Bioinorg Chem Appl
· 2022 · PMID 36193249
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The current work focuses on peanut shells and agricultural wastes richly in many nations subjected to pyrolysis treatment at various temperatures in the range of 500-800°C to determine the feasible physiochemical charact...The current work focuses on peanut shells and agricultural wastes richly in many nations subjected to pyrolysis treatment at various temperatures in the range of 500-800°C to determine the feasible physiochemical characteristics of the biochar. The biochars with the high surface area were employed to adsorb Pb (lead) ions, the heaviest pollutants in the water bodies. The raw material, biochar, and pyrolyzed biochar were characterized by SEM, FTIR, partial and elemental analysis, and BET tests. The adsorption characteristics of the biochar, pre- and postpyrolysis treatment, were studied with the assistance of batch adsorption tests under varying test conditions. Adsorbing conditions were determined by evaluating the effects of adsorbing parameters like initial concentration of the lead in water, pH of the adsorbent, contact time, and mixing speed on the effective adsorption of Pb ions from water. Langmuir, Freundlich, and Themkin isotherm expressions were employed to study the experimental results. The adsorption kinetics study showed that the synthesized biochars were chemically stable enough to adsorb the Pb ions onto the surface.
Elderdery AY, Alzahrani B, Hamza SMA
… +3 more, Mostafa-Hedeab G, Mok PL, Subbiah SK
Bioinorg Chem Appl
· 2022 · PMID 36164585
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In this study, cells from human Chronic Myelogenous Leukemia (K562) were cultivated with CuO-TiO-Chitosan-Berbamine nanocomposites. We examined nanocomposites using XRD, DLS, FESEM, TEM, PL, EDAX, and FTIR spectroscopy,...In this study, cells from human Chronic Myelogenous Leukemia (K562) were cultivated with CuO-TiO-Chitosan-Berbamine nanocomposites. We examined nanocomposites using XRD, DLS, FESEM, TEM, PL, EDAX, and FTIR spectroscopy, as well as MTT for cytotoxicity, and AO/EtBr for apoptotic morphology assessment. The rate of apoptosis and cell cycle arrests was determined using flow cytometry. Flow cytometry was also employed to identify pro- and antiapoptotic proteins such as Bcl2, Bad, Bax, P53, and Cyt C. The FTIR spectrum revealed that the CuO-TiO-Chitosan-Berbamine nanocomposites were electrostatically interlocked. The nanocomposites' XRD signals revealed a hexagonal shape. In the DLS spectrum, nanocomposites were found to have a hydrodynamic diameter. As a result of their cytotoxic action, nanocomposites displayed concentration-dependent cytotoxicity. The nanocomposites, like Doxorubicin, caused cell cycle phase arrest in K562 cells. After treatment with IC concentrations of CuO-TiO-Chitosan-Berbamine nanocomposites and Doxorubicin, a substantial percentage of cells were in G2/M stage arrest. Caspase-3, -7, -8, -9, Bax, Bad, Cyt C, and P53 expression were considerably enhanced in K562 cells, whereas Bcl2 expression was decreased, indicating that these cells may have therapeutic potential against human blood cancer/leukemia-derived disorders. As a result, the nanocomposites demonstrated outstanding anticancer potential against leukemic cells. CuO-TiO-Chitosan-Berbamine, according to our findings.
Ibrahim Abdel Aziz I, Riyad AA, Hussian AA
… +2 more, Mazen GM, Kannaiyan M
Bioinorg Chem Appl
· 2022 · PMID 36147774
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Lung cancer is one of the cancers with high mortality rate. The current therapeutic regimens have only limited success rate. The current work highlights the potential of -derived zinc oxide nanoparticle (SP-ZnONP)-induce...Lung cancer is one of the cancers with high mortality rate. The current therapeutic regimens have only limited success rate. The current work highlights the potential of -derived zinc oxide nanoparticle (SP-ZnONP)-induced apoptosis in A549 lung cancer cells. Synthesized nanoparticles were confirmed by UV-Vis spectrophotometry, X-ray diffraction (XRD), dynamic light scattering analysis (DLS), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and photoluminescence analysis. Lactate dehydrogenase (LDH), cytotoxicity, and cell viability assays revealed that the SP-ZnONP caused the cell death and the inhibition concentration (IC) was calculated to be 61.28 g/mL. Treatment with SP-ZnONPs caused morphological alterations in cells, such as rounding, which may have been caused by the substance's impact on integrins. Acridine orange/ethidium bromide dual staining revealed that the cells undergo apoptosis in a dose-dependent manner, which indicates the cell death. Furthermore, reactive oxygen species (ROS) were examined and it was shown that the nanoparticles elevated ROS levels, which led to lipid peroxidation. In short, the SP-ZnONPs increase the level of ROS, which in turn causes lipid peroxidation results in apoptosis. On the other hand, the SP-ZnONPs decrease nitric oxide level in A549 cells in a dose-dependent manner, which also supports the apoptosis. In conclusion, SP-ZnONPs would become a promising treatment option for lung cancer.
Maladeniya C, Darshani T, Samarakoon SR
… +4 more, Fronczek FR, Sameera WMC, Perera IC, Perera T
Bioinorg Chem Appl
· 2022 · PMID 36147773
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Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (1 = [PtCl((SOquin)dpa)], 2 = [PtCl((SOazobenz)dpa)]) containing quinoline and azobenzene a...Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (1 = [PtCl((SOquin)dpa)], 2 = [PtCl((SOazobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. The singlet attributable to methylene CH protons of the ligands of C1 and C2 appears as two doublets in H NMR spectra, which confirms the presence of magnetically nonequivalent protons upon coordination to platinum. Structural data of (SOquin)dpa (L1), (SOazobenz)dpa (L2) and PtCl((SOquin)dpa) confirmed the formation of the desired compounds. Time-dependent density functional theory calculations suggested that the excitation of L1 show quin-unit-based excitations (i.e., ligand-centered charge transfer, LC), while C1 shows the metal-ligand-to-ligand charge-transfer (MLLCT) character. L1 displays intense fluorescence from the LC excited state, while C1 gives phosphorescence from the LC state. Mammalian cell toxicity of ligands and complexes was assessed with NCI-H292 nonsmall-cell lung cancer cells. Further, C1 and C2 showed significantly low IC values compared with (SOazobenz)dpa and PtCl((SOquin)dpa). Fluorescence imaging data of both ligands and complexes revealed the potential fluorescence activity of these compounds for biological imaging. All four compounds are promising novel candidates that can be further investigated on their usage as potential anticancer agents and cancer cell imaging agents.
Kannaiyan S, Easwaramoorthi D, Kannan K
… +5 more, Gopal A, Lakshmipathy R, Mohammedsaleh Katubi K, Almuaikel NS, Rodriguez Rico IL
Bioinorg Chem Appl
· 2022 · PMID 36132709
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Wound infection is a major clinical challenge, impacting patient morbidity and mortality, with significant economic implications. Our research focused on how Pisonia Alba (PA) leaves, which are used to treat wounds, are...Wound infection is a major clinical challenge, impacting patient morbidity and mortality, with significant economic implications. Our research focused on how Pisonia Alba (PA) leaves, which are used to treat wounds, are used to synthesize silver nanoparticles and study their wound healing property. UV-visible spectroscopy, X-ray diffraction analysis, and s electron microscope (SEM) analysis were employed to evaluate the synthesized silver nanoparticles. Using DLS and Zeta potential analysis, the size and stability of the Pisonia Alba capped silver nanoparticle were investigated. The results showed that Pisonia Alba extract stabilized silver nanoparticles are 63.88 nm in size and have a spherical shape. Antibacterial and antibiofilm potential of synthesized silver nanoparticles against pathogenic organisms Gram-positive () and Gram-negative () bacteria were investigated. The in vitro cell scratch wounding assay is used to investigate the wound healing properties of synthesized nanoparticles. Pisonia Alba stabilized silver nanoparticles (PA@AgNPs), in comparison to Pisonia Alba (PA) extract, show effective wound healing characteristics by inducing the formation of collagen and serving as a capable wound healing agent.
Bioinorg Chem Appl
· 2022 · PMID 39281976
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A critical factor in the cause and progression of Alzheimer's disease (AD) is the growth of -amyloid peptide (A) in the brain. The mechanism of this effect is still unknown, although the effect of osthol on A-induced inf...A critical factor in the cause and progression of Alzheimer's disease (AD) is the growth of -amyloid peptide (A) in the brain. The mechanism of this effect is still unknown, although the effect of osthol on A-induced inflammation is neuroprotective in AD and supplementation with zinc might prevent or delay the onset of dementia. In the current study, by inducing APP vector in human BE (2)-M17 cells, we established a cellular model of AD and investigated the protective effect of osthol (7-methoxy-8-3-methyl-2-butenyl-2H-1-benzopyran-2-one)-zinc oxide nanoparticles. The osthol-conjugated zinc oxide nanoparticles could significantly increase cell viability by inhibiting cell apoptosis. Osthol treatment has also prevented synaptic proteins such as postsynaptic density-95 (PSD-95), synaptophysin (SYP), and synapsin-1 from decreasing in APP-induced BE (2)-M17 cells. In addition, the expression of miR-132 was significantly upregulated by osthol by triggering the Wnt/-catenin signaling pathway. We conclude from our observations that osthol is a potential drug for the treatment of a neurodegenerative disease, Alzheimer's. The key reason was that by upregulating miR-132, osthol could inhibit APP expression to prevent AD from occurring.
Ciołek L, Jaegermann Z, Zaczyńska E
… +6 more, Czarny A, Biernat M, Gąsiński A, Jastrzębska A, Gloc M, Olszyna A
Bioinorg Chem Appl
· 2022 · PMID 36111206
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The article presents the results of studies on cytotoxicity and antibacterial activity of new MTA-type cements, developed on the basis of the sintered tricalcium silicate enriched with ZnO, along with an agent introduci...The article presents the results of studies on cytotoxicity and antibacterial activity of new MTA-type cements, developed on the basis of the sintered tricalcium silicate enriched with ZnO, along with an agent introducing the radiopacity in the form of ZrO. The new materials have been developed to ensure that their physical and chemical properties are suited for endodontic applications. The cements were evaluated via characterisation of setting time, compressive strength, as well as translucency on X-ray images, and bioactivity in the simulated body fluid (SBF). The CT was used to test the influence of the ZrO grains in the powder component on the microstructure of the produced cement. Then, the cytotoxic action of the cements was evaluated by applying a reference L-929 cell line. The conditions of the culture upon contact with the tested materials or with extracts from the cements were assessed using image analysis or an MTT colorimetric assay. Two strains of streptococci, and were used to study the antibacterial activity of the tested cements with ZrO acting as the agent introducing the radiopacity. The new cements are characterised by appropriate properties as far as retrograde root canal filling is concerned.
Prabhahar M, K G, S P
… +5 more, S S, M SK, Go J, Varuvel EG, Lenin A H
Bioinorg Chem Appl
· 2022 · PMID 36082190
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Bread is one of the highest-selling food products throughout the world. Lots of demand arose from the bread producers by the consumers to convert the traditional bread into functional food. In this study, normal bread wa...Bread is one of the highest-selling food products throughout the world. Lots of demand arose from the bread producers by the consumers to convert the traditional bread into functional food. In this study, normal bread was converted to functional herbal bread by infusing it with extracts of . The functional components of the were analyzed by liquid chromatography-mass spectroscopy (LCMS). The antioxidant study revealed that the extract has high antioxidant potency. The present study also investigated the antidiabetic potency of the extract. Bread is fortified with various percentages of , such as 2, 4, and 6. The fortified bread was analyzed for various sensory and taste parameters. Biochemical assays such as the in vitro digestibility test and glycaemic index suggest that fortified bread reduces the glycaemic index. From the study, it was inferred that 6% of infused bread was found to have high potency as a functional food when compared to 2 and 4%. From the above study, it was suggested that fortified bread reduces the glycaemic index and is best suited for diabetic people and diet watchers.
Bioinorg Chem Appl
· 2022 · PMID 36072280
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Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting metho...Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting method. The physicochemical properties of the film were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Moreover, the antibacterial properties of the bionanocomposite film were investigated for wound healing applications. The characterization results confirmed the reinforcement of the gellan gum (GG) matrix with zinc oxide nanoparticles (ZnONP) and multiwall carbon nanotubes (MWCNT), as an amorphous GG/ZnONP + MWCNT bionanocomposite film was obtained. SEM morphological analysis shows that the addition of ZnONP and MWCNT nanofillers changed the film microstructure into a sponge-like structure that is more suitable for fluid uptake and thus more useful for wound healing. The GG/ZnONP + MWCNT bionanocomposite film demonstrated good antibacterial activity against all strains tested. Furthermore, macroscopic analysis shows that the wound treated with GG/ZnONP + MWCNT bionanocomposite film recovered completely (100%) in 14 days, compared to pure GG film (90.76%) and negative control (77.40%). As a result, the GG/ZnONP + MWCNT bionanocomposite film could be a promising wound dressing material.
Yu K, Xiong H, Wei X
… +5 more, Wu H, Zhang B, Wang G, Yang X, Wang Z
Bioinorg Chem Appl
· 2022 · PMID 36065391
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Age-related changes in bone tissue have always been an important part of bone research, and age estimation is also of great significance in forensic work. In our study, FTIR and Raman microspectroscopy were combined to e...Age-related changes in bone tissue have always been an important part of bone research, and age estimation is also of great significance in forensic work. In our study, FTIR and Raman microspectroscopy were combined to explore the structural and chronological age-related changes in the occipital bones of 40 male donors. The FTIR micro-ATR mode not only achieves the comparison of FTIR and Raman efficiency but also provides a new pattern for the joint detection of FTIR and Raman in hard tissue. Statistical analysis and PCA results revealed that the structure had little effect on the FTIR and Raman results. The FTIR and Raman mineral/matrix ratio, carbonate/phosphate ratio, crystallinity, and collagen maturity of the whole showed an increasing trend during maturation, and a significant correlation was found between FTIR and Raman by comparing four outcomes. Furthermore, the results indicated that the cutoff point of the change in the relative proportion of organic matrix and inorganic minerals in males was between 19 and 35 years old, and the changes in the relative proportion of organic matrix and inorganic minerals may play a key role in age estimation. Ultimately, we established age estimation regression models. The FTIR GA-PLS regression model has the best performance and is more suitable for our experiment (RMSECV = 10.405, RMSEP = 9.2654, CV = 0.814, and Pred = 0.828). Overall, FTIR and Raman combined with chemometrics are an ideal method to estimate chronological age based on age-dependent component changes in male occipital bones. Our experiment provides a proof of concept and potential experimental method for chronological age estimation.
Kothandan S, Thirumoorthy K, Rodríguez-Diéguez A
… +1 more, Sheela A
Bioinorg Chem Appl
· 2022 · PMID 36034769
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Oxoperoxovanadium (V) complexes [VO (O) (nf) (bp)] () and [VO (O) (ox) (bp)] () based on 5-nitro-2-furoic acid (nf), oxine (ox) and 2, 2' bipyridine (bp) bidentate ligands have been synthesized and characterized by FT-IR...Oxoperoxovanadium (V) complexes [VO (O) (nf) (bp)] () and [VO (O) (ox) (bp)] () based on 5-nitro-2-furoic acid (nf), oxine (ox) and 2, 2' bipyridine (bp) bidentate ligands have been synthesized and characterized by FT-IR, UV-visible, mass, and NMR spectroscopic techniques. The structure of complex 2 shows distorted pentagonal-bipyramidal geometry, as confirmed by a single-crystal XRD diffraction study. The interactions of complexes with bovine serum albumin (BSA) and calf thymus DNA (CT-DNA) are investigated using UV-visible and fluorescence spectroscopic techniques. It has been observed that CT-DNA interacts with complexes through groove binding mode and the binding constants for complexes and are 8.7 × 10 M and 8.6 × 10 M, respectively, and BSA quenching constants for complexes and are 0.0628 × 10 M and 0.0163 × 10 M, respectively. The ability of complexes to cleave DNA is investigated using the gel electrophoresis method with pBR322 plasmid DNA. Furthermore, the cytotoxic effect of the complexes is evaluated against the HeLa cell line using an MTT assay. The complexes are subjected to density functional theory calculations to gain insight into their molecular geometries and are in accordance with the results of docking studies. Furthermore, based on molecular docking studies, the intermolecular interactions responsible for the stronger binding affinities between metal complexes and DNA are discussed.
Aman J, Shahi NC, Lohani UC
… +5 more, Balodhi D, Singh R, Kumar N, Bhat MI, Kumar AP
Bioinorg Chem Appl
· 2022 · PMID 36016764
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In the current study, a guar-gum-based biodegradable hydrogel film was prepared using an initiator (potassium persulfate), crosslinker (N-N methyl bis acrylamide), and plasticizer (glycerol) for packaging of fruits and v...In the current study, a guar-gum-based biodegradable hydrogel film was prepared using an initiator (potassium persulfate), crosslinker (N-N methyl bis acrylamide), and plasticizer (glycerol) for packaging of fruits and vegetables. The effect of independent variables (initiator, crosslinker, and plasticizer) on the biodegradation (% wt. loss), color difference (ΔE), hardness (N), swelling index (%), and transparency (%) of the film was studied using Box-Behnken design, random surface methodology (RSM). The results showed significant effects on all the abovementioned parameters, and it was observed that the developed model was accurate, with a prediction error of only -3.19 to 2.99%. The optimized formulation for the preparation of hydrogel film was 0.15% initiator, 0.02% crosslinker, and 2.88% plasticizer exhibiting satisfactory biodegradability, color difference, hardness, swelling index, and transparency. Results showed that a guar-gum-based biodegradable hydrogel film has adequate physical, optical, and biodegradable properties and can be successfully utilized in the food packaging industry.
Chinnathambi A, Ali Alharbi S, Joshi D
… +1 more, Lenin H
Bioinorg Chem Appl
· 2022 · PMID 38623354
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The purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs we...The purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs were also investigated through the in-vitro approach. The obtained results show that the aqueous extract of can synthesize ZnONPs, as evidenced by a sharp absorbance peak at 375 nm. The Fourier transform infrared spectroscopy (FTIR) analysis confirmed that the aqueous extract contained significant numbers of functional groups, which were involved in reducing zinc nitrate into ZnONPs. Also, they participate in the capping and stabilization of synthesized ZnONPs and their size ranged from 27.14-35.74 nm with a spherical shape . The results obtained in ABTS radical scavenging activity 1, 1-diphenyl-2-picryl-hydroxyl (DPPH), hydrogen peroxide (HO), and 2,2'-Azino-Bis(3-ethylbenzene thiazoline-6-sulfonic acid) (ABTS) assays declared has excellent in-vitro radicals scavenging activity with reasonable IC values. Interestingly, these green synthesized ZnONPs have an excellent anticancer activity against human epidermoid carcinoma (Hep3) cell line in an in-vitro approach. These findings imply that an aqueous leaf extract of can be used to synthesize pharmaceutically valuable ZnONPs. To consider such nanomaterials as potential therapeutic agents, optimization and in-vivo biomedical studies are required.
Pei J, Prasad M, Mohamed Helal G
… +7 more, El-Sherbiny M, Abdelmonem Elsherbini DM, Rajagopal P, Palanisamy CP, Veeraraghavan VP, Jayaraman S, Surapaneni KM
Bioinorg Chem Appl
· 2022 · PMID 35992048
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Nutritional overload in the form of high-fat and nonglycolysis sugar intake contributes towards the accelerated creation of reactive oxygen species (ROS), hyperglycemia, and dyslipidemia. Glucose absorption and its subse...Nutritional overload in the form of high-fat and nonglycolysis sugar intake contributes towards the accelerated creation of reactive oxygen species (ROS), hyperglycemia, and dyslipidemia. Glucose absorption and its subsequent oxidation processes in fat and muscle tissues alter as a consequence of these modifications. Insulin resistance (IR) caused glucose transporter 4 (GLUT4) translocation to encounter a challenge that manifested itself as changes in glycolytic pathways and insulin signaling. We previously found that beta ()-sitosterol reduces IR in fat tissue via IRS-1/PI3K/Akt facilitated signaling due to its hypolipidemic and hypoglycemic activity. The intention of this research was to see whether the phytosterol -sitosterol can aid in the translocation of GLUT4 in rats fed on high-fat diet (HFD) and sucrose by promoting Rab/IRAP/Munc 18 signaling molecules. The rats were labeled into four groups, namely control rats, HFD and sucrose-induced diabetic control rats, HFD and sucrose-induced diabetic rats given oral dose of 20 mg/kg body wt./day of -sitosterol treatment for 30 days, and HFD and sucrose-induced diabetic animals given oral administration of 50 mg/kg body wt./day metformin for 30 days. Diabetic rats administered with -sitosterol and normalized the titers of blood glucose, serum insulin, serum testosterone, and the status of insulin tolerance and oral glucose tolerance. In comparison with the control group, -sitosterol effectively regulated both glycolytic and gluconeogenesis enzymes. Furthermore, qRT-PCR analysis of the mRNA levels of key regulatory genes such as SNAP23, VAMP-2, syntaxin-4, IRAP, vimentin, and SPARC revealed that -sitosterol significantly regulated the mRNA levels of the above genes in diabetic gastrocnemius muscle. Protein expression analysis of Rab10, IRAP, vimentin, and GLUT4 demonstrated that -sitosterol had a positive effect on these proteins, resulting in effective GLUT4 translocation in skeletal muscle. According to the findings, -sitosterol reduced HFD and sucrose-induced IR and augmented GLUT4 translocation in gastrocnemius muscle through insulin signaling modulation via Rab/IRAP/Munc 18 and glucose metabolic enzymes. The present work is the first of its kind to show that -sitosterol facilitates GLUT4 vesicle fusion on the plasma membrane via Rab/IRAP/Munc 18 signaling molecules in gastrocnemius muscle.
Joy D, Jose J, Bibi S
… +8 more, Bandiwadekar A, Gopan G, Mariana Gonçalves Lima C, Bin Emran T, A Alhumaydhi F, Ashtekar H, D S S, Adam Conte-Junior C
Bioinorg Chem Appl
· 2022 · PMID 35992047
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The demand for drug delivery systems (DDS) to treat Parkinson's disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxid...The demand for drug delivery systems (DDS) to treat Parkinson's disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempted to incorporate solid lipid nanoparticles (SLNs) of into dissolvable microneedle arrays and evaluate its neuroprotective activity. The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood-brain barrier at the desired concentration. The quality by design (QbD) approach was employed for optimizing the SLNs formulations. The mechanical strength, release studies, permeation investigation, skin irritation test, histopathological studies, biochemical studies, and behavioural tests SLNs loaded microneedle arrays were performed. The microneedle patches obtained were shown to be mechanically robust and were also found to be nonirritant with a decreased degree of bradykinesia, high motor coordination, and balance ability. Compared to systemic delivery systems, such an MN method can achieve a considerably lower effective dose and allow long-term home-based treatment.
Mousavi SM, Hashemi SA, Bahrani S
… +6 more, Sadrmousavi-Dizaj A, Arjmand O, Omidifar N, Lai CW, Chiang WH, Gholami A
Bioinorg Chem Appl
· 2022 · PMID 35979186
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In this study, we have developed a new platform of polyoxometalate as a biocompatible and electrosensitive polymeric biosensor for the accurate detection of doxorubicin. For this purpose, we used a green synthesis approa...In this study, we have developed a new platform of polyoxometalate as a biocompatible and electrosensitive polymeric biosensor for the accurate detection of doxorubicin. For this purpose, we used a green synthesis approach using tartaric acid, glutamic acid, and kombucha solvent. Thanks to its bioinorganic components, the biogenic approach can chemically modify and improve the performance of the biosensor, which was experimentally confirmed. Our results showed excellent sensitivity (175.72 A·M·cm), low detection limit (DL, 8.12 nM), and low quantification limit (QL, 0.056 M) when the newly developed biosensor was used. The results also show that the biosynthesized biosensor has improved performance in detecting DOX in the biological fluid with an accuracy of more than 99% depending on the components used, which underlines the high efficiency of the biosensor produced. Considering the body's physiological condition, the biosensor fabricated as a biocompatible component can show high efficiency. Therefore, its applicability for clinical use still needs to be studied in detail.
Khan AU, Khan M, Khan AA
… +3 more, Parveen A, Ansari S, Alam M
Bioinorg Chem Appl
· 2022 · PMID 35979185
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The root-knot nematode was examined using magnesium oxide nanoparticles (MgO-NPs) made from strawberries. The biologically synthesized MgO-NPs were characterized by UV, SEM, FTIR, EDS, TEM, and dynamic light scattering (...The root-knot nematode was examined using magnesium oxide nanoparticles (MgO-NPs) made from strawberries. The biologically synthesized MgO-NPs were characterized by UV, SEM, FTIR, EDS, TEM, and dynamic light scattering (DLS). Nanoparticles (NPs) were examined using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and shown to be spherical to hexagonal nanoparticles with an average size of 100 nm. MgO-NPs were tested on the root-knot nematode (Meloidogynidae) and the plant pathogenic bacteria . The synthesized MgO-NPs showed a significant inhibition of and the root-knot nematode. MgO-NPs cause mortality and inhibit egg hatching of second-stage juveniles (J2) of under the in vitro assay. This study aims to examine the biological activity of biogenic MgO-NPs. The findings marked that MgO-NPs may be utilized to manage and and develop effective nematicides. In addition, the antioxidant capacity of MgO-NPs was determined by using 2, 2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH).
Zohra T, Khalil AT, Saeed F
… +5 more, Latif B, Salman M, Ikram A, Ayaz M, Murthy HCA
Bioinorg Chem Appl
· 2022 · PMID 35979184
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Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk o...Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk of dengue infection is through controlling of vector, i.e., . Nanotechnology-based prevention strategies like biopesticides with nanoformulation are now getting popular for preventing dengue fever. Metal nanoparticles (NPs) synthesized by an eco-friendly process, through extracts of medicinal plants have indicated potential anti-dengue applications. Green synthesis of metal NPs is simple, cost-effective, and devoid of hazardous wastes. The recent progress in the phyto-synthesized multifunctional metal NPs for anti-dengue applications has encouraged us to review the available literature and mechanistic aspects of the dengue control using green-synthesized NPs. Furthermore, the molecular bases of the viral inhibition through NPs and the nontarget impacts or hazards with reference to the environmental integrity are discussed in depth. Till date, major focus has been on green synthesis of silver and gold NPs, which need further extension to other innovative composite nanomaterials. Further detailed mechanistic studies are required to critically evaluate the mechanistic insights during the synthesis of the biogenic NPs. Likewise, detailed analysis of the toxicological aspects of NPs and their long-term impact in the environment should be critically assessed.
Bioinorg Chem Appl
· 2022 · PMID 35966407
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Interest in the use of zinc oxide nanoparticles (ZnO NPs) in surface coatings and films has increased as its incorporation can significantly improve the mechanical and antimicrobial properties of coatings and film soluti...Interest in the use of zinc oxide nanoparticles (ZnO NPs) in surface coatings and films has increased as its incorporation can significantly improve the mechanical and antimicrobial properties of coatings and film solutions. In an effort to produce green or eco-friendly products, the potential use of ZnO NPs biosynthesized from natural resources to replace conventional petroleum-derived polymers has been investigated. This review provides an insight into the growing trend of incorporating ZnO NPs into synthetic or semi-synthetic or bio-based polymeric materials via different synthesis methods as well as its characteristics and potential applications in surface coatings and films. The antimicrobial potential of ZnO NPs to inhibit the growth of various types of microorganisms as well as its use in surface coatings or films to impart antimicrobial activities that prevent the spread of microorganisms, especially the COVID-19 virus, was also discussed.
Roy A, Pandit C, Gacem A
… +5 more, Alqahtani MS, Bilal M, Islam S, Hossain MJ, Jameel M
Bioinorg Chem Appl
· 2022 · PMID 35959230
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Nanotechnology is a rapidly evolving discipline as it has a wide variety of applications in several fields. They have been synthesized in a variety of ways. Traditional processes such as chemical and physical synthesis h...Nanotechnology is a rapidly evolving discipline as it has a wide variety of applications in several fields. They have been synthesized in a variety of ways. Traditional processes such as chemical and physical synthesis have limits, whether in the form of chemical contamination during synthesis operations or in subsequent applications and usage of more energy. Over the last decade, research has focused on establishing easy, nontoxic, clean, cost-effective, and environmentally friendly techniques for nanoparticle production. To achieve this goal, biological synthesis was created to close this gap. Biosynthesis of nanoparticles is a one-step process, and it is ecofriendly in nature. The metabolic activities of biological agents convert dissolved metal ions into nanometals. For biosynthesis of metal nanoparticles, various biological agents like plants, fungus, and bacteria are utilized. In this review paper, the aim is to provide a summary of contemporary research on the biosynthesis of gold nanoparticles and their applications in various domains have been discussed.