Journal Of Nutritional Science And Vitaminology[JOURNAL]
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200 papers
Structural and Functional Characteristics of FMN-Dependent NADPH-Indigo Reductase Homolog from Bacillus cohnii.
Yoneda K, Sakuraba H, Hayashi J … +3 more , Naruse Y, Araki T, Ohshima T
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301060 · Publisher ↗
We found indigo reductase homolog in Bacillus cohnii gene and succeeded in production of a large amount of the recombinant homolog in Escherichia coli. The homolog exhibited FMN-dependent NADPH-quinone reductase activity...
We found indigo reductase homolog in Bacillus cohnii gene and succeeded in production of a large amount of the recombinant homolog in Escherichia coli. The homolog exhibited FMN-dependent NADPH-quinone reductase activity, but not indigo-reducing activity. Crystal structure analysis of the enzyme revealed the formation of a binary complex with FMN, 2-propanol, and glycerol, determined at a resolution of 1.57 Å. Notably, the structure of FMN was of particular interest, as the isoalloxazine ring of FMN exhibited a butterfly-like bent conformation, with an angular deviation of approximately 9.4º to 10.9º along the axis between N5 and N10. The reason for FMN adopting a butterfly-like structure was thought that the exposure of the enzyme crystal to X-ray radiation led to the one-electron reduction of FMN, forming the semiquinone radical FMNH.
Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.
Mori N, Takano M, Nakashima A … +4 more , Inoue E, Yanai M, Kondo N, Maikuma A
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301059 · Publisher ↗
Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception...
Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the "browning" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.
Effects of Blue Rose Extract Powder Intake on Skin Characteristics in Middle-Aged and Older Japanese Women-Randomized, Double-Blind, and Placebo-Controlled Trial.
Aoyagi D, Yamada-Kato T, Okunishi I
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301058 · Publisher ↗
In this study, we aimed at evaluating the effect of improving skin conditions on petal-derived blue rose extract (BRE) powder intake in middle-aged and older women in Japan. We conducted a randomized, double-blind, and p...
In this study, we aimed at evaluating the effect of improving skin conditions on petal-derived blue rose extract (BRE) powder intake in middle-aged and older women in Japan. We conducted a randomized, double-blind, and placebo-controlled parallel study in 48 healthy Japanese women aged 40-50 y who were aware of dry skin. We divided the participants equally into two groups (i.e., 24-24 in the test and control groups, respectively). The participants consumed 100 mg either the placebo or BRE powder daily for 4 wk. We performed skin measurements before-and-after 4 wk of continuous intake. Upon 4 wk after continuous intake, the BRE group displayed improved skin quality compared with the control group. The primary outcome was stratum corneum water content, which significantly improved in the BRE group. The secondary outcomes, melanin index, stains, wrinkles, and rough texture showed improvements between the groups as well. Visual perception, roughness of texture, and wrinkles were improved between the groups. Finally, transparency yielded better scores within the groups. This study presents the results of the first functional test targeting BRE, unraveling various effect of improving skin condition and highlighting the potential of taking BRE in skin care.
Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study.
Nanri A, Sakanari M, Mantani H … +6 more , Hirabayashi A, Furuse M, Yokote N, Nakamura M, Takeda T, Ohta M
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301057 · Publisher ↗
Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is l...
Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is limited and inconsistent. We examined the cross-sectional association of calcium and vitamin D intake with PMS. Participants were 390 women aged 22-49 y who responded to a mail survey in 2022-2023. Dietary intake was assessed using a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of calcium and vitamin D intake with adjustment for potential confounding variables. The prevalence of moderate to severe PMS was 10% (39 women). Neither calcium nor vitamin D intake was significantly associated with PMS. However, calcium intake was associated with a decreased prevalence of PMS, albeit without statistical significance, with multivariable-adjusted odds ratios (95% CI) for PMS in the lowest through highest tertiles of calcium intake of 1.00 (reference), 0.47 (0.18-1.25), and 0.27 (0.07-1.08), respectively (p for trend=0.06). The odds ratio of PMS was low in the highest tertile of vitamin D intake compared with the lowest, but without statistical significance (odds ratio 0.56, 95% CI 0.19-1.66). Our findings suggest that calcium and vitamin D intake was not appreciably associated with PMS. The suggestive inverse association between calcium intake and PMS requires further investigation.
Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.
Zhang L, Li C, Gao Y … +4 more , Zhang Z, Li L, Hu J, Tian L
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301056 · Publisher ↗
The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P m...
The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P). The severity of vascular calcification was graded. The correlation between the severity of vascular calcification in patients and each of the clinical indicators was analyzed. The diagnostic value of Ca and P metabolism and microinflammatory factors for vascular calcification in malnourished uremic patients was assessed. All enrolled patients were divided into a non-vascular calcification group (n=42) and a vascular calcification group (n=36) according to coronary artery calcification (CAC) scoring, and the probability of vascular calcification was 46%. The dialysis duration, Ca×P, P, hypersensitive C-reactive protein (hs-CRP), and interleukin 6 (IL-6) levels were significantly higher in the vascular calcification group than in the non-vascular calcification group. hs-CRP, IL-6, Ca×P, and P had predictive potency for vascular calcification in patients. CAC scores were correlated positively with hs-CRP, IL-6, Ca×P, and P. Malnourished uremic patients have a higher incidence of vascular calcification. hs-CRP, IL-6, Ca×P, and P are all independent risk factors for vascular calcification in uremic patients, and are positively correlated with the severity of vascular calcification.
The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure.
Watanabe S, Onuma J, Usui M
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301055 · Publisher ↗
Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular even...
Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular events, limited data are available on the relationship between free carnitine levels and clinical outcomes in heart failure patients. This study aimed to investigate the association between free carnitine levels and clinical outcomes in patients hospitalized for heart failure. This retrospective study included 271 consecutive patients admitted to our hospital for their first episode of acute heart failure. Patients were divided into four quartiles based on free carnitine levels (quartile 1: <37.0 μmol/L, n=69; quartile 2: 37.0-49.7 μmol/L, n=68; quartile 3: 49.7-58.9 μmol/L, n=67; quartile 4: ≥58.9 μmol/L, n=67). The primary endpoints were 1-y cardiac mortality, rehospitalization due to heart failure, and its composite endpoint. The incidence of cardiovascular events was compared among the quartiles. Creatinine levels were significantly higher in quartile 4 than in other groups. There were no significant differences in age or BNP among the four groups. Additionally, the 1-y mortality rate was significantly higher in both quartile 1 and quartile 4, while the rehospitalization rate for heart failure within 1 y post-discharge was significantly higher in quartile 4. In summary, the relationship between free carnitine levels and mortality in heart failure patients showed a J-curve pattern, with both low and high levels associated with worse outcomes. Thus, extreme free carnitine levels may serve as potential risk factors for adverse clinical outcomes in this population.
Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.
Higuchi Y, Kajiyama S, Kitta K … +7 more , Miyawaki T, Matsumoto S, Ozasa N, Kajiyama S, Hashimoto Y, Fukui M, Imai S
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301054 · Publisher ↗
The aim was to evaluate the acute effect of drinking tomato juice preloaded with lemon and perilla oil 10 min before consuming carbohydrate on postprandial blood glucose, insulin, and lipids concentrations in young healt...
The aim was to evaluate the acute effect of drinking tomato juice preloaded with lemon and perilla oil 10 min before consuming carbohydrate on postprandial blood glucose, insulin, and lipids concentrations in young healthy women. In this randomized controlled crossover study, 21 women (age 21.1±0.6 y, HbA1c 5.2±0.2%, mean±SD) consumed either 200 g of tomato juice, tomato juice with 10 g of lemon juice and 5 g of perilla oil (n-3 PUFA-rich oil), or water 10 min before consuming 200 g of boiled white rice for 3 separate days. The energy and fat in tomato juice with lemon/n-3 PUFA-rich oil were higher (energy 402 kcal, fat 5.6 g) than tomato juice (354 kcal, 0.6 g) and water (315 kcal, 0.6 g). The blood parameters were measured at 0, 30, 60, and 120 min after carbohydrate consumption and compared among 3 d. The plasma glucose at 30 min in tomato juice with lemon/n-3 PUFA-rich oil was significantly lower than that of water (103.1±3.4 mg/dL vs. 127.8±4.0 mg/dL, p<0.001, mean±SE) and tended to be lower than that of tomato juice (113.9±4.9 mg/dL, p=0.078). The serum insulin at 30 min was also significantly lower in tomato juice with lemon/n-3 PUFA-rich oil than that of tomato juice (p<0.01). Adding lemon and n-3 PUFA-rich oil to tomato juice before carbohydrate meal can be practical method to lower early postprandial glucose and insulin responses in young healthy women.
Evaluation of Phylloquinone Content in 42 Species Algae Inhabiting the Japanese Coast and Relationship between Phylloquinone and Chlorophyll Contents.
Tanaka R, Shibata T, Yamamoto K … +1 more , Tanaka R
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301053 · Publisher ↗
Terrestrial green plants are rich in phylloquinone (PK), and their PK content is highly correlated with the chlorophyll content. However, there are few studies on the PK content of algae and its correlation with chloroph...
Terrestrial green plants are rich in phylloquinone (PK), and their PK content is highly correlated with the chlorophyll content. However, there are few studies on the PK content of algae and its correlation with chlorophyll content. To evaluate the PK content in algae and its correlation with chlorophyll, the PK and chlorophyll contents in algae, including Phaeophyta (18 species), Rhodophyta (17 species), and Chlorophyta (seven species), were determined. Algae, particularly Phaeophyta, contain more functional components than do other green terrestrial plants. Therefore, other components such as carotenoids, polyphenols, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability were analyzed to confirm their correlation with PK. Furthermore, terrestrial plants such as leafy vegetables, other vegetables, and tea powder were evaluated for the same components and compared with the experimental results for algae. This results showed that PK was abundant in Phaeophyta and almost all samples contained more than 100 μg/100 g of dry samples. In particular, Sargassum muticum contained 514.11±11.29 μg/100 g. However, almost all of the Rhodophyta and Chlorophyta contained a little PK. The results also confirmed a positive correlation between the PK and chlorophyll content in Rhodophyta (R=0.7085), Chlorophyta (R=0.7264), and terrestrial plants (R=0.8436). However, no correlation was observed between the PK and chlorophyll content in Phaeophyta (R=0.1013). In addition, the principal component analysis results showed no correlation between PK and other components, such as carotenoids and polyphenols, and DPPH radical scavenging ability in algae. However, Phaeophyta also contained more functional components, such as carotenoids, polyphenols, and DPPH radical scavenging ability than the other algal groups.
Serum 25-Hydroxyvitamin D Levels and the Risk of Post-Traumatic Wound Infection.
Zhang Z, Yang X, Li M … +1 more , Li B
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301052 · Publisher ↗
Post-traumatic wound infection is commonly observed in trauma patients and has a poor prognosis. Vitamin D is a significant modulator of the immune system and may play a role in preventing wound infection. However, the i...
Post-traumatic wound infection is commonly observed in trauma patients and has a poor prognosis. Vitamin D is a significant modulator of the immune system and may play a role in preventing wound infection. However, the inherent limitations and inconsistent results of previous observational studies restricted them from inferring causal effects. We employed Mendelian randomization design to estimate the causal effects of serum 25-hydroxyvitamin D levels on the risk of post-traumatic wound infection. Data in the analysis were extracted from large-scale genome-wide association studies with 417,580 individuals for serum 25-hydroxyvitamin D measurements and 218,546 individuals for post-traumatic wound infection. Multivariable Mendelian randomization analyses were performed to adjust for confounding variables. We also conducted extensive sensitivity analyses to verify the main results. The results revealed a causal relationship between higher serum 25-hydroxyvitamin D levels and a lower post-traumatic wound infection risk (OR=0.473, p=0.014). The causality remained after adjustment of potential confounding factors according to Multivariable Mendelian randomization analyses (OR=0.361, p<0.001). Sensitivity tests suggested the reliability of our findings. This study indicated a causal association between genetically predicted high serum 25-hydroxyvitamin D levels and a decreased risk of post-traumatic wound infection.
Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions.
Umegaki K, Yokotani K, Ieiri K … +1 more , Kawasaki H
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40301051 · Publisher ↗
Blood ascorbic acid (AsA) concentrations are lower in diabetic patients than in the general population, a phenomenon that is also observed in streptozotocin (STZ)-diabetic models of type 1 diabetes. However, the occurren...
Blood ascorbic acid (AsA) concentrations are lower in diabetic patients than in the general population, a phenomenon that is also observed in streptozotocin (STZ)-diabetic models of type 1 diabetes. However, the occurrence of diabetes in KK-Ay mice, a model for type 2 diabetes, the most common form of diabetes, remains unclear. Although this mouse can synthesize AsA, understanding its level changes during diabetes progression could help in analyzing AsA's effects on type 2 diabetes. Therefore, the present study investigated the relationship between hyperglycemia and AsA concentrations in the blood and organs of KK-Ay mice, and discussed the findings in relation to those observed in STZ-diabetic mice. Male KK-Ay mice were examined at different stages of diabetes (pre-diabetic, early onset, and hyperglycemic maintenance). STZ-diabetic mice were generated by administering STZ to ICR mice. AsA concentrations were measured in plasma, blood mononuclear cells, and tissues, along with hepatic L-gulonolactone oxidase (GLO) activity and mRNA expression levels. Unexpectedly, AsA concentrations in KK-Ay mice increased under hyperglycemic conditions, while they decreased in STZ-diabetic mice. A consistent relationship was not observed between organ AsA concentrations and hyperglycemia. GLO activity and mRNA expression levels increased in KK-Ay mice, but decreased in STZ-diabetic mice, suggesting an innate defense mechanism against hyperglycemia in KK-Ay mice. These results indicate that different diabetes models exhibit distinct changes in AsA concentrations and hepatic GLO activity under hyperglycemic conditions, highlighting the importance of considering endogenous AsA when evaluating the antioxidant properties of dietary components in KK-Ay mice.
Associations between the Intakes of Plant Foods and Coronary Artery Disease in Japanese Patients Undergoing Coronary Angiography.
Saita E, Kishimoto Y, Ohmori R … +2 more , Kondo K, Momiyama Y
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024753 · Publisher ↗
Several Japanese cohort studies have reported that the intakes of plant foods, such as vegetables, fruits, seaweed, and soy products, are inversely associated with coronary artery disease (CAD). However, the results of t...
Several Japanese cohort studies have reported that the intakes of plant foods, such as vegetables, fruits, seaweed, and soy products, are inversely associated with coronary artery disease (CAD). However, the results of these studies have been inconsistent. We investigated the association between CAD and the intakes of plant foods in 802 Japanese patients undergoing coronary angiography. The intakes of vegetables, fruits, seaweed, and soy products were determined by 3 categories (<3, 3-4, and >4 times/wk). CAD was found in 511 patients, of whom 173 had myocardial infarction (MI). Patients with higher vegetable and fruit intakes had a significantly lower prevalence of CAD and tended to have a lower prevalence of MI. However, no significant difference was found in the prevalence of CAD or MI among the 3 groups of seaweed and soy product intakes. In the multivariate analyses, the prevalence of CAD decreased depending on the intakes of vegetables and fruits. The odds ratios (OR) for >4 times/wk intakes of vegetables and fruits relative to <3 times/wk were 0.46 (95%CI: 0.29-0.74) and 0.62 (0.40-0.95), respectively. Thus, in Japanese patients undergoing coronary angiography, the intakes of vegetables and fruits were found to be inversely associated with CAD but not with MI. However, no significant association was found between the intakes of seaweed or soy products and CAD or MI.
Adult Chicken Bone-Derived Components Reverse the Impaired Calcium Homeostasis and Bone Mass in Mice Lacking 1,25(OH)D-VDR Signaling.
Nishiura T, Yamanaka H, Mori R … +4 more , Kato S, Nakane M, Kotoura S, Masuyama R
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024752 · Publisher ↗
Female adult chickens, known as laying hens, possess a distinctive bone structure in the intracortical region, which is responsible for storing calcium. Given the cyclical nature of calcium storage and demand during the...
Female adult chickens, known as laying hens, possess a distinctive bone structure in the intracortical region, which is responsible for storing calcium. Given the cyclical nature of calcium storage and demand during the egg-laying cycle, the medullary bone of laying hens plays a crucial role in maintaining calcium homeostasis. In this study, we examined the potential of orally administered components derived from adult chicken bones to improve calcium homeostasis and bone mass in mice. Samples from adult chickens and young chickens without egg-laying experience were prepared by pressing meat parts, including bones, and administered to wild type (WT) and vitamin D receptor knockout (VDRKO) mice respectively. The phenotypes observed in VDRKO mice, such as severe reductions in serum calcium concentration and bone mass, were normalized in mice fed the adult chicken bone-containing diet to the same extent as in WT mice. These effects were not observed in mice fed a young chicken bone-containing diet. The adult chicken bone-containing diet increased apparent calcium absorption in VDRKO mice compared to other dietary groups. To determine the effects on bone metabolism, osteoclasts activity was evaluated by histological measurements and the quantification of serum osteoclast marker, and it was restored by the adult chicken bone-containing diet. In addition, the treatment of adult chicken bone-derived components increased osteoclasts differentiation in vitro from cultured bone marrow macrophage. These results show that adult chicken bone-derived components improve calcium and bone homeostasis in mice lacking vitamin D action through combined effects that target calcium metabolism and bone turnover.
Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.
Otsuka K, Kuriki D, Kamachi K … +2 more , Tanaka A, Matsuoka R
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024751 · Publisher ↗
Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbe...
Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbene intake in humans, particularly its effect on blood microRNA (miRNA) expression levels, has not been evaluated. Accordingly, this pilot study aimed to investigate the effects of pterostilbene on blood biochemistry and blood miRNA expression levels and the safety of continuous intake at doses of 10 or 100 mg/d over 12 wk. A double-blind, placebo-controlled parallel-arm comparison trial was conducted with 30 healthy men. In the analysis of blood miRNA expression levels, miR-34a and miR-193b showed very high increases at week 4 and after week 4 of intake, respectively, suggesting that the responders might be present among participants in the pterostilbene intake group. No adverse events were reported during the trial in any participant, and no abnormalities were observed upon examination by the responsible physician. Thus, pterostilbene intake would regulate blood miRNA expression levels, and the results can be utilized in human studies investigating miRNA expression levels with functional food ingredients.
Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study.
Kume D, Nishiwaki M, Ito M
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024750 · Publisher ↗
Acute arterial stiffening occurs during postprandial hyperglycemia. Such vascular responses are suggested to be averted by suppressing the postprandial glycemic response. We previously developed an α-glucosidase-inhibiti...
Acute arterial stiffening occurs during postprandial hyperglycemia. Such vascular responses are suggested to be averted by suppressing the postprandial glycemic response. We previously developed an α-glucosidase-inhibiting tea powder from the leaves of Morus australis (M. australis), a mulberry species distributed in the Ryukyu Islands, and demonstrated that this powder has an inhibitory effect on blood glucose elevation after sucrose ingestion. This study aimed to investigate the effect of powdered M. australis leaf intake on the arterial stiffness response after sucrose ingestion. In a randomized crossover design, 12 healthy young men completed two trials: with (mulberry [M] trial) and without (control [C] trial) intake of powdered M. australis leaves before ingestion of 75 g of sucrose. Blood glucose levels and brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness, were measured at baseline and 30, 60, and 120 min after ingestion. Both trials caused a significant increase in blood glucose levels at 30 and 60 min after ingestion, with significantly lower values at 30 min after ingestion in the M trial than in the C trial. baPWV significantly increased at 60 min after ingestion in the C trial, but not in the M trial. These findings demonstrate that prior ingestion of powdered M. australis leaves can prevent the transient arterial stiffening after sucrose ingestion in healthy young men.
Association of Dietary Inflammatory Index with Omega-3 Index in Female Athlete.
Fujibayashi M, Suganuma A, Domichi M … +8 more , Hayashi I, Yamakata R, Fujikawa H, Kumano A, Kijima K, Tomokane S, Ogura Y, Sakane N
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024749 · Publisher ↗
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have unique properties that benefit female athletes. No study has examined the association between the dietary inflammatory index (DII) and omega-3 index. Therefore, we inv...
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have unique properties that benefit female athletes. No study has examined the association between the dietary inflammatory index (DII) and omega-3 index. Therefore, we investigated the association between the DII and omega-3 index. This cross-sectional study included female university athletes and age- and sex-matched controls. Data were collected from anthropometric assessments, a food frequency questionnaire (FFQ), and blood tests for lipidomics. The energy-adjusted DII was calculated using the FFQ. Seventy-four athletes (mean age=19.7±1.2 y, mean BMI=21.1±2.4) and 38 controls (mean age=20.0±0.9 y, mean BMI=20.3±2.4) were enrolled in the study. The athlete group tended to have a higher percentage of high risk/intermediate in the omega-3 index (75.7% vs. 57.9%; p=0.082) or high-risk category in the trans-fat index (9.5% vs. 0.0%; p=0.093) compared to the control group. The energy-adjusted DII negatively correlated with the omega-3 index, although n-3 PUFA intake did not correlate with the omega-3 index in either group. The present findings indicated that DII might affect omega-3 index independent of n-3 PUFAs intake in female athlete. Health care professionals and coach should consider nutritional interventions based on the omega-3 index rather than relying solely on n-3 PUFAs intake for female athletes.
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression.
Deguchi K, Ushiroda C, Kamei Y … +7 more , Kondo K, Tsuchida H, Seino Y, Yabe D, Suzuki A, Nagao S, Iizuka K
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024748 · Publisher ↗
Glucose and insulin positively regulate glycolysis and lipogenesis through the activation of carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP1c), but their re...
Glucose and insulin positively regulate glycolysis and lipogenesis through the activation of carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP1c), but their respective roles in the regulation of gluconeogenic and ureagenic genes remain unclear. We compared the effects of the insulin antagonist S961 and Chrebp deletion on hepatic glycolytic, lipogenic, gluconeogenic, and ureagenic gene expression in mice. S961 markedly increased the plasma glucose, insulin, and 3-OH-butyrate concentrations and reduced the hepatic triglyceride content, but Chrebp deletion had no additive effect. We subsequently estimated the expression of genes involved in the pathways of glycolysis, gluconeogenesis, and lipogenesis. S961 potently decreased both Chrebp and Srebf1c, but Chrebp deletion weakly decreased Srebf1c mRNA expression. Both the S961 and Chrebp deletion caused decreases in glycolytic (Gck and Pklr) and lipogenic (Fasn, Scd1, Me1, Spot14, Elovl6) gene expression. S961 increased the expression of many gluconeogenic genes (G6pc, Fbp1, Aldob, Slc37a4, Pck), whereas Chrebp deletion reduced the expression of gluconeogenic genes other than Pck1. Finally, we checked the metabolites and gene expression in the ureagenesis pathway. S961 increased ureagenic gene (Arg1, Asl, Ass1, Cps1, Otc) expression, which was consistent with the metabolite data: there were reductions in the concentrations of glutamate and aspartate and increases in those of citrulline, ornithine, urea, and proline. However, Chrebp deletion had no additive effect on ureagenesis. In conclusion, insulin rather than glucose regulate ureagenic gene expression, whereas glucose and insulin regulate gluconegenic gene expression in opposite directions.
A Compound Nutritional Supplement Relieving the Core Symptoms of Autism Rats.
Pan X, Xiu Y, Huang S … +4 more , Lai J, Wang X, Cao X, Jiang L
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024747 · Publisher ↗
Autism, with a global morbidity of approximately 0.6% annually, significantly burdens on families and society. A predominant characteristic among autistic children is intestinal dysfunction, generating nutrient absorptio...
Autism, with a global morbidity of approximately 0.6% annually, significantly burdens on families and society. A predominant characteristic among autistic children is intestinal dysfunction, generating nutrient absorption issues. This often causes vitamin and mineral deficiencies, which significantly impacts neurological development. To address this, we have developed a comprehensive nutritional supplement containing compound vitamins, minerals, and gut bacteria. The aim of this study is to investigate the behavioral effects of this supplement on autism rats. The supplement formulated in this study encompasses compound vitamins, minerals, and intestinal bacteria. The autism offspring model (VPA model) was established through intraperitoneal injection of sodium valproate into pregnant rats. Behavioral assessments, gastrointestinal microbiota analysis, and brain development evaluations were conducted to assess the effects of the supplement on VPA offspring rats. A nutritional supplement enriched with vitamins (VB6, VB12, VC, VD, folic acid), minerals (calcium, magnesium), and bifidobacteria was prepared. Open field experiments demonstrated a 3-mo supplementation intervention effectively alleviated anxiety symptoms and enhanced curiosity levels in VPA offspring. The bead embedding experiment revealed the supplementation significantly improved stereotypical behaviors in VPA offspring. The nesting experiment showed a 3-mo supplementation intervention effectively enhanced cognitive abilities in VPA offspring rats. The three-box social experiment demonstrated the supplementation improved social novelty and tendency in VPA offspring. Analysis of gastrointestinal microbiota revealed the supplementation modulated the gut microbiome, promoting better nutrient absorption and overall health. Our findings suggest the comprehensive nutritional supplement, containing compound vitamins, minerals, and gut bacteria, effectively alleviates core symptoms of autism in rats. This study provides valuable insights into the potency of nutritional interventions in improving the quality of life for autistic individuals. Future research is warranted to further explore the mechanisms underlying these observed benefits and to assess the long-term effects of this supplement in larger clinical trials.
Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study.
Ueba Y, Ikeda K, Tabara Y … +8 more , Nakayama T, Tanaka D, Takahashi Y, Kosugi S, Setoh K, Kawaguchi T, Matsuda F, Inagaki N
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024746 · Publisher ↗
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few reports on dietary patterns associated with MASLD except for the Mediterranean diet. This study examines dietary habits related to MASLD using the fatty liver index (FLI). Longitudinal analysis of a community-based cohort, the Nagahama Prospective Cohort for Comprehensive Human Bioscience, was performed. Dietary habits were assessed by a self-reported questionnaire on food intake frequency, and factor analysis was applied to identify dietary patterns. Multiple regression analysis was performed with baseline FLI or FLI after 5 y as the dependent variable and sex, age, and/or baseline FLI, and factor scores of each dietary pattern as simultaneous independent variables. The same analyses stratified by sex or body mass index (BMI) were also performed. Three thousand five hundred one participants were included. The 15 food items of the questionnaire were summarized into four dietary patterns. Dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup, which is characteristic of traditional Japanese diet, negatively correlated with FLI and FLI after 5 y (partial regression coefficient: -3.01 and -1.03, respectively; p<0.01 for both). The result was similar in sex-specific analysis and in BMI<23 kg/m group, when the participants were stratified according to BMI. Our results suggest that dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup are protective factors against MASLD especially in individuals with BMI<23 kg/m.
Effects of Excessive Sucrose Intake on Aggressive Behavior and Peripheral Stress-Related Hormone and Catecholamines in BALB/c Mice during Adolescent Development.
Miyata T, Nojima E, Minai Y
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024745 · Publisher ↗
As binge eating and unbalanced diets increase the prevalence of obesity and metabolic disorders, it has been noted that the increase in psychiatric disorders is also a consequence of diet. The present study examined aggr...
As binge eating and unbalanced diets increase the prevalence of obesity and metabolic disorders, it has been noted that the increase in psychiatric disorders is also a consequence of diet. The present study examined aggressive behavior and peripheral stress-related hormone and catecholamine levels in BALB/c mice fed a high-sucrose diet during adolescent development. BALB/c mice are rarely used in research assessing the effect of diet, but were used for ethnic and personal differences and as a new experimental model. BALB/c mice were fed a diet in which all carbohydrate components were replaced with sucrose for 4 wk and were subjected to the resident-intruder and social dominance tube test. Plasma insulin, corticosterone, and catecholamine levels were also compared to mice fed a control diet. The high-sucrose diet did not alter body weight, glucose tolerance, and plasma insulin levels in BALB/c mice, indicating that the diet was resilient to obesity. Mice fed a high-sucrose diet exhibited increased aggressive behaviors in the resident-intruder test and had a significantly higher win rate in the tube test. Increases in adrenal weight and plasma corticosterone as well as noradrenaline and adrenaline levels were exhibited in mice fed a high-sucrose diet. In particular, this is the first evidence of increased social dominance and hyperplasia of the adrenal glands by a sucrose diet. Sucrose diet intake increased aggression in mice and caused elevated peripheral hormones involving the HPA axis and the sympathetic nervous system, indicating that this may be a central nervous system-mediated effect of excess sucrose.
The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.
You Y, Wang Y, Zhang G … +1 more , Li Y
J Nutr Sci Vitaminol (Tokyo) · 2025 · PMID 40024744 · Publisher ↗
Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ...
Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ function. Cachexia seriously reduces the quality of life of (QOL) patients, affects the therapeutic effect against cancers, increases the incidence of complications, and is an important cause of death for patients with advanced cancers. To date, no effective medical intervention has completely reversed cachexia, and no medication has been agreed upon. Here, we describe recent advances in the diagnosis, molecular mechanism and treatment of cancer-related cachexia.
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