Complementary Therapies In Medicine[JOURNAL]
Sun
200 papers
Effectiveness of massage therapy for constipation in children with cerebral palsy: A systematic review and meta-analysis.
Li M, Ding G, Lan R … +5 more , Li Y, Guan S, Lu X, Zhang Y, Zhao D
Complement Ther Med · 2025 Nov · PMID 41061999 · Publisher ↗
BACKGROUND: Constipation affects 75 % of children with cerebral palsy (CP). While massage is a safe non-invasive intervention, its clinical adoption remains limited due to insufficient evidence of its efficacy. OBJECTIVE...
BACKGROUND: Constipation affects 75 % of children with cerebral palsy (CP). While massage is a safe non-invasive intervention, its clinical adoption remains limited due to insufficient evidence of its efficacy. OBJECTIVE: To evaluate the efficacy and safety of massage for CP-related constipation through meta-analysis. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched seven databases for randomised controlled trials (RCTs) on pediatric CP-related constipation treated with massage. Eligible RCTs underwent Cochrane risk-of-bias assessment. Meta-analysis using Stata evaluated the overall efficacy, defecation parameters, and heterogeneity sources. RESULTS: A total of 11 RCTs involving 728 patients were included. The results of the meta-analysis showed that, compared with traditional therapy alone, massage was more effective in treating constipation in children with CP. This difference was statistically significant (p < 0.05), as evaluated by the overall effective rate (RR, Relative Risk = 1.23; 95 % CI, 95 % Confidence Interval = 1.14, 1.33), defecation frequency (MD, Mean Difference = 1.57; 95 % CI = 0.40, 2.75), defecation time (MD = -3.23; 95 % CI = -3.82, -2.64), and stool form score (SMD, Standardized Mean Difference = 0.66; 95 % CI = 0.39, 0.94), confirming the superior efficacy of massage over conventional therapy. However, both interventions showed comparable effects on defecation difficulty (p > 0.05). The baseline patient characteristics, duration and techniques of the massage, and efficacy of the control group intervention may be the sources of heterogeneity. CONCLUSION: Massage therapy improves constipation symptoms in children with CP. These results require validation through larger, high-quality RCTs given the sample size limitations of the current study.
Effects of dance intervention on health-related outcomes in patients with depression in Mainland China: A network meta-analysis.
Mo L, Liao D, She J … +2 more , Yan B, Chen M
Complement Ther Med · 2025 Nov · PMID 41043594 · Publisher ↗
OBJECTIVE: The objective of this study was to systematically analyze the effects of different dance or dance integrated with other modalities on depressed patients in China to identify the most effective dance-based inte...
OBJECTIVE: The objective of this study was to systematically analyze the effects of different dance or dance integrated with other modalities on depressed patients in China to identify the most effective dance-based intervention. METHODS: Eight databases were searched for screening randomized controlled trials. Quality assessment was performed with the Rob-2 and network meta-analysis was conducted with Stata 17.0. RESULTS: Nineteen studies were included. Dance movement therapy(DMT) combined with Chinese dance elements(CDE) was ranked as the most effective intervention for depression (SUCRA=99.7 %). DMT combined with drugs was the most effective intervention for anxiety (SUCRA=87.7 %) and self-efficacy (SUCRA=78.8 %). Drawing therapy combined with dance intervention and drugs was the most effective intervention for improving quality of life (SUCRA=98.2 %). DMT combined with psychological intervention and drugs was the most effective intervention for positive coping (SUCRA=90.9 %). Egger's test confirmed the robustness of this research. CONCLUSIONS: DMT combined with CDE demonstrated the highest efficacy in improving depression, highlighting the importance of incorporating regional culture into dance therapy. DMT combined with drugs showed the most substantial improvements in anxiety and self-efficacy, reinforcing the recommendation that patients should keep pharmacological treatment. Drawing therapy combined with dance intervention and drugs had the most significant impact on quality of life, suggesting that patients should be encouraged to do more activities. DMT combined with psychological intervention and drugs was the most effective for positive coping. This indicates that psychological counseling is also important. To address multifaceted challenges, targeted intervention should be developed to meet diverse and complex needs comprehensively for patients.
Efficacy and safety of the Plook-Fire-Thatu recipe on breast milk volume and breast milk macronutrient composition in postpartum women: A randomised controlled trial.
Sintupattanapun P, Namvichaisirikul N, Tongdee P … +4 more , Suwannobol N, Thueng-In K, Chueadet A, Tastub S
Complement Ther Med · 2025 Nov · PMID 41043593 · Publisher ↗
BACKGROUND: Plook-Fire-Thatu (PFT) is an ancient Thai herbal formulation traditionally believed to increase breast milk volume. However, clinical studies on the PFT's effectiveness for breast milk production are lacking....
BACKGROUND: Plook-Fire-Thatu (PFT) is an ancient Thai herbal formulation traditionally believed to increase breast milk volume. However, clinical studies on the PFT's effectiveness for breast milk production are lacking. OBJECTIVE: This study aimed to evaluate the effectiveness and safety of PFT in increasing breast milk volume. MATERIALS AND METHODS: A randomised controlled trial was conducted involving 60 postpartum women. The treatment group received standard care alongside 500 mg of PFT orally, three times daily for three days, while the control group received standard care alone. Serum prolactin levels, haematological parameters and blood chemistry were assessed on days 1 and 3. Breast milk volume was measured using an electronic pump on days 1, 2 and 3. Adverse drug reactions in mothers and infants were monitored on days 1, 2, 3, 7 and 30. Breast milk samples were analysed for macronutrient content using Fourier-transform infrared spectroscopy. RESULTS: Baseline characteristics were comparable between groups. The treatment group exhibited significantly greater breast milk volume on days 2 (p = 0.028) and 3 (p = 0.002) compared with the control group. Serum prolactin levels increased significantly in the treatment group (p = 0.002). No significant differences were observed in haematological or blood chemistry between groups. Glycogen and carbohydrate levels in breast milk were significantly higher in the treatment group. Two participants reported mild epigastric discomfort on the first day, with no further adverse events reported. CONCLUSION: By the third day, PFT significantly increased breast milk volume and serum prolactin levels. Increases in glycogen and carbohydrate content in breast milk were also observed. The formulation was well tolerated, with no significant adverse effects in mothers or infants.
Effects of Baduanjin on cognitive performance and upper limb function in patients receiving chemotherapy after breast cancer surgery: A randomized controlled trial.
Wei X, Liu D, Yuan R … +3 more , Zheng W, Li K, Wu C
Complement Ther Med · 2025 Nov · PMID 41043592 · Publisher ↗
BACKGROUND: Post-operative breast cancer patients undergoing chemotherapy frequently experience concurrent upper limb dysfunction and chemotherapy-related cognitive impairment, creating a synergistic burden that complica...
BACKGROUND: Post-operative breast cancer patients undergoing chemotherapy frequently experience concurrent upper limb dysfunction and chemotherapy-related cognitive impairment, creating a synergistic burden that complicates rehabilitation. Existing interventions often target these issues in isolation. Baduanjin, a traditional Chinese mind-body exercise, integrates physical movement with cognitive engagement, making it a promising candidate for addressing both domains simultaneously. However, robust evidence from randomized controlled trials (RCTs) was lacking. This RCT aimed to evaluate the effects of Baduanjin on both cognitive performance and upper limb function in this population. METHODS: A two-arm, randomized controlled trial was conducted. Seventy women diagnosed with breast cancer and scheduled for chemotherapy were randomly assigned to either a 12-week supervised Baduanjin exercise group or a control group receiving usual care. Subjective cognitive function was assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). The neuropsychological test battery included the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT), and the Digit Symbol Substitution Test (DSST). Upper limb function was assessed using the Constant-Murley Score (CMS). All assessments were performed at baseline (T0), Week 4 (T1), Week 8 (T2), and Week 12 (T3). RESULTS: Compared to the control group, the Baduanjin group demonstrated significant improvements in total FACT-Cog scores (F=17.710, p < 0.001), perceived cognitive impairments (F=20.085, p < 0.001), and perceived cognitive abilities (F=5.116, p = 0.027). A statistically significant group effect was observed for AVLT6 (F=13.862, p < 0.001). In addition, significant differences were observed between the two groups in shoulder function (p = 0.004, 95 % CI: 1.09, 5.59) and ROM (p = 0.002, 95 % CI: 0.87, 3.98). CONCLUSION: A 12-week Baduanjin exercise intervention significantly improved subjective cognitive complaints and shoulder function in breast cancer patients undergoing post-operative chemotherapy. The findings support Baduanjin as a safe, feasible, and beneficial adjunct therapy that can concurrently address two prevalent and distressing sequelae of breast cancer treatment.
Comparative efficacy of acupuncture-related interventions for perimenopausal depression and anxiety: A systematic review and frequentist meta-analysis.
Chen L, Wang K, Huang W … +1 more , Du X
Complement Ther Med · 2025 Nov · PMID 40992703 · Publisher ↗
BACKGROUND: This study aimed to compare the efficacy and safety of different acupuncture-related interventions for perimenopausal depression and anxiety using a frequentist network meta-analysis, in order to identify the...
BACKGROUND: This study aimed to compare the efficacy and safety of different acupuncture-related interventions for perimenopausal depression and anxiety using a frequentist network meta-analysis, in order to identify the most effective treatment strategies. METHOD: We systematically searched Chinese and international databases for randomized controlled trials evaluating the efficacy and safety of acupuncture for perimenopausal depression and anxiety. Studies were screened and selected based on predefined PICOS criteria. Two reviewers independently performed study selection, data extraction, risk-of-bias assessment, and evaluation of evidence certainty using the CINeMA tool. A frequentist network meta-analysis was conducted using Stata 17.0. Mean differences were used for continuous outcomes and risk ratios for binary outcomes. Heterogeneity and consistency were assessed, and Surface under the cumulative ranking curve (SUCRA) values were calculated to rank the comparative effectiveness of different acupuncture interventions. RESULT: A total of 54 randomized controlled trials were included, involving 4406 participants. The included studies were predominantly of moderate quality, with few at low or high risk of bias. According to the CINeMA assessment, the certainty of evidence for most pairwise comparisons was rated as low to moderate. Acupuncture-related interventions showed superior efficacy to Western medicine in improving clinical response rates, depressive and anxiety symptoms, menopausal complaints, and hormone levels. For clinical response, the most effective interventions were manual acupuncture (MA) + Chinese herbal medicine (CHM) (RR = 1.52, 95 % CI: 1.12-2.08) and electroacupuncture (EA) + CHM (RR = 1.49, 95 % CI: 1.05-2.12). Regarding depressive symptoms measured by the Hamilton Depression Scale (HAMD), EA + Western medicine (WM) (MD = -5.04, 95 % CI: -6.97 to -3.12) and MA + CHM (MD = -5.69, 95 % CI: -10.47 to -0.92) achieved the greatest reductions. For anxiety symptoms assessed by the Hamilton Anxiety Scale (HAMA), EA alone significantly reduced scores (MD = -8.40, 95 % CI: -14.31 to -2.49). On the Kupperman Index, MA + WM (MD = -5.37) and MA + CHM (MD = -5.00) were most effective. EA + WM also produced the largest improvement in Self-Rating Depression Scale (SDS) scores (MD = -9.10). Hormonally, MA + WM significantly increased estradiol (E2) levels (MD = 26.25), while both EA + WM and MA + CHM lowered follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. SUCRA analysis indicated that EA + WM and MA + CHM consistently ranked among the top treatments across most outcomes. CONCLUSION: EA + WM and MA + CHM may be among the most effective acupuncture-based interventions for perimenopausal depression and anxiety. However, given the moderate quality of evidence, further high-quality trials are needed to confirm these findings.
Multidimensional factors associated with treatment adherence in Type II diabetes: The roles of spiritual well-being and mindfulness.
Yuceer B, Cinar FI
Complement Ther Med · 2025 Nov · PMID 40992702 · Publisher ↗
BACKGROUND AND PURPOSE: Type II Diabetes Mellitus (DM) is a multifaceted, chronic metabolic condition requiring persistent adherence to treatment for effective management. Previous research has largely emphasized medical...
BACKGROUND AND PURPOSE: Type II Diabetes Mellitus (DM) is a multifaceted, chronic metabolic condition requiring persistent adherence to treatment for effective management. Previous research has largely emphasized medical and behavioral determinants of adherence, while psychological and spiritual factors remain underexplored. Addressing this gap, the present study examines multidimensional factors associated with treatment adherence among individuals with Type II DM, within the framework of the Multidimensional Adherence Model (MAM), with a particular focus on the roles of mindfulness and spiritual well-being. MATERIALS AND METHODS: A cross-sectional design was employed, involving 125 patients with Type II DM. Data were collected based on five dimensions within the MAM framework. The study utilized validated instruments, including the Patient Information Form, Mindful Attention Awareness Scale, Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale, Treatment Adherence in Type II DM Scale. The data were analysed using descriptive and correlational statistics and structural equation modelling. In this hypothesized model, the independent variable was mindfulness, the mediator was spiritual well-being, and the dependent variable was treatment adherence. RESULTS: Treatment adherence was significantly related to patient-related, socio-economic, healthcare system, and condition-related factors. Higher levels of mindfulness and spiritual well-being were positively associated with improved adherence behaviors. Notably, spiritual well-being demonstrated statistically significant indirect association in the link between mindfulness and treatment adherence. CONCLUSION: This study highlights the need for a patient-centered approach to Type II DM care, integrating psychological and spiritual dimensions alongside medical management. Mindfulness and spiritual well-being emerged as key correlates of adherence, emphasizing the importance of holistic care in diabetes treatment.
Letter to Editor: Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial.
Ranjbar M, Shab-Bidar S, Rostamian A … +3 more , Mohammadi H, Tavakoli A, Djafarian K
Complement Ther Med · 2025 Nov · PMID 40992701 · Publisher ↗
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Effects of aromatherapy on sleep quality in hospitalized cardiac patients: A systematic review and meta-analysis of randomized controlled trials.
Ye C, Huang X, Wang Z … +2 more , Zuo S, Lin L
Complement Ther Med · 2025 Nov · PMID 40987424 · Publisher ↗
OBJECTIVES: To evaluate the effects of aromatherapy on sleep quality in hospitalized cardiac patients, taking into account factors such as participant age, type of essential oil, dosage, treatment duration, and daily fre...
OBJECTIVES: To evaluate the effects of aromatherapy on sleep quality in hospitalized cardiac patients, taking into account factors such as participant age, type of essential oil, dosage, treatment duration, and daily frequency of use. METHODS: A systematic search and screening of literature on the effects of aromatherapy on sleep quality in hospitalized cardiac patients, published as randomized controlled trials (RCTs) in Chinese and English from inception to 8 August, 2025, was conducted across eight databases, including PubMed, Web of Science, Embase, Cochrane Library, CNKI, CBM, VIP, and Wanfang. The methodological quality of the included studies was independently and critically assessed by two reviewers using the Cochrane Risk of Bias Assessment Tool for RCTs. Relevant data were extracted using pre-designed forms and analyzed with STATA 17.0. RESULTS: A total of nine studies comprising 13 trials with 740 hospitalized cardiac patients were included. The results indicated that aromatherapy with single essential oils was moderately effective in improving sleep quality in these patients [SMD = -0.74, 95 % CI (-1.06, - 0.42), p = 0.003]. Subgroup analyses revealed significant improvements when patients were aged ≥ 60 years [SMD = -1.08, 95 %CI (-1.91,-0.24), P = 0.012], when Rosa damascena essential oil was used [SMD = -1.43, 95 %CI (-2.73,-0.13), P = 0.031], when the dosage was > 3 drops [SMD = -1.10, 95 %CI (-1.87,-0.32), P = 0.005], or when the treatment duration was ≥ 3 days [SMD = -0.99, 95 %CI (-1.59,-0.38), P = 0.001]. No adverse events were reported. CONCLUSION: This study reveals that single essential oils are effective in improving sleep quality in hospitalized cardiac patients and can be recommended as a complementary therapy to improve sleep quality in this population. REGISTRATION: PROSPERO: CRD42024535895.
Letter to the editor regarding "Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial" by Ranjbar et al.
Ying ZK, Lin TC, Wu JN
Complement Ther Med · 2025 Nov · PMID 40987423 · Publisher ↗
Abstract loading — click title to view on PubMed.
How important are meditation and spirituality in Reiki practice?
Baldwin AL, McLelland V, Cross D … +1 more , Braveman N
Complement Ther Med · 2025 Nov · PMID 40967425 · Publisher ↗
OBJECTIVE: Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surve...
OBJECTIVE: Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surveys were developed to ascertain whether Reiki practitioners routinely use meditative and spiritual disciplines to strengthen their practice. METHOD: The surveys were promoted through email using Mailchimp and Facebook to all members of UK Reiki Federation (about 1800) and through several other Facebook groups with a global reach. An online survey tool, SurveyMonkey, was used to collect the survey data and MS Excel to analyze it. RESULTS: Most respondents were white, heterosexual females, middle aged or older, residing in the UK or USA, trained to Reiki Master level. Over one third were Christian and another third affiliated with various non-established beliefs. Most participants experienced a spiritual connection when they practiced Reiki, which opened them to a higher power, and they thought this connection enhanced their self-development. Seventy-nine percent believed that Reiki spirit guides provide personal guidance, support, and assistance. Ninety-five percent meditated weekly from one to seven times a week and most believed that meditation increased their connection and ability to channel, Reiki. CONCLUSION: Most respondents to the surveys routinely use meditation and spiritual connection to strengthen their Reiki practice and enhance their ability to channel Reiki to patients or clients. This information may stimulate inclusion of meditation and spirituality in the training of holistic healthcare professionals and help them communicate more effectively with their clients.
Effects of mindfulness meditation on blood pressure and quality of life in patients with intradialytic hypertension during haemodialysis: A randomised controlled trial.
Wu Y, Xia Q, Gao Y … +6 more , Zhang C, Xu P, Zhang H, Chao G, Yu R, Liu J
Complement Ther Med · 2025 Nov · PMID 40967424 · Publisher ↗
OBJECTIVE: To investigate the effects of mindfulness meditation on blood pressure changes and quality of life in patients with intradialytic hypertension (IDH) during haemodialysis. METHODS: This single-blind, randomised...
OBJECTIVE: To investigate the effects of mindfulness meditation on blood pressure changes and quality of life in patients with intradialytic hypertension (IDH) during haemodialysis. METHODS: This single-blind, randomised controlled trial involved 69 patients with IDH undergoing maintenance haemodialysis at Lihuili Hospital in Ningbo, Zhejiang Province, China, between August and December 2024. Patients were randomly assigned to an intervention group (n = 34) receiving mindfulness meditation and a control group (n = 35) receiving standard care. Blood pressure and quality of life were measured at baseline and after 12 weeks. RESULTS: During haemodialysis, the intervention group exhibited significantly lower systolic, diastolic and mean arterial pressures, as well as pulse rate, than the control group (p < 0.001). Quality of life, assessed using the Kidney Disease Quality of Life Short Form 36, improved significantly in the intervention group across multiple dimensions, including physical function, role limitations due to physical problems, bodily pain, general health, energy/fatigue, emotional well-being and sleep (p < 0.05). However, no significant improvement was observed in social function (p > 0.05). Laboratory tests showed a significant reduction in serum homocysteine levels in the intervention group (p < 0.05). The incidence of adverse reactions was significantly lower in the intervention group (11.76 %) than in the control group (45.71 %, p < 0.05). CONCLUSION: Mindfulness meditation can effectively improve IDH in patients undergoing haemodialysis and substantially enhance their quality of life. As a non-pharmacological intervention, mindfulness meditation is safe and easy to implement, offering a new therapeutic option for patients with IDH. TRIAL REGISTRATION: ISRCTN82788940, Registration date: 29/10/2024.
The impact of a breathing exercise program on pain, disability, and breathing patterns in patients with non-specific neck pain: A randomized controlled trial.
Heo H, Shin D
Complement Ther Med · 2025 Nov · PMID 40967423 · Publisher ↗
BACKGROUND: Upper chest breathing patterns can increase accessory muscle activation and reduce cervical stability, contributing to neck pain OBJECTIVE: To examine the effects of a respiratory exercise program on pain, ce...
BACKGROUND: Upper chest breathing patterns can increase accessory muscle activation and reduce cervical stability, contributing to neck pain OBJECTIVE: To examine the effects of a respiratory exercise program on pain, cervical range of motion, disability, breathing patterns, and muscular endurance in patients with non-specific neck pain. DESIGN: randomized controlled trial METHODS: Thirty-two patients with non-specific neck pain and upper chest breathing patterns were included. The study was conducted from July 19, 2021, to September 3, at a physical therapy center. Participants were randomly assigned to a breathing exercise (BE) or neck exercise (NE) group. Thermoelectric therapy, soft tissue relaxation, and thoracic spine mobilization were performed in both groups. The BE group performed breathing exercises, whereas the NE group performed general neck exercises. Pain intensity, neck disability index, cervical range of motion, breathing pattern, and deep cervical flexor endurance were measured before and after the intervention. Paired t-test and independent t-test compared pre- and post-test differences within and between groups. RESULTS: Both groups showed significant improvements in pain intensity and NDI (pain: BE vs NE mean difference 0.34, 95 % CI -0.25-0.93, p = .239; NDI: 0.86, 95 % CI -0.62-2.34, p = .249). Breathing pattern improved only in the BE group (mean difference 2.73, 95 % CI 1.78-3.68, p < .001). Endurance of deep cervical flexors increased in both groups, greater in NE (mean difference -15.98, 95 % CI -25.26 to -6.70, p = .010). CONCLUSION: Breathing exercises improved breathing patterns in patients with non-specific neck pain, but effects on pain and disability were inconclusive.
Transcutaneous auricular vagus nerve stimulation for functional dyspepsia: A systematic review and meta-analysis.
Lee B, Kwon CY, Jeong YK … +5 more , Sclocco R, Kuo B, Napadow V, Lee JH, Kim H
Complement Ther Med · 2025 Nov · PMID 40967422 · Publisher ↗
BACKGROUND: Transcutaneous auricular vagus nerve stimulation (taVNS) is a potential noninvasive treatment for functional dyspepsia (FD). We aimed to systematically analyze the clinical evidence of taVNS for FD. METHODS:...
BACKGROUND: Transcutaneous auricular vagus nerve stimulation (taVNS) is a potential noninvasive treatment for functional dyspepsia (FD). We aimed to systematically analyze the clinical evidence of taVNS for FD. METHODS: Eight databases were searched to identify randomized controlled trials (RCTs) using taVNS in patients with FD published by June 27, 2024. The primary outcome was dyspepsia symptoms, whereas the secondary outcomes were the total effective rate (TER), quality of life, anxiety, depression, and incidence of adverse events. The certainty of the evidence was assessed using the GRADE methodology. Detailed information on the taVNS parameters and the suggested underlying mechanism were also extracted. RESULTS: Six RCTs with 716 participants were included. Compared to the sham intervention, taVNS significantly improved dyspepsia symptoms, quality of life, and clinician-rated anxiety and depression with moderate certainty of evidence. The TER based on dyspepsia symptoms was also significantly higher with high certainty of evidence. When taVNS was used as an add-on therapy, dyspepsia symptoms were significantly improved with moderate certainty of evidence. No serious adverse events related to taVNS were reported. The stimulation sites for taVNS were concha and tragus, with common pulse frequencies of 25 or 20 Hz twice a day for 2-4 weeks. Gastric accommodation, electrogastrogram, heart rate variability, and functional magnetic resonance imaging were measured to explore the mechanism of taVNS. CONCLUSIONS: Considering the certainty of the evidence, taVNS can improve dyspepsia symptoms, quality of life, anxiety, and depression in patients with FD without serious adverse events. Additional high-quality studies are needed to establish optimal treatment protocols.
Spirulina's impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT.
Shiri H, Soleimani AA, Omidi Sarajar B … +4 more , Talebi Taheri A, Esmaeili F, Nematollahi MH, Alizadeh Sani M
Complement Ther Med · 2025 Nov · PMID 40953712 · Publisher ↗
INTRODUCTION: CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous...
INTRODUCTION: CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters. METHODS: Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results. RESULT: The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: -5.51 (mg/dl); P = 0.001, HOMA-IR; WMD: -0.68; P < 0.001, and insulin; WMD: -0.86 (ng/ml); P = 0.002), decreased dyslipidemia (TG; WMD: -14.75 (mg/dl); P < 0.001, TC: WMD: -11.5 (mg/dl); P < 0.001, LDL-C; WMD: -7.69 (mg/dl); P < 0.001, and HDL-C; WMD: 1.9 (mg/dl); P < 0.001), decreased blood pressure (SBP; WMD: -3.85 mmHg, P = 0.002, and DBP; WMD: -3.09 mmHg, P < 0.001), reduced anthropometric indexes (weight; WMD: -1.78 kg; P = 0.003, and BMI; WMD: -0.58 kg/m²; P = 0.001), and decreased inflammation (TNF-α; WMD: -0.46 pg/ml; P = 0.01, IL-6; WMD: -0.58 pg/ml; P < 0.001, and hs-CRP; WMD: -0.86 mg/L; P = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes. CONCLUSION: This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles. TRIAL REGISTRATION: PROSPERO registration cod: (CRD42024626090).
From farm to bedside: Potential of medical cannabis in global health.
Tendwa MB, Appidi T, Chitsunge B … +24 more , Moreau M, Okole B, Kalombo L, Mallum A, Ngoma T, Weadock DP, Tanifum E, Erridge S, Sodergren M, Sims R, Johnson C, Toyang N, Lowe H, Ziberi B, Richner L, Carrillo S, Avery S, Pretorius J, Chikwamba R, Biteghe FAN, Grinspoon P, Strichtartz G, Yasmin-Karim S, Ngwa W
Complement Ther Med · 2025 Oct · PMID 40935434 · Full text
INTRODUCTION: The growing opioid crisis and persistent global health disparities underscore the urgent need for alternative therapeutic strategies. Cannabis, with its long-standing historical use and recent legislative d...
INTRODUCTION: The growing opioid crisis and persistent global health disparities underscore the urgent need for alternative therapeutic strategies. Cannabis, with its long-standing historical use and recent legislative developments, presents a potentially significant avenue for addressing these challenges. This review examines the evolving landscape of medicinal cannabis, drawing from historical ethnopharmacological data and contemporary scientific discussions. METHODS: This review synthesized evidence from historical ethnobotanical records, peer-reviewed studies, and outcomes derived from recent Global Health events. These events facilitated discussions among diverse stakeholders, including healthcare professionals, policymakers, researchers, industry representatives, farmers, and patient advocates. Case studies and successful models from the USA and Africa, including the recent FDA approval for first-in-human clinical trials of a medicinal cannabis derivative for pancreatic cancer, were analysed. RESULTS: Successful models include collaborative platforms fostering stakeholder engagement, such as partnerships between African farmers and biotech firms to standardize cultivation. Successful models demonstrate the potential for adaptation and scaling in diverse healthcare settings. The FDA trial approval exemplifies progress in clinical translation. However, disparities persist, with patients within Africa facing systemic barriers to medical Cannabis certification and higher rates of punitive opioid discontinuation. CONCLUSION: Medicinal Cannabis presents a complex yet promising solution for reducing opioid-related mortality and addressing healthcare inequities. Implementing strategic frameworks like CORE (Care, Outreach, Research, Education) is essential for developing safe, high-quality, evidence-based cannabis products. Through fostering collaboration and addressing existing obstacles, the therapeutic potential of medicinal Cannabis can be harnessed to mitigate the opioid crisis and reduce global health disparities, effectively translating research from farm to bedside.
Hot spring and sauna use for improving blood lipid profiles: A systematic review and expert consensus on efficacy and recommendations.
Yamasaki S, Tokunou T, Kashiwado Y … +2 more , Makishi M, Horiuchi T
Complement Ther Med · 2025 Nov · PMID 40914321 · Publisher ↗
OBJECTIVES: Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, hav...
OBJECTIVES: Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, have recently gained attention because of their potentially beneficial effects on lipid profiles and cardiovascular health. DESIGN AND SETTING: This systematic review aimed to synthesize current evidence on the efficacy of hot spring and sauna use, alone or combined with exercise therapy, in improving blood lipid profiles, with a focus on mechanisms, benefits, and limitations. METHODS: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search of 330 records across major databases identified 127 studies for blinded screening using Rayyan (a web-based application for conducting systematic reviews). Seven randomized controlled trials (RCTs) investigating the effects of hot spring and sauna use on lipid profiles in adults were included. RESULTS: Four RCTs in younger adults (mean age < 60 years) demonstrated that hot spring and sauna use resulted in reductions in serum total cholesterol and low-density lipoprotein cholesterol; these therapies were given a weak expert recommendation. Three RCTs in older adults (mean age ≥ 60 years) showed no significant blood lipid changes. CONCLUSIONS: In younger adults, hot spring and sauna use, particularly when combined with exercise therapy, may contribute to improved lipid profiles. Emerging evidence from intervention studies could inform future guidelines for integrating these therapies into dyslipidemia management strategies.
Corrigendum to "The efficacy of physical activity or exercise among individuals with cerebral palsy: An umbrella review of systematic reviews" [Complement Ther Med 93 (2025) 103228].
Alhumaid MM, Asiri FYI, Said MA … +1 more , Haegele JA
Complement Ther Med · 2025 Oct · PMID 40897602 · Publisher ↗
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Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial.
Akhavanakbari G, Asayeshi M, Noktehsanj R … +1 more , Aslani MR
Complement Ther Med · 2025 Oct · PMID 40865738 · Publisher ↗
BACKGROUND: There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA ver...
BACKGROUND: There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA. METHODS: In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention. RESULTS: Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001). CONCLUSION: The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.
The impact of neurolinguistic programming on anxiety, self-confidence, self-esteem, and performance in non-elite finswimmers.
Saadani S, Jarai R, Szabo A … +1 more , Boros S
Complement Ther Med · 2025 Oct · PMID 40865737 · Publisher ↗
BACKGROUND: Few studies have addressed mental health in finswimmers. OBJECTIVE: This study examines the effect of NLP used as mental training on the finswimmers' anxiety, self-confidence, self-esteem, and swimming record...
BACKGROUND: Few studies have addressed mental health in finswimmers. OBJECTIVE: This study examines the effect of NLP used as mental training on the finswimmers' anxiety, self-confidence, self-esteem, and swimming records. METHODS: The NLP intervention lasted two months. The study involved thirty young finswimmers (mean age M = 15.53, SD = 1.024), divided equally into two groups: the experimental and the control group. We carried out a pre- and post-test research design and conducted a follow-up test. We used two questionnaires, the French version of the CSAI-2R and the French version of the PSPP, along with semi-structured interviews for all three tests. RESULTS: In the post-intervention test, the experimental group significantly decreased their cognitive anxiety (β = -3.47, p < .001) and somatic anxiety (β = -2.20, p = .001). Significantly increased their self-confidence (β = 2.07, p < .001), their global self-esteem (β = 1.93, p = .002), and their physical self-worth (β = 2.13, p = .004). The same parameters, except for the global self-esteem, also recorded significant change in the follow-up test, p < .005. Time effect did not show significance in the body attractiveness, physical strength, physical conditioning, and sport competence. Furthermore, outcomes showed notable between-subject variability in the mental skills, suggesting substantial variability in baseline parameter levels between individuals. Consequently, the finswimmers enhanced their swimming records. CONCLUSIONS: NLP showed a powerful impact in optimizing finswimmers' mental health and, accordingly, their athletic performance. Besides, the technique showed relatively durable effectiveness. Coaches can reinforce the effect through ongoing NLP training.
Tuina improves patellofemoral osteoarthritis by alleviating the degree of lateral patellar tilt: a correlation analysis based on a randomized controlled trial.
Gu J, Dong Y, Wei G … +5 more , Zhuo Z, Sun A, Wei D, Zhao Y, Qin W
Complement Ther Med · 2025 Oct · PMID 40858216 · Publisher ↗
PURPOSE: Abnormal patellar alignment is closely linked to patellofemoral osteoarthritis (PFOA), with laterally tilted patellae often worsening pain. This study investigates the relationship between imaging parameter chan...
PURPOSE: Abnormal patellar alignment is closely linked to patellofemoral osteoarthritis (PFOA), with laterally tilted patellae often worsening pain. This study investigates the relationship between imaging parameter changes and pain levels by analyzing the effects of Tui Na (TN) and intra-articular hyaluronic acid injections (IAHA) intervention. METHODS: This study included 126 PFOA patients from Wangjing Hospital of the China Academy of Traditional Chinese Medicine, between October 8, 2022, and December 31, 2024. Participants were randomly assigned to the TN or IAHA group. The IAHA group received one injection per week for five weeks, while the TN group underwent three Tui Na sessions per week for four weeks. The Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and patellar imaging indices (Lateral Patellar Displacement (LPD), Congruence Angle (CA), Lateral Patellofemoral Angle (LPFA), Patellofemoral Index (PFI)) were assessed before and one week after treatment. To investigate the correlation between imaging parameters and VAS scores, Spearman rank correlation analysis was applied to non-normally distributed data, with scatter plots used to elucidate trends in the association between pain and imaging parameters. A multiple linear regression model was constructed to assess the independent effects of imaging parameters on changes in VAS scores. RESULTS: Both TN and IAHA treatments significantly reduced VAS and WOMAC scores (p < 0.05). No significant difference was observed in VAS score improvements between the two groups (p > 0.05). However, the TN group showed a significantly greater improvement in WOMAC scores (p < 0.05). The TN group also exhibited better improvements in LPD and CA compared to the IAHA group (p < 0.05). Spearman's correlation showed no significant link between imaging indices and VAS scores (p > 0.05). Multiple regression analysis revealed that reductions in VAS scores were associated with decreases in LPD (β = 0.274, p = 0.038) and CA (β = 0.309, p = 0.033). CONCLUSION: Tui Na is as effective as IAHA in relieving pain in PFOA patients, potentially alleviating pain through reductions in LPD and CA. TRIAL REGISTRATION: Chinese Clinical Trial Registry(ChiCTR), ChiCTR2200059345, Registered on 28/04/2022, https://www.chictr.org.cn/showproj.html?proj=166395.
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