Zhonghua Er Bi Yan Hou Ke Za Zhi[JOURNAL]
Sun
200 papers
[Expression and distribution of aquaporin-2 in nasal polyps].
Zhang X, Yuan YY, Gu WP … +3 more , Mu JS, Qu Y, Gao HT
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743636
OBJECTIVE: To study the distribution and expression of aquaporion-2 (water channel protein; AQP-2) in nasal polyps and to evaluate the role of AQP-2 in the formation of nasal polyps. METHODS: Eleven samples of normal inf...
OBJECTIVE: To study the distribution and expression of aquaporion-2 (water channel protein; AQP-2) in nasal polyps and to evaluate the role of AQP-2 in the formation of nasal polyps. METHODS: Eleven samples of normal inferior turbinates and forty-six samples of nasal polyps were used. In the group of nasal polyps, there were ten cases of type II phase 1, twelve type II phase 2, ten type II phase 3 and fourteen type III. The expression of AQP-2 in both groups was studied with immunohistochemical technique. RESULTS: 1. Both the number of AQP-2 positive cells and the area density in the epithelial cell layer from nasal polyps were higher than those from inferior turbinates (P < 0.01, P < 0.05 respectively); In the group of nasal polyps, the area density from type III, type II phase 2 and type II phase 3 was significantly higher than that from type II phase 1 (P < 0.05); 2. Both the number of AQP-2 positive cells and the area density in the subepithelial tissue from type III, type II phase 2 and type II phase 3 nasal polyps were higher than those from type II phase 1 nasal polyps and inferior turbinates(P < 0.05), whereas the difference between the latter two was not significant(P > 0.05). CONCLUSION: The high expression of AQP-2 protein in nasal polyps may contribute to the genesis and development of nasal polyps.
[Research of relationship between endoneurial fluid pressure and electroneurography of the facial nerve].
Chen B, Wang DH, Wang ZM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743635
OBJECTIVE: The relationship between endoneurial fluid pressure (EFP) and electroneurography (ENoG) of the facial nerve was studied in order to evaluate the ENoG as the basis of pathophysiology of the decompression of the...
OBJECTIVE: The relationship between endoneurial fluid pressure (EFP) and electroneurography (ENoG) of the facial nerve was studied in order to evaluate the ENoG as the basis of pathophysiology of the decompression of the facial nerve. METHODS: The values of ENoG were recorded by an instrument of physiology on the normal and crushed facial nerves of guinea pigs. Endoneurial fluid pressures were measured by a servo-nulling micropipette system at the same time. After the EFP were measured, the facial nerves were removed and fixed properly for examination under the light and electron microscope in order to determine the differences from various periods after injury. RESULTS: EFP in the facial nerve was changed significantly during the period of three days to three weeks later after crushed injury, and the percentage of degenerated facial nerve fibre was the same. There was positive correlation between ENoG and EFP. After crushed injury 2 and 3 weeks, the coefficient was 0.88 and 0.51, respectively. It could be found that extensive edema in endoneurial and perivascular spaces of the facial nerve occurred in early stage of injury, but numerous Schwann cells proliferation appeared in the later period. CONCLUSION: The change of ENoG could reflect the value of EFP relatively within three weeks after crushed injury. It was suggested that ENoG could be useful in evaluating the pathogenesis underlying facial palsy. And it could be provided a basis indication for decompression of the facial nerve.
[Effect of linopirdine on potassium currents in isolated outer hair cells and Deiters' cells of the cochlea from guinea pig].
Chang Q, Gong SS, Ding J … +2 more , Tang M, Hescheler J
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743634
OBJECTIVE: To study the effect of linopirdine, a selective blocker of KCNQ channel family, on the whole-cell potassium currents in isolated outer hair cells (OHCs) and Deiters' cells of the cochlea from guinea pig and to...
OBJECTIVE: To study the effect of linopirdine, a selective blocker of KCNQ channel family, on the whole-cell potassium currents in isolated outer hair cells (OHCs) and Deiters' cells of the cochlea from guinea pig and to probe the distribution of KCNQ channel family in OHC and Deiters' cells. METHODS: Using the patch clamp whole-cell recording, IK (tetraethylammonium-sensitive outward potassium currents) and IKa (inward potassium currents activated at negative potential) were measured before and after the administration of linopirdine in OHCs. Simultaneously, IK (the outward rectifier potassium current) was recorded in Deiters' cells. RESULTS: IK was partly reduced after the administration of linopirdine in OHCs, moreover, IKa was totally inhibited. However, IK in Deiter's cells was not decreased. CONCLUSION: KCNQ channel family could only involve in constructing the variant potassium channels in outer hair cells, but not in Deiters' cells.
[Experimental study of sodium nitroprusside on whole cell calcium currents of outer hair cells in the cochlear of guinea pigs].
Zhou JB, Kong WJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743633
OBJECTIVE: To study the effects and mechanism of sodium nitroprusside (SNP), a donor of nitric oxide, on the calcium currents of isolated outer hair cells (OHCs) from the cochlear of guinea pigs. METHODS: Acute isolated...
OBJECTIVE: To study the effects and mechanism of sodium nitroprusside (SNP), a donor of nitric oxide, on the calcium currents of isolated outer hair cells (OHCs) from the cochlear of guinea pigs. METHODS: Acute isolated outer hair cells of guinea pigs were performed, and the whole cell patch clamp recording techniques were used. The K+, Na+ ions were excepted to study effects of SNP on the calcium currents of outer hair cells. RESULTS: SNP inhibited the inward calcium currents of OHCs. Under the condition of holding at -60 mV and stimulation voltage as +10 mV, SNP (10 mmol/L) inhibited (61.12 +/- 1.99)% of the whole cell's calcium currents (n = 5). A dose-reaction response was obtained from 5-8 cells. The half inhibiting concentration was 1.9 mmol/L while the maximum inhibiting concentration was 100 mmol/L, but Hill coefficient was 0.98. SNP could selectively block the L-type calcium channels on outer hair cells (n = 6). CONCLUSION: As a donor of nitric oxide, SNP could affect the physiology function of outer hair cells by inhibition of the calcium currents by blocking the L-type calcium channels.
[Long-term outcomes and analysis of its relative factors of nasal endoscopic sinus surgery in children].
Zhou B, Han DM, Liu HC … +5 more , Liu M, Huang Q, Zhang L, Wang JL, Zhang YJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743632
OBJECTIVE: To evaluate the results of endoscopic sinus surgery (ESS) in children with chronic sinusitis. The long-term outcomes and the relative factors were analyzed retrospectively. MATERIALS AND METHODS: A total of 26...
OBJECTIVE: To evaluate the results of endoscopic sinus surgery (ESS) in children with chronic sinusitis. The long-term outcomes and the relative factors were analyzed retrospectively. MATERIALS AND METHODS: A total of 268 children (432 sides), 186 males and 82 females, aged 3 to 17 years (average, 14.3) were included in this study (underwent ESS). The postoperative follow-up time of 188 cases (305 sides, 70.1%) was over one year. The management during follow-up was adopted under nasal endoscope and local anesthesia. The postoperative treatment included cleaning operative cavity, nasal irrigation, antibiotics, steroid, immune regulator, etc. RESULTS: Overall cases included 89 cases (147 sides) of chronic sinusitis, 86 cases (142 sides) of nasal polyps and 13 cases (16 sides) of mucocele respectively. The cure rate was 70.2% (132 cases). 43 cases (22.9%) were improved, while other 13 cases were of no effect. Overall symptoms, 93.1% children with headache were improved, 85.1% children were free of nasal obstruction and 60.1% children gained a relief of purulent discharge. 11 cases had no change and 2 cases were worse compared with before surgery. 34 cases with anosmia were improved or recovered after ESS. The total effective rate of ESS was 93.1%. 8 cases received a revision ESS. CONCLUSIONS: ESS in children with chronic sinusitis and polyps has a good long-term outcomes. The reasonable reservation of mucosa during ESS must be emphasized. The quality of follow-up is an important factor affecting the results of ESS. Whether the disciplinary preoperative management was made or not is the hypothesis of ESS indications.
[Acute fulminant invasive fungal sinusitis].
Liu M, Zhou B, Liu HC … +3 more , Zhang SZ, Wang YX, Huang Q
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743631
OBJECTIVE: To discuss the clinical presentation, diagnostic criterion and treatment principle of acute fulminant invasive fungal rhinosinusitis (AFFS). METHODS: Six patients were diagnosed as AFFS based on history, nose,...
OBJECTIVE: To discuss the clinical presentation, diagnostic criterion and treatment principle of acute fulminant invasive fungal rhinosinusitis (AFFS). METHODS: Six patients were diagnosed as AFFS based on history, nose, especially eye symptoms with or without fever, sinus CT and MRI, endoscopic and cytological findings in the nasal cavity. Surgical debridement was performed on 5 of 6 biopsy proven AFFS patients, one of them being amputated of the orbital content. With the original disease controlled simultaneously, 4 of 5 patients were prescribed with systemic amphotericin B or liposomal amphotericin B (1 case) and one with Itraconazole orally. One patient had not been involved with any of the anti-fungi measures. RESULT: Mucor (Zygomycetes) was identified on culture in 1 patient, Rhizopus species in 2, Aspergillus in 1, Alternaria in 1 and mixed Mucor and Rhizopus in 1. All patients were proved of tissue invasion histopathologically through biopsy. One patient died without any anti-fungi therapy on the 7th admission day, 3 patients survived for 88 days, 32 and 6 months respectively and died of original diseases (diabetes 1, leukaemia 2). One patient survived 9 months and lost for follow-up, 1 patient survived 11 months after treatment. CONCLUSION: A high index of suspicion and early endoscopic investigation through nasal cavity with fungal investigation should highly be strengthened for recognition of this disease. MRI findings should be considered as, or even more, important as that of CT scan on the early diagnoses. Extensive and aggressive surgical debridement, prompt and enough dosage of antifungal therapy intravenously, together with serious controlling of the underlying disease, all take important roles in the complete control of the disease.
[A study of the link between upper and lower respiratory inflammation].
Wang XD, Han DM, Zhou B … +7 more , Wei YX, Bai WZ, Liu ZY, Ju SY, Pang BS, Fan EZ, Li Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743630
OBJECTIVE: To evaluate the correlation between upper and lower respiratory inflammation. METHODS: Thirty rats were randomly divided into allergic rhinitis group (AR), asthma group (AS), and control group (Con). The pulmo...
OBJECTIVE: To evaluate the correlation between upper and lower respiratory inflammation. METHODS: Thirty rats were randomly divided into allergic rhinitis group (AR), asthma group (AS), and control group (Con). The pulmonary function was measured by pulmonary function instrument of animal model, the infiltration of eosinophils and mast cells was detected by hematotoxylin-eosin staining (HE staining) and toluidine blue staining respectively, the expression of VCAM-I and IL-13 was examined by immunohistochemistry. ELISA was used to measure the concentration of IL-5 in the peripheral serum. RESULTS: The numbers of eosinophils and mast cells in nasal mucosa and lung tissue of AR were both significantly higher than those of Con, and similar results were observed between AS and Con. The forced expiratory volume in 0.3 second (FEV0.3)/forced vital capacity (FVC) of AR and AS was both significantly lower than that of Con. The numbers of VCAM-I and IL-13 positive vessels in lung tissue of AR were both significantly higher than those of Con, and similar results were observed between AS and Con. The concentration of IL-5 in the serum of AR and AS was both significantly higher than that of Con. The concentration of IL-5 in serum was positively correlated with the number of eosinophils in peripheral blood of AR and AS. CONCLUSION: The inflammation is similar between AR and AS, and repeatedly challenge upper respiratory tract can impact on lower respiratory response.
[Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa].
Wang CS, Dong Z
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743629
OBJECTIVE: To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of na...
OBJECTIVE: To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of nasal mucosa. METHODS: Specimens from 30 patients with chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA. RESULTS: All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005). CONCLUSION: It is suggested that epithelial in nasal mucosa were not just a physical barrier, which could represent a novel defense mechanism of the host during bacterial infections through Toll-like receptors.
[Application of CO2 laser and T tube in the treatment of the laryngeal stenosis].
Wang J, Han DM, Ye JY … +3 more , Lin ZH, Li QZ, Ge XM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515787
OBJECTIVE: To introduce a new method for treating laryngeal stenosis of both children and adults using silicon T tube and CO2 laser. METHODS: Twenty-two cases stenosis of adults and children were treated with silicon T t...
OBJECTIVE: To introduce a new method for treating laryngeal stenosis of both children and adults using silicon T tube and CO2 laser. METHODS: Twenty-two cases stenosis of adults and children were treated with silicon T tube and CO2 laser. The tracheotomy were enlarged upward, the laryngeal cavity scar was removed by using CO2 laser and the laryngeal cavity was exposed by distending laryngoscope under general anesthesia. The follow up time is between 1 to 3 years. RESULTS: The 22 cases were successfully decanulated postoperatively in 12 to 24 months. Silicon 4 cases's T tube were either too high or too low and had second operation. CONCLUSION: The method for treating laryngeal stenosis of both children and adults using silicon T tube and CO2 laser are effective, easy to operate, less invasive and have a short recovery interval.
[Acoustic analysis of the voice restored by using a tracheoesophageal slit-like fistula].
Jin GW, Yang CH, Xu KX … +5 more , Xu ZR, Li SC, Chen J, Zhang JX, Zhang ZL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515786
OBJECTIVE: To evaluate the quality of voice restored by using a tracheoesophageal slit-like fistula objectively through acoustic analysis. METHODS: Seven objective voice parameters (fundamental frequency, intensity, dura...
OBJECTIVE: To evaluate the quality of voice restored by using a tracheoesophageal slit-like fistula objectively through acoustic analysis. METHODS: Seven objective voice parameters (fundamental frequency, intensity, duration, formant F1, F2, F3 and their energy, jitter, and shimmer) of esophageal speech, Blom-Singer prosthesis voice, tracheoesophageal slit-like fistula voice, primary or modified surgical restored, and normal voice were analyzed and compared. RESULTS: T test was used for statistical analysis. The maximum phonation time of slit-like fistula voice was shorter than that of normal voice, longer than that of esophageal voice, no significant difference compared with that of Blom-Singer prosthesis voice. Its sound intensity of it was similar to that of normal voice and Blom-Singer voice, better than that of esophageal voice. Its fundamental frequency was lower than that of normal voice. Its shimmer and jitter was more than that of normal voice, less than that of esophageal voice, and similar to that of Blom-singer one. Compared with esophageal voice, all formants but F1 of it were not statistically different. No statistical difference between the 2 groups of slit-like fistula patients, i.e., the instant slit-like fistula construction after total laryngectomy and the second stage slit-like fistula construction. CONCLUSION: The voice quality of the patients with tracheoesophageal slit-like fistula is similar to that of the normal and could meet the needs of daily life.
[Distant metastases and their significant indicators in laryngeal cancer].
Liu WW, Zeng ZY, Guo ZM … +3 more , Xu GP, Yang AK, Zhang Q
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515785
OBJECTIVE: To investigate the factors on distant metastases (DM) of laryngeal cancer. METHODS: 277 cases of laryngeal cancer hospitalized in Cancer Center of Sun Yat-sen University from 1990 to 1995 were reviewed. 18 cas...
OBJECTIVE: To investigate the factors on distant metastases (DM) of laryngeal cancer. METHODS: 277 cases of laryngeal cancer hospitalized in Cancer Center of Sun Yat-sen University from 1990 to 1995 were reviewed. 18 cases with DM were investigated to confirm the distant metastatic rate, target organ, time interval, and prognosis. Kaplan-Meier and Cox model analysis were used to find the significant indicators for DM in laryngeal cancer. RESULTS: The overall incidence of DM in laryngeal cancer was 6.5% (18/277). The target site of DM was mainly in lung 83.3% (15/18), liver 16.7% (3/18). 3 cases with DM in lung also combined with bone metastases which occurred in vertebra 1, lib 1 and 1 in multi-sites. 2 patients were diagnosed DM when admitted, and the rest with time interval between 1 and 103 months (median 7 months). The 3-year and 5-year cumulative survival in laryngeal cancer with DM was 23.8% and 11.9% respectively. The time interval between the presentation of DM and death was 2.77 months (median 4.6 months). The worst prognosis is liver metastasis with which the patient could survive 4.6 months at most in our study. Kaplan-Meier analysis in 277 laryngeal cancers showed that pathology, pathological differentiation of squamous cell carcinoma, N stage, and clinical stage were significant indicators for DM from laryngeal cancer. Cox model analysis showed that only N stage was the significant prognostic factor for DM in laryngeal cancer (Wald = 7.889, P = 0.005). CONCLUSION: Laryngeal cancer has certain percentage of DM, which is mainly in lung and their prognosis is usually poor. Non-squamous cell carcinoma, low pathological differentiation, cervical metastasis and advanced cancer are the possible indicators for DM, but our study shows that only N stage significantly predicts DM from laryngeal cancer.
[A pathologic analysis on 9,666 cases of tumors of nose, pharynx and throat].
Xie YC, Liu WP, Jiang YM … +4 more , Zhao Y, Tang QL, Liang CY, Liu YH
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515784
OBJECTIVE: To analyze nasal, pharyngeal and laryngeal tumor patients age, sex and tumors' sites, to find out the relationship of above indices and tumor's pathologic types. METHODS: 9,666 cases of tumors on nose, pharynx...
OBJECTIVE: To analyze nasal, pharyngeal and laryngeal tumor patients age, sex and tumors' sites, to find out the relationship of above indices and tumor's pathologic types. METHODS: 9,666 cases of tumors on nose, pharynx and throat diagnosed in West-China Hospital in 1984 to 1999 were analyzed for the constitution of histological type. RESULTS: 1. the ratio of benign and malignant tumor is 1:8.6, it is 1:62.0 in nasalpharynx; 2. papilloma, angiofibroma and angioma are more commonly seen in all 21 kinds of benign tumors; 3. differentiated squamous cell carcinoma, non-keratinized is the most common types in 25 kinds of malignant tumors, the ratio of carcinoma and sarcoma is 11.98 to 1; 4. The average age of patients with malignancy is about 10 years older than that of the patients with benign tumors, and malignant patients are male predominant; 5. squamous cell papilloma of oralpharynx was the most common in all benign tumors; nasopharyngeal carcinoma is the most common in all malignancies, nasal lymphomas are the most common seen sarcoma. CONCLUSION: The histologic types of nasal, pharyngeal and laryngeal tumors are related with patients' age, sex and sites of tumors.
[Expression of the metastasis-associated gene 1 in laryngeal squamous cell carcinoma: correlation with cervical lymph node metastasis].
Tang QF, Ji WY, Pan ZM … +2 more , Zheng Y, Guan C
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515783
OBJECTIVE: The purpose of study was to examine the mRNA expression levels of the metastasis-associated gene1 (MTA1) in laryngeal squamous cell carcinoma (LSCC), so to evaluate its relationship with metastases. METHODS: F...
OBJECTIVE: The purpose of study was to examine the mRNA expression levels of the metastasis-associated gene1 (MTA1) in laryngeal squamous cell carcinoma (LSCC), so to evaluate its relationship with metastases. METHODS: Forty-eight surgically resected primary LSCC (16 supraglotti laryngeal carcinomas with cervical lymph node metastasis, 16 supraglotti laryngeal carcinomas with cervical lymph node-negative metastasis, 16 glottic carcinoma with cervical lymph node-negative metastasis) and 16 normal laryngeal mucosa was examined for mRNA expression of MTA1 by reverse transcription-polymerase chain reaction(RT-PCR). RESULTS: The frequency of MTA1 mRNA positive expression in 16 LSCC with cervical lymph node metastasis was 100%, but no expression of MTA1 mRNA was observed in other LSCC with cervical lymph node-negative metastasis (16 supraglotti laryngeal carcinomas and 16 glottic carcinoma) and 16 normal laryngeal mucosa. CONCLUSION: MTA1 gene is strongly related to cervical lymph node metastasis of LSCC, and may serve as a early diagnosis indicator.
[Supraorbital keyhole approach in the treatment of intranasal meningoencephaloceles].
Hua QQ, Wu ZY, Liu RZ … +2 more , Liao H, Wang GA
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515782
OBJECTIVE: To explore the effect and significance of endoscopic surgery for intranasal meningoencephaloceles via the supraorbital keyhole approach. METHODS: From January 1999 to December 2001, seven cases of intranasal m...
OBJECTIVE: To explore the effect and significance of endoscopic surgery for intranasal meningoencephaloceles via the supraorbital keyhole approach. METHODS: From January 1999 to December 2001, seven cases of intranasal meningoencephaloceles were treated by mini-invasive endoscopic surgery via supraorbital keyhole approach. The operation was carried out through supraorbital keyhole craniotomy approximately 2.0-2.5 cm in diameter following a skin incision just in the eyebrow. The roughly 3-4 cm skin incision began medial to the supraorbital nerve and ended within the lateral edge of the eyebrow. After the frontal lobe was elevated and the skull base defects exposed, the hernia sac was cut off at bone defect and the lump was resected via nasal cavity. The bone defect were repaired using bone flap, self fat, fascia of rectus abdominis muscle and Ear-Brain Glue. RESULTS: Seven patients were successfully treated at initial operation without recurrence and cerebrospinal fluid leak during follow-up 6 months to 2 years after surgery. CONCLUSION: The supraorbital keyhole approach is a safe approach in the hands of experienced surgeons for the mini-invasive treatment of meningoencephaloceles.
[Management of esthesioneuroblastoma of the Fulda surgical concept].
You XJ, Draf W, Bockmühl U
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515781
OBJECTIVE: To summaries the treatment strategy of esthesioneuroblastoma (ENB). METHODS: Between 1988 and 2001, 17 patients with ENB were treated at the Department of Otorhinolaryngology of the Klinikum Fulda. All patient...
OBJECTIVE: To summaries the treatment strategy of esthesioneuroblastoma (ENB). METHODS: Between 1988 and 2001, 17 patients with ENB were treated at the Department of Otorhinolaryngology of the Klinikum Fulda. All patients were monitored on an outpatient basis after completed therapy with a median follow-up of 44 months. In a retrospective review, the patients' charts, the computed tomography, and magnetic resonance imaging scans, the operation reports, and the follow-up data were analyzed, particularly with respect to the surgical approaches. RESULTS: All tumors were staged according to Morita. One patient was classified as stage A, six stage B, nine stage C, and one stage D. All patients received surgical resection. Ten patients were disease free for at least 2 years, whereas 6 patients died because of ENB and one due to other disease. Of 10 patients who were free of disease, the tumors were removed via a transnasal approach in 6 patients using the microscope in combination with the endoscope. These tumors resected endonasally were staged as A (1 case) and B (5 cases). In ENB of stage C a craniofacial resection was performed using a subfrontal approach or the midfacial degloving. The lateral rhinotomy was applied only in cases in which an exenteration orbitae had to be carried out. CONCLUSION: ENB is best managed by complete surgical resection followed by adjuvant stereotactic radiation therapy. The Fulda surgical concept in management of anterior skull base tumors is also forwarded to resection of ENB. It classifies the following indications: 1) Endonasal approach in cases without tumor infiltration of the orbit and/or the brain; 2) Subfrontal approach in cases with extended tumor infiltration of the intradural space or the brain; 3) Midfacial degloving in cases with far lateral tumor spread, particularly fossa pterygoidea or pterygopalatina; 4) Lateral rhinotomy in all cases where an exenterative orbita is needed.
[Study of bleeding during surgery of chronic sinusitis and nasal polyp influenced by preoperative treatment].
Shi JB, Yang QT, Wen WP … +1 more , Xu G
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515780
OBJECTIVE: To explore the method of reducing bleeding during endoscopic sinus surgery for chronic sinusitis and nasal polyp. METHODS: Bleeding during surgery and the effective rate of two groups patients with chronic sin...
OBJECTIVE: To explore the method of reducing bleeding during endoscopic sinus surgery for chronic sinusitis and nasal polyp. METHODS: Bleeding during surgery and the effective rate of two groups patients with chronic sinusitis and nasal polyp were compared (68 cases in group A with preoperative treatment, 30 cases in group B without preoperative treatment). RESULTS: The effective rate between group A(91.2%) and group B (80%) is of significant difference (F = 8.617, P = 0.026); The volume of bleeding during surgery between group A that is (53.2 +/- 41.8) ml and group B that is (97.2 +/- 59.0) ml is of significant difference (F = 27.946, P = 0.002). CONCLUSIONS: Controlling the inflammatory reaction of chronic sinusitis and nasal polyp by preoperative treatment is the most important factor to reduce bleeding while undergoing endoscopic sinus surgery. However, the followings are also important factors to reduce bleeding in endoscopic sinus surgery, such as adequate use of vasoconstrictor in the middle nasal meatus during surgery, the use of deliberate hypotension during surgery, controlling the high risk factors by preoperative treatment and reducing trauma during surgery, etc.
[Hearing impairment in senile dementia of Alzheimer's type].
Wang NY, Yang HJ, Su JF … +7 more , Kong F, Zhang MX, Yan B, Dong HQ, Zhang XQ, Jia JP, Han DM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515779
OBJECTIVE: To evaluate the pure tone hearing threshold and word recognition score of senile dementia of the Alzheimer's disease (AD) patients, and to analyze the relationship between hearing loss and the cognition impair...
OBJECTIVE: To evaluate the pure tone hearing threshold and word recognition score of senile dementia of the Alzheimer's disease (AD) patients, and to analyze the relationship between hearing loss and the cognition impairment. METHODS: Pure tone audiometry, word recognition score (WRS), acoustic immittance and auditory brainstem response (ABR) are used to evaluate the auditory function of 43 patients with AD and 50 subjects of the control group. The confounding factors are controlled. RESULTS: The average age of 43 dementia patients was 72.7 +/- 6.4, and 69.7% was female. Bilateral hearing thresholds are similar in all subjects. All indices but Mini-mental scale of equastionnaire (MMSE) of patients and control group were not statistically different. There was no significant difference in pure tone audiometry (PTA), PTA2 (dB HL, mean +/- s) and WRS (%, mean +/- s) between the two groups (P > 0.05), therefore the hearing threshold of AD group (PTA = 26.3 +/- 8.5, PTA2 = 29.1 +/- 8.7, WRS = 85.5 +/- 15.5) is lower than that of control group (PTA = 23.2 +/- 10.6, PTA2 = 26.2 +/- 11.8, WRS = 87.6 +/- 16.8). No significant difference was found between the two groups in audiometry reliability, acoustic immittance and ABR (P < 0.05). CONCLUSION: No significant difference was found between the peripheral hearing dysfunction of AD patients and that normal elderly people, i.e., PTA, PTA2 and WRS were not related to MMSE.
[Vestibulotomy about the displaced facial nerve].
Zhao SQ, Guo JZ, Dai HJ … +3 more , Zheng YL, Cheng JL, Yu ZL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515778
OBJECTIVE: To investigate the feasibility of vestibulotomy above the displaced facial nerve. METHODS: From January 2000 to January 2002, eight patients with severe congenital conductive hearing loss underwent the vestibu...
OBJECTIVE: To investigate the feasibility of vestibulotomy above the displaced facial nerve. METHODS: From January 2000 to January 2002, eight patients with severe congenital conductive hearing loss underwent the vestibulotomy above displaced facial nerve and reconstruction of the ossicular chain with a total ossicular replacement prosthesis, which all for the congenital middle ear deformity and the facial nerve overhang and concealed the oval window niche or lied inferior to the oval window. In four of eight cases, the facial nerve was transposed in order to access the oval window niche. RESULTS: Hearing of this patients improved 15 dB in 2 ears, 16-25 dB in 3 ears and 26 dB or more in 3 ears. In no case was there a postoperative facial paresis. With 4 months to 28 months follow-up, the postoperative hearing gain was stable. CONCLUSIONS: Vestibulotomy above displacement of the facial nerve allows a final chance of achieving serviceable hearing through surgery. The lack of facial nerve injury and the potential for hearing restoration make this procedure feasible in otherwise marginal or poor surgical candidates.
[Clinical analysis of 95 patients with large vestibular aqueduct syndrome].
Yang WY, Zhang SZ, Zhao CJ … +1 more , Feng B
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515777
OBJECTIVE: To investigate the occurrence, genetic inheritance, and hearing loss conditions of large vestibular aqueduct syndrome (LVAS), and to measure the width of external aperture of vestibular aqueduct (VA) of LVAS,...
OBJECTIVE: To investigate the occurrence, genetic inheritance, and hearing loss conditions of large vestibular aqueduct syndrome (LVAS), and to measure the width of external aperture of vestibular aqueduct (VA) of LVAS, and to analyze the relationship between the hearing loss and the width of external aperture. METHODS: A retrospective review was conducted by the history, auditory, and vestibular function examinations in 95 patients (190 ears) of LVAS. The width of VA was measured by CT scanning criterion of each LVAS patients in the past 10 years (from 1992 to 2002). RESULTS: In 95 patients, there were male 65 cases and female 30 cases. The male cases was more than the females by a ratio of 2.2:1. Twelve cases (12.6%) would have familial genetic history. The average of the consult age was 7.6 years (range from 1.2 to 39 years). The most patients were misdiagnosed, the hearing deterioration originated from mild head trauma in 21 cases (22.1%), the hearing loss after common cold in 13 cases (13.6%). Nine cases (9.5%) misdiagnosed as sudden hearing loss, 5 cases (5.3%) as ototoxic hearing loss of Aminoglycoside antibiotic. The profound hearing loss was found in 172 ears (92.4%). The average width of external aperture of LVAS was 7.5 mm +/- 1.2 mm (mean +/- s, 77 cases, 154 ears). The level of hearing loss did not proportional to the width of VA. The hearing impairment could be derived from protein-rich endolymph refluxed into the cochlear and vestibule. CONCLUSION: The LVAS is distinct clinical entity characterized by fluctuate and progressive SNHL. The diagnosis depends upon the CT scan and MR image. If the hearing fluctuated and subsequently improved, the children were kept under conservation treatment. If the significantly decreased of hearing effected school performance, the cochlear implant might be considered.
[Expression of CD68 CD45RO CD20 and proliferating cell nuclear antigen in nasal polyps].
Wu X, Wang LF, Zang YH
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Jun · PMID 14515776
OBJECTIVE: To study the cellular expression of CD45RO, CD20, CD68 and proliferating cell nuclear antigen (PCNA) in nasal polyps. METHODS: Nasal polyp tissues from 50 patients were evaluated for cellular expression of CD4...
OBJECTIVE: To study the cellular expression of CD45RO, CD20, CD68 and proliferating cell nuclear antigen (PCNA) in nasal polyps. METHODS: Nasal polyp tissues from 50 patients were evaluated for cellular expression of CD45RO, CD20, CD68 and PCNA using immunohistochemistry SP by counting the average number in 5 chosen high-power fields, Histopathological observations were combined with HE. Analyses were performed on SPSS10.0. RESULTS: CD68+ cells were expressed more in nasal polyps dominated by eosinophils than by neutrophils(P < 0.05). There was no difference between CD45RO and CD20, but both of them had negative correlation(P = 0.05). Significant correlation was found between CD68+ cells and eosinophils or PCNA positive cells on epithelium. PCNA positive cells on epithelium had significant correlation on fibroblast (P < 0.05). CONCLUSION: Inflammatory cell infiltration (eosinophilia CD45RO, CD20, CD68) and cell proliferating in epithelium cells, glandular cell and fibroblast are strongly correlated with formation of nasal polyps. The nasal polyps are not only characteristic of eosinophilia but also by lymphocytes dominated by CD45RO and CD68 positive cells. CD68 may be stem cell of nasal polyp.
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