ARYA Atherosclerosis[JOURNAL]
Sun
200 papers
Association between egg consumption and major and minor ischemia changes on electrocardiogram: A population-based study.
Seifi N, Soflaei SS, Islampanah M … +10 more , Hatamzadeh H, Payami B, Ammarlou M, Farrokhzadeh F, Esmaily H, Yousefian S, Rezaeifard H, Ferns GA, Moohebati M, Ghayour-Mobarhan M
ARYA Atheroscler · 2025 · PMID 40625821 · Full text
BACKGROUND: Eggs, while nutrient-rich, have high cholesterol content. The link between egg consumption and cardiovascular disease (CVD) remains debated. This study investigates how egg intake correlates with minor and ma...
BACKGROUND: Eggs, while nutrient-rich, have high cholesterol content. The link between egg consumption and cardiovascular disease (CVD) remains debated. This study investigates how egg intake correlates with minor and major electrocardiogram (ECG) abnormalities, which serve as potential indicators of CVD. METHODS: In this cross-sectional study, a total of 5,928 participants without cardiovascular disease (CVD), aged between 35 and 65 years, were included. Dietary egg consumption was evaluated using a validated food frequency questionnaire. The Minnesota coding system was employed to identify minor and major ischemic abnormalities on ECG. Odds ratios (ORs) for major and minor ischemic patterns across different egg consumption categories were calculated using multivariable logistic regression. RESULTS: Using several statistical models, this study showed that higher egg consumption was associated with lower odds of isolated major ECG abnormalities in men, but not in women. In the fully adjusted model, consuming more than four eggs per week, compared to the lowest category (<1/week), was correlated with a 40% decrease in the odds of major ischemic changes on ECG in men (OR: 0.60, 95% CI: 0.39-0.93). Regarding minor ischemic abnormalities, there was no significant association with egg consumption in either women or men. CONCLUSION: Our findings suggest a gender-specific effect of egg consumption on the presence of major ischemic changes on ECG. Further research is warranted to explore the underlying mechanisms and to inform tailored dietary guidelines for different populations.
The effect of lavender aromatherapy and acetaminophen as preemptive on comfort and Nitroglycerin-induced headache in acute coronary syndrome.
Ezati-Soleiman R, Karampourian A, Khatiban M … +2 more , Tapak L, Sayadi MH
ARYA Atheroscler · 2025 · PMID 40625820 · Full text
BACKGROUND: Nitroglycerin (NTG) improves cardiac ischemia, but one of its side effects is headache. This study aimed to compare the effects of lavender aromatherapy and acetaminophen as preemptive interventions on comfor...
BACKGROUND: Nitroglycerin (NTG) improves cardiac ischemia, but one of its side effects is headache. This study aimed to compare the effects of lavender aromatherapy and acetaminophen as preemptive interventions on comfort and NTG-induced headache in patients with acute coronary syndrome (ACS). METHODS: This three-arm randomized clinical trial was conducted on 90 patients divided into three groups of 30. In the acetaminophen group, patients were given 500 mg of oral acetaminophen approximately 15 minutes before IV nitroglycerin infusion. In the lavender group, 15 minutes before nitroglycerin IV infusion, cotton gauze soaked in three drops of 2% lavender essential oil was used. In the control group, patients received routine care for the treatment of NTG-induced headaches. The severity of patients' headaches was evaluated using the visual analog scale (VAS) at 5, 10, 15, and 60 minutes after starting nitroglycerin infusion. RESULTS: The mean headache intensity at the 60th minute in the lavender and control groups was 1.37 ± 1.10 and 2.50 ± 2.43, respectively, while no headaches were reported in the acetaminophen group. The highest mean pain severity recorded at different times was 2.12 ± 0.86 in the control group. Headache severity varied across the intervention minutes among the three groups (p < 0.001). Additionally, post-intervention comfort was significantly higher in the acetaminophen and lavender groups compared to the control group (p < 0.001), with a significant difference observed between the groups (p < 0.001). CONCLUSION: The results of this study suggest that acetaminophen can be used as a preemptive agent to reduce NTG-induced headaches and improve the comfort of ACS patients.
rs17576 polymorphism of matrix metalloproteinase-9 in predicting coronary artery disease severity and its adverse outcome.
Demir H, Altuğ Tunçer M, Sheikhvatan M … +1 more , Abuqalben SM
ARYA Atheroscler · 2025 · PMID 40625819 · Full text
BACKGROUND: The role of matrix metalloproteinases in developing ischemic heart disease has been suggested. We investigated the effect of the gene polymorphism rs17576 on the severity of coronary artery disease and outco...
BACKGROUND: The role of matrix metalloproteinases in developing ischemic heart disease has been suggested. We investigated the effect of the gene polymorphism rs17576 on the severity of coronary artery disease and outcomes in affected individuals. METHODS: A total of 654 patients suspected of having coronary artery disease were assessed. Real-time PCR was performed for (rs17576) genotyping, and ELISA was used to assess plasma levels. The patients were followed up for one year. RESULTS: Coronary angiography showed coronary artery involvement in 28% of patients. The frequencies of AA, AG, and GG genotypes of rs17576 in the group without coronary artery involvement were 5.5%, 31.4%, and 63.1%, respectively, while in those with coronary artery disease, the frequencies were 55.2%, 29.5%, and 15.3%, respectively, showing a significant difference (p < 0.001). The frequency of the major allele (G allele) in the normal group and the groups with single-, two-, and three-coronary involvement was 21.1%, 65.4%, 61.8%, and 85.0%, respectively, indicating a significant difference (p < 0.001). The mean serum level of was 2,963 ± 1,077 pg/ml in the group with coronary artery disease and 2,145 ± 926 pg/ml in the group without coronary involvement, with a significant difference between the two groups (p = 0.008). The presence of the A allele of rs17576 was associated with an increased hazard of one-year mortality in the coronary artery disease group (HR = 5.764, p < 0.001). CONCLUSION: Tracking the rs17576 polymorphism of the gene can predict coronary artery disease severity and its long-term poorer outcome.
Association between epicardial and pericadial fat thickness and coronary artery calcification severity in chronic kidney disease patients: A pilot study.
Sadeghi R, Sadeghi P, Taherpour N … +5 more , Faghihi Langroudi T, Samavat S, Haji Aghajani M, Mahjoob MP, Jafari Fesharaki M
ARYA Atheroscler · 2025 · PMID 40625818 · Full text
BACKGROUND: This study aims to investigate the association between Coronary Artery Calcium (CAC) score and epicardial fat thickness (EFT) and pericardial fat thickness as indicators of inflammation in patients with chron...
BACKGROUND: This study aims to investigate the association between Coronary Artery Calcium (CAC) score and epicardial fat thickness (EFT) and pericardial fat thickness as indicators of inflammation in patients with chronic kidney disease (CKD). METHODS: This cross-sectional study measured patients' CAC scores using dual-source cardiac CT, quantified with Agatston's score and dedicated Ca-Scoring software. Epicardial and pericardial fat thicknesses were assessed via echocardiography. RESULTS: Thirty-one CKD patients participated in the study, with an average age of 54.45 ± 15.12 years. Of these, 22 were male (70.97%) and 9 were female (29.03%). Fifteen CKD patients (48.39%) had moderate to severe CAC scores. Patients with CKD exhibiting severe coronary calcification were found to be older (P = 0.003). A significant positive correlation was observed between epicardial fat thickness (r = 0.58, P < 0.001) and pericardial fat thickness (r = 0.56, P = 0.001) with CAC score. Multivariable analysis revealed that for each one-unit increase in EFT, the odds of having a moderate to severe CAC score were 2.88 times greater than those of a normal score (OR = 2.88, 95% CI = 1.04-7.96, P = 0.041). Similarly, a one-unit increase in pericardial fat thickness was associated with 1.51 times higher odds of a moderate to severe CAC score compared to a normal score (OR = 1.51, 95% CI = 0.93-2.46, P = 0.093). CONCLUSION: The insights gained from this study advocate for a holistic approach to assessing cardiac function in patients with coronary calcification. By integrating echocardiographic analysis with traditional risk factor assessment, healthcare providers can gain a more comprehensive understanding of cardiovascular health, ultimately leading to better-targeted therapies to improve CKD patient outcomes.
Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).
Zare Karizak S
ARYA Atheroscler · 2025 · PMID 40625817 · Full text
BACKGROUND: Statistics indicate that approximately 25,000 open-heart surgeries are performed annually in Iran, with coronary artery bypass grafting (CABG) surgeries accounting for 50-60% of these procedures. Although CAB...
BACKGROUND: Statistics indicate that approximately 25,000 open-heart surgeries are performed annually in Iran, with coronary artery bypass grafting (CABG) surgeries accounting for 50-60% of these procedures. Although CABG offers numerous benefits to patients with coronary artery disease (CAD), some cases have reported negative consequences, such as heart failure (HF). METHODS: This study explored several influential blood indices related to HF following CABG surgery using manuscripts extracted from PubMed, Scopus, and Google Scholar. The analysis focused on indicators that can exacerbate HF, including fibrotic factors such as catecholamines and the renin-angiotensin-aldosterone system (RAAS).Conversely, it also investigated anti-fibrotic factors, including adrenomedullin (ADM), the natriuretic peptide system (NPS), NP-converting enzymes, and NP receptors. Additionally, the study evaluated the impact of various exercise training programs on these variables. RESULTS: Some fibrotic factors, such as catecholamines and the RAAS, contrast with anti-fibrosis factors, including NPs, their producing enzymes, receptors, production and excretion processes, ADM, and others. Research suggests these elements can be positively influenced by exercise rehabilitation.This study highlights the beneficial effects of exercise rehabilitation, specifically in reducing fibrotic factors and enhancing anti-fibrosis factors. CONCLUSION: All types of exercise training-including endurance, resistance, and combined training, in both continuous and interval modes with moderate and high intensity-can delay fibrotic pathways after surgery and prevent subsequent adverse structural (pathologic hypertrophy) and functional changes in the heart, such as HF.
Hepatopathy and acute kidney injury Following Corrective Cardiac Surgery with cardiopulmonary bypass pump in Pediatric with Congenital Heart Defects.
Salehi Abarghouei F, Chahkandi T, Shaban S … +4 more , Raeiszadeh Bajestani SF, Soleimani MH, Amouzeshi A, Salehi S
ARYA Atheroscler · 2025 · PMID 40463848 · Full text
BACKGROUND: Congenital heart defects (CHDs) are common anomalies in children. Cardiopulmonary bypass (CPB) is widely used in cardiac surgeries, but it is associated with complications. Liver and kidney injuries frequentl...
BACKGROUND: Congenital heart defects (CHDs) are common anomalies in children. Cardiopulmonary bypass (CPB) is widely used in cardiac surgeries, but it is associated with complications. Liver and kidney injuries frequently occur during CPB. This study aimed to evaluate liver and kidney damage in pediatric patients with CHDs undergoing cardiac surgery with CPB. METHODS: This retrospective study examined 51 patients with CHDs who underwent cardiac surgery with CPB at Vali-Asr and Razi hospitals in Birjand, Iran. The study period spanned from 2013 to 2019. Patient information was extracted from hospital records and compiled into checklists, which included demographic data, disease severity, liver function tests, cardiac ejection fraction, and serum levels of hematocrit, direct and indirect bilirubin, albumin, total protein, and creatinine. RESULTS: Among the patients, 52.9% were male and 47.1% were female, with a mean age of 37 months. A total of 78.4% had cyanotic CHDs.After surgery, the levels of AST, ALT, and ALKP increased significantly (P < 0.001), while the levels of indirect bilirubin, albumin, and total protein decreased (P < 0.001). The cardiac ejection fraction also improved following surgery (P < 0.001). However, changes in creatinine and direct bilirubin were not significant. Notably, AST levels were markedly higher in deceased patients compared to survivors. CONCLUSION: This study revealed significant alterations in liver enzyme levels in patients undergoing cardiac surgery using CPB, potentially indicating liver damage during the procedure. Furthermore, elevated postoperative AST levels were associated with a higher risk of mortality.
Early experience of transcatheter aortic valve implantation (TAVI) procedure in Isfahan, Iran.
Aris A, Mansouri A, Dehghan H … +3 more , Tabesh F, Amini M, Khosravi Farsani A
ARYA Atheroscler · 2025 · PMID 40463847 · Full text
BACKGROUND: Valve replacement is an optional treatment for patients with severe aortic stenosis (AS) and is associated with a better prognosis and improved quality of life. However, surgical valve replacement may result...
BACKGROUND: Valve replacement is an optional treatment for patients with severe aortic stenosis (AS) and is associated with a better prognosis and improved quality of life. However, surgical valve replacement may result in severe complications, especially in the elderly. Transcatheter aortic valve replacement (TAVR) for treating symptomatic aortic stenosis has expanded exponentially, becoming a therapeutic option for intermediate- and high-risk patients. To thoroughly examine and monitor its practices and improve outcomes, our TAVI center in Isfahan established a detailed registry as the primary center for the TAVI procedure. METHODS: This prospective study was conducted among all patients who underwent the TAVR procedure from September 2022 to December 2023 in Isfahan. Baseline characteristics (demographic, clinical, and procedural), 30-day outcomes, and one-year mortality data were collected. RESULTS: A total of 50 patients underwent the TAVI procedure in Isfahan during our registry. Of these, 56% were male, and the mean age was 77.8 ± 6.7 years. The mean calculated STS score was 5.6. Cardiac death occurred in 4 patients (8%), one (2%) experienced a major vascular complication, 5 (10%) required new pacemaker implantation, and acute kidney injury was observed in 14%. Fever/sepsis occurred in 16%, cardiac tamponade in 6%, one patient (2%) had moderate AI, two patients experienced coronary obstructions, and one suffered a major cerebrovascular accident. Additionally, 4 patients (8%) developed atrial fibrillation, 1 (2%) had ventricular tachycardia, and 6 (12%) experienced AV block. CONCLUSION: We have shown good both 30-days outcome and one year mortality in our registry that could be a proper option in treating severe AS with comorbidities instead of surgical aortic valve replacement.
Role of TGF-β1 variation in type 1 diabetes and cardiovascular complications.
Jadali Z
ARYA Atheroscler · 2025 · PMID 40463846 · Full text
Abstract loading — click title to view on PubMed.
Surprising palpitation: An unexpected diagnosis of sarcoidosis.
Raffiei Jelodar H, Sadeghi R, Hamneshin Behbahani R … +1 more , Karimi Toudeshki K
ARYA Atheroscler · 2025 · PMID 40463845 · Full text
Sarcoidosis is a challenging disease characterized by the formation of granulomas in multiple organs. It presents with a variety of clinical symptoms, making diagnosis difficult for physicians. Myocardial involvement in...
Sarcoidosis is a challenging disease characterized by the formation of granulomas in multiple organs. It presents with a variety of clinical symptoms, making diagnosis difficult for physicians. Myocardial involvement in sarcoidosis is rare, but it worsens prognosis and can lead to mortality. Physicians face challenges in diagnosing cardiac sarcoidosis due to its wide range of symptoms. Cardiac sarcoidosis that affects only the heart without involvement of other organs is extremely uncommon. In this case, we examine the scenario of a middle-aged man who experienced palpitations and was diagnosed with ventricular tachycardia. He remained in stable condition without any other clinical signs suggestive of sarcoidosis. This case highlights the importance of considering sarcoidosis as a potential diagnosis in patients presenting with palpitations and ventricular tachycardia on electrocardiogram, particularly when these symptoms are accompanied by sudden new-onset systolic dysfunction despite normal coronary arteries.
The association of abdominal obesity with the incidence of in-stent restenosis and thrombosis.
ARYA Atheroscler · 2025 · PMID 40463844 · Full text
BACKGROUND: Given the association between obesity and increased risks of cardiovascular diseases, the acceleration of atherosclerosis, and the significance of patient outcomes after percutaneous coronary intervention (PC...
BACKGROUND: Given the association between obesity and increased risks of cardiovascular diseases, the acceleration of atherosclerosis, and the significance of patient outcomes after percutaneous coronary intervention (PCI), this study aimed to investigate the relationship between abdominal obesity and the incidence of in-stent restenosis (ISR) or stent thrombosis (ST) following PCI. METHODS: This cross-sectional study included 5,980 patients who underwent angioplasty at Chamran Specialty Heart Hospital from March 2023 to February 2025. Of this population, 105 patients who developed ISR or ST and returned to the hospital were evaluated. Their demographic and clinical characteristics were recorded, and waist circumference was measured to assess abdominal obesity. RESULTS: The findings revealed that ISR and ST occurred in 66 (86.8%) and 10 (13.2%) cases, respectively, among patients with abdominal obesity, whereas in patients without abdominal obesity, these complications were observed in 25 (86.2%) and 4 (13.8%) cases, respectively (P > 0.050). Additionally, the incidence of ISR or ST was reported to occur over a longer period in patients without abdominal obesity, whereas it was observed within a shorter timeframe after PCI in patients with abdominal obesity (P < 0.05). CONCLUSION: According to the results of this study, the prevalence of abdominal obesity was higher in patients with complications of ISR or ST after PCI. Also the incidence of ISR or ST occurred in a longer period of time in patients without abdominal obesity after PCI and in a shorter period of time after PCI in patients with abdominal obesity.
Distribution of Cytochrome P450 2D6 (*4, *9, *10, *41) alleles in healthy population from north-west of Iran.
Bagherinia E, Dehghani A, Khalili N … +2 more , Soraya H, Bagheri M
ARYA Atheroscler · 2025 · PMID 40463843 · Full text
BACKGROUND: The CYP2D6 gene locus is complex and highly polymorphic. Given the clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its significant alleles among different ethnic groups is...
BACKGROUND: The CYP2D6 gene locus is complex and highly polymorphic. Given the clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its significant alleles among different ethnic groups is essential for evaluating the efficacy of certain drugs. In this study, we assessed the frequency of the alleles in a healthy population from northwestern Iran. METHODS: Fifty unrelated healthy individuals from West Azerbaijan Province, Iran, were studied using PCR-RFLP and ARMS-PCR techniques. RESULTS: (rs5030656) allele was not detected. The frequency (%) of (rs3892097), (rs1065852) and (rs28371725) alleles were 10%, 13% and 8%, respectively. CONCLUSION: Our findings indicate that the frequencies of "non-functional" and "reduced function" alleles are relatively high in this population. Determining Cytochrome P450 2D6 allele variations can contribute to risk assessment and patient management regarding adverse or poor drug responses, ultimately aiding in the prevention of increased mortality risks among different populations.
Unraveling the complexities of AVNRT ablation and its impact on electrophysiological features: A comprehensive review in children?
Khorgami MR, Rahimpour F, Ramezani Nezhad D
ARYA Atheroscler · 2025 · PMID 40463842 · Full text
BACKGROUND: Paroxysmal Supraventricular Tachycardia (PSVT) is a broad term referring to any rapid heart rhythm originating above the heart's ventricles. Atrioventricular Nodal Reentrant Tachycardia (AVNRT) is a specific...
BACKGROUND: Paroxysmal Supraventricular Tachycardia (PSVT) is a broad term referring to any rapid heart rhythm originating above the heart's ventricles. Atrioventricular Nodal Reentrant Tachycardia (AVNRT) is a specific type of PSVT characterized by abnormal circuits or pathways within the atrioventricular (AV) node, a crucial component of the heart's electrical conduction system. AVNRT can cause rapid heartbeats due to abnormal electrical impulses circulating within the AV node. This study aimed to explore the association between the QT, PR, and QRS intervals before and after RF ablation. METHODS: In this cross-sectional study, 115 children with recurrent cardiac arrhythmias were screened and included between 2010 and 2023. The management of arrhythmias followed established guidelines and consensus statements. RESULTS: The mean age of the 115 children was 9.91 ± 3.30 years, and 52.2% were female. Statistical analysis revealed a significant difference in cycle length (p=0.001), ventricular drive cycle length (p=0.001), atrioventricular Wenckebach (p=0.002), and antegrade effective refractory period of the AV node (p=0.013) before and after ablation. CONCLUSION: Supraventricular arrhythmias in children present complex cases that require individualized treatment approaches. Assessing the QT, PR, and QRS intervals before and after RF ablation provides a valuable tool for evaluating the success of these procedures, particularly in cases involving AVNRT.
Comparing the power of obesity indices to predict cardiovascular diseases at different ages: An application of conditional time-dependent ROC curve in Healthy Heart Cohort of Yazd, Iran.
Khademi Kolah Loui MH, Jambarsang S, Namayandeh SM … +3 more , Tabatabaei SM, Hozhabrnia A, Sefidkar R
ARYA Atheroscler · 2025 · PMID 40401210 · Full text
BACKGROUND: This study was conducted to estimate the power of anthropometric markers to predict 10-year CVD across different age groups in the Yazd Healthy Heart cohort. METHODS: A total of 1,623 individuals aged 20 to 7...
BACKGROUND: This study was conducted to estimate the power of anthropometric markers to predict 10-year CVD across different age groups in the Yazd Healthy Heart cohort. METHODS: A total of 1,623 individuals aged 20 to 74, who were free of CVD, participated in the study. A conditional time-dependent receiver operating characteristic (ROC) curve was used to estimate the predictive power of anthropometric indices, including the Abdominal Volume Index (AVI), Body Adiposity Index (BAI), and Waist-to-Height Ratio (WHtR), adjusted for age and sex. RESULTS: Of the 1,623 participants, 818 were males (50.40%) and 805 were females (49.60%). The Area Under the Curve (AUC) for the BAI ranged from 0.50 to 0.70 for males aged 40 to 70 years. In females, the BAI biomarker demonstrated considerable to excellent predictive power (AUC > 0.8) for individuals aged 20 to approximately 33 years. For males, AVI and WHtR showed fair to considerable predictive power in participants aged 20 to 30 years. In the age group of 30 to approximately 68 years, the predictive power varied from poor to ineffective, except for individuals close to 50 years old. In females, the predictive power of the AVI and WHtR biomarkers ranged from fair to considerable for those aged 20 to around 33 years. CONCLUSION: This study found that AVI and WHtR can fairly predict 10-year CVD risk in young individuals of both sexes, while the BAI was specifically applicable for predicting risk in young women. These markers are valuable and affordable tools for youth CVD screening.
Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study.
Jahangiri S, Mosalamiaghili SA, Heydarzadeh R … +11 more , Yousefzadeh M, Golchin Vafa R, Zarifkar H, Assadian K, Sohrabizadeh S, Zarifkar H, Sadeghi M, Hosseini N, Montaseri M, Hosseini SA, Kojuri J
ARYA Atheroscler · 2025 · PMID 40401209 · Full text
BACKGROUND: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, Metabolic Score for Insulin Resistance (METS-IR), triglyceride-glucose (TyG) index, and triglyceride-glucose body mass index (TyG-BMI...
BACKGROUND: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, Metabolic Score for Insulin Resistance (METS-IR), triglyceride-glucose (TyG) index, and triglyceride-glucose body mass index (TyG-BMI) have been associated with the occurrence and severity of coronary artery disease (CAD), although evidence remains limited. METHODS: A total of 1,017 patients undergoing coronary angiography for the first time were included. Insulin resistance (IR) indices were calculated based on patients' laboratory data. Significant CAD was defined as more than 50% stenosis observed in coronary angiography. RESULTS: A positive correlation was found between CAD and the TyG index (ρ = 0.083, p = 0.008). Patients with CAD had a significantly elevated TyG index (9.02 ± 0.62) compared to those with single-vessel disease (SVD) (8.87 ± 0.59) (p = 0.012). A strong association was observed between CAD and the TG/HDL-C ratio (ρ = 0.114, p < 0.001). Patients with multi-vessel disease exhibited a considerably higher index (4.47 ± 2.46) compared to those with SVD (3.77 ± 2.45) (p = 0.003). The TyG index cut-off was 9.22 (27.5% sensitivity, 79.3% specificity, 82.2% positive predictive value (PPV), and 23.89% negative predictive value (NPV)), while the TG/HDL-C ratio cut-off was 3.6 (44% sensitivity, 65.2% specificity, 81.5% PPV, and 25.5% NPV). CONCLUSION: Our findings indicate that the TG/HDL-C ratio, with a cut-off point of 3.6, and the TyG index, with a threshold of 9.22, are associated with the presence of CAD. (ClinicalTrials.gov registration number: NCT06237244).
The study of electrocardiographic changes in 5-15 years old children referred with chest pain to Hajar and Imam Ali hospitals in Shahrekord, Southwestern Iran, in year 2017.
Asadpour N, Malekahmadi MR, Kheiri S … +1 more , Esmaeili M
ARYA Atheroscler · 2025 · PMID 40401208 · Full text
BACKGROUND: Chest pain is a common complaint among children referred to treatment centers. This study aimed to investigate the electrocardiographic changes in children aged 5-15 years with chest pain referred to Hajar an...
BACKGROUND: Chest pain is a common complaint among children referred to treatment centers. This study aimed to investigate the electrocardiographic changes in children aged 5-15 years with chest pain referred to Hajar and Imam Ali Hospitals of Shahrekord. METHODS: In this descriptive-analytic study, 350 children with chest pain who were referred to Hajar and Imam Ali Hospitals were included. After clinical examination, electrocardiography was performed. Echocardiography was conducted in cases with electrocardiographic changes, and CPK-MB and troponin I tests were performed if required. Data were analyzed using SPSS-22 software. RESULTS: The children's ages ranged from 5 to 15 years, with a mean of 10.6 ± 2.7 years. Abnormal electrocardiographic findings were observed in 28 (8%) of the 350 children. Findings included left axis deviation (2.6%), ST elevation (2.9%), ST depression (0.3%), shortened PR interval (0.9%), delta wave changes (0.06%), and cardiac hypertrophy (0.9%). Echocardiography was performed in 70 cases (23.33%), of which 28 (40%) were normal and 42 (60%) had abnormal findings. Mild changes were observed in 39 cases (55.7%), moderate changes in 2 cases (2.9%), and elevated pulmonary arterial pressure in 1 case (1.4%). Thirty girls (8.5%) and 12 boys (3.4%) experienced tachycardia, while 1 boy (0.2%) presented with bradycardia. Troponin I tests were conducted on 2 boys, with both results being negative. CONCLUSION: Given the importance of heart disease, electrocardiography is recommended for all children presenting with chest pain. Electrocardiography may also serve as a valuable tool for screening heart disease in such cases.
Vascular function and arterial stiffness in multisystem inflammatory syndrome in children with Covid-19.
Ahmadi A, Sabri MR, Ghaderian M … +7 more , Dehghan B, Mahdavi C, Ramezaninezhad D, Pourmoghaddas Z, Maracy MR, Nemat Gorgani P, Ghazanfari B
ARYA Atheroscler · 2025 · PMID 40401207 · Full text
BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endo...
BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endothelial dysfunction and arterial stiffness. METHODS: This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and fifty-nine healthy individuals were included in this cohort study. Non-invasive techniques were employed to measure the brachial artery's flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS). RESULTS: The MIS-C group demonstrated significantly higher systolic blood pressure (P = 0.012), with a mean of 100.2 (10.1) mmHg compared to 95.3 (9.6) mmHg in the healthy group. The relative risk (RR) for elevated pulse pressure in the MIS-C group was borderline higher than in the healthy group (RR 95% CI: 1.06 [1.01-1.14]; P = 0.046). However, FMD, AS, and AD values were lower in the MIS-C group, with means of 13.6 (8.9), 10.4 (4.1), and 15.5 (2.7), respectively, although no significant differences were observed (P > 0.05). CONCLUSION: Children with MIS-C exhibited higher pulse pressure, indicating potential arterial stiffness. They also showed lower FMD, suggesting endothelial dysfunction. FMD appears to be a more reliable indicator of endothelial dysfunction in MIS-C patients compared to aortic strain. These findings underscore the importance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are well-established risk factors for future cardiovascular events.
Evaluate gender differences in patients with left main coronary artery disease.
Haji Aghajani M, Mahjoob MP, Babamahmoodi A … +3 more , Sadeghi R, Kachoueian N, Hamneshin Behbahani R
ARYA Atheroscler · 2025 · PMID 40401206 · Full text
BACKGROUND: Left main coronary artery disease (LMCAD) is a potentially life-threatening situation. The medical treatment of LMCAD can lead to critical cardiovascular events. The association between LMCAD and gender has b...
BACKGROUND: Left main coronary artery disease (LMCAD) is a potentially life-threatening situation. The medical treatment of LMCAD can lead to critical cardiovascular events. The association between LMCAD and gender has been studied in the medical field. METHODS: This cross-sectional study was conducted at Imam Hossein Hospital in Tehran. At the beginning of the project, patient files were collected for 6,250 individuals who presented with heart complaints between 2016 and 2021 and underwent angiography examinations. These files were reviewed, and patients diagnosed with left main coronary artery disease during the angiography were identified. RESULTS: After reviewing 6,250 angiography results from 2016 to 2021, it was found that 274 patients had significant stenosis in the left main coronary artery, resulting in a prevalence of LMCAD of 4.38%. The mean age of the 274 patients with LMCAD was 65.98 ± 10.29 years, and 22.63% of them had premature CAD. Males constituted 75.18% of the group, with 25.18% being smokers. Common comorbidities included hypertension (51.82%), diabetes (42.70%), and chronic kidney disease (13.50%). The gender-based analysis highlighted variations, with women being older on average (P = 0.007), more likely to have premature left main involvement (P = 0.011), and exhibiting lower rates of smoking (P < 0.001) and chronic kidney diseases (P = 0.013) but higher prevalence of hypertension (P < 0.001) and diabetes (P = 0.011) compared to men. CONCLUSION: Our findings showed that these gender-specific differences are crucial for tailored management strategies in patients with left main coronary artery disease. Further research is needed to optimize outcomes for this high-risk population.
Evaluation of novel ultrathin, biodegradable polymer tetriflex (sirolimus-eluting stent) optimization using intravascular ultrasound (IVUS) in short coronary lesion (≤ 20mm) vs. long coronary lesion (≥ 20mm): Tetriflex IVUS study.
Sofi NU, Sachan M, Sinha SK … +7 more , Jha MJ, Pandey U, Razi M, Sharma AK, Aggarwal P, Shukla P, Varma R
ARYA Atheroscler · 2025 · PMID 40401205 · Full text
BACKGROUND: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) is useful for stent optimization. Outcomes of the ultrathin Supralimus Tetriflex stent (Sahajanand Medical Technologies Pvt. Ltd...
BACKGROUND: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) is useful for stent optimization. Outcomes of the ultrathin Supralimus Tetriflex stent (Sahajanand Medical Technologies Pvt. Ltd., India) using IVUS were evaluated among patients with short (≤ 20 mm) versus long lesions (≥ 20 mm). METHODS: A total of 207 patients underwent PCI, and IVUS was performed post-deployment. The primary outcome was optimal stent deployment, defined as (a) mean surface area (MSA) >5.0 mm²; (b) plaque burden <50%; (c) complete apposition; and (d) no edge dissection. Secondary outcomes were target lesion failure (TLF)-a composite of cardiac death, target vessel myocardial infarction (TVMI), and target lesion revascularization (TLR)-stent thrombosis, and major adverse cardiovascular events (MACE; a composite of death, MI, stent thrombosis, and repeat revascularization). RESULTS: Suboptimal deployment was significantly more frequent among patients with longer lesions (30.1% vs. 23.3%; p=0.03) due to higher rates of malapposition (17.3% vs. 10.6%) and MSA <5 mm² (9.6% vs. 7.7%). Following post-dilatation, suboptimal deployment was observed in 7.6% and 5.8% of patients, respectively. Residual plaque burden was 4.5% and 5.7%, respectively. The MSA in both groups was 6.3 mm² and 6.5 mm². Minimum and mean stent expansions were 82.1% versus 81.7% and 106.3% versus 109.8%, respectively, with no significant differences. TLF and stent thrombosis were observed in 0.9% versus 0.9% and 2.9% versus 3.8% of patients, respectively, with no significant differences. However, MACE was significantly higher (10.5% vs. 8.7%; p=0.05) among patients with longer lesions. CONCLUSION: Supralimus Tetriflex stent has very good optimal deployment based on angiogram and becomes better with IVUS imaging, making it safe among long lesions (≥ 20mm).
Mid-term follow-up of COVID-19 patients with permanent pacemaker implantation due to bradyarrhythmia at the acute phase of infection.
Shahabi J, Sadri S, Sattar F … +1 more , Azhari A
ARYA Atheroscler · 2025 · PMID 40401204 · Full text
BACKGROUND: Arrhythmia is one of the important cardiac manifestations of SARS-CoV-2 disease with possible mechanisms such as direct damage to the myocardium, hypoxia, myocardial damage, cytokine storm, and electrolyte im...
BACKGROUND: Arrhythmia is one of the important cardiac manifestations of SARS-CoV-2 disease with possible mechanisms such as direct damage to the myocardium, hypoxia, myocardial damage, cytokine storm, and electrolyte imbalances. Bradyarrhythmia is a manifestation of conduction system involvement, which is associated with an unfavorable prognosis and sometimes requires treatments such as implanting a pacemaker. Whether bradycardia in the acute phase of the COVID pandemic is a transient complication of the virus or whether it will be permanent can affect the treatment approach.Is the effect of SARS-CoV-2 on the conduction system of the heart temporary or permanent, and in the one-year follow-up, how many patients will need a pacemaker? METHODS: The study population was among patients with symptomatic bradyar-rhythmias who were referred to Chamran Heart Center, Isfahan, Iran, from the outbreak of SARS-CoV-2 (February 2020) until February 2022 and were diagnosed with COVID-19 based on the polymerase chain reaction (PCR) test. They underwent permanent pacemaker implantation and were monitored for 1 month and 12 months after device implantation. RESULTS: The most common comorbid disease was hypertension. Systolic blood pressure and respiratory rate in hospitalized patients decreased significantly during discharge. Also, oxygen saturation and heart rate increased significantly during discharge (P < 0.001). In this study, high-degree atrioventricular block remained permanent in most patients and was not transient. CONCLUSION: Based on the experiences gained from this study, the implantation of a permanent pacemaker for the treatment of bradyarrhythmia should be done based on the existing guidelines, regardless of the status of COVID-19.
Evaluation of RehaCom cognitive rehabilitation on different aspects of visual attention in patients with middle cerebral artery ischemia: A nonblinded randomized clinical trial.
Gharaati M, Hassani-Abharian P, Saadatnia M … +1 more , Zarrindast MR
ARYA Atheroscler · 2024 · PMID 39717427 · Full text
BACKGROUND: Cerebral ischemia or stroke is the second leading cause of death in the world, and most surviving patients suffer from long-term physical and cognitive disabilities, which create many social and economic prob...
BACKGROUND: Cerebral ischemia or stroke is the second leading cause of death in the world, and most surviving patients suffer from long-term physical and cognitive disabilities, which create many social and economic problems for them and society. Visual attention impairment is a common cognitive complication among patients with cerebral ischemia, especially in the Middle Cerebral Artery (MCA). One way to improve attention in these patients is cognitive rehabilitation. RehaCom software is one of the computer-based tools to rehabilitate visual attention in these patients. The purpose of this study was to evaluate RehaCom cognitive rehabilitation on different aspects of visual attention in patients with middle cerebral artery ischemia. METHODS: In this single-blind randomized clinical trial, 30 patients with cerebral ischemia in MCA territories were selected and randomly divided into control (n=15) and intervention (n=15) groups. Visual attention of both groups was assessed before the treatments using the Integrated Visual-Auditory test (IVA). Then the intervention group was rehabilitated for 8 sessions of 45 minutes each with RehaCom cognitive software, according to our selected modules, while the control group was only under intervention by non-targeted computer games. After applying the treatments, visual attention in the two groups was assessed using the IVA test. RESULTS: There were no significant differences in visual focus attention between the intervention and control groups before the intervention (29.20±30.06 and 49.53±29.69, P value >0.05). In addition, there were no significant differences in visual selective attention in both groups before the study (23.07±24.73, 39.27±27.08, P value >0.05). However, significant differences were found in visual sustained attention, visual alternating attention, and visual divided attention at baseline (P value <0.05). After the intervention, visual focus attention in the intervention group was significantly higher than in the control group (84.67±26.51, 57.20±31.44, P value <0.05). RehaCom cognitive software intervention increased visual divided attention in the intervention group (88.40±14.85 versus 72.70±25.73, P value <0.05). CONCLUSION: These results demonstrate that using RehaCom cognitive software can improve focus attention and visual attention in the intervention group. Cognitive rehabilitation with RehaCom was able to improve visual attention deficits in patients with middle cerebral artery ischemia.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe