Yusof ENM, Azam M, Sirat SS
… +5 more, Ravoof TBSA, Page AJ, Veerakumarasivam A, Karunakaran T, Razali MR
Bioinorg Chem Appl
· 2022 · PMID 35959229
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S-4-methylbenzyl--N-(2-methoxybenzylmethylene)dithiocarbazate ligand, 1, prepared from S-(4-methylbenzyl)dithiocarbazate, was used to produce a novel series of transition metal complexes of the type, [M (L)] [M = Cu(II)...S-4-methylbenzyl--N-(2-methoxybenzylmethylene)dithiocarbazate ligand, 1, prepared from S-(4-methylbenzyl)dithiocarbazate, was used to produce a novel series of transition metal complexes of the type, [M (L)] [M = Cu(II) (), Ni(II) (), and Zn(II) (), L = ]. The ligand and its complexes were investigated by elemental analysis, FTIR, H and C-NMR, MS spectrometry, and molar conductivity. In addition, single X-ray crystallography was also performed for ligand, , and complex . The Hirshfeld surface analyses were also performed to know about various bonding interactions in the ligand, , and complex . The investigated compounds were also tested to evaluate their cytotoxic behaviour. However, complex showed promising results against MCF-7 and MDA-MB-213 cancer cell lines. Furthermore, the interaction of CT-DNA with ligand, and complex was also studied using the electronic absorption method, revealing that the compounds have potential DNA-binding ability via hydrogen bonding and hydrophobic and van der Waals interactions. A molecular docking study of complex was also carried out, which revealed that free binding free energy value was -7.39 kcal mol.
Devasena T, Iffath B, Renjith Kumar R
… +4 more, Muninathan N, Baskaran K, Srinivasan T, John ST
Bioinorg Chem Appl
· 2022 · PMID 35959228
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The manufacturing rate of nanoparticles (10-100 nm) is steadily increasing due to their extensive applications in the fabrication of nanoproducts related to pharmaceuticals, cosmetics, medical devices, paints and pigment...The manufacturing rate of nanoparticles (10-100 nm) is steadily increasing due to their extensive applications in the fabrication of nanoproducts related to pharmaceuticals, cosmetics, medical devices, paints and pigments, energy storage etc. An increase in research related to nanotechnology is also a cause for the production and disposal of nanomaterials at the lab scale. As a result, contamination of environmental matrices with nanoparticles becomes inevitable, and the understanding of the risk of nanoecotoxicology is getting larger attention. In this context, focusing on the environmental hazards is essential. Hence, this manuscript aims to review the toxic effects of nanoparticles on soil, water, aquatic, and terrestrial organisms. The effects of toxicity on vertebrates, invertebrates, and plants and the source of exposure, environmental and biological dynamics, and the adverse effects of some nanoparticles are discussed.
Natrayan L, Arul Kumar PV, Dhanraj JA
… +5 more, Kaliappan S, Sivakumar NS, Patil PP, Sekar S, Paramasivam P
Bioinorg Chem Appl
· 2022 · PMID 35959227
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Industrial wastes contain more toxins that get dissolved in the rivers and lakes, which are means of freshwater reservoirs. The contamination of freshwater leads to various issues for microorganisms and humans. This pape...Industrial wastes contain more toxins that get dissolved in the rivers and lakes, which are means of freshwater reservoirs. The contamination of freshwater leads to various issues for microorganisms and humans. This paper proposes a novel method to remove excess copper from the water. The nanotubes are used as a powder in membrane form to remove the copper from the water. The multiwalled carbon nanotube is widely used as a membrane for filtration. It contains many graphene layers of nm size that easily adsorbs the copper when the water permeates through it. Activated carbon is the earliest and most economical method that also adsorbs copper to a certain extent. This paper proposes the methods of involving the activated carbon in the multiwalled carbon nanotube to improve the adsorption capability of the copper. Here, activated carbon is impregnated on the multiwalled carbon nanotube's defect and imperfect surface areas. It makes more adsorption sites on the surface, increasing the adsorption amount. The same method is applied to Hydroxyl functionalized multiwalled carbon nanotubes. Both the methods showed better results and increased the copper removal. The functionalized method removed 93.82% copper, whereas the nonfunctionalized method removed 80.62% copper from the water.
Kumar N, Gaur P, Kaliappan S
… +4 more, Natrayan L, Socrates S, Patil PP, Thanappan S
Bioinorg Chem Appl
· 2022 · PMID 35910304
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The main focus of this research is to enhance the use of eco-friendly materials these days. The current materials used in building construction are chemical-based and are harmful to humans and the environment. This resea...The main focus of this research is to enhance the use of eco-friendly materials these days. The current materials used in building construction are chemical-based and are harmful to humans and the environment. This research work has developed a new type of hybrid brick by using natural fibres and waste materials. This research focuses on fabricating novel bricks reinforced with different percentages of coconut waste fibre, wheat straw fibre, waste wood animal dung ash, gypsum, sand, and cement. The fabricated novel brick's physical, mechanical, chemical, acoustic, and heat-absorbing properties were evaluated.
Rajeshkumar S, Santhoshkumar J, Parameswari RP
… +3 more, Saravanan S, Balusamy SR, Arunachalam K
Bioinorg Chem Appl
· 2022 · PMID 35903518
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Several industries have become major contributors to waterbody contamination due to the improper removal of dyes and effluents into water bodies. Due to their carcinogenic properties and low biodegradability, dye degrada...Several industries have become major contributors to waterbody contamination due to the improper removal of dyes and effluents into water bodies. Due to their carcinogenic properties and low biodegradability, dye degradation is a considerable danger to people, animals, and the oceanic environment. As part of this study, leaf extract was used as a reducing and stabilizing agent to synthesize zinc nanoparticles and degrade dyes such as methyl red and eosin. Zinc oxide nanoparticles (ZnONPs) showed a surface plasmon resonance peak at 430 nm in the UV spectrum. The FTIR result showed a band at 597.93 cm that confirmed the formation of zinc nanoparticles. AFM results revealed spherical ZnONPs. The SEM results predicted an average particle size of 60 nm for crystalline particles. Biologically synthesized zinc nanoparticles exhibited greater antibacterial activity against spp. and spp. but lesser activity against spp. and . At 1000 g/ml concentration, ZnONPs had the highest antioxidant activity of 45.34%. An ultraviolet-visible spectrophotometer measured dye degradation progress between 300 and 800 nm. For methyl red, the maximum absorption peak was measured at 415 nm, and for eosin, the maximum peak value was measured between 500 and 515 nm.
Khalid A, Ahmad P, Khan A
… +10 more, Muhammad S, Khandaker MU, Alam MM, Asim M, Din IU, Chaudhary RG, Kumar D, Sharma R, Faruque MRI, Emran TB
Bioinorg Chem Appl
· 2022 · PMID 35873731
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Environmental problems with chemical and biological water pollution have become a major concern for society. Providing people with safe and affordable water is a grand challenge of the 21st century. The study investigate...Environmental problems with chemical and biological water pollution have become a major concern for society. Providing people with safe and affordable water is a grand challenge of the 21st century. The study investigates the photocatalytic degradation capabilities of hydrothermally prepared pure and Cu-doped ZnO nanoparticles (NPs) for the elimination of dye pollutants. A simple, cost-effective hydrothermal process is employed to synthesize the Cu-doped ZnO NPs. The photocatalytic dye degradation activity of the synthesized Cu-doped ZnO NPs is tested by using methylene blue (MB) dye. In addition, the parameters that affect photodegradation efficiency, such as catalyst concentration, starting potential of hydrogen (pH), and dye concentration, were also assessed. The dye degradation is found to be directly proportional to the irradiation time, as 94% of the MB dye is degraded in 2 hrs. Similarly, the dye degradation shows an inverse relation to the MB dye concentration, as the degradation reduced from 94% to 20% when the MB concentration increases from 5 ppm to 80 ppm. The synthesized cost-effective and environmentally friendly Cu-doped ZnO NPs exhibit improved photocatalytic activity against MB dye and can therefore be employed in wastewater treatment materials.
Kumar N, Natrayan L, Kasirajan G
… +4 more, Kaliappan S, Raj Kamal MD, Patil PP, Chewaka MD
Bioinorg Chem Appl
· 2022 · PMID 35859704
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Natural fibre reinforcement is used in important sectors such as medical, aerospace, automobile, and many other fields. Many articles have reported that natural fibre has the potential to replace synthetic fibres. Natura...Natural fibre reinforcement is used in important sectors such as medical, aerospace, automobile, and many other fields. Many articles have reported that natural fibre has the potential to replace synthetic fibres. Natural fibre reinforcement has given good results as a brake friction material. It has already been proven that asbestos causes lung cancer and mesothelioma in brakes. Many people died from the effects of asbestos. According to the World Health Organization's trending brake report, this material leads to serious health issues. This work is going on for the replacement of these materials. Mulberry fibre is a unique material, and PAN fibre is combined with mulberry fibre and used as a brake reinforcement material to replace Kevlar fibre. The brake pads were fabricated with the various wt% of mulberry fibres and PAN fibre [3-12%] with an equal ratio and aramid fibre [3-6%] in the hydraulic hind brake moulding machine. The mechanical, chemical, physical, tribological, and thermal properties were evaluated. MF-2 [6 wt%] mulberry-PAN-fibre-based brake pad composites have shown better results for ultimate shear strength and proof stress, tensile strength, compressive strength, and impact energy.
Dong W, Wang H, Liu H
… +4 more, Zhou C, Zhang X, Wang S, He L
Bioinorg Chem Appl
· 2022 · PMID 35859703
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Black phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band...Black phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band gap, biodegradability, and biocompatibility properties, BP is considered promising for cancer therapy. For example, BP under irradiation can convert near-infrared (NIR) light into heat and reactive oxygen species (ROS) to damage cancer cells, called photothermal therapy (PTT) and photodynamic therapy (PDT). Compared with PTT and PDT, the novel techniques of sonodynamic therapy (SDT) and photoacoustic therapy (PAT) exhibit amplified ROS generation and precise photoacoustic-shockwaves to enhance anticancer effect when BP receives ultrasound or NIR irradiation. Based on the prospective phototherapy, BP with irradiation can cause a "double-kill" to tumor cells, involving tumor-structure damage induced by heat, ROS, and shockwaves and a subsequent anticancer immune response induced by in situ vaccines construction in tumor site, which is referred to as photoimmunotherapy (PIT). In conclusion, BP shows promise in natural antitumor biological activity, biological imaging, drug delivery, PTT/PDT/SDT/PAT/PIT, nanovaccines, nanoadjuvants, and combination immunotherapy regimens.
do Nascimento Silva Leandro MK, Barbosa Moura JV, Justino de Araújo AC
… +13 more, Freitas PR, Roque Paulo CL, de Sousa AK, Rocha JE, Garcia Leandro LM, Macedo da Silva RO, Costa Dos Santos C, Ribeiro-Filho J, da Luz Lima C, Siyadatpanah A, Seifi Z, Kim B, Coutinho HDM
Bioinorg Chem Appl
· 2022 · PMID 35855788
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The present study reports the synthesis, characterization, and antibacterial properties of silver trimolybdate (AgMoO.2HO) nanorods. The synthesis was performed using a conventional hydrothermal method. The sample was ch...The present study reports the synthesis, characterization, and antibacterial properties of silver trimolybdate (AgMoO.2HO) nanorods. The synthesis was performed using a conventional hydrothermal method. The sample was characterised by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV-Vis-NIR diffuse reflectance, thermogravimetric analysis (TGA), and differential scanning calorimeter (DSC). The direct antibacterial activity was evaluated using the microdilution method to determine the minimum inhibitory concentration (MIC). To assess the ability of AgMoO.2HO nanorods to modulate antibacterial resistance, the MIC of aminoglycosides was established in the presence of a subinhibitory concentration of this substance alone and associated with LED light exposure. The characterization of the sample indicated that the synthesis of silver trimolybdate generated nanometric crystals with rod-like morphology, without secondary phases. The treatment with AgMoO.2HO nanorods alone or combined with visible LED lights exhibited clinically relevant antibacterial activity against both Gram-negative and Gram-positive bacteria. This nanostructure presented a variable antibiotic-modulating action, which was not improved by visible LED light exposure. Nevertheless, LED lights showed promising antibiotic-enhancing activities in the absence of AgMoO.2HO nanorods. In conclusion, silver trimolybdate dihydrate nanorods have antibacterial properties that can be photocatalysed by visible-light exposure. While showing the potential use to combat antibacterial resistance, the simultaneous combination of silver trimolybdate, visible LED lights, and antibacterial drugs should be carefully analysed to avoid antagonist effects that could impair the effectiveness of antibiotic therapy.
Bioinorg Chem Appl
· 2022 · PMID 35855787
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The in vitro antibacterial, anticancer, and antioxidant activities of a few plant extracts were widely known for decades, and they were used for application in the conventional way. Specifically, electrospun nanofibrous...The in vitro antibacterial, anticancer, and antioxidant activities of a few plant extracts were widely known for decades, and they were used for application in the conventional way. Specifically, electrospun nanofibrous mats have recently exhibited great antibacterial, anticancer, and antioxidant activities. The herbal extracts infused into these formations are expected to have a more efficient and integrated effect on in vitro biological applications. The purpose of this study is to develop polycaprolactone- (PCL-) based nanofiber mats that are infused with a traditional plant extract using leaves to improve the synthesized nanofibers' antibacterial, anticancer, and antioxidant efficacy. This study examined the morphology, thermal properties, mechanical properties, structure, and in vitro drug release studies of electrospun nanofibers. Antibacterial, anticancer, and antioxidant activities of the electrospun nanofibrous mats were also studied. The HRTEM and FESEM pictures of PCL and PCL-CPM nanofibers provide that smooth, defect-free, and homogeneous nanofibers were found to be 602.08 ± 75 nm and 414.15 ± 82 nm for PCL and PCL-CPM nanofibers, respectively. The presence of extract in the electrospun nanofibers was approved by UV-visible and FTIR spectroscopy. The incorporation of extract to nanofiber mats resulted in substantial antibacterial activity against bacterial cells. PCL-CPM mats exposed to oral cancer (HSC-3) and renal cell carcinoma (ACHN) cell lines displayed promising anticancer activity with less than 50% survival rate after 24 h of incubation. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay performed on PCL-CPM nanofibers revealed the antioxidant scavenging activity with maximum inhibition of 34% suggesting the role of the secondary metabolites release from scaffold. As a result, the findings of this study revealed that extract encapsulating PCL electrospun nanofibers has a high potential for usage as a biobased antibacterial, anticancer, and antioxidant agent.
Yahya Tahir M, Ahmad A, A Alothman A
… +2 more, Mushab MSS, Ali S
Bioinorg Chem Appl
· 2022 · PMID 35813489
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The green synthesis method was used to effectively fabricate Ag-NPs by using bark extract. The structural, morphological, elemental composition, and optical properties of as-synthesized Ag-NPs were characterized by powd...The green synthesis method was used to effectively fabricate Ag-NPs by using bark extract. The structural, morphological, elemental composition, and optical properties of as-synthesized Ag-NPs were characterized by powder X-ray diffraction (P-XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDAX), transmission electron microscopy (TEM), and UV-Vis spectroscopy. Their photocatalytic efficiency as a photocatalyst was examined by degradation of methylene blue (MB) dye under direct sunlight irradiation. After 120 minutes of sunlight irradiation, Ag-NPs show photocatalytic degradation efficiency (DE percent) of 92%. The hydroxyl and superoxide radicals were found to be responsible for biodegradation. To the best of our acquaintance, this is the first research to use Ag-NPs as a photocatalyst for the efficient degradation of MB dye and its antimicrobial activity by using bark extract. The cytotoxic viability against SK-MEL cell line with a median inhibitory concentration (IC) of 45 L/mg proved its potent anticancer property. Based on the findings, the study revealed the significance of as-synthesized green Ag-NPs over other physically/chemically prepared Ag-NPs.
Bioinorg Chem Appl
· 2022 · PMID 35800067
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At the moment, unserviceable magnesium implants make a good case in point for further responsible study in this field. Whether we are willing to admit it or not, existing methods for corrosion monitoring are exposed to s...At the moment, unserviceable magnesium implants make a good case in point for further responsible study in this field. Whether we are willing to admit it or not, existing methods for corrosion monitoring are exposed to susceptibility and instability. Interdisciplinary theories and the existing corrosion experiments were combined based on their various merits for developing an accurate and precise corroding experiment for Mg/Mg alloys. We used the water-soluble tetrazolium-8 (WST-8) reagent to further complete the immersion experiment. The color change of the solution reflects the rationale of corrosion, followed by monitoring the degree of corrosion. The feasibility of this idea will be demonstrated.
Bioinorg Chem Appl
· 2022 · PMID 35783989
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The recreational belt around the city has low population density, good ecological environment, and rich natural and cultural landscapes, which can meet the tourism needs of urban residents to get close to nature and expe...The recreational belt around the city has low population density, good ecological environment, and rich natural and cultural landscapes, which can meet the tourism needs of urban residents to get close to nature and experience culture. Particularly in today's increasingly normal epidemic prevention and control, outing and microtourism have become the first choice of urban public tourism and an important part of rural tourism development. In the process of developing rural tourism, there are two distinct voices: one is to pay attention to the local complex and strive to let people "see mountains and water and remember nostalgia." In the era of cultural tourism integration, we should promote rural tourism with culture, highlight rural culture with rural tourism, and give full play to the bridge between cultural tourism and rural cultural innovation. In view of this situation, this paper discusses the theme orientation of the advanced development of the recreational belt around the city through three studies. In Study 1, tourists' perceptions of local complex and rural cultural creation were compared through field investigation. In Study 2, brand trust was used as a calibration variable to further test the robustness of the conclusion. Study 3 analyzed the "distortion" mechanism of rural cultural creation and tested the intermediary effect of psychological distance. At the same time, it discusses the evolution model of the recreational space system around the city. The development of recreation space shows that the recreation space around the city is the product of the agglomeration of population and economic activities, and its occurrence and development process is closely related to the expansion of urban space and the change of human living space. This paper analyzes the spatial process of the development of recreation around the city, focuses on the types of recreation space that continue to appear in the development and evolution of modern recreation space, and then tries to find the context of the gradual development and evolution of recreation around the city with the process of urbanization and excavate the organic connection between the recreational space and the city and its surrounding areas in the process of development and evolution. It is found that (1) tourists' perception of local culture is further distorted, which leads to a further reduction in tourists' perception of "local culture" and "recreation," and (2) the increase in psychological distance is the key psychological mechanism for tourists to perceive "lost property."
Subramanian K, Balaraman D, Kaliyaperumal K
… +8 more, Devi Rajeswari V, Balakrishnan K, Ronald Ross P, Perumal E, Sampath Renuga P, Panangal M, Swarnalatha Y, Velmurugan S
Bioinorg Chem Appl
· 2022 · PMID 35770237
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Hydrogel refers to a three-dimensional cross-linked polymeric network made of synthetic or natural polymers that can hold water in its porous structure. The inclusion of hydrophilic groups in the polymer chains, such as...Hydrogel refers to a three-dimensional cross-linked polymeric network made of synthetic or natural polymers that can hold water in its porous structure. The inclusion of hydrophilic groups in the polymer chains, such as amino, carboxyl, and hydroxyl groups, contributes to the hydrogel's water-holding ability. At physiological temperature and pH, these polymeric materials do not dissolve in water, but they do swell significantly in aqueous media. Hydrogel can be manufactured out of almost any water-soluble polymer, and it comes in a variety of chemical compositions and bulk physical properties. Hydrogel can also be made in a variety of ways. Hydrogel comes in a variety of physical shapes, including slabs, microparticles, nanoparticles, coatings, and films. Due to its ease of manufacture and self-application in clinical and fundamental applications, hydrogel has been widely exploited as a drug carrier. Contact lenses, artificial corneas, wound dressing, suture coating, catheters, and electrode sensors are some of the biomedical applications of hydrogels. The pigment color changes were observed from colorless to pale pink followed by dark reddish-pink. Anthocyanin was produced in large quantities and tested using a UV-visible spectrophotometer. At 450-550 nm, the largest peak (absorbance) was detected, indicating the presence of anthocyanin. The FTIR analysis of this study shows the different stretches of bonds at different peaks: 2918.309 (-C-H alkane stretch), 2812.12 (-C-H aldehyde weak intensity), 192320.37/cm (C-O bend), 21915.50, 2029.08/cm (-C=C arene group), 1906.94/cm (=C-H aromatics), 1797.78/cm (=C-H), 1707.94 (-C=O ketene), 1579.70, 1382.96 (C-H alkane strong bend), 889.18/cm (C-H aromatics plane bend), and 412.77/cm (-C-CI strong bond). The spectra of the PVA/chitosan film depict the peak's formation: 1571.88, 1529.55, 1500.62/cm (C-H alkene strong bend), 1492.90, 1483.26, 1467.83/cm (C-H alkene strong bond), 670.48, 443.63, 412.77/cm (-O-H carboxylic acids with great intensity), 1708.93 (-C=O ketone), and 1656.0/cm (alkenyl C=C stretch strong bond).
Elganzory HH, Hassan SS, Aly SA
… +1 more, Abdalla EM
Bioinorg Chem Appl
· 2022 · PMID 38435083
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A new series of Zr(IV), V(IV), Ru(III), and Cd(II) complexes with the ligand N-((5-hydroxy-4-oxo-4H-pyran-3-yl)methylene)-2-(p-tolylamino)acetohydrazide () have been prepared. FT-IR, H-NMR, electronic spectra, powder X-r...A new series of Zr(IV), V(IV), Ru(III), and Cd(II) complexes with the ligand N-((5-hydroxy-4-oxo-4H-pyran-3-yl)methylene)-2-(p-tolylamino)acetohydrazide () have been prepared. FT-IR, H-NMR, electronic spectra, powder X-ray, and thermal behavior methods were applied to elucidate the structural composition of new compounds. Geometry optimization for all synthesized compounds was conducted using the Gaussian09 program via the DFT method, to obtain optimal structures and essential parameters. Moreover, the antibacterial and antitumor activity of the ligand and its complexes were studied, where the Cd(II) complex acquires probably the best antibacterial activity followed by the Ru(III) complex towards bacterial species than others when using ampicillin and gentamicin were used as standard drugs. The complexes exhibited interestingly antitumor potential against the MCF-7 breast cancer cell line. The cytotoxicity of the new complexes has been arranged to follow the order: Ru(III) complex > Cd(II) complex > Zr(IV) complex > V(IV) complex > ligand. Molecular docking was performed on the active site of ribosyltransferase and obtained good results. Structure-based molecular docking is used to identify a potential therapeutic inhibitor for NUDT5.
Roupa I, Flampouraris C, Shegani A
… +7 more, Ischyropoulou M, Makrypidi K, Raptopoulou C, Pirmettis I, Papadopoulos MS, Psycharis V, Chiotellis A
Bioinorg Chem Appl
· 2022 · PMID 35734344
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In the pursuit of hydrophilic model -[Re(CO)] complexes for (radio) pharmaceutical applications, six novel [2 + 1] mixed-ligand complexes of the general type -[Re(CO)(bid)P] were synthesized and characterized, where bid...In the pursuit of hydrophilic model -[Re(CO)] complexes for (radio) pharmaceutical applications, six novel [2 + 1] mixed-ligand complexes of the general type -[Re(CO)(bid)P] were synthesized and characterized, where bid is a bidentate ligand bearing either (N, O) or (S, S') donor atom sets and P is the hydrophilic phosphine 1,3,5-triaza-7-phosphoadamantane (PTA) or its macrocyclic homologue 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP). The (N, O) ligands used in this study were picolinic and quinaldic acid, while the (S, S') ligand was diethyldithiocarbamate. The complexes were synthesized in generally high yields and purity and the characterization was performed by spectroscopic methods, IR, NMR, and elemental analysis. Detailed X-ray crystallographic study of molecular packing by using Hirshfeld analysis tools revealed a plethora of intermolecular interactions such as hydrogen bond, ⋯, C-H⋯, and carbonyl-carbonyl interactions. To our knowledge, the CAP complexes reported herein are the first example of [2 + 1] mixed-ligand -[Re(CO)] complexes with CAP. The new complexes might have the potential to serve as platforms for the design of target-specific complexes with favorable pharmacokinetics.
De Castro F, Stefàno E, De Luca E
… +4 more, Muscella A, Marsigliante S, Benedetti M, Fanizzi FP
Bioinorg Chem Appl
· 2022 · PMID 35721691
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NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt(II) complex, [Pt(ƞ-CHOMe)(DMSO)(phen)] (phen = 1,10-phenanthroli...NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt(II) complex, [Pt(ƞ-CHOMe)(DMSO)(phen)] (phen = 1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight human cancer cell lines. Pt-EtOMeSOphen showed higher cytotoxic effects than cisplatin in most of the cancer cell lines and in particular against the neuroblastoma cell line (SH-SY5Y). In this study, the mechanism of action of Pt-EtOMeSOphen on SH-SY5Y cells was investigated using H NMR-based metabolomics and compared with cisplatin. The observed time response of SH-SY5Y cells under treatment revealed a faster action of Pt-EtOMeSOphen compared with cisplatin, with a response already observed after six hours of exposure, suggesting a cytosolic target. NMR-based metabolomics demonstrated a peculiar alteration of the glutathione metabolism pathway and the diacylglycerol expression.
Bioinorg Chem Appl
· 2022 · PMID 35706847
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A three-year in situ remediation experiment was carried out to understand the effect of combined phytoremediation with chemical materials on the bioavailability of heavy metals in soil. Indigenous weed (Setaria pumila),...A three-year in situ remediation experiment was carried out to understand the effect of combined phytoremediation with chemical materials on the bioavailability of heavy metals in soil. Indigenous weed (Setaria pumila), energy plant (Pennisetum sp.), cadmium (Cd)-hyperaccumulator (Sedum plumbizincicola), and copper (Cu)-tolerant plant (Elsholtzia splendens) were used as the phytoremediation plants aided by micron hydroxyapatite (1% wt). The bioavailability of Cu and Cd in soil was evaluated during the three years. The results showed that the four plants combined with micron hydroxyapatite significantly increased soil pH and soil organic carbon (SOC), and decreased Cu and Cd fractions extracted by CaCl and diffusive gradients in thin films (DGT) than the untreated soils, respectively. Because of the large biomass, the accumulation of Cu and Cd is the largest in Pennisetum sp. followed by Elsholtzia splendens, Sedum plumbizincicola, and Setaria pumila. The bioavailability of Cu and Cd is significantly negatively correlated with pH, soil organic carbon, available phosphorus, and available potassium. Moreover, the correlation is mainly related to the addition of micron hydroxyapatite. The accumulation of Cu and Cd is the combined action of the soil bioavailability of Cu, Cd, and biomass. Our results suggest that Pennisetum sp. can act as an appropriate remediation plant for phytoremediation aided by amendments.
Bioinorg Chem Appl
· 2022 · PMID 35706846
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OBJECTIVE: In order to study the application of nanoparticles in the diagnosis and treatment of pancreatic cancer, we retrospectively analyzed pancreatic cancer patients after operation. METHOD: 60 cases of pancreatic ca...OBJECTIVE: In order to study the application of nanoparticles in the diagnosis and treatment of pancreatic cancer, we retrospectively analyzed pancreatic cancer patients after operation. METHOD: 60 cases of pancreatic cancer and surgical treatment were selected from our hospital. The time ranged from March 2018 to March 2019. The age ranged from 27 to 81 years. There were 36 males and 24 females, with an average age of 46.23 (7.63) years. Among them, the observation group consisted of nanotube artificial tubes, 16 males and 14 females, while the control group adopted nylon tube, male 18 and female 12. The patient was diagnosed by abdominal CT, and the patient's demographic data and basic clinical data were recorded at the same time. RESULT: In this study, 60 patients were divided into groups and compared. The patients underwent surgical resection of pancreaticoduodenum and reconstruction of pancreaticoduodenal papillary duct. Among them, the observation group used nanocomposite artificial tube, while the observation group used nanocomposite artificial tube and placed drainage tube to drain the peritoneal effusion to prevent the effusion from forming in abdominal hypertension and infection. The amount of postoperative bleeding, operation time, and postoperative concomitant symptoms were observed, and the differences between the two materials were analyzed. CONCLUSION: The reconstruction of pancreaticoduodenal papillary duct with nanomaterials has certain advantages for postoperative recovery, reduces postoperative complications, reduces the probability of infection, and improves the therapeutic effect.
Esther Nimshi R, Judith Vijaya J, Al-Najar B
… +5 more, Hazeem L, Bououdina M, John Kennedy L, Kombaiah K, Bellucci S
Bioinorg Chem Appl
· 2022 · PMID 35686291
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Multifunctional core@shell nanoparticles have been synthesized in this paper through 3 stages: NiFeO nanoparticles by microwave irradiation using leaf extract as a fuel, core@shell NiFeO@TiO nanoparticles by sol-gel, an...Multifunctional core@shell nanoparticles have been synthesized in this paper through 3 stages: NiFeO nanoparticles by microwave irradiation using leaf extract as a fuel, core@shell NiFeO@TiO nanoparticles by sol-gel, and NiFeO@TiO@rGO by sol-gel using preprepared reduced graphene oxide obtained by modified Hummer's method. XRD analysis confirmed the presence of both cubic NiFeO spinel and tetragonal TiO rutile phases, while Raman spectroscopy analysis displays both and bands ( / = 1.04) associated with rGO. Morphological observations by HRTEM reveal a core-shell nanostructure formed by NiFeO core as confirmed by SAED with subsequent thin layers of TiO and rGO. Magnetic measurements show a ferromagnetic behavior, where the saturation magnetization drops drastically from 45 emu/g for NiFeO to 15 emu/g after TiO and rGO nonmagnetic bilayers coating. The as-fabricated multifunctional core@shell nanostructures demonstrate tunable self-heating characteristics: rise of temperature and specific absorption rate in the range of Δ = 3-10°C and SAR = 3-58 W/g, respectively. This effectiveness is much close to the threshold temperature of hyperthermia (45°C), and the zones of inhibition show the better effective antibacterial activity of NTG against various Gram-positive and Gram-negative bacterial strains besides simultaneous good efficient, stable, and removable sonophotocatalyst toward the TC degradation.