The Aging Male[JOURNAL]
Sun
200 papers
Frailty and frailty progression in relation to the risk of benign prostatic hyperplasia/lower urinary tract symptoms among Chinese middle-aged and older men: a prospective cohort study.
Li L, Dong A, Liu K … +2 more , Wu Y, Gong Y
Aging Male · 2026 Dec · PMID 41793280 · Publisher ↗
BACKGROUND: Frailty and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) are age-related conditions, but their longitudinal relationship remains unclear. This study investigated associations between f...
BACKGROUND: Frailty and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) are age-related conditions, but their longitudinal relationship remains unclear. This study investigated associations between frailty index (FI) trajectories, baseline frailty status, and incident BPH/LUTS in Chinese middle-aged and older men. METHODS: Data from three waves (2011-2015) of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Group-based trajectory modeling identified FI trajectories. Multivariable logistic regression examined associations of baseline frailty status (robust, prefrail, frail) and FI trajectories with incident BPH/LUTS. Incremental predictive value of trajectories beyond baseline status was quantified using net reclassification improvement (NRI) and integrated discrimination improvement (IDI). RESULTS: Among 4,449 men, four distinct FI trajectories were identified. Compared to the Persistently Low trajectory, Moderately Increasing and High-Increasing trajectories showed significantly higher BPH/LUTS risk (ORs: 2.01 [1.38-2.99] and 2.82 [1.79-4.45]; -trend < 0.001). Baseline prefrail and frail status were also associated with elevated risk (ORs: 1.47 [1.13-1.90] and 1.67 [1.10-2.49], respectively). Dynamic frailty trajectories demonstrated improved risk reclassification over baseline assessment alone (continuous NRI: 0.284, < 0.001; IDI: 0.011, = 0.001). CONCLUSIONS: Both baseline frailty status and dynamic FI trajectories were independently associated with BPH/LUTS risk. Longitudinal trajectories exhibited stronger associations and greater predictive value, highlighting the importance of monitoring frailty progression for improved risk stratification and targeted prevention.
Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses.
Ma J, Wei J, Li J … +7 more , Yu M, Lu S, Zeng H, Xu L, Dong Y, Ma Z, Zhang P
Aging Male · 2026 Dec · PMID 41792626 · Publisher ↗
OBJECTIVE: This umbrella review aimed to summarize and provide a general evaluation of the effectiveness of current treatments for erectile dysfunction (ED) and assess the quality of evidence. METHODS: This umbrella revi...
OBJECTIVE: This umbrella review aimed to summarize and provide a general evaluation of the effectiveness of current treatments for erectile dysfunction (ED) and assess the quality of evidence. METHODS: This umbrella review available in PubMed, Web of Science, the Cochrane Library, and Embase, covering studies published up to October 2025, was conducted. The International Index of Erectile Function (IIEF) or its simplified version and the erectile hardness score (EHS) were used as endpoints to evaluate the effectiveness of the treatments. RESULTS: Of 1191 studies, 23 published meta-analyses were extracted, yielding 42 summary effects on IIEF (= 20), the international index of erectile function-5 (IIEF-5) (= 9), the international index of erectile function-erectile function (IIEF-EF) (= 6), and EHS (= 7) on 36 interventions. All meta-analyses were analyzed via the AMSTAR-2, of which 13 (56.5%) were rated as critically low quality, 7 (30.5%) were rated as low quality, 2 (8.7%) were rated as moderate quality, and 1 (4.3%) was rated as high quality. Of the 42 summary effects, only two studies were rated as high-quality and moderate-quality respectively, whereas 47.6% (= 20) and 47.6% (= 20) were rated low and very low, respectively. CONCLUSIONS: The current evidence base for ED treatments is predominantly of low or very low quality. While statistically significant improvements in ED were observed with both pharmacological and nonpharmacological interventions, these findings should be interpreted with caution due to the limited number of patients and the subjective nature of outcome indicators. The treatment landscape for ED is increasingly diverse, yet the reliability of the evidence is poor. Further well-designed studies on single treatments and high-quality meta-analyses of intertreatment comparisons are urgently recommended.
Possible cross‑talk between sarcopenia and obstructive sleep apnea revealed by WGCNA analysis and machine learning.
Lu K, Lei H, Wu C … +3 more , Lin D, Li Y, Deng Y
Aging Male · 2026 Dec · PMID 41784220 · Publisher ↗
BACKGROUND: Emerging evidence suggests a potential link between obstructive sleep apnea (OSA) and sarcopenia. OSA-induced hypoxia and sleep disturbances may promote the loss of muscle mass, thereby increasing the risk of...
BACKGROUND: Emerging evidence suggests a potential link between obstructive sleep apnea (OSA) and sarcopenia. OSA-induced hypoxia and sleep disturbances may promote the loss of muscle mass, thereby increasing the risk of sarcopenia. This study employed bioinformatics approaches to identify key diagnostic candidate genes underlying the interaction between OSA and sarcopenia. METHODS: In this study, gene expression datasets for OSA and sarcopenia were retrieved from the GEO. WGCNA was employed to identify shared common genes. Subsequently, two machine learning algorithms, SVM-RFE and RF, were utilized to determine candidate hub genes for diagnosing OSA combined with sarcopenia. The diagnostic performance of candidate hub genes was evaluated in both the discovery and validation datasets using a nomogram and ROC curve analysis. RESULTS: Our analysis identified 20 shared common genes associated with the comorbidity of sarcopenia and OSA. From this gene set, LGR6 and ARRDC2 were identified as candidate hub genes. The developed diagnostic model demonstrated robust predictive performance in both the discovery and validation datasets. CONCLUSION: Our findings identify LGR6 and ARRDC2 as potential biomarkers for diagnosing comorbid OSA and sarcopenia. Moreover, a diagnostic model based on these two hub genes can predict the risk of sarcopenia in patients with OSA.
Causal links between brain multimodal features (morphometry, metabolomics, networks) and erectile dysfunction: evidence from Mendelian randomization.
Xie L, Wu C, Fu F … +1 more , Deng S
Aging Male · 2026 Dec · PMID 41715886 · Publisher ↗
BACKGROUND: Integrating brain multimodal features (e.g. structural, functional, and cerebrospinal fluid metabolomic data) offers a promising approach to elucidate the neural mechanisms underlying erectile dysfunction (ED...
BACKGROUND: Integrating brain multimodal features (e.g. structural, functional, and cerebrospinal fluid metabolomic data) offers a promising approach to elucidate the neural mechanisms underlying erectile dysfunction (ED). METHODS: Using two-sample Mendelian randomization, we assessed causal effects of 83 whole-brain morphological, 191 resting-state fMRI, and 338 cerebrospinal fluid metabolite phenotypes on ED. A -value < 0.05 indicated statistical significance. RESULTS: Reduced volumes in the left and right accumbens and enlarged volumes in the left pars opercularis and right putamen were associated with increased ED risk. Increased connectivity between occipital/precuneus and superior frontal gyrus (default/executive networks) elevated ED risk, while connectivity between postcentral/precentral and subcortical regions (motor/subcortical-cerebellum networks) reduced risk. Several metabolites were identified: elevated 4-Methylcatechol sulfate, adenine, gulonate, pyroglutamine, and thioproline increased ED risk, while higher cortisone, malate, phosphate, and X-21733 decreased risk. CONCLUSION: We identified four morphological, two functional connectivity, and nine metabolic causal relationships with ED, enhancing understanding and suggesting novel therapeutic targets.
Association between chronic inflammation status and serum testosterone and free testosterone in adult males.
Zhang SZ, Meng YH, Qi SD … +3 more , Wu J, Su L, Jiao YZ
Aging Male · 2026 Dec · PMID 41708584 · Publisher ↗
BACKGROUND: Chronic inflammation may contribute to biochemical hypogonadism, but evidence regarding composite inflammatory indicators is limited. This study examined the associations of the systemic inflammation response...
BACKGROUND: Chronic inflammation may contribute to biochemical hypogonadism, but evidence regarding composite inflammatory indicators is limited. This study examined the associations of the systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) with serum testosterone and free testosterone (FT) in adult males. METHODS: Data were obtained from NHANES 2011-2016 and 2021-2023, including 7,576 men for serum testosterone and 3,590 for FT. Multivariable regression, smoothing curves, threshold effect, and age-stratified analyses were conducted. RESULTS: Higher SIRI and AISI were significantly associated with lower serum testosterone and FT levels ( < 0.0001). Testosterone levels were lowest in the highest quartiles of SIRI and AISI. Nonlinear inverse associations with serum testosterone were observed for both indices, and AISI also showed a nonlinear association with FT, while SIRI showed a linear inverse association. A positive association with biochemical hypogonadism was observed only when defined by serum testosterone. The inverse associations were consistent across all ages for serum testosterone but were evident for FT only in men aged 20-39 and ≥60 years. CONCLUSION: SIRI and AISI are independently associated with lower serum testosterone in men, while associations with FT appear age-dependent.
Is transurethral enucleation of the prostate combined with internal incision of peripheral zone abscesses a safe treatment for prostate multilocular abscesses?
Du J, Yuan X, Wang Y … +10 more , Wang K, Wang L, Zhou H, Yu Z, Ren A, Lun X, Liu W, Shen T, Bi Y, Han B
Aging Male · 2026 Dec · PMID 41688873 · Publisher ↗
BACKGROUND: To evaluate the effectiveness and safety of performing transurethral enucleation of the prostate in combination with internal incision of prostate abscesses located in the peripheral zone for multilocular pro...
BACKGROUND: To evaluate the effectiveness and safety of performing transurethral enucleation of the prostate in combination with internal incision of prostate abscesses located in the peripheral zone for multilocular prostate abscesses. METHODS: This retrospective study included 10 patients aged 45 to 89 years who were diagnosed with multilocular prostate abscesses. All patients underwent transurethral bipolar plasmakinetic enucleation of enlarged prostatic adenomas with internal incision of peripheral zone abscesses. Clinical and demographic characteristics, intraoperative parameters, urination status, postoperative complications, and recurrence of abscesses were systematically analyzed to determine the outcomes of this procedure. RESULTS: All patients successfully completed the operation without intraoperative complications. After surgery, infection-related parameters, including white blood cell count, C-reactive protein, procalcitonin and body temperature, returned to normal ranges, while urinary function indices such as post-void residual urine volume, maximum urinary flow rate, International Prostate Symptom Score, and quality-of-life score showed significant improvement compared with preoperative values. During follow-up, all patients achieved complete resolution of their prostate abscesses without evidence of recurrence. CONCLUSIONS: Transurethral enucleation of the prostate combined with internal incision of peripheral zone abscesses appears to be a safe and reliable surgical approach for multilocular prostate abscesses.
Vitamin D levels in relation to sexual steroids, sexual function, and quality of life in patients of an andrology outpatient clinic.
Haider KS, Zitzmann M
Aging Male · 2026 Dec · PMID 41688870 · Publisher ↗
OBJECTIVE: This study sought to delineate a putative synergistic interplay between vitamin D and testosterone and their conjoint associations with sexual function and quality of life in men presenting with symptoms of hy...
OBJECTIVE: This study sought to delineate a putative synergistic interplay between vitamin D and testosterone and their conjoint associations with sexual function and quality of life in men presenting with symptoms of hypogonadism. METHODS: A retrospective cohort analysis was performed in men attending the andrological clinic of the University Hospital Münster (Germany) between 2016 and 2021. Individuals exhibited complete biochemical, clinical, and questionnaire datasets. Endocrine parameters, validated psychometric instruments, and demographic variables were systematically evaluated. RESULTS: Among 5,324 screened men, 2,059 fulfilled inclusion criteria (mean age 43.9 years). The cohort displayed a pronounced symptom burden (mitigated wellbeing and erectile function). 25-hydroxyvitamin D and testosterone concentrations resided predominantly within suboptimal ranges. Both vitamin D and testosterone correlated inversely with BMI and AMS scores, and positively with IIEF-EF scores (all < 0.001). Effect size analyses and multiples regressions indicated a robust dependency of symptom severity on vitamin D as well as testosterone status across somatic, sexual, and metabolic indices, underscoring an interdependent relationship between vitamin D and testosterone in shaping sexual function and well-being. CONCLUSION: Albeit causality cannot be inferred, this analysis highlights a clinical convergence of vitamin D and testosterone in modulating sexual health and quality of life in men.
Trends in self-perceived physical and mental health problems causing functional limitations in US men aged 60 years or older.
Storz MA, Ronco AL, Huber R
Aging Male · 2026 Dec · PMID 41680127 · Publisher ↗
BACKGROUND: Understanding aging men's perspective on functional ability is of utmost importance to tailor the delivery of medical care and to inform policy makers about aging men's primary health concerns. METHODS: The p...
BACKGROUND: Understanding aging men's perspective on functional ability is of utmost importance to tailor the delivery of medical care and to inform policy makers about aging men's primary health concerns. METHODS: The purpose of this analysis was to describe trends in self-perceived physical and mental health problems causing functional limitations in US men aged ≥60 years based on National Health and Nutrition Examination Surveys data from 2011 to 2018. RESULTS: Data from 2,494 males with a mean age of 68.56 years was analyzed. Participants reported a median number of 1 health problem causing functional limitations. With 20.54% and 17.75%, respectively, arthritis/rheumatism and back/neck problems emerged as the main problems. The predicted prevalence of arthritis/rheumatism causing functional limitations increased significantly from 2011-2012 to 2017-2018 by 9% ( = 0.028). Back/neck problems increased by 10% from 2011-2012 to 2015-2016 ( = 0.004). The predicted number of health problems causing functional difficulties was 1.81 times higher in those aged ≥80 years when compared to those aged 60 years ( < 0.001). CONCLUSIONS: Health conditions which attract higher attention from a public health point of view (e.g. cardiovascular disease or metabolic disorders) are less frequently reported among aging men when it comes to functional disabilities and physical functioning.
Association between triglyceride-glucose index and AVSS-rigiscan test parameters in men with erectile dysfunction.
Qian X, Gong Y, Ran C … +7 more , Yang R, Cai X, Xiang L, Jiang M, Tian H, Feng Y, Liu H
Aging Male · 2026 Dec · PMID 41671684 · Publisher ↗
BACKGROUND: Although elevated triglyceride-glucose (TyG) index has been shown to affect penile erection, the relationship between the TyG index and erection at the tip or base of the penis has not been extensively studie...
BACKGROUND: Although elevated triglyceride-glucose (TyG) index has been shown to affect penile erection, the relationship between the TyG index and erection at the tip or base of the penis has not been extensively studied. METHODS: We investigated the effect of the TyG index on penile tip and base erection through a retrospective analysis, including 276 patients with erectile dysfunction (ED) as the case group and 28 men without sexual dysfunction (from health checkups or premarital examinations) as the control group. The correlation between TyG index levels and penile tip/base erection was analyzed. RESULTS: We found that TyG index levels were negatively correlated with the average event rigidity of the tip (r = -0.220; 0.0001), the average event rigidity of the base (r = -0.143; = 0.013), and the average maximum rigidity of the tip (r = -0.165; = 0.004). Additionally, TyG index levels showed a negative correlation with ∆ tumescence of the tip (r = -0.124; = 0.031). CONCLUSION: Our data indicate that elevated TyG index is significantly associated with ED, and TyG index levels are negatively correlated with the parameters of the AVSS-RigiScan test.
Association between allostatic load and long-term survival in populations with high or low PSA levels: a national population-based analysis from NHANES 2003-2010.
Liu Y, Tian X, Zhu K … +6 more , Liu Z, Long Z, Hou K, Zhou Y, You Y, Chang D
Aging Male · 2026 Dec · PMID 41656497 · Publisher ↗
BACKGROUND: The present study aims to investigate the associations between the allostatic load index (ALI), prostate-specific antigen (PSA) levels, and certain causes of death among the participants. METHODS: Participant...
BACKGROUND: The present study aims to investigate the associations between the allostatic load index (ALI), prostate-specific antigen (PSA) levels, and certain causes of death among the participants. METHODS: Participants in this study were selected from the NHANES database (2003-2010) and linked to mortality files (the National Death Index, 2003-2010). Multivariate Cox proportional hazards models were used to analyze the effect of the allostatic load (AL) on PSA levels and all-cause mortality in participants. RESULTS: This study found that an increase in ALI exerted a certain impact on PSA levels in the entire participant population (especially in the subgroup with WWI < 0.5). Participants in the third quartile (T3) with the highest ALI index had a significantly 52% increased probability of all-cause mortality compared to those in T1 (OR = 1.52, 95% CI: 1.28, 1.76, < 0.01). Both RCS analysis and the K-M curve provide corroboration. When treated as a continuous variable, it is also associated with cardiac mortality (OR = 1.14, 95% CI: 1.04, 1.26, < 0.01). CONCLUSIONS: In a specific range, higher ALI was significantly and positively associated with PSA levels, all-cause mortality, and cardiovascular disease risk, though its link to cancer-specific mortality risk was not statistically significant in this study.
Examining the relationship between erectile dysfunction and the ZJU index in US adults: results from NHANES 2001-2004.
Ning W, Jia S, Li L … +2 more , Chen D, Wu B
Aging Male · 2026 Dec · PMID 41653065 · Publisher ↗
BACKGROUND: The ZJU index is a composite metric incorporating triglyceride (TG), fasting plasma glucose (FPG), the alanine aminotransferase (ALT) to aspartate aminotransferase ratio (AST) (ALT/AST), and body mass index (...
BACKGROUND: The ZJU index is a composite metric incorporating triglyceride (TG), fasting plasma glucose (FPG), the alanine aminotransferase (ALT) to aspartate aminotransferase ratio (AST) (ALT/AST), and body mass index (BMI). This study aimed to investigate the relationship between the ZJU index and the risk of erectile dysfunction (ED). METHODS: This analysis utilized data from 1,906 participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) dataset. We employed logistic regression modeling, smooth curve fitting, subgroup analysis, and threshold effect analysis to evaluate the association between the ZJU index and ED. The missing values in the covariates were filled by multiple interpolation. RESULTS: A significant positive association was observed between the ZJU index and ED risk (OR [95% CI] = 1.03 [1.01,1.05]). Analysis revealed a threshold at a ZJU index of 33.4, above which ED risk increased markedly, while the association was not significant below this value. Subgroup analysis indicated a stronger association in participants under 60 years of age. CONCLUSION: Higher ZJU index values are positively associated with an increased risk of erectile dysfunction, particularly among individuals under 60 years old. These findings suggest the potential utility of the ZJU index as a screening tool for ED risk assessment.
The role of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in erectile dysfunction: an integrated mendelian randomization, network pharmacology, and multi-omics study.
Li Y, Zhu G, Tan C
Aging Male · 2026 Dec · PMID 41634900 · Publisher ↗
PURPOSE: This study investigated the causal effect of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) on erectile dysfunction (ED) and elucidated its underlying molecular mechanisms through multi-omics integrati...
PURPOSE: This study investigated the causal effect of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) on erectile dysfunction (ED) and elucidated its underlying molecular mechanisms through multi-omics integration. METHODS: Mendelian randomization (MR) was applied to evaluate the causal effects of CMPF on ED and metabolic risk factors. Network pharmacology was used to identify overlapping molecular targets, followed by molecular docking to assess binding affinity. Multi-omics validation incorporated Summary-data-based MR (SMR) analyses of expression and protein quantitative trait loci (eQTL/pQTL) to confirm genetically regulated CMPF-related targets. RESULTS: MR analyses demonstrated a protective effect of CMPF on ED in both discovery (OR: 0.78, 95% CI: 0.62-0.98) and replication cohorts (OR: 0.82, 95% CI: 0.69-0.98), along with favorable associations with glucose metabolism, blood pressure, and lipid traits. Network analysis identified 42 shared targets, with DPP4, LGALS3, and NR3C2 as hub targets. Molecular docking showed strong binding affinities (≤-6.0 kcal/mol). SMR analyses highlighted LGALS3 as a key genetic mediator, supported by consistent eQTL and pQTL signals. CONCLUSIONS: CMPF exerts protective effects against ED and metabolic dysfunction through multi-target modulation, with LGALS3, DPP4, and NR3C2 as central regulators. These findings support CMPF as a diet-derived bioactive metabolite with potential for nutritional interventions and multi-target therapeutic strategies in ED.
Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis.
Li W, Li C, Li X … +1 more , Gao Z
Aging Male · 2026 Dec · PMID 41532675 · Publisher ↗
BACKGROUND: Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear. METHODS: We screened genetic instruments rel...
BACKGROUND: Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear. METHODS: We screened genetic instruments related to the gut microbiota and paired them with PCa genome-wide association study data to conduct Mendelian randomization (MR) analysis. Positive MR findings were then subjected to colocalization analysis. Subsequently, we utilized the Gene Expression Omnibus (GEO) dataset to perform differential expression analysis, aiming to identify differentially expressed associated genes (DEAGs). We determined the importance scores of these DEAGs through four machine learning models and constructed a nomogram based on these findings, and then validated it in another group of the GEO dataset. RESULTS: MR analysis found 16 gut bacteria causally linked to PCa (7 risk, 9 protective), with 144 related genes. PLCL1, VSNL1, ROR2, NRXN3, and TEAD1 were identified as feature genes for constructing a nomogram that provides a quantitative prediction of the risk of PCa onset. CONCLUSIONS: This study indicates that there are causal links between the gut microbiota and PCa. Feature genes may affect the occurrence of PCa by inhibiting the epithelial-mesenchymal transition, proliferation, migration, and invasion of cells.
A current profile of digital health literacy: patients undergoing holmium laser enucleation of the prostate (HoLEP). Different outcomes with population variation. A new prospective study.
Coşkun A, Mert MS, Akyol YK … +3 more , Can U, Çanakçi C, Di̇nçer E
Aging Male · 2026 Dec · PMID 41527383 · Publisher ↗
BACKGROUND: Digital health literacy (e-HL) is an increasingly popular analysis of patients' awareness of appropriate treatment modalities. This study aimed to evaluate e-HL levels in men undergoing Holmium laser enucleat...
BACKGROUND: Digital health literacy (e-HL) is an increasingly popular analysis of patients' awareness of appropriate treatment modalities. This study aimed to evaluate e-HL levels in men undergoing Holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH) and its potential impact on their quality of life. METHODS: A total of 106 patients scheduled for HoLEP were included. Age, body mass index (BMI), prostate-specific antigen (PSA), prostate volume, preoperative uroflowmetry values, e-HL scores, International Standard Classification of Education (ISCED) levels, and internet usage data were recorded. The EuroQoL Quality of Life (EQ-5D-5L) questionnaire was administered at three months postoperatively. Follow-up uroflowmetry results, IPSS scores, and quality of life (QoL) assessments were compared with e-HL scores. A cutoff value for digital health literacy was identified. RESULTS: The mean age was 68 years, BMI 29.1 kg/m², prostate volume 86.6 cc, and PSA 7.5 ± 4.6 ng/ml. The mean e-HL score was 16.8 ± 9.8, which was negatively correlated with age and BMI, positively with ISCED level and internet use ( < 0.001). The cutoff for adequate e-HL was 18.5. No significant correlation was found between e-HL and postoperative IPSS, EQ-5D-5L scores. CONCLUSION: e-HL levels in HoLEP patients were not associated with symptom severity, postoperative outcomes, or quality of life. Further multicenter studies are needed.
The reduction in total motile sperm count and the increase in sperm DNA fragmentation are associated with paternal age in normozoospermic men.
Liu CM, Chen HY, Hou HC … +5 more , Kuo JH, Lin TY, Lin YM, Wu MH, Cheng YS
Aging Male · 2026 Dec · PMID 41518014 · Publisher ↗
BACKGROUND: Normozoospermia does not guarantee fertility. Sperm DNA fragmentation (SDF) reflects intrinsic sperm quality and adverse reproductive outcomes, and double-strand breaks (DSBs) indicate more severe DNA damage....
BACKGROUND: Normozoospermia does not guarantee fertility. Sperm DNA fragmentation (SDF) reflects intrinsic sperm quality and adverse reproductive outcomes, and double-strand breaks (DSBs) indicate more severe DNA damage. METHODS: From July 2021 to February 2025, semen parameters, total motile sperm count (TMSC), and SDF from 534 normozoospermic men at National Cheng Kung University Hospital were retrospectively analyzed. Total DNA fragmentation (Total DFI) was measured using the sperm chromatin dispersion (SCD) test, and DSB DFI was assessed using the SDF Releasing (SDFR) assay. RESULTS: Paternal age correlated negatively with ejaculatory volume ( = -0.214, < 0.001), progressive motility ( = -0.184, < 0.001), and TMSC ( = -0.118, = 0.003), but positively with total DFI ( = 0.186, = 0.025). Although Total DFI did not differ significantly across the three age groups ( = 0.081), men ≥ 40 years had higher Total DFI than those < 40 years ( = 0.032). DSB DFI showed no difference. Total DFI correlated with DSB DFI ( = 0.298, = 0.005). Oligoasthenoteratozoospermic men exhibited higher total DFI than normozoospermic men ( = 0.048). CONCLUSION: Advancing paternal age is associated with reduced semen quality and increased sperm DNA fragmentation even among normozoospermic men.
Association between oxidative balance score and benign prostatic hyperplasia: an analysis based on the NHANES from 2003 to 2008.
Xie F, Yang Z
Aging Male · 2026 Dec · PMID 41510672 · Publisher ↗
PURPOSE: The pathophysiology of benign prostatic hyperplasia (BPH), a prevalent condition among aging males, remains unclear. Given emerging evidence implicating oxidative stress (OS) in prostatic pathogenesis, this stud...
PURPOSE: The pathophysiology of benign prostatic hyperplasia (BPH), a prevalent condition among aging males, remains unclear. Given emerging evidence implicating oxidative stress (OS) in prostatic pathogenesis, this study investigated the association between the comprehensive Oxidative Balance Score (OBS) and BPH prevalence. MATERIALS AND METHODS: The National Health and Nutrition Examination Survey (NHANES) database was selected to determine BPH using a self-report questionnaire, and multivariate logistic regression was performed to explore the correlation between OBS and BPH. Smoothed curve fitting, threshold effect analysis, and stratified analysis were performed. RESULTS: The present study, which ultimately included 621 participants, showed that after adjusting for potential confounders, an increase in OBS was associated with a slightly increased risk of developing BPH compared with the lowest tertile (T1) (OR = 1.07, 95% CI: 1.02,1.13, = 0.015; OR = 1.09, 95% CI: 1.01, 1.17, = 0.029). Smoothed curve fitting showed that when OBS was >21, the risk of developing BPH was associated with a 27% increase in the risk (OR = 1.27, 95% CI: 1.13, 1.43). CONCLUSION: This study reveals a significant non-linear association between OBS and BPH: when OBS > 21, higher OBS scores are associated with an increased risk of BPH.
Correlation of urodynamics and prostate-specific antigen levels with acute urinary retention in patients with benign prostatic hyperplasia.
Weng Y
Aging Male · 2026 Dec · PMID 41504374 · Publisher ↗
OBJECTIVE: Benign prostatic hyperplasia (BPH) is a common urinary disease in elderly men, with acute urinary retention (AUR) severely impacting quality of life. Urodynamic abnormalities and prostate-specific antigen (PSA...
OBJECTIVE: Benign prostatic hyperplasia (BPH) is a common urinary disease in elderly men, with acute urinary retention (AUR) severely impacting quality of life. Urodynamic abnormalities and prostate-specific antigen (PSA) levels reflect urinary obstruction and prostate enlargement/inflammation. This study was to correlate the two factors with AUR in BPH patients. METHODS: A total of 120 BPH patients were divided into AUR group and non-AUR group, with 60 cases in each group. Clinical, laboratory, and urodynamic data were collected. Independent variables with significant differences in univariate analysis were included in multifactorial logistic regression analysis. The diagnostic value of urodynamic parameters and PSA for AUR in BPH patients was assessed. A spline regression model was established to analyze the relationship between AUR and PSA. RESULTS: Elevated levels of urodynamic parameters volume at first desire to void (FDV), bladder compliance (BC), total PSA (tPSA), and free PSA (fPSA) were independent risk factors for AUR in BPH patients. FDV and tPSA showed high predictive efficacy, while BC and fPSA relatively weaker. tPSA was positively correlated with both FDV and BC. fPSA was positively correlated only with FDV. CONCLUSION: FDV and BC with tPSA and fPSA are significantly elevated in BPH patients with AUR and show a strong association.
Development and validation of a nomogram for the overall survival of patients with locally advanced prostate cancer treated with radiotherapy and surgery.
Zhang B, Yang Q, Sun H … +3 more , Liu M, Liang H, Ji H
Aging Male · 2026 Dec · PMID 41503827 · Publisher ↗
BACKGROUND: Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery....
BACKGROUND: Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery. METHODS: Clinical and pathological information was downloaded from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. The selected patients were randomly divided into a training cohort and a validation cohort at a ratio of 7:3. Univariate, multivariate Cox, and stepwise backward regression analyses were used to identify independent risk factors for OS. RESULTS: A total of 2810 elderly patients with locally advanced PC who received radiotherapy and surgery from 2010 to 2015 were included in this study. Age, marital status, Gleason score, tumor stage were identified as independent risk factors for PC patients. Age and marital status primarily reflect background mortality risk. The nomogram demonstrated favorable discrimination and calibration, with AUCs of 0.676-0.774 for 3-, 5-, and 8-year OS, indicating good predictive performance. Decision curve analysis further confirmed its superior clinical net benefit compared with the traditional tumor-node-metastasis staging model. CONCLUSIONS: We developed a new nomogram to predict OS in elderly patients with locally advanced PC treated with radiotherapy and surgery.
PhenoAgeAccel mediates the association between metabolic syndrome and cancer risk in males: a cross-sectional NHANES study.
Yang J, Zhang Y, Zeng P … +1 more , Jian X
Aging Male · 2026 Dec · PMID 41498362 · Publisher ↗
BACKGROUND: The relationship between metabolic syndrome (MetS) and cancer risk, and the potential mediating role of biological aging as measured by Phenotypic Age Acceleration (PhenoAgeAccel), remains insufficiently char...
BACKGROUND: The relationship between metabolic syndrome (MetS) and cancer risk, and the potential mediating role of biological aging as measured by Phenotypic Age Acceleration (PhenoAgeAccel), remains insufficiently characterized. METHODS: We conducted a cross-sectional study of 12,664 participants from the National Health and Nutrition Examination Survey (NHANES, 1999-2010, 2015-2020). MetS was defined according to established criteria, cancer status was self-reported, and PhenoAgeAccel was derived from clinical biomarkers. Weighted multivariable logistic regression and formal causal mediation analysis were employed. RESULTS: After full adjustment, MetS was significantly associated with increased cancer prevalence (OR = 1.338, 95% CI: 1.074-1.666, = 0.010). This association was more pronounced in males (OR = 2.383, < 0.05) and adults aged 20-65 years (OR = 1.573, < 0.05). Mediation analysis revealed that PhenoAgeAccel significantly accounted for 16.5% of the total effect of MetS on cancer (Average Causal Mediation Effect = 0.00352, < 0.001). Gender stratification indicated a statistically significant mediating effect in males (proportion mediated = 10.9%, = 0.002) but not in females (proportion mediated = 10.9%, = 0.086). The direct effect of MetS remained significant (OR = 1.265, = 0.050). CONCLUSION: MetS is associated with elevated cancer risk, with PhenoAgeAccel serving as a significant mediating pathway, particularly among males. These findings identify younger males as a high-risk subgroup for targeted preventive strategies.
Association of frailty index with all-cause mortality in US adults with testosterone deficiency: mediation by the platelet-to-HDL-C ratio (PHR).
Sun Y, Yin M, Zhou L
Aging Male · 2026 Dec · PMID 41460252 · Publisher ↗
BACKGROUND: The frailty index (FI), reflecting cumulative health deficits, is a strong predictor of adverse outcomes in older adults. However, its prognostic value for mortality among patients with testosterone deficienc...
BACKGROUND: The frailty index (FI), reflecting cumulative health deficits, is a strong predictor of adverse outcomes in older adults. However, its prognostic value for mortality among patients with testosterone deficiency (TD) remains unclear. METHODS: We analyzed 1,688 adults with TD from three NHANES cycles (2011-2016) with mortality follow-up through 2019. FI was constructed using a 49-item deficit model. Survival differences were evaluated with Kaplan-Meier curves, and survey-weighted Cox models assessed the association between FI and all-cause mortality. Restricted cubic splines and threshold analyses explored dose-response relationships. Mediation analysis examined the role of the platelet-to-HDL-C ratio (PHR). RESULTS: Frail participants exhibited significantly higher mortality risk than non-frail individuals (log-rank < 0.001). Per 1-SD increase in FI, mortality risk rose by 76% (HR = 1.76, 95% CI: 1.57-1.96, < 0.001). Threshold analysis showed a sharp increase in mortality when FI exceeded 0.095, approximating the conventional pre-frailty cut-off. PHR mediated 8.46% of the FI-mortality association. CONCLUSION: Higher FI was independently associated with increased all-cause mortality in TD patients, partly mediated by PHR. These findings highlight the prognostic significance of frailty and suggest PHR as a potential marker for personalized risk stratification and targeted intervention.
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