OVX), and ovariectomized exercise (OVX + EX) groups were established. The OVX model was established by bilateral ovariectomy. Bone metabolism indicators, structural mechanical properties of the femur, material mechanical properties of the femur, BMD and bone mineral content were assessed. RESULTS: Compared with the OVX group, the OVX + EX group had lower levels of Ca, P, and STR-ACP, higher BGP levels, increased maximum load, elastic load, maximum stress, and elastic stress of the tibia, elevated serum E2 levels, decreased LH and FSH levels, and higher BMD (all < 0.05). CONCLUSION: Moderate-intensity aerobic exercise can enhance serum hormone levels, improve bone metabolism and biomechanical properties, and increase bone density in ovariectomized rats.
Management of Diabetes in Patients with Chronic Kidney Disease.
Ambalavanan J, Caramori ML
Endocr Res · 2025 May · PMID 40119502 · Publisher ↗
BACKGROUND: Patients with diabetes and chronic kidney disease (CKD) are at increased risk of kidney disease progression and cardiovascular events. METHODS: In this article, we will summarize the 2022 consensus report by...
BACKGROUND: Patients with diabetes and chronic kidney disease (CKD) are at increased risk of kidney disease progression and cardiovascular events. METHODS: In this article, we will summarize the 2022 consensus report by the ADA and KDIGO on diabetes management in CKD and include newly available evidence to assist health care professionals in providing optimal care to patients living with diabetes and CKD. RESULTS: Comprehensive care strategies include lifestyle interventions, optimal glycemic, blood pressure, weight, and lipid management, and preferential use of therapies with proven heart and kidney beneficial effects. CONCLUSIONS: This article offers a concise overview of the multiple strategies aimed at reducing cardiovascular and kidney risk among people with diabetes and CKD, as recommended by multiple societies.
Associations of Palmito-leic Acid and Nervonic Acid Hexosylceramides with Type 2 Diabetes Mellitus in a Prospective Nested Case-control Study Among Chinese Population.
Ruan C, Sun J, Liang X … +3 more , Huang H, Zhang M, Zhang S
Endocr Res · 2025 May · PMID 40088080 · Publisher ↗
OBJECTIVES: We aimed to evaluate the associations of hexosylceramides (HexCers) and their ratio with incident type 2 diabetes mellitus (T2DM) and explore underlying mechanisms. METHODS: We conducted a nested case-control...
OBJECTIVES: We aimed to evaluate the associations of hexosylceramides (HexCers) and their ratio with incident type 2 diabetes mellitus (T2DM) and explore underlying mechanisms. METHODS: We conducted a nested case-control study using the Suzhou chronic disease cohort including 234 T2DM cases and 468 controls, 1:2 matched on age (±2 y) and sex. HexCer(d18:1/16:1) and HexCer(d18:1/24:1) were measured by targeted UPLC-MS/MS. Multivariable conditional logistic regression was used to estimate the associations of these HexCer species and their ratio with T2DM risk. RESULTS: After adjustment for potential confounders, compared with the lowest quartile, the highest quartile of HexCer(d18:1/24:1) was positively associated with T2DM risk (OR: 1.91; 95%CI, 1.12, 3.26; -trend <0.05). The ratio of HexCer(d18:1/24:1) to HexCer(d18:1/16:1) showed a positive association with T2DM risk (OR: 1.89; 95%CI, 1.13, 3.18; -trend <0.05). On the natural log scale, each SD increases in HexCer(d18:1/24:1) and its ratio to HexCer(d18:1/16:1) increased by 29% and 30%, respectively. No significant association for HexCer(d18:1/16:1) was found. Additive value of HexCer(d18:1/24:1) or HexCer(d18:1/24:1)/HexCer(d18:1/16:1) ratio for prediction of T2DM above traditional risk factors. CONCLUSIONS: HexCer(d18:1/24:1) and its ratio to HexCer(d18:1/16:1) are positively associated with incident T2DM in a community-based Chinese population. Future studies are warranted to confirm our findings.
Melatonin attenuates responses to angiotensin II in isolated aortic rings of STZ-induced type 1-like DM rats.
Mahmood NMS, Mahmud AMR, Maulood IM
Endocr Res · 2025 May · PMID 39719865 · Publisher ↗
BACKGROUND: In patients with diabetes mellitus (DM), vascular endothelial dysfunction (VED) is the main reason for impaired life expectancy. Melatonin (MEL) demonstrates wide-ranging effects across various organs and exh...
BACKGROUND: In patients with diabetes mellitus (DM), vascular endothelial dysfunction (VED) is the main reason for impaired life expectancy. Melatonin (MEL) demonstrates wide-ranging effects across various organs and exhibits pleiotropic characteristics. The current study aims to investigate the modulatory roles of MEL vascular response to angiotensin II (Ang II) and its receptors including angiotensin type 1 receptor (AT-1 R) and angiotensin type 2 receptor (AT-2 R) in isolated thoracic aorta of non-diabetes (non-DM) and diabetes (DM) rats. METHODS: The thoracic aortae were isolated in order to investigate the influence of MEL on AT-1 R, using valsartan (VAL) and MT-2Rusing luzindole (LUZ) dose-response curve (DRC) measurement of Ang II reactivity. In addition, AT-1 R was involved in this study, under PD123319 with ADInstrument organ bath (Panlab apparatus, Harvard University, USA). RESULTS: The maximum response of Ang II was increased significantly in DM condition. In addition, AT-1 R was completely blocked under VAL, while AT-2 R was upregulated in the DM group. The combination of VAL and PD123319 led to abolishing the Ang II effect dramatically as well. Melatonin alone reduced Ang II in the DM group dramatically. This effect was also observed with MEL, PD1213319, and VAL combination, as well as, with MEL, LUZ, and PD1213319 combination. CONCLUSIONS: Melatonin has been demonstrated to modulate both AT-1 R and AT-2 R and has influenced the reactivity of Ang II in the aortas of diabetic rats through highly complex mechanisms.
The Effects of Weight Loss and Aerobic Exercise on Cortisol and Cortisol Suppression in Postmenopausal Women with Overweight and Obesity.
Ryan AS, Serra MC, Bigman G … +1 more , Jaber S
Endocr Res · 2025 May · PMID 39665581 · Full text
PURPOSE: The goal of this study was to explore the complex relationship between obesity, dietary content, weight loss, and cortisol concentrations in postmenopausal women with overweight and obesity. METHODS: Women compl...
PURPOSE: The goal of this study was to explore the complex relationship between obesity, dietary content, weight loss, and cortisol concentrations in postmenopausal women with overweight and obesity. METHODS: Women completed basal cortisol testing, a dexamethasone suppression test (DST), DXA scan, 3-hour oral glucose tolerance test (OGTT), and food records before ( = 60) and a subset after 6-months of weight loss (WL; = 15) or aerobic exercise training+weight loss (AEX+WL, = 34). RESULTS: At baseline, plasma cortisol concentrations decreased significantly after DST in the entire group, a 54% suppression which was associated with basal glucose. Basal glucose levels and glucose AUC from the OGTT are associated with basal cortisol levels ( = 0.44 and = 0.29, < 0.05 respectively). The intervention resulted in significant weight loss (-8%) but no significant changes in basal cortisol or changes in cortisol from basal to DST were observed. CONCLUSION: Additional research is necessary to better comprehend cortisol regulation in postmenopausal women particularly in response to effective weight reduction interventions.
Association Between Serum Uric Acid and Pregnancy Outcomes: A Study in Chinese Women.
Zhou Y, Gao X, An Y … +2 more , Liu J, Wang G
Endocr Res · 2025 May · PMID 39543083 · Publisher ↗
OBJECTIVE: The study aims to explore the relationship between serum uric acid (UA) levels in the first trimester and pregnancy outcomes. METHODS: The clinical data of 1381 pregnant women who delivered in the Department o...
OBJECTIVE: The study aims to explore the relationship between serum uric acid (UA) levels in the first trimester and pregnancy outcomes. METHODS: The clinical data of 1381 pregnant women who delivered in the Department of Obstetrics and Gynecology of Beijing Chao-Yang Hospital from June 2021 to July 2022 were collected. All patients were categorized into four groups (Q1-Q4) according to quartiles of UA, using the first quartile of UA as the reference group. Logistic regression analysis was used to observe the correlation between UA and pregnancy outcomes. Restricted cubic spline (RCS) was drawn to observe the dose-response relationship between UA and pregnancy outcomes. RESULTS: The numbers of GDM patients in Q1-Q4 were 40 (11.70%), 46 (13.49%), 60 (17.29%) and 83 (23.65%), respectively ( < 0.001). Logistic regression analysis showed that higher quartiles of UA were significantly associated with an increased prevalence of gestational diabetes mellitus (GDM). After adjusting for confounding factors (maternal age, prepregnancy BMI, gestational weight gain, and gestational age), compared with the lowest quartile of UA, the highest quartile of UA had 2.06 times odds of GDM (OR, 2.06; 95% CI, 1.34, 3.18; = 0.001) in Q4. RCS suggested that the risk of GDM increased slowly until UA levels reached 219.43 µmol/L and then began to increase rapidly afterward (overall = 0.0037). CONCLUSIONS: Increased uric acid concentrations in the first trimester are associated with an increased risk of GDM and gestational hypertension.
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