Haghparast Z, Ghaffarifar F, Sharifi Z
… +1 more, Bahadory S
Iran J Parasitol
· 2025 · PMID 40206374
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BACKGROUND: Theoretically, there is a possible association between emerging SARS-CoV-2 infection and parasites such as . We aimed to evaluate the seroepidemiology of in COVID-19 patients and the control group as well as...BACKGROUND: Theoretically, there is a possible association between emerging SARS-CoV-2 infection and parasites such as . We aimed to evaluate the seroepidemiology of in COVID-19 patients and the control group as well as its correlation with risk factors. METHODS: Totally, 450 sera samples were taken from COVID-19 positive patients and controls from the Tehran, Karaj, and Shiraz cities, Iran. Anti- IgG and IgM were evaluated using the ELISA technique. After two months, the participants were followed for recovery or non-recovery and even death. The association between seroprevalence and severity of viral infection as well as other risk factors was statistically estimated. RESULTS: IgG prevalence in patients and healthy individuals was 59.11% and 61.77%, respectively; these values were estimated at 2.22% and 0% for IgM, respectively. There was no significant association between the prevalence of IgG with COVID-19 infection, while this association was statistically significant for IgM prevalence. The Karaj had the highest prevalence, and a significant association was observed between the seroprevalence and some variables. CONCLUSION: Despite the non-significant association between the chronic phase of (sero) prevalence and COVID-19 symptomatic forms, the parasite prevalence was estimated remarkable and the viral infection and parasite-related acute phase antibodies relationship was estimated to be statistically significant. Due to immunosuppressive therapies for this viral inflammatory infection, it makes it more difficult to interpret the results, and because of the vulnerability of the immune system of these individuals, toxoplasmosis is likely to be hazardous in them; therefore, screening for this parasitic complication seems necessary.
Iran J Parasitol
· 2025 · PMID 40206373
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BACKGROUND: Helminthic infections cause helminthiasis, including infections by , a kind of helminths that cause reinfection and lead to severe infections, can be transmitted through the soil. We aimed to identify and ot...BACKGROUND: Helminthic infections cause helminthiasis, including infections by , a kind of helminths that cause reinfection and lead to severe infections, can be transmitted through the soil. We aimed to identify and other helminthic infections in rubber tree plantations in Thailand's lower northern regions. The specific goals include assessing prevalence using Formalin Ethyl-acetate Concentration Technique (FECT) and Agar Plate Culture (APC) and constructing phylogenetic tree. METHODS: Overall, 646 fecal samples from rubber plantation workers in five provinces in northern Thailand were examined using FECT and APC under microscope. DNA from larvae confirmed as spp. by Polymerase Chain Reaction (PCR) was sequenced for phylogenetic analysis. The DNA sequences were also submitted to the GenBank database. RESULTS: Prevalence of helminthic infections was 8.82%, with soil transmitted helminths (STH) prevalence at 6.81%; accounted for 5.41%, with at 0.62%, hookworm 0.46%, and 0.31%. PCR analysis successfully amplified the 18S rRNA gene in 26 out of 34 genomic DNAs, indicating a detection rate of 70.59%. Sequencing of these PCR products identified strains closely related to those reported in the Republic of Lao, Myanmar, and Japan, suggesting genetic diversity within the species. CONCLUSION: STH prevalence, predominantly , highlights public health concerns in rubber plantation areas, necessitating enhanced monitoring and intervention strategies. Phylogenetic analysis of , revealing a close genetic relationship among strains from various Southeast Asian countries, which underscores potential patterns of transmission and evolutionary relationships in the regions.
Berenji F, Shamsian SA, Teimourisani Z
… +6 more, Bagherpoor MR, Zarean M, Jamali J, Ghomian N, Rezazadeh MB, Hosseini Farash BR
Iran J Parasitol
· 2025 · PMID 40206372
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BACKGROUND: Iron deficiency anemia (IDA) is a common health issue during pregnancy and may be influenced by parasitic infections such as . This study aims to assess the role of infection as a potential risk factor for I...BACKGROUND: Iron deficiency anemia (IDA) is a common health issue during pregnancy and may be influenced by parasitic infections such as . This study aims to assess the role of infection as a potential risk factor for IDA in pregnant women. METHODS: A total of 208 pregnant women were enrolled in this cross-sectional study, including 98 women with IDA (case group) and 110 women without IDA (control group), conducted at Imam Reza and Ghaem Hospitals in Mashhad, Iran during 2022-2023. Hemoglobin and ferritin levels were measured in all participants, with anemia defined as hemoglobin <11 g/dL and ferritin <15 μg/L. Stool samples were collected from all participants to detect and other parasitic infections using direct smear, formalin-ether concentration, and modified acid-fast staining methods. Statistical analyses were performed using independent samples t-test and chi-square test, with a significance level of 0.05. RESULTS: The prevalence of infection was significantly higher in the case group (38.8%) compared to the control group (10.9%) (0.001). Hemoglobin and ferritin levels were significantly lower in the case group (0.001). However, no significant difference was observed between the groups in terms of socioeconomic status, education, or occupation. CONCLUSION: infection may contribute to iron deficiency anemia in pregnant women. Screening for parasitic infections in anemic pregnant women, particularly , could improve anemia management during pregnancy.
Javanmard E, Rahimi HM, Taghipour A
… +6 more, Nemati S, Mohebali M, Rezaeian M, Badrifar A, Kazemirad E, Mirjalali H
Iran J Parasitol
· 2025 · PMID 40206371
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BACKGROUND: We aimed to investigate the prevalence of and the circulating genotypes in wild boar in the western regions of Iran. METHODS: Fifty-two fecal samples were collected from wild boars in Lorestan province, Iran...BACKGROUND: We aimed to investigate the prevalence of and the circulating genotypes in wild boar in the western regions of Iran. METHODS: Fifty-two fecal samples were collected from wild boars in Lorestan province, Iran. After DNA extraction, the presence of was evaluated by real-time PCR. A nested PCR targeting the internal transcribed region (ITS) was employed to characterize genotypes. The PCR products were sequenced, and the genetic diversity and relationships among the genotypes were identified using MEGA X and DnaSp (V5) software. RESULTS: Sixteen (30%) samples were positive for using real-time PCR, and 11 (21%) were positive for nested PCR, which was sequenced. All 11 positive samples were identified as the BEB6 genotype (Group 2). The haplotype diversity was noted to be 0.182, and the nucleotide diversity, calculated using DnaSp, was 0. 00085. CONCLUSION: The findings highlight the high prevalence of the genotype BEB6 in wild boars. The presence of this genotype suggests the circulation of between domesticated animals and wild boars in Iran.
Bayraktar YA, Eryılmaz MA, Ulutaş ME
… +3 more, Şahin A, Şimşek G, Yüksekkaya Ş
Iran J Parasitol
· 2025 · PMID 40206369
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BACKGROUND: Approximately 25% of hepatic hydatid cysts rupture into the biliary tract. The precise effect of bile within the cyst on protoscoleces remains unclear. We aimed to elucidate the effect of bile on protoscolece...BACKGROUND: Approximately 25% of hepatic hydatid cysts rupture into the biliary tract. The precise effect of bile within the cyst on protoscoleces remains unclear. We aimed to elucidate the effect of bile on protoscoleces. METHODS: The contents of hydatid cysts from the livers of three sheep were aspirated under sterile conditions. The aspirated contents were divided into 50 separate Eppendorf tubes (5 cc). Samples from each tube were stained with 0.1% eosin Y. Pink stained protoscoleces were considered dead under light microscopy (×100). A total of 100 protoscoleces were counted in each sample, and the number of live and dead protoscoleces was recorded. The tubes were randomly divided into five groups. Group 1 served as the control, Group 2 received normal saline (NS), Group 3, received hypertonic saline, Group 4 received bile, and Group 4 received diluted bile. The number of live and dead protoscoleces was recorded at the end of the first and second hours. RESULTS: Compared to the initial count of live protoscoleces, the number of live protoscoleces increased at hours 1 and 2 in Groups 2 and 4. No live protoscoleces remained at hours 1 and 2 in Group 3. There was no significant change in Group 5. When compared to the control group, a significant increase in viability was observed only in Group 4 (=0.001). CONCLUSION: Bile of sheep does not exhibit scolicidal effects; rather, it positively affects protoscoleces by increasing viability.
Hamedanipour M, Barati M, Mirabedini Z
… +3 more, Mohebali M, Latifi A, Kakooei Z
Iran J Parasitol
· 2025 · PMID 40206368
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BACKGROUND: Cutaneous Leishmaniasis (CL) is a highly infectious parasitic disease in Iran. Although various diagnostic methods are available, identifying a sensitive and specific approach remains essential for effective...BACKGROUND: Cutaneous Leishmaniasis (CL) is a highly infectious parasitic disease in Iran. Although various diagnostic methods are available, identifying a sensitive and specific approach remains essential for effective treatment and disease management. We aimed to compare microscopy, the Skin Test (LST), and the Direct Agglutination Test (DAT) for diagnosis of human CL. METHODS: Fifty samples were obtained from clinically suspected CL cases. The results of conventional methods, including microscopy, the LST, and the DAT, were then compared among these samples. For microscopical examination considered a gold standard, smears were stained with Giemsa 10% and then examined for the observation of amastigote forms for the LST, 0.1 ml of standard solution was intradermally injected into positive patients, and then indurations were measured after 48-72 hours; an induration of ≥5 mm was considered positive. Additionally, anti- antibodies were detected using DAT on positive collected serum samples. RESULTS: Out of 50 samples collected from individuals suspected of CL, 66% (33/50) of them showed positive results using microscopic examination. Among these 33 patients diagnosed with CL, 9% (3/33) tested positive in the LST, and only 1 (3%) patient showed specific antibodies against using DAT. CONCLUSION: The microscopy method appears to be more suitable for diagnosing CL. However, there is a clear need for additional diagnostic methods with more validity for CL.
Aghaei M, Aghaei S, Shahmoradi Z
… +1 more, Hejazi SH
Iran J Parasitol
· 2025 · PMID 40206367
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BACKGROUND: Apoptosis, a determined form of programmed cell death (PCD), occurs in multi-cellular and single-celled organisms. Given that a general understanding of apoptosis in single-cell is crucial for designing dise...BACKGROUND: Apoptosis, a determined form of programmed cell death (PCD), occurs in multi-cellular and single-celled organisms. Given that a general understanding of apoptosis in single-cell is crucial for designing disease control policies, we reviewed the apoptosis mechanism and the proteins involved. METHODS: The information was obtained from articles published in PubMed, SciELO, Science Direct, Scopus, Google Scholar, and Web of Science databases (1998-2021). Search terms used were" apoptosis" or" Leishmaniasis". RESULTS: The 77 subjects were included in the study that revealed the significance of the apoptosis process for survival. Although, various stimuli induce apoptosis, the proteins involved in apoptosis have been poorly understood. Metacaspases in instead of caspase and death receptors in mammals play the same role in the PCD pathways. Also, other apoptotic proteins in such as endonuclease G (EndoG), caspases- like cysteine proteases, TSN (Tudor Staphylococcal Nuclease), and Zinnia endonuclease 1 (ZEN1) lead to phenotype similar to mammalian apoptosis. Furthermore, there are differences in these mechanisms between the different species of and studies to illustrate downstream events related to the serine phosphatidylcholine exposure, cytochrome C secretion, etc. remain an ongoing challenge. CONCLUSION: Determining the essential regulatory proteins in the apoptosis and the specific present of metacaspases in parasite, is effective for designing new therapeutic strategies against leishmaniasis and vaccine development.
Mahmoudvand H, Khalaf AK, Moghadam EF
… +3 more, Yadegari JG, Adineh A, Jalili A
Iran J Parasitol
· 2025 · PMID 40206366
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BACKGROUND: Medicinal plants and their derivatives due to having high availability, low cost, low toxicity, and high efficacy are recognized as significant reservoirs of a diverse array of valuable therapeutic compounds....BACKGROUND: Medicinal plants and their derivatives due to having high availability, low cost, low toxicity, and high efficacy are recognized as significant reservoirs of a diverse array of valuable therapeutic compounds. We aimed to investigate the lethal effects of carvone (CV) on protoscoleces of hydatid cyst, in laboratory and conditions. METHODS: The protoscolicidal effects of CV were investigated both and on hydatid cyst protoscoleces using the eosin exclusion assay. Furthermore, the impact of CV on the induction of apoptosis and DNA damage in the protoscoleces was assessed through a colorimetric protease assay and Real-time PCR analysis, respectively. RESULTS: CV, particularly at a concentration of 150 μg/ml, effectively eradicated protoscoleces of hydatid cysts within a 20-minute exposure period. Furthermore, CV exhibited sustained anti-parasitic effects in the , leading to the complete elimination of hydatid cyst protoscoleces after a 30-minute exposure, in contrast to its immediate lethal effects observed in vitro. CV concentrations of 1/3 IC, 1/2 IC, and IC ( < 0.001) resulted in caspase-3 activation levels of 11.3%, 19.8%, and 28.4%, respectively. The expression levels of the and genes significantly upregulated after treatment with CV (<0.001). CONCLUSION: The findings demonstrated the potential of CV to eliminate protoscoleces by inducing apoptosis and causing DNA damage. However, further studies are required to clarify the specific mechanisms underlying its action and to assess its efficacy in clinical trials, which may facilitate the application of CV in the context of hydatid cyst surgical procedures.
Darabi E, Sadjjadi SM, Mohammadzadeh T
… +3 more, Karamian M, Owji SM, Sedaghat B
Iran J Parasitol
· 2025 · PMID 40206365
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BACKGROUND: We aimed to determine the genotypes of () using DNA regions within the () mitochondrial genes in formalin-fixed paraffin-embedded (FFPE) isolates of human cystic echinococcosis cysts (CE cysts) and compare...BACKGROUND: We aimed to determine the genotypes of () using DNA regions within the () mitochondrial genes in formalin-fixed paraffin-embedded (FFPE) isolates of human cystic echinococcosis cysts (CE cysts) and compare their histopathologic alterations. METHODS: Out of 135 samples, 21 high-quality PCR positive samples were selected for sequencing and were deposited into GenBank database. Moreover, histopathological changes of (G1 genotype) and (G6 genotype) cases were also compared. RESULTS: Based on the sequencing results, 16 cases were diagnosed as (G1-G3 genotype) and 5 cases as (G6 genotype). Five haplotypes of were identified from 21 sequences. The histopathological alterations in both genotypes showed laminated layer of CE without inflammatory cells. In a few cases of the G6 genotype, neutrophils in the outer cuticular layer with mild vascular and congestion were observed. Cell debris with multiple areas of necrosis, as well as scanty lymphoplasma cells in the outer cuticular layer were observed in G1-G3 genotype cases. So, the histopathological differences between the two genotypes are not noticeable enough to be differentiated by microscopical observations. CONCLUSION: (G1-G3) and (G6 genotype) are prevalent among CE patients. In general, five haplotypes were identified by genes analysis. The histopathological differences between the two genotypes have not been so big to be differentiated by microscopic observations.
Heidari MM, Fazaeli A, Nadri S
… +2 more, Torabi N, Saraei M
Iran J Parasitol
· 2025 · PMID 40206364
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BACKGROUND: We aimed to investigate the effect of chitosan nanoparticles loaded azithromycin on reducing the number of tissue cysts in the brain of a mouse model. METHODS: Chitosan nanoparticles and azithromycin loaded...BACKGROUND: We aimed to investigate the effect of chitosan nanoparticles loaded azithromycin on reducing the number of tissue cysts in the brain of a mouse model. METHODS: Chitosan nanoparticles and azithromycin loaded nanoparticles were synthesized using microfluidic system and characterized using dynamic light scattering (DLS) and TEM images. Forty BALB/c mice after infection with a cyst forming strain, were divided into four groups daily receiving PBS, 10 mg/kg azithromycin, 10 mg/kg chitosan nanoparticles, and 10 mg/kg chitosan nanoparticles loaded azithromycin, respectively, for 10 days. Immediately after end of the treatment, the mice were sacrificed and the tissue cyst burden in their brain was investigated using an optical microscope and compared by ANOVA statistical test. RESULTS: The average particle size and dispersion index for chitosan nanoparticles were 193.66 nm and 0.43, and for nanoparticles containing azithromycin drug, they were 233.66 nm and 0.21, respectively. The amount of drug loading was 1.8% and the drug release was more than 90% after less than 48 hours. The stability of nanoparticles did not change significantly after 28 days of observation. tissue cyst numbers obtained in a range of 1.48 to 1.95 in 10 ul brain suspension with no significant differences among the groups of treated mice. CONCLUSION: The synthesis of chitosan nanoparticles loaded with azithromycin by microfluidic system could make the particles with more uniformity and stability and high loading of the drug with low cost and more convenient conditions.
Iran J Parasitol
· 2025 · PMID 40206363
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BACKGROUND: We aimed to determine the seroprevalence of in horses in West Azerbaijan Province, Iran a region known for its wildlife interactions. METHODS: The study was conducted in March 2016 across four cities in West...BACKGROUND: We aimed to determine the seroprevalence of in horses in West Azerbaijan Province, Iran a region known for its wildlife interactions. METHODS: The study was conducted in March 2016 across four cities in West Azerbaijan: Urmia, Chaldoran, Sardasht, and Khoy, Iran. A total of 184 equines, ranging from three to over ten years of age, were randomly sampled. Blood samples were collected and were analyzed using the ID Screen® Indirect Multi-species ELISA to detect antibodies. RESULTS: Of the 184 serum samples, 4 (4.3%) from northern counties and 2 (2.2%) from southern counties tested positive for trichinellosis. Chi-square and Fisher's exact tests indicated no significant correlations between age, gender, or residential location and disease prevalence. The logistic regression model was not statistically significant ( = 0.754), revealing that these demographic factors do not substantially influence trichinellosis risk in the studied equines. CONCLUSION: This study provides crucial insights into the low seroprevalence of in horses in West Azerbaijan, suggesting that equines may not be primary reservoirs of the parasite despite overlapping habitats with infected wildlife.
Azad NS, Kalantari M, Amin M
… +1 more, Barazesh A
Iran J Parasitol
· 2025 · PMID 40206362
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Myiasis infection is caused by the invasion of flies' eggs and larvae into different tissues of the host's body. The rarest form is urogenital myiasis, which can occur even in men with a much lower probability than women...Myiasis infection is caused by the invasion of flies' eggs and larvae into different tissues of the host's body. The rarest form is urogenital myiasis, which can occur even in men with a much lower probability than women, especially in tropical and subtropical regions. The case of this study is a 5-year-old boy from suburbs of Bushehr City, southern Iran who referred to the Pediatrics Department of Persian Gulf Hospital in Bushehr due to constant fever and significant weight loss. In urine evaluation, the presence of larvae was confirmed. The larvae of several species of myiasis-producing flies can attack the urinary-genital system of people and cause urogenital symptoms. Therefore, it is necessary to diagnose and accurately identify the species of larvae that cause myiasis in order to properly treat affected patients.
Akkuzu MZ, Yavuz A, Ebik B
… +3 more, Karabulut Ü, Üzel A, Bacaksız F
Iran J Parasitol
· 2024 · PMID 39735852
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This article discusses infection, a zoonotic parasite that lives in the liver bile ducts. A 31-year-old female patient was diagnosed with symptoms such as nausea, increased liver enzymes, and right upper quadrant pain f...This article discusses infection, a zoonotic parasite that lives in the liver bile ducts. A 31-year-old female patient was diagnosed with symptoms such as nausea, increased liver enzymes, and right upper quadrant pain for about a year. The parasite was detected in the common bile duct by Endoscopic Ultrasound (EUS) and removed by Endoscopic Retrograde Cholangio Pancreatography (ERCP). Treatment was performed with 10 mg/kg triclabendazole. Eosinophilia, abdominal pain, and dietary history are important clues in the diagnosis of infection. Imaging methods, especially EUS, play a critical role in diagnosis. With this method, parasites can be seen as mobile hyperechogenic structures. If untreated, parasites can survive in their hosts for many years, therefore early diagnosis and treatment are important in preventing complications. It is recommended to monitor the eosinophil levels and serological test results of patients after treatment. As a result, EUS is a very valuable diagnostic tool in suspected cases.
Iran J Parasitol
· 2024 · PMID 39735851
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BACKGROUND: We aimed to shed light on the risks of elevated levels of IL-18 in aborted women with toxoplasmosis by evaluating the risk or protective function of alleles or genotypes for single nucleotide polymorphism (SN...BACKGROUND: We aimed to shed light on the risks of elevated levels of IL-18 in aborted women with toxoplasmosis by evaluating the risk or protective function of alleles or genotypes for single nucleotide polymorphism (SNP) of IL-18 (rs 1946519), which might be related to the susceptibility to toxoplasmosis. METHODS: IL-18 levels in patient and control blood samples were determined using ELISA, and the SNP IL-18 (ra 1946519) was subjected to the high-resolution method. RESULTS: Compared to healthy pregnant women (HP), the IL-18 serum levels of recurrent abortion with toxoplasmosis (RAWT), recurrent abortion without toxoplasmosis (RAWOT), and healthy non-pregnant (HNP) women decreased with significant differences. Additionally, a strong association between patients and controls was found in the SNP IL-18 data. RAWT and RAWOT with the genotypes AA and AC had significantly lower IL-18 serum levels than women HP, according to the distribution of IL-18 serum levels by SNP. CONCLUSION: The serum level of IL-18 varied by genotype in patients with substantial differences compared to controls, while the SNP of IL-18 has been linked as a risk factor in toxoplasmosis-infected recurrent abortion women.
Bessi C, Ercole ME, Fariña FA
… +5 more, Montalvo F, Fassa V, Acerbo M, Ribicich MM, Pasqualetti MI
Iran J Parasitol
· 2024 · PMID 39735850
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BACKGROUND: The aim of this study was to investigate the survival of and in decaying wild boar tissue and assess their freezing tolerance in experimentally infected animals. METHODS: The present study was conducted in...BACKGROUND: The aim of this study was to investigate the survival of and in decaying wild boar tissue and assess their freezing tolerance in experimentally infected animals. METHODS: The present study was conducted in Buenos Aires City, Argentina during the 2018-2019 period. Two wild boars were used, one infected with 20,000 muscle larvae (ML) of and the other with . Both animals were euthanized 19 weeks post-infection. Limbs from each boar were placed over soil in plastic containers to assess ML survival in decaying tissue, under natural temperature and humidity, shielded from rain. Weekly samples were taken for artificial digestion, and the ML were inoculated into mice to determine their reproductive capacity index (RCI). Additionally, to evaluate the freezing tolerance of the ML, muscle samples were stored at -18°C. Six samples were taken and digested after 2, 4, 7, 9, 11, and 14 days, with subsequent inoculation into mice to assess RCI. RESULTS: remained infective in decaying wild boar tissue for 11 weeks, while remained infective for only 4 weeks. The freezing tolerance assay showed that ML remain infective for 9 days. However, ML remain infective for only 2 days at -18°C. CONCLUSION: The findings highlight the survival strategies of and in different environmental conditions, which may have implications for understanding their transmission dynamics in wild animals.
Iran J Parasitol
· 2024 · PMID 39735849
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From a global perspective, hepatocellular carcinoma (HCC) and hydatid cyst disease are both common; however, the endemic and zoonotic nature of hydatid cysts (due to larvae) makes the simultaneous detection of the two c...From a global perspective, hepatocellular carcinoma (HCC) and hydatid cyst disease are both common; however, the endemic and zoonotic nature of hydatid cysts (due to larvae) makes the simultaneous detection of the two conditions a rare occurrence. In this case report, in a 43-year-old male patient, we aim to draw attention to the potential coexistence of HCC and liver hydatid cysts by presenting a case in which HCC tissue was detected in the cyst wall-removed by emergency surgery due to cyst perforation. Hydatid lesions in the liver may exhibit tumor-like growth characteristics. Consequently, identifying a hydatid cyst concomitant with HCC can be challenging, particularly when HCC has developed within the cystic structure. Careful assessment of resected tissues and detailed diagnostic approaches can facilitate the identification of such cases, even if the risk of HCC in patients with hydatid cysts is marginal. It may be advisable to suggest periodic monitoring with HCC-related markers and liver imaging methods.
Arif SA, Lahkar D, Gogoi SM
… +5 more, Changkija B, Kakati P, Buragohain L, Pathak M, Das T
Iran J Parasitol
· 2024 · PMID 39735848
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A 2-year-old female Assam Hill goat was presented with a clinical history of anorexia, fever, mild anemia, rough body coat, dehydration, tachycardia, dyspnea and swelling of palpable lymph nodes. Hematology revealed low...A 2-year-old female Assam Hill goat was presented with a clinical history of anorexia, fever, mild anemia, rough body coat, dehydration, tachycardia, dyspnea and swelling of palpable lymph nodes. Hematology revealed low hemoglobin, packed cell volume, red blood cell and thrombocyte count. Biochemical analysis showed increased serum concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and urea in comparison to the normal reference range. Microscopic examination showed intra-erythrocytic forms of Theileria species. Molecular and phylogenetic analysis of partial 18S rRNA gene sequence confirmed Theileria luwenshuni infection. The goat was treated with buparvaquone and oxytetracycline and recovered uneventfully. A three-month follow-up showed no recurrence. This study reveals the presence of T. luwenshuni in Assam, India and it should be considered in differential diagnosis and as one of the important pathogens of clinically sick goats. The present case report provides a rational approach to diagnosis and treatment for a goat infected with pathogenic T. luwenshuni in Assam, India. To our knowledge, the present communication describes about the first successful therapeutic management of pathogenic T. luwenshuni infection in a goat supported with molecular evidence from Assam, a north-eastern state of India.
Karcioglu O, Kara A, Kurtulan O
… +2 more, Uysal S, Selçuk ZT
Iran J Parasitol
· 2024 · PMID 39735846
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remains a global public health issue. Although predominantly affecting the liver, the lungs are the second most affected organ and often undergo surgical intervention. Here, a case managed by bronchoscopy and medical the...remains a global public health issue. Although predominantly affecting the liver, the lungs are the second most affected organ and often undergo surgical intervention. Here, a case managed by bronchoscopy and medical therapy is presented. A 26-year-old woman was presented with a cough, hemoptysis, and a 5 kg weight loss in the last two months. Chest imaging identified a 4 cm centrally cystic mass lesion in the middle lobe of the right lung, which was suspicious of lung cancer. Bronchoscopy revealed a whitish, plastic-like object that was difficult to extricate and obstructed the middle lobe bronchus. We removed the material and purulent secretions covering it and opened the middle lobe bronchus totally. The histopathological study verified its consistency with hydatid cyst. There was no evidence of a hydatid cyst on computerized thomography after bronchoscopy. The lesion in the left lobe of the liver, confirmed to be suggestive of a hydatid cyst via ultrasonography, was treated using the PAIR technique. We administered oral albendazole to continue the treatment. It may be a reasonable approach to postpone surgery in order to preserve lung tissue in patients who have undergone complete removal of hydatid cyst material via bronchoscope.