The Aging Male[JOURNAL]
Sun
200 papers
Effects of targeted therapy for RCC on LUTS in elderly male patients.
Xiaona L, Hailin R
Aging Male · 2025 Dec · PMID 40512120 · Publisher ↗
OBJECTIVE: Study on the effect of targeted drugs on lower urinary tract symptoms (LUTS) in elderly men. METHODS AND MATERIALS: A retrospective study was conducted on elderly male patients aged 60 and above with pathologi...
OBJECTIVE: Study on the effect of targeted drugs on lower urinary tract symptoms (LUTS) in elderly men. METHODS AND MATERIALS: A retrospective study was conducted on elderly male patients aged 60 and above with pathologically diagnosed renal cell carcinoma who received targeted drug therapy. Analyze the prostate volume, international prostate symptom score (IPSS), physical fitness score, and other indicators of these patients before and after receiving targeted therapy. So as to study the effect of targeted drugs on LUTS. RESULTS: A total of 47 patients were surveyed, with an average age of 70.32 ± 7.724 years, and age was significantly correlated with worsening of LUTS. The medication duration is 2-49 months; The average duration of medication was 13.72 ± 9.611 months. With the prolongation of targeted drug treatment time, the occurrence and aggravation of LUTS significantly increase.he logistic regression analysis results indicate that age and duration of medication are both risk factors for the deterioration of LUTS. CONCLUSIONS: It should be cause for concern that use of anti-vascular targeting drugs in elderly men may promote the side effects of LUTS.
Prevalence and association of functional dyspepsia in the elderly patients: a systematic review and meta-analysis.
Guo H, Zhong S, Wang X … +1 more , Chen J
Aging Male · 2025 Dec · PMID 40488355 · Publisher ↗
BACKGROUND: In the elderly, diagnosing and treating functional dyspepsia may be more challenging. The objectives of the study were to evaluate the prevalence and association of functional dyspepsia in adult individuals a...
BACKGROUND: In the elderly, diagnosing and treating functional dyspepsia may be more challenging. The objectives of the study were to evaluate the prevalence and association of functional dyspepsia in adult individuals and elderly populations (especially ≥64 years) in the year 2024-2025 literature available. METHODS: The study included a search of electronic articles, electronic books, and electronic book chapters using the keywords "dyspepsia" and "age" in PubMed, PubMed Central, and Google. RESULTS: A total of 27.5 ± 21.39%, 24.8 ± 21.86%, 23.83 ± 23.54%, 23.5 ± 25.06%, and 21.9 ± 24.63% are reported prevalence of dyspepsia in all study populations (1-100 years; 23 articles), for patients ≥50 years (20 articles), for patients >55 years (15 articles), for patients ≥64 years (15 articles), and for patients >70 years (12 articles), respectively. Mostly gastric symptoms, specific treatments, older age, and female gender were associated with functional dyspepsia. CONCLUSIONS: One in four individuals in every age group has functional dyspepsia among the included patients (25% of patients). The study reported a 23.5 ± 25.06% prevalence of functional dyspepsia for ≥64 years patients regardless of the definition used. Helicobacter infection, specific treatments, female gender, poorer sleep quality, and smoking are independent factors for the prevalence of functional dyspepsia in ≥64 years patients.
The INTIMA: development and validation of a new psychometric tool for the evaluation of perceived 'Viagra Jealousy' in erectile dysfunction therapy.
Mollaioli D, Sansone A, Jannini TB … +5 more , Hoai Nguyen B, Cao Nguyen T, Minh Pham Q, Ciocca G, A Jannini E
Aging Male · 2025 Dec · PMID 40439350 · Publisher ↗
BACKGROUND: In erectile dysfunction (ED) management the partner could support therapies or may sabotage them, as in the phenomenon of the "Viagra Jealousy" (VJ). Thus, we aimed to study the extent of cognitive and emotio...
BACKGROUND: In erectile dysfunction (ED) management the partner could support therapies or may sabotage them, as in the phenomenon of the "Viagra Jealousy" (VJ). Thus, we aimed to study the extent of cognitive and emotional discomfort in communicating and sharing ED treatment by creating a new tool, called INTIMA (Impact of Negotiating Treatment Intake on Marital Intimacy/Alliance Assessment). METHODS: 134 men diagnosed with ED completed a series of validated psychometric questionnaires, including INTIMA, the Fear of Intimacy Scale (FIS), and the Relationship Questionnaire (RQ). Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were conducted to assess the dimensionality and factorial validity of the INTIMA and its psychometric strength. RESULTS: CFA confirmed a single-factor structure with robust goodness-of-fit indices ([9] = 11.7, = 0.234; SRMR = 0.030; CFI = 0.991; TLI = 0.985; RMSEA = 0.047). The INTIMA demonstrated excellent internal consistency. Convergent validity was supported by significant correlation with FIS and adequate Average Variance Extracted. ROC analysis revealed high discriminatory power for detecting insecure attachment patterns, with an optimal cut-off score of 17. CONCLUSION: INTIMA is a reliable psychometric tool for assessing perceived VJ and predicting the risks of involving or not the partner in ED treatment and to identify optimal strategies for better adherence and outcomes.
Comment on: "the efficacy of platelet-rich plasma (PRP) alone or in combination with low-intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials".
Anıl H
Aging Male · 2025 Dec · PMID 40351026 · Publisher ↗
Abstract loading — click title to view on PubMed.
Central obesity and its association with benign prostatic hyperplasia: insights from a cross-sectional study of NHANES 2001-2008.
Wang H, Tang R, Hou H … +5 more , Liu M, Wang Y, Wang J, Liu J, Wang J
Aging Male · 2025 Dec · PMID 40325946 · Publisher ↗
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated. METHODS: In this stu...
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated. METHODS: In this study, we included a total of 4,625 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2008. We calculated indices related to central obesity for each participant and then employed univariate logistic regression, multivariate logistic regression, restricted cubic splines (RCS), and Akaike's Information Criterion (AIC) analysis. RESULTS: we found that the indices of Weight, Waist Circumference (WC), waist-to-Height Ratio (WHtR), and Body Roundness Index (BRI) were significantly elevated in the BPH group. In terms of dietary intake, we found that the intake of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol was significantly higher in the BPH group, with polyunsaturated fatty acids and cholesterol meeting the criteria for both univariate and multivariate regression analyses. CONCLUSION: Weight, WC, WHtR, and BRI can effectively improve the prediction of BPH, which may be associated with the high intake of polyunsaturated fatty acids and cholesterol. Appropriately adjusting the types and total amount of fat intake may prevent the occurrence of prostatic hyperplasia.
Concerns over the association between sperm DNA fragmentation and male infertility.
Sathian B, Al Hamad H, Iqbal J
Aging Male · 2025 Dec · PMID 40296785 · Publisher ↗
Abstract loading — click title to view on PubMed.
Prostatitis and male infertility.
Hua L, Gao X, Zhan J … +2 more , Wu X, Liu H
Aging Male · 2025 Dec · PMID 40270187 · Publisher ↗
Infertility is a pressing reproductive health issue in modern society, with male factors accounting for approximately 50% of all cases. However, most research on male infertility has primarily focused on the testis, ofte...
Infertility is a pressing reproductive health issue in modern society, with male factors accounting for approximately 50% of all cases. However, most research on male infertility has primarily focused on the testis, often ignoring the critical role of the prostate. As the largest male reproductive gland, the prostate plays a vital role in semen quality. Prostatic fluid, a major component of semen, significantly influences sperm function and overall male fertility. Prostatitis, the most common prostate disorder among men, particularly with advancing age, can severely impair reproductive health. This article aims to explore the fundamental physiological functions of the prostate, the etiology of prostatitis, and its impact on sperm health. It also discusses potential treatment strategies for prostatitis. Through this review, we hope to deepen understanding of the prostate's crucial role in male infertility.
Analysis of outcomes from a geriatrician-led evidence-based falls prevention clinic: a retrospective study from Qatar.
Al Hamad H, Sathian B
Aging Male · 2025 Dec · PMID 40110801 · Publisher ↗
BACKGROUND: Falls are an important health concern among older persons. This study attempted to evaluate the characteristics and risk factors of falls in older persons attending a geriatric falls clinic in Qatar, with a p...
BACKGROUND: Falls are an important health concern among older persons. This study attempted to evaluate the characteristics and risk factors of falls in older persons attending a geriatric falls clinic in Qatar, with a particular emphasis on the impact of the COVID-19 epidemic. METHODS: A retrospective analysis was performed on 265 patients aged ≥ 65 years who visited the Falls Clinic between January 1, 2019, and November 28, 2021. RESULTS: The study population showed a significant prevalence of chronic diseases, with hypertension (94.3%) and diabetes (87.5%) being the most common diseases. A substantial percentage of people reported functional difficulties, such as falls during the recent year and injuries. Interestingly, people recruited during the pandemic used assistive devices at a far higher proportion (46.9% vs. 5.5% previously). This group also reported higher rates of dizziness (54.9% vs. 26.7%, respectively) and pain (50.2% vs. 20.0%, respectively). Participants recruited during the epidemic had significantly elevated systolic blood pressure. CONCLUSION: This study showed an increased incidence of comorbidities and functional impairments in older adults who visited a fall prevention clinic in Qatar. These findings suggest that the pandemic may exacerbate population vulnerability.
National prevalence and incidence of benign prostatic hyperplasia/lower urinary tract symptoms and validated risk factors pattern.
Lin L, Wang W, Shao Y … +2 more , Li X, Zhou L
Aging Male · 2025 Dec · PMID 40084396 · Publisher ↗
BACKGROUND: To date, limited research has been conducted within China to elucidate the national prevalence and incidence rates of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Additionally, there...
BACKGROUND: To date, limited research has been conducted within China to elucidate the national prevalence and incidence rates of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Additionally, there is a scarcity of studies that have systematically investigated the reliable risk factor patterns associated with the development of BPH/LUTS among the Chinese population. METHODS: The study was in both cross-sectional and prospective cohort study design. The participants were derived from the China Health and Retirement Longitudinal Study (CHARLS). National prevalence and incidence of BPH/LUTS, average onset age of BPH/LUTS, medication rate of BPH/LUTS, and validated risk factors pattern of BPH/LUTS in the Chinese population were investigated. RESULTS: The overall prevalence and annual incidence of BPH/LUTS were 11.10% and 2.23%. In China, the male population affected by BPH/LUTS typically presented at an average age of 55-65 years. However, the medication rate was merely more than 30%. After conducting univariate and multivariate logistic regression analysis in both cross-sectional and prospective cohort study designs, we observed that dyslipidemia was the most stable risk factor of BPH/LUTS occurrence in three adjusted models (OR [95% CI]: 2.41 [1.37-4.25]; 2.05 [1.10-3.81] and 2.40 [1.19-4.84], respectively). CONCLUSIONS: This is the first study to delineate the prevalence and incidence of BPH/LUTS in Chinese, at the national level. The study reminded us that it was dyslipidemia rather than other chronic diseases or bad habits that posed a detrimental influence on BPH/LUTS occurrence in Chinese. Our data would facilitate the disease's early screening and medical policy formulation.
Sperm DNA damage and disturbed chromatin condensation indexes (DFI and CMA3) in normozoospermic men with unexplained infertility problem.
Abedinzadeh M, Abedinzadeh S, Sadeghi-Nodoushan F … +1 more , Pourrajab F
Aging Male · 2025 Dec · PMID 40062749 · Publisher ↗
PURPOSE: The quantitatively measured sperm DNA damage and disturbed chromatin condensation indexes (%DNA fragmentation index [DFI%] and %high DNA staining index [%HDS]) and their relationships with sperm quality in normo...
PURPOSE: The quantitatively measured sperm DNA damage and disturbed chromatin condensation indexes (%DNA fragmentation index [DFI%] and %high DNA staining index [%HDS]) and their relationships with sperm quality in normospermic men with unexplained infertility were investigated. The aim was also highlighting the impact of age on both DFI and CMA3 staining and on sperm quality, and their associations with male infertility. METHODS: In this retrospective study, conventional semen tests, including sperm motility and morphological evaluations and DFI and disturbed chromatin condensation indexes (DFI, CMA3) were performed according to the World Health Organization (WHO) 2021 criteria. DFI and CMA3 were evaluated using sperm chromatin dispersion (SCD) and chromomycin A3 (CMA3) staining assays and then correlation and regression analysis were done. RESULTS: By analyzing SCD and CMA3 results, notable differences were found in sperm parameters among different DFI and CMA3 groups (all < 0.05). It was found that in the male fertility quality sperm concentration, progressive (PR)/non-progressive (NP) motility, immobility, and morphology were significantly associated with sperm DFI and CMA3, but not with age ( < 0.05). CONCLUSIONS: Sperm molecular index DFI and CMA3 negatively affect male fertility quality through semen parameters (sperm concentration, motility, and morphology). SCD and CMA3 indexes show a significant negative correlation with sperm quality in normospermic males, which highlights its role in the assessment of male fertility potential and molecular evaluation of infertility treatment.
The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials.
Zhou Z, Wang Y, Chai Y … +4 more , Wang T, Yan P, Zhang Y, Yang X
Aging Male · 2025 Dec · PMID 40037837 · Publisher ↗
BACKGROUND: The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED)...
BACKGROUND: The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED). METHODS: This study integrated and analyzed the data using Cochrane method and GRADEpro GDT grading system. The registration number for this study was CRD42024618240. RESULT: Seven randomized controlled trials with 660 patients were analyzed. The results indicated that compared with the control group, IIEF score of patients in the PRP group improved significantly at 12-week ( = 0.03) and 24-week ( = 0.0004), while there was no significant difference at 4-week. The PRP group had no significant advantages over the control group in terms of MCID and SEP Q3. For peak systolic velocity, patients in the PRP group demonstrated greater improvement than those in the control group ( < 0.00001). Subgroup analysis revealed that adding PRP regimen can considerably improve IIEF scores of ED patients compared to using Li-SWT alone ( < 0.0001). CONCLUSION: PRP demonstrated a better efficacy in treating ED, especially during a follow-up period of 6 months. Compared with using Li-SWT alone, the addition of PRP can considerably improve the IIEF score of ED patients. These findings still required large-scale clinical trials for verification.
Preservation of sexual function with blue laser vaporization in the treatment of benign prostatic hyperplasia: a prospective study.
Hu ZJ, Liu F, Li BH … +5 more , Hu Y, Huang Q, Zhu C, Zeng XT, Zhao YW
Aging Male · 2025 Dec · PMID 40036096 · Publisher ↗
OBJECTIVE: Sexual function preservation is a paramount concern for patients undergoing benign prostatic hyperplasia (BPH) surgery, increasingly recognized by physicians. Blue laser vaporization, a novel approach for BPH...
OBJECTIVE: Sexual function preservation is a paramount concern for patients undergoing benign prostatic hyperplasia (BPH) surgery, increasingly recognized by physicians. Blue laser vaporization, a novel approach for BPH treatment, has yet to be thoroughly investigated for its effects on sexual function. This prospective study assesses the impact of blue laser vaporization on sexual function in BPH patients, focusing on patient perceptions. METHODS: This study prospectively enrolled BPH patients undergoing blue laser vaporization at our hospital since January 2023. We evaluated the treatment's effectiveness and its impact on preserving sexual function using standardized questionnaires. These included the International Index of Erectile Function (IIEF-5), the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD), and both the International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ-MLUTS) and its sexual function component (ICIQ-MLUTSsex). RESULTS: We included 67 BPH patients with a median age of 65 years in this study, monitoring them for over three months. The results indicate that blue laser vaporization significantly improved International Prostate Symptom Score, Quality of Life, and ICIQ-MLUTS scores in BPH patients ( < 0.001), along with a reduction in post-void residual volume ( < 0.001). Importantly, there were no significant changes in the IIEF-5 score, MSHQ-EjD score, and ICIQ-MLUTSsex score, indicating preservation of sexual function post-surgery. CONCLUSION: Blue laser vaporization effectively alleviates lower urinary tract symptoms in BPH patients while preserving erectile and ejaculatory functions.
Risk factors influencing fall risk in geriatric patients with type 2 diabetes: a comprehensive analysis.
Bayrak M, Kaşali K, Güner M … +3 more , Cadirci K, Kılıç AF, Binici DN
Aging Male · 2025 Dec · PMID 40022664 · Publisher ↗
BACKGROUND AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group. This study aime...
BACKGROUND AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group. This study aimed to identify fall risk factors in older adults with T2DM. MATERIALS AND METHODS: From January to June 2024, 242 T2DM patients aged 65 and older were followed at the internal medicine outpatient clinic. Fall risk was assessed using the Performance Oriented Mobility Assessment (POMA), Hendrich II Fall Risk Model (HIIFRM), Barthel Activities of Daily Living Index, and Clinical Frailty Scale (CFS). RESULTS: Among the patients (median age = 70 years), 41.3% had experienced at least one fall in the previous year. Factors, such as age and diabetes duration were associated with falls. Notably, hypoglycemia (aPR: 1.90, = 0.017), polypharmacy (aPR: 2.39, = 0.004), osteoarthritis (aPR: 2.48, = 0.017), (aPR: 1.70, = 0.025), and malnutrition (aPR: 1.90, = 0.007) were independently associated with fall risk. CONCLUSIONS: Fall risk in elderly outpatients with T2DM was linked to various factors, including hospitalization, malnutrition, osteoarthritis, polypharmacy, neuropathy, and hypoglycemia. To mitigate this risk, patient-specific care plans are recommended.
Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.
Sobay R
Aging Male · 2025 Dec · PMID 39967442 · Publisher ↗
BACKGROUND: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some p...
BACKGROUND: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation. OBJECTIVE: To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients. METHODS: A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups. RESULTS: Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, = 0.001) and SIRI(OR = 2.420, = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity. CONCLUSION: Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.
Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study.
Yao W, Wu J, Wang H … +6 more , Jia Z, Zhou Y, Yang C, Xu F, Kong Y, Huang Y
Aging Male · 2025 Dec · PMID 39773306 · Publisher ↗
OBJECTIVES: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States. METHODS: Analysis included multivariate linea...
OBJECTIVES: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States. METHODS: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests. RESULTS: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point. CONCLUSION: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.
The association between frailty and falls among individuals aged 60 years and older residing in community settings and experiencing hip fractures in China: a cross-sectional study.
Jiang L, Ding S, Wang J
Aging Male · 2025 Dec · PMID 39761176 · Publisher ↗
OBJECTIVES: Previous studies have established a correlation between frailty and an increased risk of falls among middle-aged and elderly individuals within community settings. The frailty status of hospitalized and commu...
OBJECTIVES: Previous studies have established a correlation between frailty and an increased risk of falls among middle-aged and elderly individuals within community settings. The frailty status of hospitalized and community-dwelling adults aged 60 or older with hip fractures is poorly investigated. This study aims to examine the relationship between frailty status and falls in China among community-dwelling and hospitalized individuals with hip fractures aged 60 and older. METHODS: Data from the Huangshan City People's Hospital's Department of Trauma and Orthopedics (a single center), and the China Health and Retirement Longitudinal Study (CHARLS) were used in this investigation. Falls were self-reported, and frailty was measured using the FRAIL scale. The association between frailty and falls was examined using logistic regression models, restricted cubic splines (RCS), and subgroup analysis. Appropriate adjustments were made for confounding factors, such as age, gender, marital status, education level, smoking, drinking, body mass index (BMI), hearing and vision impairment, hypertension, diabetes, medication history, exercise, and hip fracture. RESULTS: After applying the inclusion and exclusion criteria, 5224 subjects from CHARLS (male: 52.2%, female: 47.8%) and 174 patients from the trauma and orthopedic ward (male: 36.2%, female: 63.8%) were included. Analysis revealed a strong association between each additional point in the frailty score and an increased risk of fall in patients aged 60 and older (CHARLS, OR: 1.53, 95% CI: 1.41-1.66; A single center, OR: 1.57, 95% CI: 0.92-2.71). This association was even more pronounced in the pre-frail (CHARLS, OR: 1.95, 95% CI: 1.65-2.32; A single center, OR: 1.67, 95% CI: 0.46-6.08) and frail (CHARLS, OR: 3.43, 95% CI: 2.51-4.68; A single center, OR: 4.01, 95% CI: 0.61-26.41) groups compared to the control group. Subgroup studies revealed a sex-related interaction between frailty and falls in patients with hip fractures but not in older persons residing in the community. Furthermore, RCS regression revealed a linear correlation between frailty and falls in both groups. CONCLUSIONS: This study found a positive association between frailty status and falls in CHARLS and hip fracture patients from a single center. Gender differences in this relationship were observed only in hip fracture patients. These findings highlight the importance of frailty to community workers and clinical practitioners.
Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia.
Nguyen Cao T, Nguyen Hoai B, Dinh Huu V … +1 more , A Jannini E
Aging Male · 2025 Dec · PMID 39673527 · Publisher ↗
INTRODUCTION: Infertility is a major public health issue, with male factors alone contributing to 20-30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection t...
INTRODUCTION: Infertility is a major public health issue, with male factors alone contributing to 20-30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction. MATERIALS AND METHODS: We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns. RESULTS: The patients' mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men ( = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns. CONCLUSIONS: Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.
Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003-2004 data.
Wu L, Li B, Zhou H … +1 more , Liu X
Aging Male · 2025 Dec · PMID 39655442 · Publisher ↗
BACKGROUND: The aim of this study was to examine the relationship between the type/frequency of consuming beverages and ED among men in America. METHODS: We used data on erectile function and the frequency of beverage co...
BACKGROUND: The aim of this study was to examine the relationship between the type/frequency of consuming beverages and ED among men in America. METHODS: We used data on erectile function and the frequency of beverage consumption from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Associations between ED and beverage consumption were analyzed using univariate and multivariate logistic regression. We also stratified by age and adjusted for potential confounders using propensity score matching (PSM). RESULTS: After fully adjusting for covariates, logistic regression showed that regular grape juice consumption (≥ 5 times/week) was related to a lower prevalence of ED (OR = 0.21, 95% CI: 0.08-0.54, = 0.001). Subgroup analyses found that this correlation remained significant for those over 40 years of age (all < 0.05). After PSM adjustment, the association between grape juice consumption and ED remained statistically significant (OR = 0.12, 95% CI: 0.03-0.44, = 0.001). Various beverage types, encompassing tomato, orange, apple, pineapple, and lemonade juices, as well as soft drinks, exhibited a correlation with ED in the initial univariate regression analysis. CONCLUSIONS: In men, regular intake of grape juice (≥ 5 times/week) was associated with a lower prevalence of ED, which was particularly significant in men over 40 years of age.
Artificial urinary sphincter implantation after transperineal open reconstruction of post-prostatectomy vesicourethral anastomotic stenosis.
Marks P, Dahlem R, Fisch M … +4 more , Schuettfort VM, Vetterlein MW, Filipas DK, Ludwig TA
Aging Male · 2025 Dec · PMID 39654439 · Publisher ↗
PURPOSE: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontine...
PURPOSE: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence. METHODS: Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included. Primary outcomes were AUS explantation rates and patient-reported continence. Median follow-up was calculated using reverse Kaplan-Meier estimates, and explantation-free survival illustrated Kaplan-Meier analyses. RESULTS: At final follow-up, 19 patients were included at a median follow-up of 79 months. Explantation occurred in 16% ( = 3) of cases, with a median time to explantation of 107 months. No urethral erosion was observed. Explantation-free survival at 2, 5, and 10 years was 100%, 87%, and 73%, respectively. The median number of pads/day decreased significantly postoperatively, with 78% ( = 14) reporting subjective continence and 89% ( = 16) achieving social continence. CONCLUSION: AUS implantation following transperineal reanastomosis for VUAS post-RP offers favorable long-term outcomes, with low explantation rates and no erosion, making it a viable management strategy.
Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people.
Ojardias E, Leman M, Lafaie L … +3 more , Oriol P, Calmels P, Celarier T
Aging Male · 2025 Dec · PMID 39648754 · Publisher ↗
OBJECTIVE: to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations. CASE PRESENTATION: We report the diagnosis of FHH in an 88-y...
OBJECTIVE: to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations. CASE PRESENTATION: We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene. CONCLUSION: This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure.
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