European Journal Of Oncology Nursing[JOURNAL]
Sun
200 papers
When the body becomes unfamiliar: symptom severity and experiences of chemotherapy-induced peripheral neuropathy in a sequential explanatory mixed-methods study.
Eskigülek Y, Kav S, Çevik B … +3 more , Turgay G, Özençakır H, Erten B
Eur J Oncol Nurs · 2026 Jul · PMID 42398396 · Publisher ↗
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and distressing adverse effect of neurotoxic chemotherapy that can lead to functional limitations and reduced quality of life. This study aimed to de...
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and distressing adverse effect of neurotoxic chemotherapy that can lead to functional limitations and reduced quality of life. This study aimed to determine the symptom severity of CIPN and to explore patients' experiences of living with neuropathic symptoms. METHODS: A sequential explanatory mixed-methods design was used. In the quantitative phase, 69 patients receiving neurotoxic chemotherapy were assessed using the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool (CIPNAT). Descriptive statistics, group comparisons (independent t-tests and ANOVA), and multiple linear regression analyses were performed. In the qualitative phase, in-depth interviews were conducted with 12 patients reporting multiple daily life interference related to CIPN to explore their experiences and coping strategies. Qualitative data were analyzed using thematic analysis, and integration of quantitative and qualitative findings was performed during interpretation. RESULTS: Participants reported a substantial burden of neuropathic symptoms, with a mean CIPNAT total score of 91.64 ± 57.55 and a daily life interference score of 25.88 ± 25.63. Qualitative analysis revealed three main themes: bodily estrangement, the quiet erosion of daily life, and coping efforts, describing patients' altered sensory experiences, disruptions in daily functioning and independence, and various strategies used to manage and adapt to symptoms. CONCLUSION: CIPN affects not only physical sensations but also patients' daily functioning, independence, and sense of self. Comprehensive assessment and supportive nursing care are essential to address its broader impact.
Effect of narrative interventions on psychological outcomes, sleep quality and quality of life in patients with cancer: Systematic review and meta-analysis of randomized controlled trials.
Çetiner E, Turan Kavradim S, Özer Z
Eur J Oncol Nurs · 2026 Jun · PMID 42398395 · Publisher ↗
PURPOSE: The primary aim of this study was to examine the effects of narrative interventions on psychological outcomes. Secondary outcomes included sleep quality and quality of life in patients with cancer. METHODS: Seve...
PURPOSE: The primary aim of this study was to examine the effects of narrative interventions on psychological outcomes. Secondary outcomes included sleep quality and quality of life in patients with cancer. METHODS: Seven databases were searched without any year restrictions. Comprehensive Meta-Analysis Software was used for the analysis, and the random effects model was used to determine the effects of narrative interventions. The Cochrane Risk of Bias Tool 2.0 was used for assessing the risk of bias. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline was utilized in reporting study. RESULTS: Eleven randomized controlled studies included in the systematic review and meta-analysis were conducted between 2011 and 2025 in China (n = 8), the United States of America (n = 2), and Spain (n = 1). The results of the meta-analyses indicate that narrative interventions have moderate-quality evidence regarding quality of life (Hedge's g = 2.182, 95% CI 0.86, 3.50, p < 0.001) and self-efficacy (Hedge's g = 1.595, 95% CI 1.02, 2.16, p < 0.001), and low-quality evidence regarding anxiety (Hedge's g = -2.396, 95% CI -3.84, -0.94, p = 0.001), depression (Hedge's g = -1.473, 95% CI: -2.49, -0.45, p = 0.001), psychological resilience (Hedge's g = 1.430, 95% CI 0.69, 2.16, p < 0.001) and sleep quality (Hedge's g = 1.292, 95% CI 0.53, 2.04, p = 0.005). Regarding fear of cancer recurrence, no significant effect was found, with very low-quality evidence. CONCLUSIONS: This systematic review and meta-analysis show that narrative interventions may offer potential benefits for certain outcomes, although the certainty of the evidence remains varied. The current evidence supports a cautious approach to clinical interpretation and highlights the need for high-quality trials.
Self-management support in oncology: A concept analysis.
Yang P, Gong Z, Hu Q … +2 more , Wu Y, Lu Q
Eur J Oncol Nurs · 2026 Jul · PMID 42391711 · Publisher ↗
PURPOSE: To clarify the concept of self-management support in the oncology context. METHODS: Walker and Avant's concept analysis method was used. A comprehensive search was conducted in PubMed, Web of Science, Scopus, CI...
PURPOSE: To clarify the concept of self-management support in the oncology context. METHODS: Walker and Avant's concept analysis method was used. A comprehensive search was conducted in PubMed, Web of Science, Scopus, CINAHL, Cochrane Library, Wanfang, SinoMed, CNKI and ProQuest from database inception to 25 November 2025. Thirty-three publications were included. Data were extracted using a standardised form and analysed using directed content analysis. RESULTS: Five defining attributes were identified: multidimensional support, an ongoing supportive process, collaborative partnership, person-centred care, and professional guidance and resource connection. Four antecedents were identified: the need for long-term illness management, unmet support needs, insufficient self-management capacity, and the complexity of self-management tasks. Five consequences were identified: strengthened self-management capacity, improved self-management behaviours, improved health outcomes, enhanced quality of life, and maintenance of social roles and functioning. CONCLUSION: Self-management support in oncology is an ongoing, person-centred, professionally guided and collaborative process that integrates multidimensional support and resources to strengthen patients' capacity to manage illness-related problems. This concept analysis provides a clearer conceptual foundation for measurement development, intervention design and oncology nursing practice.
Digital behavioural weight loss interventions for weight management in breast cancer survivors: A meta-analysis.
Mei H, Yue W, Zhang L … +1 more , Huang S
Eur J Oncol Nurs · 2026 Jun · PMID 42385539 · Publisher ↗
OBJECTIVE: This study aims to systematically evaluate the effectiveness of digital behavioural weight-loss interventions on body weight, BMI, waist circumference, physical activity, and quality of life in breast cancer s...
OBJECTIVE: This study aims to systematically evaluate the effectiveness of digital behavioural weight-loss interventions on body weight, BMI, waist circumference, physical activity, and quality of life in breast cancer survivors. METHODS: A comprehensive search was conducted across six databases, including PubMed, Scopus, Embase, Web of Science, CINAHL, and Cochrane Library, to identify eligible randomised controlled trials that investigated the effectiveness of digital behavioural weight loss interventions in weight management among breast cancer survivors. Data synthesis was performed using Stata 18.0 and Review Manager 5.4.1, and the quality of evidence was assessed using the GRADE system. RESULTS: A total of 17 RCTs involving 4644 breast cancer survivors who met the inclusion criteria were included. The meta-analysis results showed that digital weight loss interventions significantly reduced body weight (MD = -2.41, 95% CI: -3.32 to -1.49, P < 0.001), BMI (MD = -0.94, 95% CI: -1.51 to -0.37, P = 0.001) and waist circumference (MD = -3.06, 95% CI: -4.20 to -1.93, P < 0.001), and significantly increased levels of physical activity (SMD = 0.53, 95% CI: 0.42 to 0.65, P < 0.001). The improvement in quality of life was not statistically significant (P > 0.05). CONCLUSION: Digital behavioural weight loss interventions can effectively improve weight, BMI, waist circumference, and physical activity levels in breast cancer survivors, and thus hold significant clinical value. Future research should further explore standardised frameworks for digital weight-loss interventions and examine their impact on quality of life. TRIAL REGISTRATION: PROSPERO CRD420261304996; https://www.crd.york.ac.uk/PROSPERO/view/CRD420261304996.
Unmet needs of patients with cancer undergoing radiotherapy in Korea: A qualitative study.
Yoon J, Lee TH, Park H … +6 more , Yang K, Pyo H, Noh JM, Yu JI, Oh D, Park HC
Eur J Oncol Nurs · 2026 Jun · PMID 42385538 · Publisher ↗
PURPOSE: To identify key unmet needs among patients receiving radiotherapy for cancer and to provide insights for developing tailored supportive care interventions. METHODS: This qualitative descriptive study was conduct...
PURPOSE: To identify key unmet needs among patients receiving radiotherapy for cancer and to provide insights for developing tailored supportive care interventions. METHODS: This qualitative descriptive study was conducted at a tertiary hospital in Seoul, Korea, between March 2024 and March 2025. Purposive sampling was utilized to recruit patients with diverse cancer types and radiotherapy experiences before, during and after treatment. Semi-structured interviews were audio-recorded, transcribed verbatim, and analyzed using thematic content analysis until data saturation was achieved. RESULTS: A total of 24 patients participated, including nine with head and neck cancer, eight with hepatocellular carcinoma, and seven with lung cancer. Five major themes emerged: (1) lack of information and communication gaps; (2) physical and procedural burdens; (3) treatment-related adverse effects and functional decline; (4) psychosocial challenges; and (5) limited accessibility due to travel distance. Patients faced multifaceted unmet needs shaped by clinical factors, institutional systems, and societal expectations within the healthcare context. CONCLUSION: Addressing the five identified domains of unmet needs through multilevel strategies and policy-level interventions is essential to fostering a more holistic and equitable cancer care system. These findings provide a framework for nurses and radiotherapy teams to develop targeted supportive care strategies that address the diverse unmet needs of patients throughout the radiotherapy experience.
Cancer-related stigma in gynaecological cancers: A mixed-methods systematic review of quantitative associations and qualitative experiences.
Yeh YC, Chen SL
Eur J Oncol Nurs · 2026 Jun · PMID 42385537 · Publisher ↗
PURPOSE: To synthesise quantitative and qualitative evidence on cancer-related stigma among women with gynaecological cancers and examine its associations with psychosocial outcomes and healthcare engagement. METHODS: A...
PURPOSE: To synthesise quantitative and qualitative evidence on cancer-related stigma among women with gynaecological cancers and examine its associations with psychosocial outcomes and healthcare engagement. METHODS: A mixed-methods systematic review was conducted in accordance with PRISMA 2020. MEDLINE, CINAHL, PsycINFO, Embase, and Scopus were searched from January 2015 to May 2026. Quantitative and qualitative studies examining cancer-related stigma among women with gynaecological cancers were included. Quantitative findings were narratively synthesised, qualitative findings were thematically synthesised, and both were integrated using a convergent integrated approach. RESULTS: Nineteen studies were included, comprising eight quantitative and eleven qualitative studies. Quantitative evidence indicated that higher levels of cancer-related stigma were associated with greater psychological distress, depressive symptoms, reduced social support, symptom burden, and poorer quality of life. Qualitative findings revealed experiences of shame, self-blame, concealment, fear of disclosure, social withdrawal, relational disruption, and barriers to healthcare engagement. Cancer-related stigma was often shaped by sociocultural meanings related to sexuality, femininity, and reproductive identity, particularly in cervical cancer contexts. Integrated findings informed an interpretive framework highlighting interrelated intrapersonal, interpersonal, and sociocultural dimensions of stigma experiences. CONCLUSION: Cancer-related stigma represents an important psychosocial concern for women with gynaecological cancers, particularly those with cervical cancer. Findings highlight the importance of stigma-sensitive psychosocial assessment, communication, and supportive care in oncology nursing practice. Given the predominance of cross-sectional evidence, further longitudinal and intervention research is needed to strengthen the evidence base and inform culturally responsive care.
Dyadic emotional and behavioral experiences in pediatric leukaemia: An interpretative phenomenological analysis of parent-child dynamics in Pakistan.
Rahman FU, Alam I, Mengjia W … +2 more , Khan H, Ruixing Z
Eur J Oncol Nurs · 2026 Jun · PMID 42385536 · Publisher ↗
PURPOSE: Pediatric leukaemia disrupts children's emotional development and places sustained psychological demands on parents. In Pakistan, formal psychological rehabilitation services remain limited, and little is known...
PURPOSE: Pediatric leukaemia disrupts children's emotional development and places sustained psychological demands on parents. In Pakistan, formal psychological rehabilitation services remain limited, and little is known about how emotional coping unfolds within parent-child relationships during illness. This study aims to explore the lived emotional and behavioral experiences of children with leukaemia and their parents using a dyadic interpretative framework. METHODS: An interpretative phenomenological analysis (IPA) was conducted with 15 parent-child dyads recruited from the pediatric oncology unit in Peshawar, Pakistan. Semi-structured interviews were conducted separately with children and their primary caregivers in Urdu or Pashto, transcribed verbatim, translated into English, and analyzed using IPA. NVivo 14 facilitated data organization and management, while coding and interpretation remained researcher-led. Ethical approvals were obtained from Zhengzhou University, China, and Hayatabad Medical Complex, Pakistan. RESULTS: Three superordinate themes were identified: (1) emotional distress and meaning-making in diagnosis and treatment-related changes, (2) dyadic emotional regulation and mutual protection, including role reversal, protective silence, and shared normalcy, and (3) faith and spiritual meaning-making through prayer, patience, hope, and gratitude. Across themes, dyadic emotional symmetry captured how children and parents mutually interpreted and regulated distress, hope, silence, and coping within the parent-child relationship. CONCLUSIONS: Coping with pediatric leukaemia in Pakistan is a relational, culturally embedded process rather than an individual psychological response. Oncology nursing practice may benefit from dyad-focused psychological assessment and interventions that support safe emotional expression, structured parent-child communication, therapeutic play, and spiritually sensitive care.
Factors associated with reproductive concerns among adolescent and young adult cancer survivors: A cross-sectional study.
Zhao S, Wang X, Zhong T … +4 more , Tang D, Li HCW, Xia W, Chung OKJ
Eur J Oncol Nurs · 2026 Jun · PMID 42378789 · Publisher ↗
PURPOSE: Cancer and its treatment-related effects may impair fertility and increase reproductive concerns (RCs) among adolescent and young adult (AYA) survivors at their peak reproductive years. To assess RCs in survivor...
PURPOSE: Cancer and its treatment-related effects may impair fertility and increase reproductive concerns (RCs) among adolescent and young adult (AYA) survivors at their peak reproductive years. To assess RCs in survivors and examine their associated factors and pathways. METHODS: A cross-sectional study was conducted with 209 AYA cancer survivors aged 15-39 years from June 2023 to December 2024. Participants' RCs, cancer-related sexual and reproductive health knowledge, attitudes, and needs were measured. Multiple linear regression and structural equation modeling were performed. RESULTS: Participants' mean RCs score was 70.17 ± 6.70. Regression showed that cancer-related sexual and reproductive health attitudes (B = 0.646, p < 0.001), needs (B = 0.516, p = 0.001) were positively associated with RCs. Awareness of fertility preservation options, including sperm donation (B = 2.034, p = 0.005) and testicular replacement (B = 2.224, p = 0.044), was also positively associated with RCs. Conversely, endorsement of artificial uterus technology (B = -3.032, p = 0.007), perceived impact of habitual sleep deprivation on fertility (B = -1.491, p = 0.030), and a history of hematologic malignancy (B = -6.256, p = 0.003) were negatively associated with RCs. Structural equation modeling showed that attitudes (β = 0.531, p < 0.001), knowledge (β = 0.201, p = 0.003), and needs (β = 0.295, p = 0.006) were significantly associated with RCs. CONCLUSIONS: RCs among AYA cancer survivors are associated with sexual and reproductive health-related attitudes, knowledge, needs. Integrated education and supportive care may be relevant for addressing RCs in this population.
Resilience among family caregivers of women with breast cancer: a systematic review and meta-synthesis of qualitative studies.
Daniels-Donkor SS, Epstein B, Mitchell EM
Eur J Oncol Nurs · 2026 Jun · PMID 42378788 · Publisher ↗
PURPOSE: To identify, synthesize, and interpret qualitative evidence on resilience among family caregivers of women with breast cancer and to develop an integrated understanding of the processes that shape resilience in...
PURPOSE: To identify, synthesize, and interpret qualitative evidence on resilience among family caregivers of women with breast cancer and to develop an integrated understanding of the processes that shape resilience in this caregiving context. METHODS: We systematically searched Ovid MEDLINE, CINAHL, Web of Science, and PsycINFO for English-language qualitative studies published from January 2000 through October 2025. Two researchers independently screened titles, abstracts, and full texts in Covidence and appraised methodological quality using the Critical Appraisal Skills Programme checklist. Data were extracted using a standardized form, and findings were synthesized thematically to develop analytical themes. RESULTS: Ten studies from eight countries involving 161 family caregivers were included in this review. The analysis identified four interrelated analytical themes: (1) Spiritual beliefs as an anchoring foundation, using faith for meaning and stability; (2) Relational buffering, mobilizing practical and emotional support; (3) Adaptive flexibility, restructuring roles and integrating care into daily life; (4) Cognitive reframing, finding purpose and positivity. These themes illustrate resilience as a dynamic, context-dependent process rather than a fixed trait. CONCLUSION: These findings may inform family-centered nursing strategies that support caregivers by addressing spiritual, relational, behavioral, and cognitive processes throughout the breast cancer trajectory. Further culturally sensitive and longitudinal research is needed to examine how these resilience processes evolve and how they can be supported in practice.
Rural cancer research activity across Europe: A bibliometric analysis on patterns, gaps and policy implications.
Kleinhappel TK, Calanzani N, Cooke S … +10 more , Pickwell-Smith B, Spencer K, Kane R, Naqvi SA, de Sá J, Couespel N, Selby P, Lawler M, Murchie P, Nelson D
Eur J Oncol Nurs · 2026 Jun · PMID 42378787 · Publisher ↗
PURPOSE: Rural populations comprise around 27% of Europeans and face persistent challenges across the cancer pathway. Although rurality is recognised as a contributor to cancer inequalities, most evidence has historicall...
PURPOSE: Rural populations comprise around 27% of Europeans and face persistent challenges across the cancer pathway. Although rurality is recognised as a contributor to cancer inequalities, most evidence has historically been generated outside Europe. No comprehensive mapping of European rural cancer research exists and understanding where evidence is concentrated or absent is important for informing equitable cancer-policy planning. We mapped rural cancer research activity across Europe, including publication trends, geographical distribution, collaboration patterns, and thematic focus. METHODS: We conducted a bibliometric review in accordance with the BIBLIO Guidelines for Reporting Bibliometric Reviews of the Biomedical Literature. Data were retrieved from Scopus and Web of Science (1940-2025), processed in R (4.5.1), and analysed using the bibliometrix package. Analyses included annual output, citation metrics, country and institutional productivity, collaboration networks, thematic mapping, and Multiple Correspondence Analysis. RESULTS: A total of 2050 publications were analysed. Annual output increased at a growth rate of 6.04%. Research activity was unevenly distributed, with the UK, France, Germany, Poland, and Italy as the most productive countries. Collaboration networks were strong, especially among Western European nations. Thematic analysis showed a focus on screening, epidemiology, and specific tumour types, with limited research on treatment, survivorship, and service delivery-patterns relevant for European cancer policy. CONCLUSIONS: Rural cancer research in Europe is uneven and thematically narrow. Integrating rurality into cancer-inequality monitoring, incorporating rural indicators into EU policy frameworks, and strengthening research capacity in under-represented countries are timely, achievable steps to support more equitable cancer policy and planning.
Effect of an aerobic exercise-based programme throughout chemotherapy on cognitive function in patients with breast cancer: A non-randomized controlled study.
Liu Y, Su Y, Bai L … +4 more , Yang A, Zhao F, Liu JE, Chen S
Eur J Oncol Nurs · 2026 Jun · PMID 42365683 · Publisher ↗
PURPOSE: Chemotherapy-related cognitive impairment (CRCI) is a prevalent neurotoxicity in patients with breast cancer (BC), leading to cognitive decline and reduced quality of life. Exercise is recommended as a potential...
PURPOSE: Chemotherapy-related cognitive impairment (CRCI) is a prevalent neurotoxicity in patients with breast cancer (BC), leading to cognitive decline and reduced quality of life. Exercise is recommended as a potential strategy to mitigate CRCI; however, optimal exercise modalities and protocols remain unclear. Moreover, implementing exercise during chemotherapy presents practical and adherence challenges, highlighting the need for feasible, targeted exercise interventions. This study aimed to evaluate the effects of an aerobic exercise programme delivered throughout chemotherapy on cognitive function in patients with BC. METHODS: A non-randomized controlled clinical trial was conducted in patients aged 18-65 years with stage I-III breast cancer undergoing chemotherapy. Participants received either usual care or an aerobic exercise-based programme delivered throughout chemotherapy, incorporating behavioural and social support components. Subjective and objective cognitive function, fatigue, quality of life, and physical fitness were assessed at baseline, mid-chemotherapy, and post-intervention. RESULTS: Fifty-nine patients (intervention group, n = 28 vs. control group, n = 31) were enrolled into the study, and 48 (24 per group) completed all tests at final-chemotherapy. Compared with the control group, significant improvements were observed in all measurements of cognitive function, fatigue, quality of life, and grip strength (healthy) after the intervention (p < .05). CONCLUSION: The aerobic exercise-based program had beneficial effects on cognitive function, fatigue, quality of life, and grip strength.
Development and validation of an interpretable model for pre-chemotherapy triage of fatigue-pain-sleep disturbance burden in lung cancer.
Zhu B, Luo Y, Xi R … +7 more , Qian Q, Zhang L, Mao D, Chen X, Liu X, Miao J, Zhang L
Eur J Oncol Nurs · 2026 Jun · PMID 42349032 · Publisher ↗
PURPOSE: The aim of the study is to develop an interpretable machine learning model that can effectively identify patients at risk of high fatigue-pain-sleep disturbance (FPS) burden before chemotherapy. METHODS: A two-c...
PURPOSE: The aim of the study is to develop an interpretable machine learning model that can effectively identify patients at risk of high fatigue-pain-sleep disturbance (FPS) burden before chemotherapy. METHODS: A two-centre observational study was conducted in two tertiary hospitals. Candidate predictors were assessed approximately two weeks before chemotherapy initiation, whereas fatigue, pain, and sleep disturbance outcomes were assessed after chemotherapy completion. Pre-chemotherapy demographic, clinical, laboratory, and patient-reported variables were collected, and latent profile analysis (LPA) of post-chemotherapy FPS identified symptom-burden subgroups. Machine-learning models were trained in one hospital-based development cohort and validated in an independent institutional cohort from a second hospital; performance was assessed with discrimination, calibration, and clinical-utility metrics, and the best model was interpreted using Shapley Additive Explanations (SHAP). RESULTS: A total of 1444 patients were included for model development and independent institutional validation. The macro area under the receiver operating characteristic curve (ROC-AUC) of four candidate models in institutional validation ranged from 0.761 to 0.821. The Multi-XGBoost model showed the best discrimination in the independent institutional validation cohort (micro AUC = 0.853; macro AUC = 0.821), with classification results summarised by the confusion matrix. CONCLUSION: The interpretable machine-learning model developed and evaluated through independent institutional validation demonstrated good predictive performance. This model may help oncology nurses and clinicians identify high-risk patients before chemotherapy and support earlier, risk-stratified symptom-management planning.
The silent struggle of nurses caring for children battling leukemia: An in-depth examination of compassion fatigue.
Onel AE, Akcay Didisen N, Uluhan C … +1 more , Yilmaz Karapinar D
Eur J Oncol Nurs · 2026 Jun · PMID 42349031 · Publisher ↗
PURPOSE: To explore in depth the views and experiences of pediatric nurses caring for children diagnosed with acute lymphoblastic leukemia in relation to compassion fatigue. METHOD: Data were collected between December 2...
PURPOSE: To explore in depth the views and experiences of pediatric nurses caring for children diagnosed with acute lymphoblastic leukemia in relation to compassion fatigue. METHOD: Data were collected between December 2023 and February 2024 through semi-structured focus group interviews with nurses working in a university hospital's Pediatric Hematology Clinic. Of the 10 nurses employed in the unit, eight participated in the study following a pilot interview conducted with two nurses. Interviews were audio-recorded, transcribed verbatim, and analysed using inductive content analysis. The study was reported in accordance with the COREQ checklist. RESULTS: Six themes were identified: (1) nurses' perceptions of compassion fatigue, (2) emotional bonding in long-term care, (3) managing empathy and professional boundaries, (4) compassion fatigue as a dynamic process, (5) emotional withdrawal and burnout, and (6) coping strategies and emotional support. CONCLUSIONS: Compassion fatigue among pediatric oncology nurses represents not only an occupational challenge but also a profound emotional process that tests personal and professional resilience. Nurses' internal resources, professional identity, and coping strategies play a central role in managing this experience. The findings underscore the importance of supporting pediatric nurses in recognising, preventing, and managing compassion fatigue. Psychosocial support programmes, training to balance empathy with professional boundaries, and organisational strategies to optimise workload may help reduce risk and enhance the quality of care provided to children and their families.
Effectiveness of non-pharmacological interventions for chemotherapy-induced peripheral neuropathy-related pain: A systematic review and network meta-analysis.
Kobayashi M, Kako J, Sakuramoto H … +5 more , Kakeda T, Ito Y, Kajiwara K, Tsubaki M, Yamanaka M
Eur J Oncol Nurs · 2026 Jun · PMID 42341448 · Publisher ↗
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, distressing, adverse effect of neurotoxic chemotherapy that can persist post-treatment, and may affect therapy and daily functioning. Pharmacologica...
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, distressing, adverse effect of neurotoxic chemotherapy that can persist post-treatment, and may affect therapy and daily functioning. Pharmacological options remain limited; therefore, non-pharmacological strategies are increasingly used. However, their comparative effectiveness remains unclear. We aimed to compare and rank the effectiveness of non-pharmacological interventions for CIPN-related pain. METHOD: We conducted a systematic review and frequentist network meta-analysis (NMA) of randomised controlled trials (RCTs). PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL databases were searched through 23, May 2025. Interventions were grouped as acupuncture-based, electrical stimulation-based, exercise-based, psychological, cryotherapy, or control. Pairwise meta-analyses and random-effects NMA were performed. Treatments were ranked using P-scores. The risk of bias was assessed independently by reviewer pairs using RoB 2.0. RESULTS: Thirty-two RCTs (n = 1612) met the inclusion criteria, and 19 were used for NMA. Acupuncture-based interventions significantly reduced pain versus controls (standardised mean difference 0.66; 95% confidence interval 0.16-1.17). Treatment ranking based on P-scores suggested that cryotherapy ranked highest (P-score = 0.86), followed by exercise-based (P-score = 0.68), acupuncture-based (P-score = 0.54), and electrical stimulation-based (P-score = 0.42) interventions. No other intervention demonstrated a statistically significant reduction in pain compared with control conditions. Substantial heterogeneity was observed (τ = 0.54, I = 83.8%). CONCLUSIONS: The effectiveness of cryotherapy and exercise remains unclear. However, our findings suggest that there is significant evidence to consider acupuncture as a supportive option for managing CIPN-related pain. Future well-powered RCTs are needed to support implementation in multidisciplinary oncology.
Before the next treatment: Pain interference as an interprofessional care signal in head and neck cancer.
Liu YT, Cheng CH, Liu HC … +2 more , Chang HH, Tu CY
Eur J Oncol Nurs · 2026 Jun · PMID 42341447 · Publisher ↗
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Non-invasive brain stimulation and cognitive training for depressive symptoms and cancer-related cognitive impairment in breast cancer survivors (ONCODEP).
Salgado-Blanco C, Alcántara Espinosa JM, Pinal D … +5 more , Pérez IF, Blanco BV, Rodríguez PÁ, Spuch C, Carrillo de la Peña MT
Eur J Oncol Nurs · 2026 Jun · PMID 42335551 · Publisher ↗
PURPOSE: Depression and cancer-related cognitive impairment (CRCI) are frequent after-effects in breast cancer survivors (BCS). Despite being closely related and sharing some features, there is no intervention addressing...
PURPOSE: Depression and cancer-related cognitive impairment (CRCI) are frequent after-effects in breast cancer survivors (BCS). Despite being closely related and sharing some features, there is no intervention addressing them comprehensively. Transcranial direct current (tDCS) and alternating stimulation (tACS), combined with computerized cognitive training (CCT), provided benefits for improving mood and cognition in several populations and have several advantages, but evidence in BCS is limited. This study aims to explore the effectiveness and feasibility of a home-based combined intervention (tDCS or tACS + CCT) to improve depressive symptoms and CRCI in BCS. METHODS: BCS presenting depressive symptoms (Beck Depression Inventory Fast Screen >4) were randomly assigned to four groups: tDCS + CCT; tACS + CCT; sham transcranial stimulation + CCT; CCT. Home-based intervention consisted of 15 daily 20-min sessions combining prefrontal tDCS or tACS simultaneously with CCT. Linear mixed-effects models and Minimal Clinically Important Differences assessed the effectiveness of the intervention on depressive symptoms, cognitive complaints and neuropsychological performance. RESULTS: Eighty-two BCS participated (range 46.3 - 48.9 years). Most participants completed the intervention without significant side effects. No significant differences between intervention groups were found, although improvements over time were observed across groups in depressive and cognitive outcomes. CONCLUSION: The home-based intervention was feasible. Improvements in mood and CRCI were observed, but the additive effect of tDCS/tACS was not demonstrated. Future studies should be powered using population-specific effect sizes, consider other neuromodulation protocols and clinical outcomes and optimize home-based stimulation fidelity. The effectiveness of CCT should be further investigated.
Co-design of a pre-surgical care intervention to support people undergoing prostatectomy for prostate cancer.
Bolte J, Gaffney J, Bowes W … +7 more , McKinnnon V, Nguyen A, Trevor D, Hancock P, Wright T, Mahendran N, Roberts N
Eur J Oncol Nurs · 2026 Jun · PMID 42335550 · Publisher ↗
PURPOSE: To co-design a pre-surgical care intervention to support patients treated with a radical prostatectomy. METHODS: This work took place in a university hospital providing care to other sites within a large public...
PURPOSE: To co-design a pre-surgical care intervention to support patients treated with a radical prostatectomy. METHODS: This work took place in a university hospital providing care to other sites within a large public health service in Australia. Participants included patients who had been treated with a robotic prostatectomy for prostate cancer, and the clinical teams providing care to this population of patients. The multi-methods study involved two study phases: (i) an evaluation of current robotic-assisted radical prostatectomy care using the RE-AIM framework, and, (ii) the co-design of a pre-surgical care intervention with a Steering Committee of experts using Nominal Group Technique. Qualitative findings were analysed using a Framework Method. Quantitative findings were descriptively reported using counts and proportions. RESULTS: Phase One identified unmet needs relating to treatment toxicities, and potential care inequities due to variation in care delivery. The co-design in Phase Two resulted in the development of a pre-surgical care intervention that featured early patient screening, a defined clinical pathway of care, and defined education priorities. CONCLUSIONS: The development of a co-designed pre-surgical care intervention provides a structured approach to addressing unmet information needs among patients undergoing prostatectomy and informing person-centred models of care. Further work is needed to evaluate feasibility, acceptability, and clinical impact.
Exploring continuous nursing needs among outpatients undergoing central venous access device maintenance in the smart healthcare context: A qualitative study.
Zhou Q, Wu W, Wu Y … +1 more , Ying L
Eur J Oncol Nurs · 2026 Jun · PMID 42322882 · Publisher ↗
PURPOSE: This study qualitatively explored the continuous needs of patients undergoing central venous access device maintenance within the context of smart healthcare. METHOD: A descriptive qualitative design was used to...
PURPOSE: This study qualitatively explored the continuous needs of patients undergoing central venous access device maintenance within the context of smart healthcare. METHOD: A descriptive qualitative design was used to explore the continuity-of-care needs of patients undergoing central venous access device maintenance within smart healthcare. Twenty outpatients from a tertiary oncology hospital in Zhejiang, China, were purposively sampled and interviewed face-to-face for 15-30 min between June and August 2025 until data saturation. Transcripts were analyzed using conventional content analysis with NVivo 12 following COREQ guidelines. Credibility was ensured through reflexive journaling and peer debriefing during data analysis. Ethical approval was obtained, and all participants provided written informed consent. RESULTS: Five themes emerged from the analysis, reflecting patients' diverse needs during central venous access device maintenance within the smart healthcare context. These included (1) feeling vulnerable during catheter care at home; (2) experiencing uncertainty across different care settings; (3) struggling to find clear and personalized information; (4) seeking more convenient and coordinated care; and (5) staying connected for emotional reassurance. CONCLUSIONS: This study highlights needs for safety, continuity, and emotional connection in patients undergoing central venous access device maintenance. It suggests that smart healthcare must evolve from technical monitoring to holistic support, informing the development of patient-centered smart nursing platforms.
Examining informed consent quality in oncology clinical trial participants: A cross-sectional study.
Zhang J, Kang S, Pang D … +5 more , Yang H, Liu X, Gu Y, Guo R, Lu Y
Eur J Oncol Nurs · 2026 Jun · PMID 42308704 · Publisher ↗
PURPOSE: This cross-sectional study was designed to assess the informed consent quality in cancer clinical trials in China. We further examined the consistency between cancer patients' objective knowledge and subjective...
PURPOSE: This cross-sectional study was designed to assess the informed consent quality in cancer clinical trials in China. We further examined the consistency between cancer patients' objective knowledge and subjective understanding of the trial, as well as patient-related factors that influence the quality of informed consent. METHODS: This cross-sectional research was conducted at a tertiary cancer hospital in Beijing, China, between April 2023 and March 2024. To assess objective knowledge and subjective understanding of the consent provision and clinical trial, all participants completed a form comprising demographic items and the Quality of Informed Consent Questionnaire. Data were analyzed using correlation analyses, descriptive statistics, and quantile regression. RESULTS: For 304 cancer patients, the median objective knowledge as well as subjective understanding scores were 69.20 (IQR, 60.08-76.90) and 61.60 (IQR, 37.50-82.10), respectively. The correlation coefficients of the total score and each dimension between objective knowledge and subjective understanding ranged from 0.113 to 0.633, p < 0.050. Quantile regression analysis showed that age, level of education, marital status, primary caregiver, previous participation in clinical trials, and anti-tumor treatment experience significantly influenced both objective knowledge and subjective understanding. CONCLUSION: Cancer patients who participated in clinical studies showed moderate informed consent quality. Objective knowledge and subjective understanding of the trial content were significantly positively correlated. The correlations in the "Alternatives" dimension were weak and warrant improvement. The informed consent quality with different patient characteristics was heterogeneous, and the influence of these characteristics varied across quantiles.
Medical cannabis treatment non-adherence among oncology patients: A prospective cohort analysis in Israel.
Aviram J, Zgairy S, Meiri D … +1 more , Snitzman SR
Eur J Oncol Nurs · 2026 Jun · PMID 42302583 · Publisher ↗
PURPOSE: Oncology patients frequently experience distressing symptoms. Medical cannabis (MC) is increasingly used, yet real-world MC discontinuation remains insufficiently characterized. This study aimed to identify base...
PURPOSE: Oncology patients frequently experience distressing symptoms. Medical cannabis (MC) is increasingly used, yet real-world MC discontinuation remains insufficiently characterized. This study aimed to identify baseline factors associated with voluntary MC non-adherence over six months among oncology patients. METHOD: Voluntary MC non-adherence was defined as patient-initiated discontinuation due to perceived ineffectiveness and/or MC-related adverse effects (AEs) at any follow-up point. Patients who continued MC through scheduled follow-ups were classified as adherent. Death, clinical recovery, and loss to follow-up were not classified as voluntary non-adherence events and were excluded from the primary adherence analysis. RESULTS: Of 324 patients who initiated MC and completed baseline assessments, 186 were eligible for non-adherence analysis. At six months, 126/186 (68%) remained adherent and 60/186 (32%) were non-adherent. Among non-adherent patients, discontinuation was attributed to perceived ineffectiveness in 24/60 (40%) and MC-related AEs in 36/60 (60%). In bivariate analyses, non-adherence was more frequent among patients without prior cannabis experience (12% vs. 26%; p < 0.05), with less positive MC-attitudes scores (median 16 vs. 18; p < 0.001), and, among women, lower Female Sexual Function Index scores (median 10 vs. 24; p < 0.005). Penalized multivariable logistic regression associated bladder cancer, stomach cancer, and cardiac comorbidity with higher odds of non-adherence, whereas mood-related MC use and more positive MC-attitudes scores were associated with lower odds. CONCLUSIONS: Voluntary MC non-adherence in oncology was associated with diagnostic, clinical, and psychosocial factors. These exploratory findings may identify patients requiring closer counseling, but require validation in larger prospective studies accounting for competing risks and socioeconomic barriers.
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