Complementary Therapies In Medicine[JOURNAL]
Sun
200 papers
Corrigendum to "AI-assisted drawing therapy for children with ADHD: A randomised controlled trial" [Complement Ther Med 94 (2025) 103262].
Xu J, Lin R, Zhang A … +15 more , Chen Q, Li D, Chen J, Song M, Chen S, Yang B, Li L, Xu H, Peng J, Tang Y, Yang W, Luo X, Zhou X, Wang J, Huang G
Complement Ther Med · 2025 Dec · PMID 41173706 · Publisher ↗
Abstract loading — click title to view on PubMed.
The effects of Sitting Baduanjin intervention based on the COM-B model for elderly patients with osteoporosis after vertebroplasty: A randomized controlled trial.
Yang L, Lu F, Chen J … +6 more , Wu J, Li J, OuYang J, Zheng C, Zhang J, Zheng X
Complement Ther Med · 2025 Dec · PMID 41167568 · Publisher ↗
BACKGROUND: Osteoporosis and osteoporotic vertebral fractures can cause decreased quality of life and increased hospitalization, morbidity, and mortality for older people. Sitting Baduanjin (SBDJ) is suitable for frail e...
BACKGROUND: Osteoporosis and osteoporotic vertebral fractures can cause decreased quality of life and increased hospitalization, morbidity, and mortality for older people. Sitting Baduanjin (SBDJ) is suitable for frail elderly patients, but its application to elderly osteoporosis patients after vertebroplasty has not yet been explored. METHODS: A randomized controlled trial was conducted with 123 participants from a hospital in China. Participants were randomly assigned to one of three groups: control (n = 41, routine care), SBDJ (n = 41, routine care plus five weekly 30-minute sessions of SBDJ), and SBDJ-based on the COM-B model (SBDJ-CB, n = 41). The SBDJ-CB group received additional interventions, including monthly 30-minute face-to-face lectures, daily practice videos via a WeChat group, weekly online instructions, and monthly 30-minute focus group meetings. The primary outcomes were osteoporosis self-efficacy, measured using the Osteoporosis Self-efficacy Scale (OSES), and quality of life, assessed by the 12-item Short-Form Health Survey (SF-12). Secondary outcomes included bone mineral density (BMD), measured via dual-energy X-ray absorptiometry (DXA), and biochemical markers of bone metabolism analyzed from blood samples. Data were collected at baseline (T0), three-month intervention (T1), and six-month intervention (T2). Statistical analyses were performed using Generalized Estimating Equation (GEE) and Analysis of Variance (ANOVA) to evaluate intervention effects. RESULTS: Both intervention groups showed higher osteoporosis self-efficacy, physical, and mental scores at T1 and T2 (all P < 0.001), and greater BMD and osteogenic activity at T2 compared to the control group. The SBDJ-CB group had significantly better outcomes than the SBDJ group (all P < 0.05). At T2, only the SBDJ-CB group exhibited significantly lower osteoclastic activity than the control group (P < 0.001). The SBDJ-CB group also had a higher rate of osteoporosis remission and practice compliance at T2 than the SBDJ group (all P < 0.001). CONCLUSIONS: The SBDJ intervention demonstrated efficacy in enhancing self-efficacy, psychophysical health, and bone health among elderly osteoporosis patients post-vertebroplasty. Notably, the SBDJ-CB achieved superior outcomes and is recommended as a priority intervention for postoperative rehabilitation. TRIAL REGISTRATION: ChiCTR2500095266, registration date:2025.01.03.
The combined effect of myofascial release and hip strength training on iliotibial band syndrome: A preliminary randomized controlled trial.
Ming Z, Dong G, Luo L … +2 more , Yuan L, Li Y
Complement Ther Med · 2025 Dec · PMID 41167567 · Publisher ↗
OBJECTIVE: To compare the short-term outcomes and maintenance effects of myofascial release therapy (MFR) combined with hip strength training versus hip strength training alone on pain, patellofemoral function, and iliot...
OBJECTIVE: To compare the short-term outcomes and maintenance effects of myofascial release therapy (MFR) combined with hip strength training versus hip strength training alone on pain, patellofemoral function, and iliotibial band (ITB) thickness in patients with iliotibial band syndrome (ITBS). DESIGN: Double-blind, randomized controlled trial. PARTICIPANTS: 16 patients (mean age 22.2 ± 1.6 years) with ITBS randomly assigned to an experimental group (MFR combined with hip strength training, n = 8) or a control group (hip strength training alone, n = 8). MAIN OUTCOME MEASURES: VAS and Kujala scale was measured at baseline, week 2, week 4 and week 8 during intervention. ITB thickness was measured at week 4. RESULTS: The experimental group demonstrated significantly greater reductions in pain (VAS) at week 2 (mean difference = -1.25 cm, 95 % CI: [-2.10 cm, -0.40 cm]) and ITB thickness at week 4 (mean difference = -0.66 mm, 95 % CI: [-1.15 mm, -0.16 mm]) compared to the control group. However, no significant between-group differences were observed in Kujala scale at any follow-up time point (p > 0.05 for all comparisons). CONCLUSIONS: Preliminary evidence suggests MFR may accelerate early pain relief and ITB structural normalization when combined with hip strengthening. Future trials with larger samples,broader functional outcome measures, and longer follow-up are needed to confirm clinical relevance.
Clinical evidence on acupuncture for symptom improvement in multiple sclerosis.
Chen Y, Cui Y, Zhou X … +7 more , Zhang S, Wang Z, Yang J, Zeng X, Guo Y, Sun Z, Yin H
Complement Ther Med · 2025 Dec · PMID 41161577 · Publisher ↗
BACKGROUND: Clinical trials on acupuncture for multiple sclerosis (MS) have been growing, but the findings are ongoing controversy. OBJECTIVE: To evaluate the existing randomized clinical trials (RCTs) for evidence of th...
BACKGROUND: Clinical trials on acupuncture for multiple sclerosis (MS) have been growing, but the findings are ongoing controversy. OBJECTIVE: To evaluate the existing randomized clinical trials (RCTs) for evidence of the efficacy of acupuncture on MS. METHODS: We searched PubMed, Embase, CENTRAL, Web of Science, four Chinese-language databases, clinical research registration, gray literature, and reference lists of the selected studies. We evaluated the risk of bias in the included studies with RoB 2, and performed meta-analysis, subgroup analysis, meta-regression, and publication bias detection using STATA version 15.1. Moreover, we assessed the certainty of evidence using the GRADE approach. The protocol for this review was registered with PROSPERO (Prospective Register of Systematic Reviews) (CRD42024530800). RESULTS: A total of 11 RCTs (with 574 patients) were included in the study. The meta-analysis results showed that acupuncture, when combined with medicine, is more effective at improving disability status and enhancing the quality of life than medicine alone Acupuncture-related adverse events were rare and mild. The evidence grade was generally low because of the substantial heterogeneity among studies. CONCLUSIONS: Acupuncture therapies are potential treatment options for MS, and are relatively safe. However, owing to the limitations of this study, these conclusions should be interpreted with caution.
Meta analysis of the intervention of Baduanjin in middle-aged and elderly patients with essential hypertension.
Zhang T, Chen L, Guo M
Complement Ther Med · 2025 Dec · PMID 41151628 · Publisher ↗
PURPOSE: We systematically evaluated Baduanjin efficacy for improving blood pressure, lipid metabolism, and heart rate in middle-aged and elderly patients with essential hypertension, explored its physiological mechanism...
PURPOSE: We systematically evaluated Baduanjin efficacy for improving blood pressure, lipid metabolism, and heart rate in middle-aged and elderly patients with essential hypertension, explored its physiological mechanisms, and assessed evidence quality using GRADE criteria. METHODS: We searched CNKI, PubMed, and Web of Science (January 2010-March 2025) for randomized controlled trials (RCTs). Twenty-four RCTs (1994 participants, aged 35-80 years, interventions: 3-12 months) met inclusion criteria. PRIMARY OUTCOMES: systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol (TC), heart rate (HR). We assessed risk of bias using Cochrane/PEDro tools and performed meta-analysis using random-effects models. Sensitivity analyses excluded studies with high bias risk, non-standard interventions, or inconsistent control groups. RESULTS: Baduanjin significantly reduced SBP by 8.3 mmHg (3 months), 11.4 mmHg (6 months), and 5.4 mmHg (12 months); DBP by 3.9 mmHg (3 months), 6.2 mmHg (6 months), and 4.1 mmHg (12 months). It improved TG (SMD = -0.34 [95 % CI: -0.49, -0.19]), TC (SMD = -0.92 [-1.49, -0.34]; high heterogeneity), and HR (SMD = -1.07 [-1.76, -0.38]). GRADE rated evidence quality as moderate (most BP outcomes), low (TG), and very low (TC), primarily due to methodological limitations. CONCLUSION: Baduanjin is an effective, low-cost adjunct intervention for essential hypertension, particularly reducing blood pressure within 3-6 months. We recommend implementing 3-6-month Baduanjin programs (5-6 sessions/week) in clinical practice. Benefits on lipid metabolism and heart rate require confirmation via higher-quality trials. Future research should standardize protocols and explore mechanisms.
Efficacy and safety of acupressure for primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials.
Yu X, Liu B, Li J … +5 more , Gao Y, Chen J, Qi R, Yuan Y, Liu Y
Complement Ther Med · 2025 Dec · PMID 41138782 · Publisher ↗
OBJECTIVE: This systematic review aimed to evaluate the existing randomized controlled trials (RCTs) for evidence of the association between using acupressure and reducing pain and related symptoms of primary dysmenorrhe...
OBJECTIVE: This systematic review aimed to evaluate the existing randomized controlled trials (RCTs) for evidence of the association between using acupressure and reducing pain and related symptoms of primary dysmenorrhea (PD). METHODS: Six electronic databases were searched for published reports on RCTs-from database inception until May 2025-that compared the use of acupressure with that of placebo acupressure, oral medication, or usual treatment and measured the intensity of menstrual pain and related symptoms. Two independent reviewers extracted and assessed the data. Risk of bias was assessed for each article; the meta-analysis was conducted according to the type of control. Results are presented as mean differences (MDs) or standardised mean differences (SMDs) and 95 % confidence intervals (CIs). RESULTS: In total, 23 RCTs were included in the systematic review and data from 20 RCTs were evaluated in the meta-analysis. Most studies showed a low or unclear risk of bias. We found that using acupressure was more effective in reducing menstrual pain than using placebo acupressure (MD = -1.58; 95 % CI, [-1.96, -1.20]), oral medication (MD = -1.11; 95 % CI, [-1.79, -0.43]), or usual treatment (MD = -1.29; 95 % CI, [-1.77, -0.80]). The adverse events, reported in only two studies, were mild. CONCLUSION: Acupressure can effectively reduce the pain and related symptoms of PD, though the current evidence is of low quality. Future studies with rigorous designs and larger sample sizes are warranted to verify the efficacy and safety of acupressure. Subsequent findings should be incorporated into clinical practice and nursing care to refine the treatment strategies for PD.
Porcine placenta peptides as a complementary functional food for skin rejuvenation: A 12-week randomized, double-blind, placebo-controlled trial.
Nguyen NH, Lee YI, Chau NH … +5 more , Lee SJ, Kim I, Kim J, Baek KS, Lee JH
Complement Ther Med · 2025 Dec · PMID 41138781 · Publisher ↗
Skin aging is characterized by the deterioration of collagen and elastin in the dermis, leading to wrinkles, dryness, and pigmentation irregularities. Porcine placenta peptides (Placenderm®, hereinafter PPP), a bioactive...
Skin aging is characterized by the deterioration of collagen and elastin in the dermis, leading to wrinkles, dryness, and pigmentation irregularities. Porcine placenta peptides (Placenderm®, hereinafter PPP), a bioactive ingredient commonly used in complementary functional foods and rich in collagen and growth factors, have demonstrated regenerative properties that may counteract these aging effects. This randomized, double-blind, placebo-controlled trial aimed to evaluate the efficacy of oral PPP supplementation in improving signs of skin aging. Ninety participants aged 35-60 with dry skin and visible periorbital wrinkles were randomly assigned to receive either PPP or a placebo twice daily for 12 weeks. Skin parameters, including wrinkle depth, hydration, transepidermal water loss (TEWL), elasticity, pigmentation, and gloss, were assessed at baseline and at 4, 8, and 12 weeks. Compared to the placebo group, the PPP group showed significant reductions in wrinkle depth, melanin index, erythema index, and TEWL, alongside notable improvements in skin hydration, elasticity, and gloss. Importantly, no adverse events were reported, and investigator evaluations supported the objective findings. Taken together, PPP may serve as a safe and effective complementary therapy to conventional dermatological treatments, offering a non-invasive strategy to promote skin health and counteract photoaging. Given its origin as a functional food and its role in traditional East Asian medicine, PPP may also be integrated into holistic anti-aging regimens or wellness programs. Further studies in diverse populations are warranted to confirm these benefits and explore underlying mechanisms.
Effects of yoga facial massage on computer vision syndrome and ocular motor function: A randomised controlled trial.
Chen H, Ratanapakorn T, Sukonpatip M … +4 more , Asawaphureekorn S, Thinkhamrop W, Wang X, Eungpinichpong W
Complement Ther Med · 2025 Dec · PMID 41135797 · Publisher ↗
Computer vision syndrome (CVS), resulting from prolonged screen use, is characterised by visual fatigue and may exacerbate pre-existing refractive errors. This randomised controlled trial aimed to evaluate the effects of...
Computer vision syndrome (CVS), resulting from prolonged screen use, is characterised by visual fatigue and may exacerbate pre-existing refractive errors. This randomised controlled trial aimed to evaluate the effects of Specialised Thai Yoga Facial Massage (STYFM) on visual fatigue, accommodative function, refractive status, and musculoskeletal parameters in 32 young adults with CVS. Participants were randomly assigned to either the Specialised Thai Yoga Facial Massage Group (FMG, n = 16), receiving 10-15 min of STYFM, or the Control Group (CTG, n = 16), resting with eyes closed for 15 min. Computer Vision Syndrome Questionnaire (CVS-Q), near point of convergence (NPC), amplitude of accommodation (AMP), visual acuity (VA), spherical equivalent refraction (SE), handgrip strength (HS), and cervical range of motion (CROM) were assessed at baseline, week 2, and week 4. By week 4, the FMG showed significantly greater improvement in CVS-Q (-27.6 points), NPC (-3.6 cm), AMP (+1.3 D), and VA (+7.3 points), all p < 0.001. The SE changes were minimal in both groups, with no significant differences observed between them (p = 0.065). Musculoskeletal parameters also improved in the FMG, with significant increases in CROM and HS (p < 0.001). This study provides supportive evidence that STYFM may effectively alleviate visual fatigue symptoms, improve accommodative function, enhance convergence ability, and improve related musculoskeletal health in patients with CVS.
Long-term farming lifestyle strongly associated with lower sarcopenia prevalence in older Adults: A cross-sectional study in an urban-rural transition zone.
Zhoujian Y, Haihong Z, Hui Z … +9 more , Qi Z, Zhufeng W, Haihong S, Jun L, Aihua L, Huan Z, Hong L, Jiachen W, Shanjin W
Complement Ther Med · 2025 Dec · PMID 41115597 · Publisher ↗
OBJECTIVE: In the context of rapid urbanization and escalating population aging, lifestyle factors play a critical role in sarcopenia development. This study aimed to clarify the prevalence of sarcopenia in elderly adult...
OBJECTIVE: In the context of rapid urbanization and escalating population aging, lifestyle factors play a critical role in sarcopenia development. This study aimed to clarify the prevalence of sarcopenia in elderly adults in the urban-rural transition zone of southern Pudong, Shanghai, and explore the association between lifestyle factors (with a focus on long-term farming history) and sarcopenia. METHODS: A cross-sectional study was conducted between January and November 2024, recruiting 654 community-dwelling individuals aged ≥ 60 years (mean age 69.43 ± 3.42 years) via convenience sampling from local health centers. Sarcopenia was diagnosed according to the 2023 Chinese Consensus criteria, based on assessments of muscle mass using bioelectrical impedance analysis (BIA), grip strength, and gait speed. Information on demographics, comorbidities, and pre-retirement primary occupation (categorized as farming vs. other non-farming) was collected through structured interviews. A farming lifestyle was defined as having engaged in agriculture as a primary occupation for at least 20 years. Multivariate logistic regression was used to identify independent factors associated with sarcopenia. RESULTS: The overall prevalence of sarcopenia was 6.42 % (42/654), with no significant difference between sexes (6.21 % in men vs. 6.63 % in women, P = 0.841). In univariate analysis, a history of farming (P < 0.001) and diabetes (P < 0.001) were significantly associated with sarcopenia. After adjusting for potential confounders in the multivariate logistic regression model, a long-term farming history emerged as a strong, independent protective factor against sarcopenia (adjusted Odds Ratio aOR = 0.050, 95 % Confidence Interval CI: 0.021-0.119, P < 0.001). The association between diabetes and sarcopenia was no longer statistically significant in the adjusted model (aOR = 0.749, 95 % CI: 0.293-2.088, P = 0.545). CONCLUSION: The prevalence of sarcopenia in this urban-rural transition zone is lower than in highly urbanized centers in China. A long-term farming lifestyle is strongly and independently associated with a reduced risk of sarcopenia in this population. This finding highlights the potential protective effects of traditional agricultural lifestyle patterns and suggests that public health strategies for sarcopenia prevention should prioritize integrated, activity-diverse, and culturally relevant interventions.
Corrigendum to "The need for increasing pediatric obesity advocacy." [Volume 80 (2024) 1-2].
Bomberg EM, Kyle TK, Stanford FC
Complement Ther Med · 2025 Nov · PMID 41109782 · Publisher ↗
Abstract loading — click title to view on PubMed.
A systematic review of the chronic effects of self-myofascial release on athletic performance.
Yang Q, Soh KG, Mohd Moklas MAB … +3 more , Wang M, Pan X, Ma K
Complement Ther Med · 2025 Dec · PMID 41106488 · Publisher ↗
BACKGROUND: Self-myofascial release (SMR) is widely used by athletes and coaches during warm up and recovery to increase joint range of motion. Its long term effects on performance are less clear. OBJECTIVE: To evaluate...
BACKGROUND: Self-myofascial release (SMR) is widely used by athletes and coaches during warm up and recovery to increase joint range of motion. Its long term effects on performance are less clear. OBJECTIVE: To evaluate the chronic effects, defined as at least 4 weeks, of SMR interventions on athletes physical fitness and sport specific performance, focusing on flexibility, strength, balance, and skill execution. DESIGN: Systematic review. DATA SOURCES: PubMed, SPORTDiscus, Web of Science, and Scopus were searched in February 2025 in line with PRISMA. ELIGIBILITY CRITERIA: Experimental studies in peer reviewed English journals that examined SMR for 4 weeks or longer and reported performance related outcomes in athletes. RESULTS: Of 1391 records screened, 12 studies met inclusion, totaling 388 athletes aged 12-30 from soccer, tennis, water polo, volleyball, and mixed sports. Most studies reported significant gains in joint mobility, especially hip and shoulder flexibility. Several studies also showed moderate improvements in strength, such as maximal voluntary contraction and jump height, and in dynamic balance measured by the Y-Balance Test. Effects on static balance, isokinetic strength across all planes, and sport specific skills such as serve speed or sprint swimming were variable and often non significant. CONCLUSION: Chronic SMR appears effective for improving flexibility and dynamic balance in athletes and may confer additional benefits for strength and motor control. Heterogeneity in protocols, comparators, and outcome measures, along with modest methodological quality, limits firm conclusions. More high quality, sport specific trials are needed to define optimal SMR parameters across training phases.
Impact of ginger supplementation on obesity indices and Adipokine profiles in adults: A GRADE-based systematic review and dose-response meta-analysis of randomized controlled trials.
Rjabi S, Seyedhatami SS, Makhtoomi M … +7 more , Ahmadi MR, Alimohamadi S, Aliabadi E, Talakesh S, Nouri M, Zamani B, Askarpour M
Complement Ther Med · 2025 Nov · PMID 41101746 · Publisher ↗
BACKGROUND: Overweight and obesity are major health concerns. The impact of ginger on weight has been studied. In the present systematic review and dose-response meta-analysis we aim to sum up the findings from randomize...
BACKGROUND: Overweight and obesity are major health concerns. The impact of ginger on weight has been studied. In the present systematic review and dose-response meta-analysis we aim to sum up the findings from randomized controlled trials (RCTs) on the effect of ginger on various weight measurements/indices. METHODS: Several databases (PubMed, Scopus, Web of Science Core Collection, and Google Scholar) were comprehensively searched. Relevant studies were selected using defined criteria. Outcomes included: body weight (BW), body mass index (BMI), waist circumference (WC), body fat percentage (BFP), adiponectin and leptin. Weighted mean difference (WMD) and confidence interval (CI) were reported. Subgroup analysis was carried out. Linear and non-linear associations, based on dosage and duration of interventions, were investigated. RESULTS: Thirty-six RCTs were included. Ginger supplementation significantly improved WC (WMD: -0.65 cm, 95 % CI: -1.07, -0.24), BFP (WMD: -1.49 %, 95 % CI: -2.65, -0.32), and serum adiponectin levels (WMD = 0.84 μg/mL; 95 % CI: 0.01). Other measurements were not improved by the intervention. An inverse, linear association was found between the duration of intervention and changes in BW (BW: coefficient = -0.471, P = 0.001). Also, a non-linear direct association was observed between ginger dosages and WC (P-nonlinearity = 0.023). CONCLUSIONS: Ginger supplementation does not seem effective in improving major measurements/indices of weight, including body weight and BMI. However, ameliorations in other measurements of local adiposity, findings from subgroup analyses, and investigations of linear and non-linear association on dosage and duration, indicate that further studies with longer intervention periods are needed to make a conclusive decision.
Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial.
Dehnayebi MJ, Zeidy P, Shamsikhani S … +2 more , Salehi M, Safarabadi M
Complement Ther Med · 2025 Dec · PMID 41101745 · Publisher ↗
BACKGROUND: Hypertension is one of the most prevalent chronic diseases worldwide, and stage 1 hypertension provides a critical window for implementing non-pharmacological interventions. Herbal remedies such as Melissa of...
BACKGROUND: Hypertension is one of the most prevalent chronic diseases worldwide, and stage 1 hypertension provides a critical window for implementing non-pharmacological interventions. Herbal remedies such as Melissa officinalis and Echium amoenum have shown promising effects on cardiovascular health. METHODS: In this randomized, triple-blind clinical trial, 105 patients with stage 1 hypertension were randomly assigned to three groups: Melissa officinalis (n = 35), Echium amoenum (n = 35), and control (n = 35). Participants received 10 mL of the assigned extract or placebo daily for four weeks. Systolic and diastolic blood pressure were measured weekly. Data were analyzed using SPSS version 26. The Shapiro-Wilk test indicated that the distribution of blood pressure values was not normal (p < 0.05); therefore, non-parametric tests were used RESULTS: Significant within-group reductions in both SBP and DBP were observed in the Melissa officinalis and Echium amoenum groups (p < 0.001). The Melissa officinalis group had the greatest decrease in SBP (8 mmHg) and DBP (4 mmHg). Between-group comparisons showed significant differences favoring Melissa officinalis over both other groups at weeks 2, 3, and 4 (p < 0.001). CONCLUSION: Both Melissa officinalis and Echium amoenum effectively reduced blood pressure in patients with stage 1 hypertension, with Melissa officinalis demonstrating superior efficacy. These findings support the use of Melissa officinalis as a complementary treatment for hypertension management.
A narrative review of aromatherapy: Mechanisms and clinical value in physiological and psychological regulation.
Men L, Liang LL, Wu SW … +7 more , Sun Y, Liu H, Mi Q, Mazhar M, Luo G, Liu QY, Liu MN
Complement Ther Med · 2025 Nov · PMID 41101744 · Publisher ↗
OBJECTIVE: This narrative review comprehensively explores the physiological mechanisms, psychological effects, and theoretical hypotheses of aromatherapy, along with its applications in clinical practice. BACKGROUND: Aro...
OBJECTIVE: This narrative review comprehensively explores the physiological mechanisms, psychological effects, and theoretical hypotheses of aromatherapy, along with its applications in clinical practice. BACKGROUND: Aromatherapy, utilizing plant-derived essential oils, is a significant component of complementary medicine widely implemented in clinical practice. Recent research advancements demonstrate its regulatory effects physiologically and psychologically, showing clinical potential for nervous, circulatory, and immune systems. METHODS: Searches were conducted in the China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases to identify relevant studies published in recent years. Based on the retrieved literature, the biological effects of aromatherapy on the nervous, circulatory, and immune systems are summarized in this review. DISCUSSION: From a physiological perspective, olfactory molecules can enter the bloodstream either through the olfactory system or via transdermal absorption, subsequently modulating the immune system. They have been shown to inhibit the release of pro-inflammatory cytokines, enhance the expression of anti-inflammatory factors, scavenge free radicals, reduce cellular oxidative stress, and mitigate systemic inflammatory responses. Regarding psychological effects, aromatherapy modulates the secretion of neurotransmitters such as gamma-aminobutyric acid (GABA), thereby alleviating anxiety. Additionally, it influences emotional states and cognitive functions by stimulating the olfactory system, which interacts with the limbic system and brain regions involved in emotional processing. Specific essential oils like lavender demonstrate substantial evidence for analgesic and anxiolytic effects, while Rosmarinus officinalis shows efficacy in enhancing cognitive function. The review particularly focuses on its mechanisms and clinical applications in pain relief, anti-inflammatory activity, antioxidative properties, antidepressant and anxiolytic effects, and adjunctive care. CONCLUSION: Future research should prioritize elucidating mechanisms of action, bioavailability, and long-term safety to fully uncover its therapeutic potential.
AI-assisted drawing therapy for children with ADHD: A randomised controlled trial.
Xu J, Lin R, Zhang A … +15 more , Chen Q, Li D, Chen J, Song M, Chen S, Yang B, Li L, Xu H, Peng J, Tang Y, Yang W, Luo X, Zhou X, Wang J, Huang G
Complement Ther Med · 2025 Nov · PMID 41093023 · Publisher ↗
OBJECTIVE: This randomized controlled trial evaluated the efficacy of AI-assisted drawing therapy for children with ADHD, comparing its impact on core symptoms and functional impairments against traditional drawing inter...
OBJECTIVE: This randomized controlled trial evaluated the efficacy of AI-assisted drawing therapy for children with ADHD, comparing its impact on core symptoms and functional impairments against traditional drawing interventions while assessing engagement and the rapeuticoutcomes. METHODS: Forty-one children (ages 7-10) with ADHD were randomized into AI-assisted (n = 19) or traditional drawing therapy (n = 22) groups (Trial registered in ChiCTR: ChiCTR2400089640). The AI intervention employed a process that captured children's drawings, converted them into keywords, generated AI responses based on those keywords, and provided feedback to the children, while the control group received therapist-guided verbal feedback. SNAP-IV-26(Swanson, Nolan and Pelham-IV rating scales) and WFIRS-P(Weiss Functional Impairment Rating Scales-Parent) scales assessed at baseline (T1) and post-intervention (T2) at a 24-week interval, with data analyzed using independent t-tests (p < 0.05). RESULTS: Both AI-assisted and traditional drawing therapies significantly reduced core ADHD symptoms. In the before-and-after comparison within the group, the AI group showed targeted improvements in attention (p = 0.039) and oppositional defiant behaviour (p = 0.025), while traditional therapy produced broader symptom reductions across all domains (p < 0.05). Between-group comparisons showed that the AI-assisted group achieved greater improvement in inattention (Δ = -1.09, p = 0.035), whereas the traditional drawing group improved more on oppositional defiant behavior (Δ=+1.706, p = 0.010) and the SNAP-IV total score (Δ=+4.777, p = 0.041). On the WFIRS-P, the AI group showed advantages for the Family domain (p = 0.041) and the total score (p = 0.047), while Self-Concept favored the traditional drawing group (p = 0.036). CONCLUSION: AI-assisted, drawing-based art therapy produced greater improvement in the pre-specified primary outcome (SNAP-IV inattention) and select WFIRS-P domains (e.g., Family, total score), whereas conventional drawing therapy yielded broader reductions in oppositional defiant symptoms and the overall SNAP-IV severity. Effects were modest and domain-specific; larger, multi-center trials are needed to confirm efficacy and identify which children benefit most.
Acupuncture with micro-needle for dry eye disease: A study protocol for a randomized, sham-controlled, clinical trial.
Sun M, Li G, Xu S … +5 more , Yin X, Li S, Li X, Liu J, Liu B
Complement Ther Med · 2025 Dec · PMID 41093022 · Publisher ↗
INTRODUCTION: Dry Eye Disease (DED) is a prevalent and significant condition that affects a large number of people. Artificial tears can alleviate the symptoms in patients with mild to moderate dry eyes, but they do not...
INTRODUCTION: Dry Eye Disease (DED) is a prevalent and significant condition that affects a large number of people. Artificial tears can alleviate the symptoms in patients with mild to moderate dry eyes, but they do not have a long-term effect. Micro-needle is a novel type of acupuncture, with needle tips arrayed on a silicon chip attached to medical plaster, without penetrating the skin. Its effectiveness and efficacy need to be proven clinically. METHODS AND ANALYSIS: This is a single-center, randomized, sham-controlled trial. In total, 129 DED patients will be recruited and randomized into three groups: micro-needle, sham, and artificial tears. They will receive four weeks of treatment and undergo follow-up at six and ten weeks. The primary outcome is measured by the Objective Symptoms Scoring Sheet (OSSS). Secondary outcomes include the China Dry Eye Questionnaire (CDEQ), Ocular Surface Disease Index (OSDI), non-invasive tear film break-up time (NIBUT), Schirmer Test I (SIT), Tear Meniscus Height (TMH), and Corneal Fluorescein Staining (CFS). Questionnaires, including OSSS, CDEQ, and OSDI, will be administered at screening, at the end of week two, and at the conclusion of week four, when treatment is completed. They will also be conducted at follow-up in week six and week ten; OSSS will be taken additionally on day two of the treatment. Tests of Intraocular Pressure (IOP), Best Corrected Visual Acuity (BCVA), NIBUT, SIT 1, TMH, and CFS are conducted at screening and upon completion of treatment. At week two, NIBUT, SIT 1, TMH, and CFS tests are taken as intermittent measurements. ETHICS AND DISSEMINATION: The trial protocol and informed consent document were reviewed and approved by the Ethics Committee of the Shanghai Municipal Hospital of Traditional Chinese Medicine (Approval Number: 2023SHL-KY-101-01). Prior to enrollment, each potential participant undergoes a structured informed consent process conducted by a trained research coordinator, which includes explaining the trial purpose, design, interventions, benefits, risks, and time commitments; providing sufficient time for participants to review the plain-language written informed consent document; addressing all questions to ensure comprehension; and obtaining signed written consent, with a copy provided to the participant and the original stored in the trial file. To safeguard participant confidentiality, all data are labeled with a unique study ID instead of personal identifiers; paper records are stored in locked cabinets in a restricted-access office, and electronic data are stored on password-protected, encrypted servers accessible only to authorized team members via unique logins; de-identified data are used solely for analysis and reporting, with personal identifiers accessible only to the trial coordinator for enrollment and follow-up and never shared with other parties; and study findings in publications and presentations will be aggregated to prevent individual identification. The findings of this investigation will be disseminated through peer-reviewed publications, and any protocol amendments will be submitted to the ethics committee for re-approval and updated in the trial registry. TRIAL REGISTRATION NUMBER: ChiCTR2300078187 TRIAL REGISTRATION DATE: 2023.11.30 TRIAL REGISTRY: China Clinical Trial Registration Center https://www.chictr.org.cn.
Effectiveness of 10.6-μm laser therapy for diabetic peripheral neuropathy: A double-blind, randomized controlled trial.
Yin Y, Huang Z, Li Y … +8 more , Chen Y, Cheng K, Deng H, Lv W, Wang Y, Shen X, Zhao L, Lin L
Complement Ther Med · 2025 Dec · PMID 41093021 · Publisher ↗
OBJECTIVE: To observe the clinical effects of 10.6-μm laser moxibustion (LM) on diabetic peripheral neuropathy (DPN) and quality of life in patients. METHODS: Sixty-eight patients with DPN were randomly assigned to two g...
OBJECTIVE: To observe the clinical effects of 10.6-μm laser moxibustion (LM) on diabetic peripheral neuropathy (DPN) and quality of life in patients. METHODS: Sixty-eight patients with DPN were randomly assigned to two groups in a 1:1 ratio and received LM or sham LM 3 times/week for a total of 12 treatments. Outcome parameters were assessed at baseline, at Weeks 2 and 4 of treatment, and at 4 and 8 weeks post-treatment (Weeks 8 and 12) using Michigan Neuropathy Screening Instrument (MNSI) and Diabetes-Specific Quality of Life (DSQL) scores, nerve conduction velocity (NCV), and blood rheology parameters. RESULTS: Most (58/68) patients completed the trial. MNSI scores were significantly lower at every time point (P < 0.01), and DSQL scores were significantly lower at Weeks 4, 8, and 12 (P < 0.001), compared with baseline in both groups. The LM group had lower MNSI scores at Week 4 (P < 0.05), and lower DSQL scores at Weeks 4, 8, and 12 (P < 0.05) compared with the sham LM group. At Week 4, there was no significant between-group difference in NCV (P > 0.05). Post-treatment, there were no significant differences in blood rheology parameters compared with baseline within each group (P > 0.05). Whole blood high-shear reductive viscosity and red blood cell rigidity index were significantly lower in the LM group than in the sham LM group (P < 0.01). No serious adverse events were recorded. CONCLUSION: Treatment with 10.6-μm LM improved clinical symptoms and quality of life in patients with DPN. CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2000029329. Registered 25 January 2020, https://www.chictr.org.cn/showproj.html?proj=48490.
Auricular electro-acupuncture for smoking cravings in young smokers with nicotine dependence: A pilot fMRI study.
Zhang YY, Liu YJ, Wang Y … +6 more , Liang SB, Yin T, Zheng YS, Liu JP, Robinson N, Qiao HF
Complement Ther Med · 2025 Dec · PMID 41093020 · Publisher ↗
BACKGROUND: This pilot study aims to evaluate the efficacy of auricular electro-acupuncture (AEA) for smoking cravings induced by quitting in young smokers and to investigate the underlying neural mechanism using functio...
BACKGROUND: This pilot study aims to evaluate the efficacy of auricular electro-acupuncture (AEA) for smoking cravings induced by quitting in young smokers and to investigate the underlying neural mechanism using functional magnetic resonance imaging (fMRI). METHODS: We recruited 16 young participants with nicotine dependence (ND) and 15 matched healthy non-smoking controls (HCs). ND participants were treated with AEA for 4 weeks, and underwent brain fMRI scanning following 24-hour abstinence, 20 min of smoking satisfaction, after 1 week, and 4 weeks of AEA treatment. HCs underwent a single fMRI scanning. Fractional Amplitude of Low-Frequency Fluctuations (fALFF) was assessed. RESULTS: Compared with HCs, fALFF values in ND participants following 24-hour abstinence decreased in the bilateral anterior cerebellar lobes (ACL), anterior cingulate cortex (ACC) and central tegmental area (CTA) /insula (P < 0.05). However, after 20 min of smoking satisfaction, fALFF values for ACC and bilateral ACL significantly increased (P < 0.05). Compared to 24-hour abstinence, the fALFF value of ACC and cerebellum in ND group significantly increased after 4 weeks of AEA treatment (P < 0.05). Compared to baseline, both smoking cravings (t = 3.87, P < 0.01) and nicotine dependence levels (t = 3.83, P < 0.01) showed significant reductions after 4 weeks of AEA treatment. CONCLUSION: The results of this pilot study indicate that AEA may be effective in suppressing smoking cravings and alleviating nicotine dependence. ACC, cerebellum, CTA, and insula may be involved in modulating smoking cravings. AEA may inhibit cravings through regulating the functional activity of ACC and cerebellum.
Short-term effects of arm baths on blood pressure in participants with arterial hypertension - a randomized crossover study.
Reiter E, Huber R
Complement Ther Med · 2025 Nov · PMID 41093019 · Publisher ↗
BACKGROUND: Hypertension is the predominant risk factor for premature cardiovascular disease, and contributes to heart failure, chronic kidney disease, and stroke. As of recently, scientists began to systematically inves...
BACKGROUND: Hypertension is the predominant risk factor for premature cardiovascular disease, and contributes to heart failure, chronic kidney disease, and stroke. As of recently, scientists began to systematically investigate the vast physiological potential of hydrotherapy in individuals with cardiovascular disease. Hot baths in particular have been shown to transiently reduce arterial stiffness and to exert vasodilatory effects. Potentially beneficial in patients with uncontrolled hypertension, hot arm baths (HAB) have rarely been put to the test in randomized-controlled trials. METHODS: Based on the hypothesis that HAB may exert short-term blood pressure-lowering effects, a monocentric, randomized-controlled pilot study was performed in participants with arterial hypertension. In a crossover design, participants received a HAB with a temperature of 45 °C and a thermoneutral arm bath (TAB) with a temperature of 28 °C for five minutes each, with a post-interventional observation period of 90 min. Effects on systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as on heart rate (HR) and hand and foot temperature (HT, FT) were measured in close intervals (after 1, 5, 10, 15, 30, 60 and 90 min). The washout period between both interventions was seven days. RESULTS: 54 participants with uncontrolled hypertension were included to the study, of which four participants had to be excluded from the analysis because they did not show up for the second intervention. The mean age of the remaining 50 participants in group A und in group B were 61 and 62 years, respectively. The participants in both groups were slightly overweight (group A: BMI 25.2 kg/m, group B: BMI 27.1 kg/m). The majority of participants in both groups took antihypertensive medication. Analysis revealed no carry-over effect. The analyses of treatment effects showed a significant decrease from baseline of DBP 5, 10 and 15 min after the HAB in comparison with the TAB. In addition, we found statistically significant differences of the two interventions in the changes from baseline of the HR after 1 and 5 min and HT after 1, 5, 10, 15 and 30. No major side effects were reported. CONCLUSIONS: HAB could be used as rapid-acting add-on tool in conjunction with pharmacotherapy to manage uncontrolled hypertension in various contexts at home.
Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis.
Inprasit C, Bunyamahote S, Boonpattharatthiti K … +3 more , Thimkorn P, Intakhiao S, Dhippayom T
Complement Ther Med · 2026 Mar · PMID 41082950 · Publisher ↗
BACKGROUND: Herbal interventions such as Curcuma longa (CL) and Boswellia serrata (BS) have demonstrated efficacy and safety in managing knee osteoarthritis (KOA); however, the effects of their combined formulation, incl...
BACKGROUND: Herbal interventions such as Curcuma longa (CL) and Boswellia serrata (BS) have demonstrated efficacy and safety in managing knee osteoarthritis (KOA); however, the effects of their combined formulation, including both direct and indirect outcomes, remain insufficiently explored. We performed systematic review and network meta-analysis for clinical effects of CL, BS, and their mixed formulation in alleviating KOA symptoms. METHODS: The CENTRAL, PubMed, EMBASE, and EBSCO Open Dissertations, databases and also from Snowballing and citation searching were searched through March 2025. The randomized controlled trials (RCTs) that studied effectiveness of CL or BS in KOA participants using Visual Analog Scale (VAS) and KOA severity by the Western Ontario and McMaster Universities Arthritis Index (WOMAC), and adverse events as the main outcomes, were eligibly included. The Cochrane Risk of Bias a random-effects model, standardized mean differences (SMDs) along with 95 % confidence intervals (CIs) were employed. RESULTS: In total, 20 RCTs comprising 1633 participants were included. The modified formulations of CL showed a significant reduction in VAS compared to placebo (SMD: -2.82; 95 %CI: -5.30 to -0.33), while the modified formulations of BS demonstrated significant improvement in WOMAC pain, stiffness, and knee function compared to other intervention groups. No significant differences in adverse events were observed among all comparisons. CONCLUSIONS: BS extract, particularly in modified formulations, improves joint function in patients with mild to moderate KOA, while only the modified formulation of CL demonstrates notable pain-reducing efficacy. The potential benefits of combined CL and BS preparations warrant further investigation.
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