Searches
/
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology[JOURNAL]
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology[JOURNAL]
Sun
200 papers
[Clinical symptoms and cone beam computed tomography imaging analysis of patients with temporomandibular joint osteoarthritis with chewing side preference before and after treatment of stabilization splint].
Li X, Wang J, Xu L … +5 more , Xu X, Li H, Hu M, Liu H, Jiang H
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919547 · Full text
OBJECTIVES: This study aimed to explore the clinical efficacy of stabilization splint (SS) and the characteristics of cone beam computed tomography (CBCT) imaging changes by analyzing the CBCT images and clinical symptom...
OBJECTIVES: This study aimed to explore the clinical efficacy of stabilization splint (SS) and the characteristics of cone beam computed tomography (CBCT) imaging changes by analyzing the CBCT images and clinical symptoms of patients with temporomandibular joint osteoarthritis (TMJOA) complicated with chewing side preference before and after treatment with SS. Me⁃thods A retrospective analysis was conducted on 74 TMJOA patients (aged 18-40 years) who visited the Department of Stomatology, First Medical Center, Chinese PLA General Hospital from June 2021 to January 2025. Among them, 31 patients had no chewing side preference (mean age: 29.81±2.99 years), and 43 patients had chewing side preference (mean age: 30.88±5.65 years). The CBCT imaging features and clinical symptoms of the two groups at the initial visit and follow-up (6 months later) were observed and analyzed. SPSS 27.0 software was used for data analysis. RESULTS: Comparison of patients without chewing side preference before and after SS treatment: the incidence of pain decreased from 100% to 3.23%, limited mouth opening from 96.77% to 3.23%, and joint noise from 80.65% to 38.71%, with statistically significant differences (<0.05). CBCT showed that the ipsilateral posterior joint space and superior joint space increased significantly (<0.05), whereas no significant differences were observed in the temporomandibular joint (TMJ) indices between the two sides (>0.05). Comparison of patients with chewing side preference before and after SS treatment: the incidence of pain decreased from 100% to 4.65%, limited mouth opening from 88.37% to 2.33%, and joint noise from 79.07% to 39.53%, with statistically significant differences (<0.05). CBCT showed that the medial-lateral diameter of the condyle, anterior-posterior diameter of the condyle, intra-articular space, posterior joint space, superior joint space, slope of the articular eminence, and condylar height on the habitual chewing side increased significantly (<0.05). Moreover, the medial-lateral diameter of the condyle, anterior-posterior diameter of the condyle, intra-articular space, posterior joint space, and superior joint space on the non-habitual chewing side increased significantly (<0.05). The posterior joint space, intra-articular space, and condylar height on the habitual chewing side were significantly larger than those on the non-habitual chewing side (<0.05). Comparison between patients with and without chewing side preference after SS treatment: no significant differences were found in pain, limited mouth opening, and joint noise between the two groups (>0.05). CONCLUSIONS: SS is effective in treating patients suffering from TMJOA with or without chewing side preference because it can effectively relieve joint pain, significantly improve mouth opening, and reduce the incidence of joint noise to a certain extent. Chewing side preference is closely related to the progression of TMJOA. Patients with TMJOA are recommended to receive early intervention with SS treatment, which is particularly important for those cases complicated with chewing side preference.
[Retrospective analysis of localized juvenile spongiotic gingival hyperplasia].
Lin Y, Cao R, Yao R … +1 more , Shang J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919546 · Full text
OBJECTIVES: This study aimed to review and summarize the clinical presentation and pathological features of localized juvenile spongiotic gingival hyperplasia (LJSGH) to enhance pediatric dentists' understanding of this...
OBJECTIVES: This study aimed to review and summarize the clinical presentation and pathological features of localized juvenile spongiotic gingival hyperplasia (LJSGH) to enhance pediatric dentists' understanding of this condition. METHODS: A retrospective analysis was conducted on the clinical and pathological data of patients with LJSGH diagnosed in the Department of Oral Pathology, Tianjin Stomatological Hospital from January 2019 to December 2024. RESULTS: Twelve cases were retrieved, the male-to-female ratio was 1.4∶1, and nine of the cases were children and adolescents (<18 years old). The typical clinical presentation was characterized by erythematous, hyperplastic gingiva exhibiting a papillary or granular appearance. The lesion was predominantly solitary and primarily located on the labial gingiva of the maxillary anterior region. The typical histopathological features were as follows: the superficial epithelium of the lesional area consisted of nonkeratinized stratified squamous epithelium with intercellular edema and spongiosis; irregular elongation of rete ridges; neutrophil infiltration in the superficial epithelial layer; marked vascular dilation and congestion in the subepithelial papillary layer; and a distinct boundary between the lesional epithelium and adjacent normal mucosal epithelium. CK19 exhibited strong positive expression throughout the lesion epithelium. By contrast, only the basal layer showed a strong positive expression in normal gingival tissues. CONCLUSIONS: LJSGH exhibits distinctive clinical features, and its diagnosis can be confirmed through histopathological examination. The fin-dings of this study contribute to enhancing pediatric dentists' understanding and recognition of LJSGH.
[Three-dimensional finite element analysis of the cantilever fixed bridge restoration for mandibular central incisors supported by narrow-diameter implants].
Zhou X, Gong Y, Peng W … +1 more , Fu G
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919545 · Full text
OBJECTIVES: To investigate the biomechanical behavior of three distinct types of narrow-diameter implants (NDIs) supporting a single-cantilever fixed bridge for mandibular central incisors using three-dimensional finite...
OBJECTIVES: To investigate the biomechanical behavior of three distinct types of narrow-diameter implants (NDIs) supporting a single-cantilever fixed bridge for mandibular central incisors using three-dimensional finite element analysis. METHODS: Three commonly used NDIs were selected: group Z1, Osstem one-piece implant with a dia-meter of 2.5 mm; group Z2, Anthogy Morse taper connected two-piece implant with a diameter of 2.8 mm; group Z3, Nobel Active screw-retained two-piece implant with a diameter of 3.0 mm. The three-dimensional finite-element model of cantilever fixed bridge supported by NDIs was constructed using finite element software. Vertical loads of 65 and 130 N and 45° oblique load were applied. von Mises stress of the implants and metal components, principal stress of the bone tissue, and stress distribution cloud map were calculated and analyzed. RESULTS: Under vertical load, only Z3 group implant reached a von Mises stress peak of 1 004.5 MPa at a load of 130 N, exceeding the material's yield strength. Under the 45° oblique load, the von Mises stress peaks of all three groups of NDIs excee-ded the material's yield strength. The stress cloud map revealed that the implant neck and surrounding bone tissue were the stress concentration areas. CONCLUSIONS: All three NDIs groups proved theoretically feasible under a 65 N axial load, with this study delineating the biomechanical safety boundary and highlighting the important risks posed by excessive or oblique loading.
[Mechanism of silibinin in renal injury induced by periodontitis in mice].
Hu M, Shang Y, Che Z … +3 more , Liu X, Deng Y, Yu W
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919544 · Full text
OBJECTIVES: This study aimed to explore the role and mechanism of silibinin in renal injury induced by periodontitis. METHODS: Twenty-four male C57BL/6J mice were randomly divided into three groups: normal control (Contr...
OBJECTIVES: This study aimed to explore the role and mechanism of silibinin in renal injury induced by periodontitis. METHODS: Twenty-four male C57BL/6J mice were randomly divided into three groups: normal control (Control), periodontitis (P), and periodontitis+silibinbin intervention (P+SB). Ligation with 7-0 silk thread around the maxillary second molar's neck was performed to generate a periodontitis animal model. Hematoxylin-eosin (HE), Masson staining, and micro-CT techniques were used to verify the successful construction of the periodontitis model. Renal injury degree was evaluated by renal histological exa-mination (HE, periodic acid-schiff, and Masson staining), ultrastructure observation under a transmission electron microscope, and blood biochemical index detection. The balance of oxidation and antioxidation in kidney tissue was observed by detecting the index of oxidative stress and MitoSOX Red fluorescence staining. The mRNA expression of mammalian target of rapamycin (mTOR) was detected by quantitative reverse transcription polymerase chain, and the localization and expression of mTOR in mouse kidney was further clarified using immunohistochemical staining. RESULTS: Compared with that in the Control group, gingival destruction and inflammation around the second molar were more evident in the P group. The alveolar bone was absorbed remarkably, as characterized by a decrease in bone volume fraction (BV/TV) and trabecular thickness and the widening of trabecular spacing. Renal tissue showed signs of renal injury, such as widening of Bowman space, exfoliation of renal tubular epithelial cells, morphological destruction of foot process, swel-ling of mitochondria, and disappearance of mitochondrial crest, accompanied with a significant increase in malondialdehyde (MDA) level, a decrease in glutathione (GSH) and superoxide dismutase (SOD) activities, and the activation of mTOR signal pathway. In the P+SB group, the destruction of gingiva and alveolar bone was significantly reduced, kidney injury was effectively alleviated, the MDA level decreased, SOD and GSH activities were recovered, and the mTOR signal pathway was significantly inhibited. CONCLUSIONS: Silibinin can effectively alleviate the oxidative stress injury of kidney and alleviate the renal injury caused by periodontitis by regulating the mTOR signal pathway.
[Safety study of resin-based dental materials using gas chromatography-mass spectrometry techniques].
Li Y, Zeng Y, Du Z … +1 more , Ren G
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919543 · Full text
OBJECTIVES: To investigate the clinical application safety of dental adhesives and composite resin-based dental materials. METHODS: A non-targeted screening of migrants from clinically used dentin adhesives and composite...
OBJECTIVES: To investigate the clinical application safety of dental adhesives and composite resin-based dental materials. METHODS: A non-targeted screening of migrants from clinically used dentin adhesives and composite resin materials was conducted using gas chromatography-mass spectrometry (GC-MS). Migration media included saliva simulants with pH of 5.5, 6.2, 7.4, and 8.0, 50% ethanol solution, and ultrapure water. By simulating migration under va-rious oral environments, six migrants were detected in the migration media. GC-MS/flame ionization detector was used for quantitative analysis of these migrants, and risk assessment was performed by combining their toxicity data. RESULTS: In all six migration media, the exposure levels of monomers and photoinitiators released from four commercially avai-lable resin-based dental materials were all within established safety thresholds. CONCLUSIONS: This study conducted nontargeted detection and safety assessment of migrants from dental restorative materials. The exposure levels of all detected compounds were below safety limits, providing scientific evidence supporting the clinical safety of composite resin-based dental materials.
[Dihydroartemisinin inhibits the progression of oral squamous cell carcinoma].
Shan T, Liu J, Liu T … +3 more , Sun D, Wang X, Liu Y
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919542 · Full text
OBJECTIVES: This study aimed to explore the impact of dihydroartemisinin (DHA) on cell proliferation, migration, and invasion in oral squamous cell carcinoma (OSCC). Our findings offer a theoretical foundation for advanc...
OBJECTIVES: This study aimed to explore the impact of dihydroartemisinin (DHA) on cell proliferation, migration, and invasion in oral squamous cell carcinoma (OSCC). Our findings offer a theoretical foundation for advancing the research and development of novel therapeutic agents for OSCC. METHODS: Bioinformatics analysis was conducted using the cancer genome database to classify OSCC patients based on the presence or absence of extracapsular spread and metastasis in tumor tissues, and to compare the differences in survival rates among different OSCC cell lines. The cell proliferation of different OSCC cell lines treated with different DHA concentrations was detected by CCK-8 cytoto-xicity assay, and the optimal drug concentration was screened. The CCK-8 cytotoxicity assay was used to detect the cell proliferation of different OSCC cell lines (CAL27, HN30, and SCC9) after treatment with different concentrations of DHA, and to screen out the optimal drug concentration. The effects of DHA on the proliferation of OSCC cells were detected by CCK-8 cell proliferation assay and cell cloning assay. The effect of DHA on the migration and invasion ability of tumor cells was detected by scratch test and Transwell test. A nude mouse subcutaneous tumor model was constructed to study the effects of DHA on OSCC tumor tissues and major organ. RESULTS: Bioinforma-tics analysis showed that the survival rate of patients with extracapsular spread and metastasis in tumor tissues was lower than that of patients without such phenomena (<0.05). According to CCK-8 cytotoxicity results, the maximum safe concentrations for different OSCC cell lines CAL27, HN30, and SCC9 were 20, 10, and 5 μmol/L, respectively. Proliferation and cloning experiments of CCK-8 cells showed that DHA could inhibit the proliferation of three squamous cell lines (<0.05). Scratch test and Transwell test showed that the migration and invasion levels of CAL27, HN30, and SCC9 cells were significantly decreased under DHA treatment (<0.05). experiments showed that the growth rate of tumor tissue significantly decreased after DHA treatment (<0.05). CONCLUSIONS: DHA exhibits significant inhibitory effects on the proliferation, migration, and invasion of various OSCC cells and growth of tumor tissues.
[Oral homeostasis imbalance under hypoxia].
Xu Y, Wang S, Zhou J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919541 · Full text
Hypoxia disrupts oral homeostasis through multiple interconnected pathways, including interference with tooth germ development, impairment of salivary gland function and salivary buffering capacity, compromise of the ora...
Hypoxia disrupts oral homeostasis through multiple interconnected pathways, including interference with tooth germ development, impairment of salivary gland function and salivary buffering capacity, compromise of the oral mucosal barrier, imbalance in jawbone and alveolar bone remodeling, and alterations in the diversity and functionality of the oral microbiome. These disturbances collectively contribute to the onset and progression of oral diseases. Moreover, disruption of oral homeostasis may, in turn, affect systemic homeostasis, increasing the risk of disorders in other organ systems through mechanisms involving inflammatory mediator release and microbial translocation. Here, we systematically review the effects and underlying mechanisms of hypoxia exposure on oral homeostasis, and further explore the interconnections between hypoxia-induced oral dysregulation and systemic homeostatic imbalance. This review aims to provide a comprehensive understanding of the regulatory networks linking oral and systemic homeostasis under hypoxia, thereby offering potential insights for maintaining homeostatic balance.
[Whole genome sequencing and analysis of familial nonsyndromic congenital tooth agenesis].
Zheng Y, Wang D, Jiang T … +2 more , Yang D, Lu H
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919540 · Full text
Congenital tooth agenesis impairs masticatory function and aesthetics and adversely affects craniofacial development. Although largely considered genetic in origin, its exact etiology remains unclear. This study reports...
Congenital tooth agenesis impairs masticatory function and aesthetics and adversely affects craniofacial development. Although largely considered genetic in origin, its exact etiology remains unclear. This study reports three familial cases of nonsyndromic congenital tooth agenesis (NSTA). Whole genome sequencing (WGS) revealed five pathogenic variants: filamins-B (FLNB) (c.5186C>A, p.Ser1729Ter), methylcrotonyl coenzyme a carboxylase 2 (MCCC2) (c.91C>T, p.Gln31Ter; c.484C>T, p.Gln162Ter; c.340C>T, p.Gln114Ter), laminin subunit alpha 2 (LAMA2) (c.1084A>T, p.Arg362Ter), cathepsin C (CTSC) (c.748C>T, p.Arg250Ter), and chromatin remodeling protein microrchidia family CW-type zinc finger 4 (MORC4) (c.1726C>T, p.Arg576Ter). Among these variants, LAMA2 was associated with a severe tooth agenesis phenotype. The findings offer novel clues toward understanding the etiopathogenesis of this condition.
[Comparative analysis of microbial communities in different oral ecological niches of preschool children].
Liu J, Sun Y, Wu J … +2 more , Tang S, Ding G
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919539 · Full text
OBJECTIVES: This study aims to investigate the structural differences, dominant bacterial genera, and potential functions of microbial communities in different oral ecological niches (dorsal tongue, tooth surface, and bu...
OBJECTIVES: This study aims to investigate the structural differences, dominant bacterial genera, and potential functions of microbial communities in different oral ecological niches (dorsal tongue, tooth surface, and buccal mucosa) of preschool children to clarify the influence of local microenvironments on microbial colonization and provide a theoretical basis for the microbiota-targeted regulation of pediatric oral diseases. METHODS: A total of 105 plaque samples were collected from the dorsal tongue, tooth surface, and buccal mucosa of 35 healthy preschool children (aged 4-6 years). High-throughput sequencing of the 16S rRNA gene was performed to analyze the microbial community structure and alpha/beta diversity. Principal coordinate analysis, UPGMA clustering, and LEfSe analysis were used to identify niche-specific dominant genera. PICRUSt2 was applied to predict the potential metabolic functional profiles across niches. RESULTS: Spatial hete-rogeneity in microbial composition and structure was observed across the three oral niches. Species richness was significantly higher on the tooth surface and buccal mucosa than on the dorsal tongue. The dominant phyla included Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Fusobacteria, and Patescibacteria. At the genus level, Actinomyces and Corynebacterium were enriched on the tooth surface, Veillonella was enriched on the dorsal tongue, and Streptococcus was predominant on the buccal mucosa. Beta diversity and clustering analyses confirmed distinct microbial community structures among the niches. LEfSe analysis identified several niche-specific genera. PICRUSt2 functional prediction revealed significant differences in amino acid metabolism, carbohydrate metabolism, cell motility, translation, signal transduction, immune system, infectious disea-ses, and membrane transport (<0.05). CONCLUSIONS: The dorsal tongue, tooth surface, and buccal mucosa in preschool children harbor distinct microbial communities with different taxonomic composition, diversity, and functional potential. The findings suggest that local microenvironmental factors shape oral microbiota and may contribute to the early onset of oral diseases. This study provides foundational data and theoretical insights for early microbiome-based risk assessment and personalized oral health interventions in children.
[Clinical efficacy and prognostic factors of pulpotomy combined with fragment reattachment in treating complicated crown-root fractures of maxillary young permanent anterior teeth].
Yang X, Wang Y, Chen C … +3 more , Ding G, Liao X, Liao Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919538 · Full text
OBJECTIVES: This study aimed to evaluate the clinical efficacy of pulpotomy combined with fragment reattachment in treating complicated crown-root fractures of maxillary young permanent anterior teeth. METHODS: A retrosp...
OBJECTIVES: This study aimed to evaluate the clinical efficacy of pulpotomy combined with fragment reattachment in treating complicated crown-root fractures of maxillary young permanent anterior teeth. METHODS: A retrospective analysis of 37 cases of complicated crown-root fractures treated at Shenzhen Children's Hospital from January 2019 to December 2023 was conducted. Outcomes such as fragment retention rate, pulp survival rate, root development, and periodontal health were assessed, and the influencing factors were analyzed. RESULTS: The fragment retention rates were 80.9% at 1 year and 69.5% at 2 years. The remaining crown height (cervical half group vs. incisal half group) emerged as a critical predictor of retention (<0.05, hazard ratio=7.45, 95% confidence interval: 1.28-43.48). The pulp survival rate reached 91.6% at 1 year, with no significant influencing factors identified. In cases where the fractured crown retained for over one year, teeth at Nolla stage 8 showed significantly greater root elongation and apical foramen narrowing compared to those at Nolla stage 9 (<0.05), normal periodontal scores were observed in 59.3%. CONCLUSIONS: Pulpotomy combined with fragment reattachment effectively preserves pulp vitality and restores dental function and morphology in young permanent anterior teeth. The remaining crown height serves as a key prognostic indicator for fragment retention. This approach also promotes root development and demonstrates favorable clinical outcomes.
[Analysis of associated factors for the ectopic eruption of adjacent first permanent molars after stainless steel crown restoration of second primary molars].
Dai W, Huang S, Zhang Z … +2 more , Sun X, Zhang F
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919537 · Full text
OBJECTIVES: This study aims to analyze the related factors of ectopic eruption of adjacent first permanent molars after the restoration of stainless-steel crowns of the second primary molars. METHODS: The experimental gr...
OBJECTIVES: This study aims to analyze the related factors of ectopic eruption of adjacent first permanent molars after the restoration of stainless-steel crowns of the second primary molars. METHODS: The experimental group consisted of 19 patients, and 25 second primary molars with stainless steel crown restorations were examined. The patients presented with ectopic eruption of the corresponding first permanent molars. The control group included 19 patients, from whom 29 second primary molars with stainless steel crown restorations were examined. Notably, the corresponding first permanent molars erupted normally. The panoramic radiographs of all participants were analyzed, and va-riables, such as patient age, gender, ectopic eruption positions of the first permanent molars, and the distal margi-nal adaptation of the stainless-steel crowns, were asses-sed. The tilt angles of the first permanent molars, second primary molars, and the intersection angle between the long axes of the two teeth were measured. Data were subjected to statistical analysis using Pearson's chi-square test and independent -tests. RESULTS: A significant positive correlation was identified between the distal marginal adaptation of the stainless-steel crowns and the ectopic eruption of the corresponding first permanent molar (OR=9.14, 95% CI: 1.06-79.26, <0.05). Compared with the control group, the experimental group exhibited a smaller angle between the long axes of the maxillary first permanent molar and the second primary molar (6.51°±4.46°, <0.05). Additionally, the mandibular first permanent molar had a more pronounced inclination (43.66°±10.56°, <0.05), and the angle between the long axes of the mandibular first permanent molar and the second primary molar was significantly larger (25.39°±10.79°, <0.05) in the experimental group. CONCLUSIONS: Prior to the restoration of second primary molars with stainless steel crowns, evaluating the potential risk of ectopic eruption of the corresponding first permanent molar is essential. This step is particularly important when ectopic eruption is present in the remaining quadrants. When the angle between the long axes of the maxillary first permanent molar and the second primary molar is excessively small, the inclination of the mandibular first permanent molar is extremely large, or the angle between the long axes of the mandibular first permanent molar and the second primary molar is extremely large, the use of stainless-steel crowns should be minimized, or preventive measures should be considered. Special attention must be given to the distal marginal adaptation during stainless steel crown restoration to prevent the formation of steps on the distal surfaces.
[Facial scarless surgical approach for mandibular condyle fracture].
Chen J, Liu L
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919536 · Full text
The selection of surgical approaches for mandibular condylar fractures faces dual challenges of anatomical complexity and the risk of complications. This article reviews conventional approaches and proposes a classificat...
The selection of surgical approaches for mandibular condylar fractures faces dual challenges of anatomical complexity and the risk of complications. This article reviews conventional approaches and proposes a classification system centered on anatomical pathways. In light of the growing emphasis on aesthetic demands and advances in minimally invasive techniques, the evolution and implementation of the "facial scarless" concept are discussed. Particular attention is given to the endoscopic intraoral and retroauricular transmeatal approaches, with analysis of their clinical applications, advantages, and limitations, aiming to provide insights for optimizing individualized surgical strategies in the management of condylar fractures.
[Expert consensus on perioperative management of tooth extraction in patients receiving denosumab therapy].
Ye L, Cao Y, Sun G … +25 more , Xue Y, Cui N, Cai Y, Zou D, Tang H, Hu Y, Luo T, Sun L, Gong Z, Zhu F, Zhang F, You M, Guo Y, Wang Y, Wang L, Chen S, Han B, Zhang W, Zhou Q, He Y, Zhao J, Hu K, Liu L, Liu J, Pan J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Apr · PMID 41919535 · Full text
Denosumab is a humanized monoclonal antibody targeting receptor activator of nuclear factor-κB ligand (RANKL) and is commonly used in the treatment of osteoporosis and cancer-related bone metastases. However, the persist...
Denosumab is a humanized monoclonal antibody targeting receptor activator of nuclear factor-κB ligand (RANKL) and is commonly used in the treatment of osteoporosis and cancer-related bone metastases. However, the persistent use of denosumab has been associated with an increasing incidence of denosumab-related osteonecrosis of the jaw (DRONJ), particularly following tooth extraction. This expert consensus aims to develop clinical management guidelines for the perioperative period of tooth extraction in patients who are currently receiving or have previously received denosumab therapy. The consensus covers the definition, etiology, epidemiology, staging, and risk factors of DRONJ, focusing on preoperative assessment, risk-based prevention strategies, minimally invasive surgical techniques, and postoperative follow-up protocols. The core management strategy for DRONJ emphasizes individualized decision-making based on a comprehensive preoperative assessment of medication history, local infection, and systemic conditions. The main risk factors for DRONJ include high-dose and long-term denosumab therapy, preexisting oral infections, such as periodontitis and periapical periodontitis, and invasive dental procedures, including tooth extraction, diabetes, and concomitant use of glucocorticoids or antiangiogenic agents. Core preventive measures include strict perioperative oral care, risk assessment-based antibiotic prophylaxis, long-term drug holidays, which were developed by dentists and physicians prio-ritizing the primary disease, and minimally invasive surgical techniques for managing trauma, preserving local blood supply, thoroughly removing infected tissues, and ensuring tight wound closure. This consensus highlights the importance of multidisciplinary collaboration between dental and clinical medicine experts in managing DRONJ. High-quality research is necessary to provide an evidence-based foundation for optimizing DRONJ prevention and treatment strategies.
[Clinical study on bi-rooted primary canines].
Xu L, Qiu F, Shu L … +2 more , Meng S, Cai J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916719 · Full text
OBJECTIVES: The incidence and clinical characteristics of bi-rooted primary canines were investigated by performing oral panoramic radiographs. METHODS: A total of 100 976 oral panoramic radiograph of subjects aged 3-9 y...
OBJECTIVES: The incidence and clinical characteristics of bi-rooted primary canines were investigated by performing oral panoramic radiographs. METHODS: A total of 100 976 oral panoramic radiograph of subjects aged 3-9 years old were collected, and the incidence and distribution of bi-rooted primary canines were observed and recorded. The obtained data were analyzed using SPSS 25.0 statistical software, and the literature on bi-rooted primary canine was reviewed to record patient's data. RESULTS: The incidence of bi-rooted primary canines was 0.37‰ (37/100 976), of which 0.59‰ (32/54 276) occurred in males and 0.12‰ (5/46 700) in females. Statistically significant difference was observed between males and females (=15.955, =0.000). The number of bi-rooted primary canine in 37 children was mainly 1-2. Among them, 11 subjects (29.73%) had one bi-rooted primary canine, and 18 subjects (48.65%) had two bi-rooted primary canines. The tooth position distribution of 76 bi-rooted primary canines showed no significant difference between the left and right sides (=1.316, =0.251). However, significant difference was found between the upper and lower jaws (=15.213, =0.000) and between the unilateral and bilateral sides (=6.083, =0.014). CONCLUSIONS: Bi-rooted primary canines are rare, mostly occur in 1-2 teeth, and are more common in males than females, in the upper jaw than in the lower jaw, and on both sides than on one side.
[Comparative study on the treatment of molar-incisor hypomineralization].
Shan X, Yang Q, Yang X … +4 more , Yang Y, Ma Y, Zhao Z, Li R
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916718 · Full text
OBJECTIVES: This study aimed to evaluate the efficacy of different treatment methods on local plaque lesions of incisors and the sealing of pits and fissures in first permanent molars in patients with mild molar-incisor...
OBJECTIVES: This study aimed to evaluate the efficacy of different treatment methods on local plaque lesions of incisors and the sealing of pits and fissures in first permanent molars in patients with mild molar-incisor hypomineralization (MIH). METHODS: Patients clinically diagnosed with mild MIH were selected as research subjects for a prospective clinical comparative study on the treatment of local plaque lesions in incisors and the pits and fissures of first permanent molars. Infiltrative resin and fluoride varnish were used to treat local plaque lesions on incisors. The area of local plaque lesions on incisors and lightness (L), red-green hue (a), and yellow-blue hue (b) of the lesion area were measured before treatment and at 1, 3, and 6 months after treatment. The color difference value (ΔE) and tooth whiteness index (WI) were then calculated. Two methods, phosphoric acid etching pit and fissure sealing and self-etching pit and fissure sealing, were used for the treatment of pits and fissures of first permanent molars. The incidence rate of caries, sealant retention rate, and success rate of pit and fissure sealing for the two methods were calculated at 1, 3, and 6 months after treatment. RESULTS: In patients with mild MIH, local plaque lesions on incisors exhibited a significant reduction in area at 1, 3, and 6 months post-treatment in the infiltrative resin group (<0.05), whereas no significant change was observed in the fluoride application group (>0.05). After infiltrative resin treatment, the L value and ΔE value showed a decreasing trend (<0.05), whereas the L value in the fluoride application group did not change significantly (>0.05). In patients with first permanent molars, the phosphoric acid etching pit and fissure sealing group exhibited superior success and retention rates at 6 months post-treatment compared with the self-etching pit and fissure sealing group (<0.05) and a lower loss rate than the self-etching pit and fissure sealing group (<0.05). CONCLUSIONS: Infiltrative resin treatment can reduce the L value and ΔE value of local plaque lesions on incisors in patients with mild MIH. It demonstrates a significant improvement in plaque lesion area, with relatively stable effects within 6 months. Phosphoric acid etching is recommended for the pit and fissure sealing of first permanent molars in patients with mild MIH.
[Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries].
Yang C, Yu J, Zhang Y … +5 more , Liu F, Pang Q, Xie Y, Ran L, Qiu R
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916717 · Full text
OBJECTIVES: A community intervention mo-del was used to investigate the preventive effects and cost-effectiveness of I-ReHealth and Duraphat in early childhood caries. METHODS: Children from Yizhou District, Hechi City,...
OBJECTIVES: A community intervention mo-del was used to investigate the preventive effects and cost-effectiveness of I-ReHealth and Duraphat in early childhood caries. METHODS: Children from Yizhou District, Hechi City, were enrolled and randomly assigned into two groups: the I-ReHealth group and the Duraphat group. Each group received topical fluoride varnish applications and dental health education every 6 months. After 1.5 years, the incidence of caries and associated costs were compared between the two groups before and after the intervention. Cost minimization analysis was employed to evaluate economic efficiency, and sensitivity analysis was performed to assess the influence of variations in key parameters on result stability and to quantify the probabilistic differences in cost benefits between the two fluoride varnishes under equivalent caries-preventive effects. RESULTS: Prior to the intervention, we found no statistically significant differences in caries prevalence or mean dmft scores between the two groups (>0.05). After 1.5 years of treatment, both groups still showed no statistically significant differences in caries prevalence (>0.05), mean dmft scores (>0.05), caries incidence rate (>0.05), or increment in mean dmft (>0.05). The one-sided 97.5% confidence interval for the difference in mean dmft increment was below the non-inferiority threshold, confirming non-inferiority (<0.025). Cost minimization analysis revealed lower total costs in the I-ReHealth group (¥25 411.44) than in the Duraphat group (¥26 692.98). One-way sensitivity analysis identified material price as the most influential parameter affecting total costs. Monte Carlo simulation with 1 000 iterations demonstrated a 73.1% probability that the I-ReHealth group will yield cost savings compared with the Duraphat group. CONCLUSIONS: I-ReHealth is non-inferior to Duraphat® in caries-preventive efficacy but superior in cost-effectiveness in reducing patient expenses.
[Clinical efficacy of simple taper-retained external connection narrow-diameter implants applied in the narrow alveolar ridge of the premolar region: a 5-8-year follow-up study].
Wu H, Cao N, Cao L … +5 more , Yu F, Zhang X, Wei S, Wei H, Guo S
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916716 · Full text
OBJECTIVES: To evaluate the clinical efficacy of the simple taper-retained external connection narrow-diameter implant JUST J1 MINI (J1 implant) applied in the narrow alveolar ridge of the premolar region for 5-8 years....
OBJECTIVES: To evaluate the clinical efficacy of the simple taper-retained external connection narrow-diameter implant JUST J1 MINI (J1 implant) applied in the narrow alveolar ridge of the premolar region for 5-8 years. METHODS: Sixty-six patients who attended the Department of Stomatology of the Fourth Affiliated Hospital of Nanchang University for implant restoration in the premolar region from January 2017 to March 2020 were selected. A total of 87 simple taper-retained external connection narrow-diameter implants were implanted into the narrow alveolar ridge of the premolar region in the immediate postoperative period after implantation without any bone augmentation surgery. CBCT and surface tomography films were taken after the completion of final crown restoration and at the time of final follow-up. With a mean follow-up of 78.9±9.0 months, the survival rate of the J1 implants, rate of abutment loosening and shedding, amount of bone resorption at peri-implant margins, and changes in the bone width and height of the implants were observed. RESULTS: At the final follow-up of 5-8 years, two implants failed when they loosened at three and four months after surgery, and the implant survival rate was 97.7%. The bone resorption values of the distal and mesial margins were 0.719 mm±0.495 mm and 0.722 mm± 0.604 mm, respectively. The bone height and width resorption of the implants were 0.581 mm±0.346 mm, 0.209 mm±0.118 mm. CONCLUSIONS: The results of long-term follow-up after 5-8 years showed that J1 implants in the narrow alveolar ridge of premolar teeth without bone augmentation can reduce surgical trauma, simplify implant surgery, and satisfy a certain degree of aesthetics and masticatory function in patients. Therefore, J1 implants have good long-term clinical results and expand the indications for implant restorations in the narrow alveolar ridge.
[Root fracture in endodontically versus nonendodontically treated posterior teeth: the cone beam computed tomography characteristics in Chinese population].
Fu C, Pan X, Liu S … +1 more , Lin Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916715 · Full text
OBJECTIVES: This study aimed to investigate the clinical and cone beam computed tomography (CBCT) characteristics of root fractures in endodontically versus nonendodontically treated posterior teeth. METHODS: A total of...
OBJECTIVES: This study aimed to investigate the clinical and cone beam computed tomography (CBCT) characteristics of root fractures in endodontically versus nonendodontically treated posterior teeth. METHODS: A total of 340 posterior teeth from 305 patients were retrospectively collected. The fractured teeth were divided into endodontically treated (ET) teeth and nonendodontically treated (NET) teeth. The clinical information (age and gender of patients) was recorded. The type of fractured tooth, fractured root, orientation of fracture lines (vertical, horizontal, oblique, and irregular), direction of vertical fracture lines, location of horizontal root fractures, and bone resorption around fractured roots were evaluated and recorded based on CBCT images. RESULTS: 1) The distribution of teeth was significantly different between NET and ET teeth (=0.028). Root fractures predominantly occurred in mandibular and maxillary molars. However, the proportion of premolars was significantly higher in ET teeth (27.2%) than in NET teeth (14.2%). 2) We observed a significant difference in root distribution between NET roots and ET roots (=0.037). The mesial roots of mandibular molars were the most common fractured roots in NET and ET roots (36.4% in NET roots and 32.2% in ET roots); however, the second most common roots were the palatal roots of maxillary molars in NET roots (23.0%) and the maxillary premolar roots in ET roots (20.3%). 3) A statistically significant difference in the orientation of root fractures was observed between the two groups (<0.001). Vertical root fractures accounted for only 43.6% of all root fractures in NET root fractures, whereas they accounted for 75.6% in ET root fractures. 4) For vertical root fractures, the direction of fracture lines between NET and ET root fractures was not significantly different (=0.58), with both types predominantly presenting as buccal-palatal fractures (86.0% and 84.1%). 5) No significant difference was observed in the location of horizontal fractures between NET and ET root fractures (=0.132), and the most common site was the cervical third of roots. 6) Bone loss around fractured lines significantly differed between NET and ET root fractures (<0.001). Around 59% exhibited obvious bone loss around fractured roots in NET root fractures, whereas 91.8% of fractured roots presented bone loss in ET root fractures. CONCLUSIONS: The NET root fractured teeth and ET root fractured teeth presented quite different clinical and CBCT characteristics. The complex and diverse traits of NET root fractured teeth indicate the influence of multifaceted occlusal factors in their occurrence. By contrast, ET root fractured teeth demonstrate high uniformity, indicating that their occurrence may be related to the structural changes caused by endodontic treatment.
[Adhesive property and flexural strength of patterned microstructured zirconia posts fabricated by 3D printing].
Jiang Q, Yin L
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916714 · Full text
OBJECTIVES: This study aims to design surface patterns using integrated programming software on zirconia posts fabricated through 3D printing. METHODS: A type 3 3M fiber post was built as a research model, and HyperMill...
OBJECTIVES: This study aims to design surface patterns using integrated programming software on zirconia posts fabricated through 3D printing. METHODS: A type 3 3M fiber post was built as a research model, and HyperMill 2021 software was applied to design linear overflow grooves extending from the apex to the base on the post surface. The design parameters included the number, depth, and width of the overflow grooves. Five groups of patterned microstructured zirconia posts were designed, with the 3M fiber post as the control group. Micro-push-out and three-point bending tests were used to measure the bon-ding and flexural strengths of the patterned microstructured zirconia posts. The failure mode of bonding was analyzed by using a stereomicroscope. RESULTS: The patterned microstructure significantly increased the bond strength of zirconia posts (<0.05). Bonding strength ranged from 9.80 MPa±0.64 MPa to 26.49 MPa±0.94 MPa at the base of the root, from 9.26 MPa±1.08 MPa to 18.51 MPa±0.93 MPa at the center of the root, and from 6.74 MPa±0.31 MPa to 13.00 MPa±0.71 MPa at the apex of the root. The implementation of patterned microstructures reduced the flexural strength of the zirconia post (<0.05), and flexural strength ranged from 378.3 MPa±24.18 MPa to 587.4 MPa±36.60 MPa. The failure mode of zirconia post adhesions treated with patterned microstructures was mainly mixed failure. CONCLUSIONS: Patterned microstructured zirconia posts with improved flexural strength and adhesive properties could be produced by using 3D printing. The bonding and flexural strengths of the patterned zirconia posts can meet the clinical requirements for custom post-and-core design.
[Mechanism underlying carvacrol-induced alveolar bone repair via the phosphatidylinositol 3-kinase pathway in periodontal disease].
Teng N, Li Z, Gao T … +3 more , Xiang Y, Zhou L, Gao X
Hua Xi Kou Qiang Yi Xue Za Zhi · 2026 Feb · PMID 41916713 · Full text
OBJECTIVES: This study aims to explore the mechanism of carvacrol (CV) in regulating alveolar bone repair in periodontal disease. METHODS: A rat model of periodontal disease (P group) was created by ligating the first mo...
OBJECTIVES: This study aims to explore the mechanism of carvacrol (CV) in regulating alveolar bone repair in periodontal disease. METHODS: A rat model of periodontal disease (P group) was created by ligating the first molar and injecting lipopolysaccharide (LPS). A control model (C group) was also created. The treatment models received low (L group), medium (M group), and high (H group) doses of CV hydrogel. Hematoxylin-eosin (HE) staining was used to observe the pathological changes in periodontal tissues. Immunohistochemical staining was employed to analyze the expression of collagen typeⅠ(COL1) and Runt-related transcription factor 2 (Runx2). , the rat osteoblast cells were divided into C, P, L, M, H, CV and CV+LY294002 (CV+LY) groups. Western blot analysis detected the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK-3β) pathway-related and osteoblastic proteins. Quantitative reverse-transcription po-lymerase chain reaction was used to measure the expression of inflammatory factors and osteoblastic proteins. The alkaline phosphatase (ALP) colorimetric kit and alizarin red S staining kit were utilized to assess osteogenic ability. Immunofluorescence (IF) was used to detect COL1 expression in osteoblasts. Transmission electron microscopy was applied to detect cell apoptosis. RESULTS: CV hydrogel alleviated periodontal symptoms, upregulated PI3K/AKT/GSK-3β pathway-related and osteoblastic proteins, and increased the expression of ALP and the number of calcified nodules. However, it decreased cell apoptosis and inflammatory factors. LY294002 inhibited the PI3K/AKT pathway and decreased osteoblastic protein expression, ALP coloration, and calcified nodule quantity. CONCLUSIONS: CV hydrogel promotes the proliferation and differentiation of alveolar bone osteoblasts by activating the PI3K pathway and inhibiting inflammation-induced bone resorption. This study emphasizes the potential of CV for the treatment of periodontal diseases.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe