Postepy Biochemii[JOURNAL]
Sun
200 papers
[The role of peroxisome proliferator-activated receptors (PPARs) in the male gonad and prostate].
Górowska-Wójtowicz E, Kudrycka M
Postepy Biochem · 2025 Oct · PMID 41263798 · Publisher ↗
So far, three types of peroxisome proliferator-activated receptors have been characterized: PPARα, PPARβ (also known as δ) and PPARγ, each characterized by different expression, localization and role. PPAR receptors regu...
So far, three types of peroxisome proliferator-activated receptors have been characterized: PPARα, PPARβ (also known as δ) and PPARγ, each characterized by different expression, localization and role. PPAR receptors regulate a number of processes, including lipid and glucose metabolism, adipogenesis and inflammation. Literature data also indicate their key role in maintaining the balance of sex hormone levels and the function of the male reproductive system. The involvement of PPAR in the male gonad has been demonstrated by their effect on the testis morphology as well as steroidogenesis, spermatogenesis, spermiogenesis and sperm motility. In the prostate, PPAR regulate lipid synthesis, mitochondrial biogenesis and the maintenance of prostate secretory functions. Disruption of PPAR signaling in the male gonad and prostate results in its structural and functional changes, which can even lead to carcinogenesis. Importantly, further exploration of the molecular mechanisms of PPAR action in the male reproductive system may contribute to understanding the course of certain pathologies and developing methods for their treatment.
[KLF1 (Krüppel-like factor 1) as a key regulator of erythroid gene expression].
Kulczynska-Figurny K, Siatecka M
Postepy Biochem · 2025 Jun · PMID 41263797 · Publisher ↗
KLF1 (Krüppel-like factor 1) is an essential transcription factor involved in almost all stages of erythropoiesis. KLF1 promotes the transition of myeloid progenitor cells towards the erythroid lineage, while inhibiting...
KLF1 (Krüppel-like factor 1) is an essential transcription factor involved in almost all stages of erythropoiesis. KLF1 promotes the transition of myeloid progenitor cells towards the erythroid lineage, while inhibiting the megakaryopoietic pathway. Its expression is tissue-specific and limited to hematopoietic organs. It begins in the yolk sac, then in the liver and in bone marrow. KLF1 plays a role as a global regulator of erythrocyte development. It regulates many processes, including globin synthesis, heme, iron acquisition, red blood cell membrane antigens expression. KLF1 is composed of two domains: an N-terminal transactivation domain and a C-terminal DNA-binding domain. KLF1 is the first known transcription factor from the Kruppel-like Factor family, which currently includes 17 members. Their characteristic feature is C2H2 zinc finger motifs interacting with DNA. In addition to erythropoiesis, KLF factors play a key role in regulating gene expression of various biological processes, including cell proliferation, differentiation, and apoptosis.
[KLF1 (Krüppel-like factor 1) variants in the pathogenesis of hematological diseases].
Kulczynska-Figurny K, Siatecka M
Postepy Biochem · 2025 Jun · PMID 41263796 · Publisher ↗
KLF1 (Krüppel-like factor 1) is an erythroid transcription factor involved in various stages of red blood cell formation. KLF1 plays key functions at the megakaryocyte-erythrocyte progenitor stage, where it is involved i...
KLF1 (Krüppel-like factor 1) is an erythroid transcription factor involved in various stages of red blood cell formation. KLF1 plays key functions at the megakaryocyte-erythrocyte progenitor stage, where it is involved in the development of the erythrocyte lineage. It participates in the global expression of erythrocyte genes, playing a direct role in globin switching. KLF1 also participates in the final maturation of erythrocytes, controlling exit from the cell cycle and the enucleation process. KLF1 has a domain structure: N-terminal transactivation domain and C-terminal DNA-binding domain. Many variants (mutations) have been described in the KLF1 gene, which lead to the development of a whole spectrum of phenotypes: from clinically insignificant morphological changes, through mild changes, to severe pathological conditions. Two mutations are dominant. One occurs in mice and causes neonatal anemia with congenital spherocytosis (Nan), the other in humans and leads to congenital dyserythropoietic anemia type IV (CDA).
[The role of hyperbaric oxygenation in glioma therapy - a review of experimental studies].
Wójtowicz W, Iwan M, Czarnota M … +5 more , Jankowska K, Chodań F, Wilk Ł, Świderski N, Bielecka Wajdman A
Postepy Biochem · 2025 Oct · PMID 41263795 · Publisher ↗
Glioma is one of the most aggressive brain tumors. Despite the progress made in recent years in better understanding the changes at the molecular level of glioma and in neuroimaging techniques, the survival rates of pati...
Glioma is one of the most aggressive brain tumors. Despite the progress made in recent years in better understanding the changes at the molecular level of glioma and in neuroimaging techniques, the survival rates of patients with glioma have not shown any significant improvement and only about 10% still survive the period of 5 years from the moment of diagnosis. An inherent feature of glioma is slow oxygenation of tumor areas (hypoxia), which supports its malignant nature, contributes to radio-chemo-resistance and, consequently, to relapse. Attempts to modulate the glioma microenvironment by increasing the content of cellular oxygen through the use of hyperbaric oxygen therapy (HBOT) seem to be a promising, non-invasive concept complementing the basic treatment of the tumor. Although it has been used for years with good results in specialist centers in the treatment of various diseases, such as carbon monoxide poisoning, decompression sickness in divers, difficult-to-heal wounds, hearinglossor circulatory disorders, there is currently no consistent position on the importance of hyperbaric oxygen in cancer diseases, include in glioma. This paper reviews the results of in vitro and in vivo studies and clinical trials on the potential role of hyperbaric oxygen therapy in adjuvant therapy for glioma.
[The dual role of autophagy in colorectal cancer].
Wojtkowicz J, Senkowska Z, Niewinna K … +2 more , Lewandowska U, Owczarek K
Postepy Biochem · 2025 Oct · PMID 41263794 · Publisher ↗
In recent years, increasing attention has been devoted to cellular processes that modulate tumor progression, particularly autophagy. Current studies indicate a dual role of autophagy in the pathogenesis of colorectal ca...
In recent years, increasing attention has been devoted to cellular processes that modulate tumor progression, particularly autophagy. Current studies indicate a dual role of autophagy in the pathogenesis of colorectal cancer. In the early stages, autophagy serves a protective function by degrading damaged organelles and proteins, whereas in advanced stages, it promotes cancer cell survival. The regulation of autophagy primarily involves the PI3K/Akt/mTOR and AMPK/mTOR signalling pathways, as well as the Beclin-1/PI3K complex. Autophagy-related proteins such as LC3, p62/SQSTM1, and Beclin-1 hold significant diagnostic and prognostic value. Given the impact of autophagy on the efficacy of chemotherapy and targeted therapies, pharmacological modulation of this process has garnered increasing interest. Natural compounds, particularly polyphenols, demonstrate promising multitargeted effects on autophagy. This review comprehensively analyses the molecular mechanisms underlying autophagy in colorectal cancer and evaluates its potential as a therapeutic target.
[Glutathione deficiency and disturbances of sulfur homeostasis in the pathophysiology of schizophrenia].
Górny M, Lorenc-Koci E, Iciek M
Postepy Biochem · 2025 Oct · PMID 41263793 · Publisher ↗
Schizophrenia is a mental illness characterized by positive and negative symptoms and cognitive function disorders. Animal models are used in studies of the pathophysiology of schizophrenia and in the search for new drug...
Schizophrenia is a mental illness characterized by positive and negative symptoms and cognitive function disorders. Animal models are used in studies of the pathophysiology of schizophrenia and in the search for new drugs. In one of the recently developed rat’s neurodevelopmental model, schizophrenic-like changes were induced by administration of buthioninesulfoximine (BSO) - an inhibitor of glutathione synthesis and a dopamine reuptake inhibitor - the compound GBR 12909 during the developmental period. Behavioral tests conducted on adult rats showed that deficits in social behavior and cognitive functions were observed in the model animals, and rats that received a combination of both compounds additionally showed positive symptoms. The usefulness of the developed model was tested by the effect of the antipsychotic drug aripiprazole and N-acetylcysteine. Behavioral tests showed that N-acetylcysteine reversed the changes in the animals' behavior similarly to aripiprazole. At the biochemical level, both drugs significantly reduced the elevated concentration of bound sulfane sulfur in the hippocampus of model rats. Recent studies indicate that in the neurodevelopmental pathophysiology of schizophrenia, disturbances in the homeostasis of sulfur compounds play an important role, which are corrected by the action of drugs.
[At the intersection of immunology and oncology: TAM receptors in the regulation of immune responses and tumorigenesis-related processes].
Tokarska-Domżałowicz W, Zdżalik-Bielecka D
Postepy Biochem · 2025 Oct · PMID 41263792 · Publisher ↗
TAM receptor tyrosine kinases (TYRO3, AXL, MER) and their ligands, protein S (PROS1) and growth inhibition-specific protein 6 (GAS6), play a key role in maintaining homeostasis and regulating the immune response through...
TAM receptor tyrosine kinases (TYRO3, AXL, MER) and their ligands, protein S (PROS1) and growth inhibition-specific protein 6 (GAS6), play a key role in maintaining homeostasis and regulating the immune response through involvement in efferocytosis, i.e., phagocytic removal of apoptotic cells and suppression of the innate immune response. Thus, their dysfunction leads, among others, to the development of autoimmune diseases. In turn, excessive production of TAM receptors correlates with the invasive phenotype of cancer cells, metastasis, drug resistance, and poor prognosis for patients with cancer. Moreover, activation of these receptors contributes to the promotion of an immunosuppressive tumor microenvironment and evading the immune response by cancer cells. Interestingly, recent studies suggest that these receptors are also involved in the cellular entry of viruses such as Zika or SARS-CoV-2. Therefore, in recent years, various therapeutic strategies targeting TAM receptors have been intensively developed, and their effectiveness has been assessed in numerous preclinical and clinical studies.
[Biomedical applications of metallic nanoparticles and their green synthesis].
Asztemborska M, Stęborowski R, Jakubiak M
Postepy Biochem · 2025 Oct · PMID 41263791 · Publisher ↗
The maim goal of modern medicine is early and accurate disease diagnosis and effective treatment with minimal side effects. Nanotechnology offers great potential in this area. Nanomaterials exhibit unique properties – bi...
The maim goal of modern medicine is early and accurate disease diagnosis and effective treatment with minimal side effects. Nanotechnology offers great potential in this area. Nanomaterials exhibit unique properties – biocompatibility, anti-inflammatory and antibacterial effects - due to their size, chemical composition, and large surface to mass ratio. Metal nanoparticles are used in diagnostics to improve imaging precision and in therapy to enhance drug delivery and control their release. These properties can be tailored during synthesis for specific applications. A promising approach is green synthesis, which uses plant-derived metabolites and enzymes as natural bioreductants and stabilizers. This method produces biocompatible nanoparticles with functional surface coatings suitable for medical use. The article discusses the key properties of nanoparticles that make them valuable in medicine, outlines selected diagnostic ant therapeutic applications of metallic nanomaterial, and highlights the role of plants in the controlled, eco-friendly synthesis of nanoparticles for medical and pharmaceutical purposes.
[Activity of flavonoids of natural origin on SARS-CoV-2 infections].
Sergiel I
Postepy Biochem · 2024 Dec · PMID 39772327 · Publisher ↗
Coronaviruses cause diseases of the respiratory tract, gastrointestinal tract and central nervous system, which threaten human health and contribute to economic losses. Innovative production technologies make it possible...
Coronaviruses cause diseases of the respiratory tract, gastrointestinal tract and central nervous system, which threaten human health and contribute to economic losses. Innovative production technologies make it possible to use bioactive compounds as antiviral agents. Most fruits, vegetables and plant products contain flavonoids. Numerous studies have demonstrated the health-promoting effect of this group of compounds resulting from their antioxidant potential. The activity of an antioxidant in the body is the result of many factors that modulate the reactivity and physicochemical properties, among which the chemical structure is the most important. Bioinformatics tools using molecular modeling often precede research using in vitro and in vivo methods. The aim of this review is to present the mechanism of antiviral action of flavonoids against SARS-CoV-2, responsible for COVID-19. Studies using virtual molecular docking models were collected to test the affinity of flavonoids for key proteins of the SARS-CoV-2 virus replication cycle. Among the flavonoids with antiviral activity, the most active were apigenin, luteolin, isorhamnetin, kaempferol, myricetin, quercetin, hesperetin, naringenin and genistein. Food products with a high content of these compounds are indicated.
[Flavonoids – natural compounds with antiviral and anticancer potential].
Sergiel I
Postepy Biochem · 2024 Dec · PMID 39772326 · Publisher ↗
Flavonoids are a group of plant secondary metabolites that have a number of health-promoting properties and have both preventive and therapeutic effects. Research confirms that flavonoids work, among others: antiviral an...
Flavonoids are a group of plant secondary metabolites that have a number of health-promoting properties and have both preventive and therapeutic effects. Research confirms that flavonoids work, among others: antiviral and anticancer. Apigenin, luteolin, isorhamnetin, kaempferol, myricetin, quercetin, hesperetin, naringenin, epicatechin and genistein have documented antiviral activity. The discovery of the anticancer activity of flavonoids (including apigenin, naringenin, hesperetin) initiated a number of studies to identify the most active compounds against various cancers and to understand the mechanism of their action. However, the relationship between flavonoid intake and cancer risk appears to be non-linear. Available literature data suggest that flavonoids may act as therapeutic agents in the early stages of virus infection and as an anticancer agent and should be included in the daily diet by increasing the consumption of primarily fruit (chokeberry, elderberry, cherry, mandarin), vegetables (parsley, celery, onion) and herbs and spices (mint, oregano, lovage, moringa, saffron). Flavonoids present in food are transported by passive diffusion (hydrophobic aglycones) and by active transport (hydrophilic glycosides). Individual classes of flavonoids differ in the amount they appear in food, the metabolites they produce and their possible impact on health. The aim of this review is to summarize the current knowledge on the potential use of selected flavonoids in the treatment of diseases of various etiologies, with an indication of their anticancer and antiviral effects. The perspectives and possibilities of using these compounds are presented, taking into account the problems resulting from their bioavailability.
[Pharmacogenomics in the treatment of mental disorders].
Kania W, Wilanowski T
Postepy Biochem · 2024 Dec · PMID 39772325 · Publisher ↗
Pharmacogenomics lies at the intersection of pharmacology and genomics. It analyzes the impact of genetic variants on patient’s response to a specific drug. Pharmacogenomic tests involve the analysis of variants of genes...
Pharmacogenomics lies at the intersection of pharmacology and genomics. It analyzes the impact of genetic variants on patient’s response to a specific drug. Pharmacogenomic tests involve the analysis of variants of genes responsible for drug metabolism, to determine the rate of drug metabolism and apply this information to clinical practice. Pharmacogenomics assists in selecting the appropriate drug and adjusting its dose to minimize side effects while maximizing the effectiveness of a drug, which accelerates the introduction of effective therapy. The prospects for its application in psychiatry are promising, although the creation of uniform recommendations is difficult due to the complexity of mental disorders and the influence of other factors, such as interactions between medications. Therefore, recommendations created by different institutions differ significantly. The aim of this article is to discuss the current possibilities of using pharmacogenomics in psychiatry and the difficulties of introducing it as a standard of psychiatric treatment.
[The role of gut microbiota and its metabolites in obesity and diabetes].
Raczkowska A, Arak K, Jaworska K
Postepy Biochem · 2024 Dec · PMID 39772324 · Publisher ↗
The gut microbiota is an essential component of the proper functioning of the human body, as gut microorganisms and their metabolites strongly influence the host’s metabolism and immune functions. They also contribute to...
The gut microbiota is an essential component of the proper functioning of the human body, as gut microorganisms and their metabolites strongly influence the host’s metabolism and immune functions. They also contribute to the biosynthesis of vitamins, production of gut hormones, maintenance of intestinal barrier integrity, protection against pathogens, as well as digestion and absorption of nutrients. There is increasing emphasis on the relationship between disturbances in gut microbiota composition and the onset of metabolic diseases such as obesity and type 2 diabetes. Understanding the significance of the microbiota in the course of these diseases, its composition, and activity may offer new approaches to their treatment. Increasing attention is being paid to individual species of gut bacteria, among which Akkermansia muciniphila holds a special position. A decreased number of this commensal bacterium in the gut is associated with many diseases, including obesity and diabetes.
[Fatty acid transporters as potential diagnostic markers for colorectal cancer].
Jankowski WM, Fichna J, Tarasiuk A
Postepy Biochem · 2024 Dec · PMID 39772323 · Publisher ↗
Colorectal cancer (RJG) is one of the most frequently diagnosed malignant neoplasms: approximately 1.9 million new cases are reported annually. Notwithstanding the advent of techniques for the early detection of RJG and...
Colorectal cancer (RJG) is one of the most frequently diagnosed malignant neoplasms: approximately 1.9 million new cases are reported annually. Notwithstanding the advent of techniques for the early detection of RJG and the introduction of novel therapeutic modalities, this disease remains the second leading cause of cancer-related mortality. The results of recent studies highlight the role of fatty acid transporters, including fatty acid translocase/cluster of differentiation 36 (FAT/CD36), fatty acid transport proteins (FATPs), and fatty acid-binding proteins (FABPs), in the pathogenesis of RJG. Changes in serum concentrations and in expression levels in tumor tissue may serve as promising biomarkers for the early diagnosis of the disease and/or the monitoring of its progression and the efficacy of its treatment. Moreover, the fatty acid carriers present a promising avenue for the development of efficacious therapies against RJG.
[From bench to beadside: experimental animal models in ischemic stroke research].
Piątek S, Milewska P, Ziemlińska E … +1 more , Malik A
Postepy Biochem · 2024 Dec · PMID 39772322 · Publisher ↗
Stroke is a devastating cardiovascular disease with a high mortality rate, leading to a significant reduction in quality of life and life expectancy. Due to the complexity of the pathophysiological processes following st...
Stroke is a devastating cardiovascular disease with a high mortality rate, leading to a significant reduction in quality of life and life expectancy. Due to the complexity of the pathophysiological processes following stroke in humans, the use of animal models of stroke, in particular rodent models, is essential for the development of treatments for patients. Transient or permanent middle cerebral artery occlusion (MCAo) and photothrombotic models are the most commonly used to simulate ischemic stroke and are discussed in this review in detail. Furthermore, we provide an overview of the current knowledge on the inflammatory and regenerative responses to stroke, executed mainly by glial cells but also by macrophages infiltrating the post-ischemic brain. Understanding the advantages and disadvantages of different animal models is the basis for their further refinement, allowing for better simulation of post-stroke events and the development of new therapeutic approaches for cerebral ischemia in humans.
[Silica nanoparticles in sustainable agriculture].
Szymańska R, Orzechowska A, Trela-Makowej A
Postepy Biochem · 2024 Dec · PMID 39772321 · Publisher ↗
The increasing population, shrinking arable land, and climate change prompt the search for new solutions in agriculture. In a sustainable approach, agriculture should be based on improving the quality and quantity of yie...
The increasing population, shrinking arable land, and climate change prompt the search for new solutions in agriculture. In a sustainable approach, agriculture should be based on improving the quality and quantity of yields while maintaining biodiversity and protecting the natural environment. Nanotechnology, present in many areas of our lives, offers opportunities to support the development of sustainable agriculture on many levels. Among the numerous solutions and nanomaterials, silicon, which is a natural component of the ecosystem, deserves special attention. In its nanoparticle form, it acquires new, unique properties. This article focuses on the significant role of silicon nanoparticles in organic farming, with particular emphasis on their function as nanofertilizers. The authors analyze the impact of silicon nanoparticles on plant growth and development and their potential in mitigating the negative effects of abiotic stress factors caused by drought, salinity, and exposure to metals. Additionally, the beneficial effects of silicon nanoparticles on plants growing under biotic stress conditions induced by microorganisms such as bacteria and fungi are presented. The paper includes a review of original research results conducted in recent years in this area, as well as possible mechanisms and strategies of silicon nanoparticle action at the physiological, cellular, and molecular levels. The issue of the safety of using nanoparticles in agriculture and the prospects for their further use as a factor enhancing the resistance and productivity of crops are also discussed.
[Mutations and their consequences in the development of pancreatic cancer].
Panek P, Rachuna J, Madej Ł … +2 more , Tomasiuk R, Jezela-Stanek A
Postepy Biochem · 2024 Dec · PMID 39772320 · Publisher ↗
Pancreatic cancer is a common cancer with a very poor prognosis and aggressive course. The main reason for the highly unfavorable prognosis of patients with pancreatic cancer is its long-term asymptomatic development, wh...
Pancreatic cancer is a common cancer with a very poor prognosis and aggressive course. The main reason for the highly unfavorable prognosis of patients with pancreatic cancer is its long-term asymptomatic development, which results in the diagnosis being made at a stage when the cancer process is significantly advanced. Despite extensive research in the field of effective diagnosis and treatment of this cancer, patient survival rates are increasing slowly and insignificantly. Pancreatic cancer cells contain many mutations, the most frequently found of which concern the KRAS, TP53, CDKN2A, SMAD4, BRCA1 and BRCA2 genes. Each of these mutations is associated with specific consequences at the molecular level and translates into further cell functioning, including uncontrolled cell division. The occurrence of specific mutations influences the planning of therapeutic procedures and patient prognosis. Many mutations are associated with a hereditary predisposition to cancer, including pancreatic cancer.
[Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome].
Spławska K, Zybaczyński Ł, Wierzbicki M … +1 more , Koziak K
Postepy Biochem · 2024 Dec · PMID 39772319 · Publisher ↗
Prostaglandins are hormones found in almost all mammalian tissues. As signaling molecules, they play a key role in the regulation of many physiological processes, including hair growth cycle. The article describes the hi...
Prostaglandins are hormones found in almost all mammalian tissues. As signaling molecules, they play a key role in the regulation of many physiological processes, including hair growth cycle. The article describes the history of the discovery of prostaglandins, including the work of Professor Ryszard Gryglewski – the discoverer of prostacyclin. Particular attention was paid to the synthetic analogue of prostaglandin F2α - latanoprost. Indicated for the treatment of glaucoma, the drug is known for inducing eyelash growth as a side effect. A prodrug, latanoprost is converted to its active metabolite, latanoprost acid. Recent research demonstrated that latanoprost acid has a chance to become an effective alternative to minoxidil and finasteride - the only drugs currently registered for the treatment of androgenetic alopecia. The development of anti-alopecia drugs containing prostaglandin derivatives, including latanoprost acid, will be a much faster process compared to the traditional path of product development based on a new chemical compound.
[Epigenetics and the improvement of crop plants].
Bernacka K, Achrem M, Kalinka A
Postepy Biochem · 2024 Sep · PMID 39365576 · Publisher ↗
Epigenetics is a term that refers to the changes in gene expression that are heritable and induced by DNA methylation, histones post-translational modifications, or sncRNA, not resulting from the DNA sequence rearrangeme...
Epigenetics is a term that refers to the changes in gene expression that are heritable and induced by DNA methylation, histones post-translational modifications, or sncRNA, not resulting from the DNA sequence rearrangements. Epigenetic modifications influence gene expression, and thus, the plasticity of plants' development and phenotype in response to external and internal factors. Until recently, the only known epigenetic modification of the DNA in eukaryotic organisms was 5-methylcytosine. The growing interest in epigenetics and the development of sensitive detection methods enabled the discovery of other modifications of the DNA nitrogenous bases, i.e., 4-methylcytosine and 6-methyladenine. However, whilst research on the 5mC distribution and role in eukaryotic organisms is widespread, analyses regarding 6mA are scarced. Nevertheless, there are indications of a potential epigenetic role of 6-methyladenine in eukaryotic genomes. Understanding epigenetic mechanisms, which are triggered in response to environmental changes, is crucial for agriculture. This review shows epigenetic mechanisms, with particular emphasis on adenine methylation in plants, as well as the role of epigenetic variation in epibreeding, affecting the improvement of agronomic traits.
[Insect immunity - adaptive mechanisms and survival strategies].
Kordaczuk J
Postepy Biochem · 2024 Sep · PMID 39365575 · Publisher ↗
Host-pathogen interactions play an important role in understanding the dynamics of the insect immune system. The analysis of environmental modulators, both biotic and abiotic, directs our attention to the impact of the s...
Host-pathogen interactions play an important role in understanding the dynamics of the insect immune system. The analysis of environmental modulators, both biotic and abiotic, directs our attention to the impact of the surroundings on the effectiveness of immunological responses. This knowledge is essential for the comprehensive understanding of insect’s immune reaction after infection with a pathogen. This article discusses the role of the immune system in insect, with a special emphasis on greater wax moth Galleria mellonella and highlights its adaptive capabilities. The processes are not only extremely interesting area of scientific research but also indicate potential practical applications in the context of plan protection, pest population control and medicine.
[Plant lipases – molecular structure, role in ontogeny and biotechnological potential].
Stafiej A, Wleklik K, Przybylak M … +1 more , Borek S
Postepy Biochem · 2024 Sep · PMID 39365574 · Publisher ↗
Lipases are enzymes commonly found in microorganisms, fungi, plants and animals. Their main function in cell metabolism is the hydrolysis (lipolysis) of ester bonds between fatty acids and glycerol in mono-, di- and tria...
Lipases are enzymes commonly found in microorganisms, fungi, plants and animals. Their main function in cell metabolism is the hydrolysis (lipolysis) of ester bonds between fatty acids and glycerol in mono-, di- and triacylglycerols. In plants, lipases play an important role in ontogeny, participating in both vegetative development and generative stages. These enzymes may also be a component of plant responses to biotic and abiotic stresses. Based on the similarity of the amino acid sequence and vacuolar localization of some plant lipases to yeast Atg15, we present a hypothesis about the participation of lipases in autophagy (precisely, in the degradation of the autophagic body) in plants. Despite the narrow substrate specificity and the type of reactions catalysed in cells, lipases find numerous biotechnological applications. The physicochemical features of lipases, which determine, for example, wide substrate specificity in vitro or high stability in a wide range of pH and temperature, make these enzymes the subject of applied research, and plant lipases show an increasing potential in this area of science and industry.
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