Zhonghua Er Bi Yan Hou Ke Za Zhi[JOURNAL]
Sun
200 papers
[Interleukin-5 regulate the bone marrow response in the model of allergic rhinitis].
Wang XD, Han DM, Zhou B … +4 more , Wei YX, Bai WZ, Liu ZY, Ju SY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040109
OBJECTIVE: To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis. METHODS: Twenty SD rats were randomly divided into allergic rhinitis (AR) group and contr...
OBJECTIVE: To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis. METHODS: Twenty SD rats were randomly divided into allergic rhinitis (AR) group and control group. The leucocytes in the smears of bone marrow and peripheral blood were counted, and the expression of IL-5 was detected by immunohistochemistry. RESULTS: The ratio of eosinophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of basophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of eosinophils to white cells in peripheral blood smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of IL-5 positive cells to white cells in bone marrow smears of AR group was significantly higher than that of control group (P < 0.05). The ratio of IL-5 positive cells to white cells was significantly positively correlated with the ratio of eosinophils to white cells in bone marrow smears of AR group (R = 0.85, P < 0.01). CONCLUSION: IL-5 regulates the proliferation and differentiation of eosinophils in bone marrow.
[Histo-morphological changes of eustachian tube of guinea pigs with effusion after being treated by pulmonary surfactant].
Ma ZX, Chen XH, Li M … +3 more , Huang P, Cao Y, Cai JF
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040108
OBJECTIVE: To study the effect of pulmonary surfactant on otitis media with effusion in guinea pigs to find a new way to manage otitis media with effusion. METHODS: Nonviable heat-killed pneumococci (HKP) solution was in...
OBJECTIVE: To study the effect of pulmonary surfactant on otitis media with effusion in guinea pigs to find a new way to manage otitis media with effusion. METHODS: Nonviable heat-killed pneumococci (HKP) solution was inoculated into the middle ear cavity in guinea pigs via a transeardrum approach to set up a model of otitis media with effusion in guinea pigs. Seven days after being injected with pulmonary surfactant (PS) by transeardrum approach, ABR threshold and histomorphological changes of eustachian tube mucosa of guinea pigs were examined by light microscopy and scanning microscopy. RESULTS: Five days following inoculation of HKB serous effusion were present in the middle ear cavity of guinea pigs, but disappearance of light cone. Response (mean +/- s) threshold raised from (14.0 +/- 3.1) dB to (45.0 +/- 5.7) dB. The eustachian tube mucosa was thickened and lined eosin-stained structureless matter over mucosa, while cilia of eustachian tube mucosa irregularly arranged. Seven days after being treated by PS, serous effusion of tympanum was reduced or disappeared, and response threshold decreased from (45.0 +/- 5.7) dB to (23.5 +/- 6.3) dB. There was significantly difference between them (P < 0.001). Eustachian tube mucosa was thinned, Cilia of eustachian tube mucosa regularly arranged to the nasopharynx. CONCLUSION: Pulmonary surfactant plays a important role in otitis media with effusion of guinea pigs.
[Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis].
Liu JX, Li XP, Dong Y … +2 more , Han HW, Liu GQ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040107
OBJECTIVE: To elucidate the neurological mechanism of lidocaine's suppression to tinnitus. METHODS: Thirty-four Wistar rats weighing 300-350 grams were randomly divided into IC group (n = 17) and AC group (n = 17), accor...
OBJECTIVE: To elucidate the neurological mechanism of lidocaine's suppression to tinnitus. METHODS: Thirty-four Wistar rats weighing 300-350 grams were randomly divided into IC group (n = 17) and AC group (n = 17), according to microdialysis region. Each group was randomly subdivided into saline treatment group (n = 4), salicylate treatment group (n = 6), and salicylate + lidocaine treatment group (n = 7). Using in vivo microdialysis technique coupled with microbore HPLC-electrochemical detection, the present study first monitored the 5-HT release in IC and AC in salicylate-induced tinnitus animal models, and then, examined the effects of lidocaine on salicylate-induced 5-HT changes in IC and AC. The statistical analysis was performed using two-way ANOVA for repeated measures of raw data with time and treatment condition as main effects. Individual time-point values between no more than two groups were compared with the unpaired Student's t-test. The accepted level of significance was 0.05, two-tailed. RESULTS: The 5-HT level increased to a maximum of 268% +/- 27% (mean +/- s) basal level in IC 2 h after salicylate application and of 277% +/- 24% basal level in AC around 3 h after application. And then, the 5-HT level gradually decreased to 157% +/- 16% of baseline in IC and 180% +/- 18% of baseline in AC by the end of the sixth hour. Saline did not alter the IC and AC dialysate 5-HT level in control rats. Two-way ANOVA with repeated measures indicated a significant effect of the condition factor [F (1, 8) = 413.949, P < 0.000001 in IC group; F(1,8) = 192.184, P < 0.000001 in AC group]. The increases of 5-HT levels in salicylate treatment groups were significantly reduced to 85% +/- 8% basal level in IC and 92% +/- 26% basal level in AC after local infusion of 1% lidocaine (P < 0.05). Compared with corresponding control value at that time (unpaired student t-test). Two-way ANOVA with repeated measures showed a significant difference between the salicylate group and salicylate + lidocaine group [P < 0.000001 with F(1, 11) = 329.267 for the condition factor in IC subgroup; P < 0.000001 with F(1, 11) = 133.844 for the condition factor in AC subgroup]. CONCLUSION: The suppression of lidocaine to tinnitus may be associated with the decrease of 5-HT level in IC and AC.
[Surgical management of primary cervical tracheal cancer].
Pan XL, Lei DP, Xu FL … +4 more , Zhang LQ, Liu DY, Xie G, Luan XY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040106
OBJECTIVE: To review the experience of surgical treatment of primary cervical tracheal cancer. METHODS: Six patients with primary cervical tracheal cancer were treated surgically from January 1997 to April 1999. The trac...
OBJECTIVE: To review the experience of surgical treatment of primary cervical tracheal cancer. METHODS: Six patients with primary cervical tracheal cancer were treated surgically from January 1997 to April 1999. The trachea anastomosis, platysmamyocutaneous flap combiend with the facial flap of the sternohyoid muscle, sternocleidomastoid myoperiosteal flap and the pectoralis major muculocutaneous flap were applied to restore the defects of cervical trachea. By pathology, there were two squamous cell carcinomas, three adenoid cystic carcinomas, and one adenocarcinoma. RESULTS: Six cases were decannulated from 23 days to 3 months after operation. The length of follow-up was more than 3 years. Five cases have stable airway by fiberscope and good voice after decannulation and there is no recurrence. One case died of lung metastasis 2 years after operation. CONCLUSION: Trachea anastomosis is suited for small partial defect. The platysmamyocutaneous flap combined with the facial flap of the sternohyoid muscle, sternocleidomastoid myoperiosteal flap and the pectoralis major muculocutaneous flap are ideal transplant for cervical tracheal reconstruction.
[Tracheoesophageal shunt for voice reconstruction after total laryngectomy to prevent from deglutition disorders].
Kang J, Chai L, Yu GJ … +1 more , Pang YG
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040105
OBJECTIVE: To observe the effect of tracheoesophageal shunt on voice reconstruction after total laryngectomy. METHODS: Seventy-nine patients with laryngeal cancer of T3 and T4 stages were conducted an operation of trache...
OBJECTIVE: To observe the effect of tracheoesophageal shunt on voice reconstruction after total laryngectomy. METHODS: Seventy-nine patients with laryngeal cancer of T3 and T4 stages were conducted an operation of tracheoesophageal shunt after total laryngectomy. The vertical voiced slit with a length of 0.8-0.12 cm was made between the posterior wall of trachea and the frontal wall of esophagus, while the cricoid cartilage flap with the length of 2.0 cm and width of 1.2 cm was reserved to form cartilage mucosa flap as an edge to prevent deglutition disorders. Finally, membranous part of trachea was sutured together with the neck skin as an inclination edge. RESULTS: In this series, 71 of 79 patients kept good voice function, and 65 of 71 patients avoided deglutition disorders, but other patients failed to do so. The 3-year survival rate was 66.7% (14/21, for stage T3) and 64.9% (24/37, for stage T4), respectively. The 5-year survival rate was 6/10 (for stage T3) and 50.0% (10/20, for stage T4), respectively. CONCLUSION: The operation of tracheoesophageal shunt is advantageous to prevent deglutition disorders as well as to restore the voice function of larynx.
[The application of epiglottis and cervical anterior muscle to laryngeal reconstruction].
Ma SY, Zhan XD, Xu SX … +5 more , Zu ZJ, Yang JS, Shu JH, Wang WZ, Jiang CY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040104
OBJECTIVE: To evaluate the methods of reconstruction of laryngeal function after the extended laryngectomy. METHODS: The laryngeal functions were reconstructed after the extended laryngectomy performed on 22 cases with t...
OBJECTIVE: To evaluate the methods of reconstruction of laryngeal function after the extended laryngectomy. METHODS: The laryngeal functions were reconstructed after the extended laryngectomy performed on 22 cases with the laryngocarcinoma of T2 and T3 stages of glottic type, using epiglottis and cervical anterior muscle to reconstruct the laryngeal cavity and larynx bracket, from September 1998 to October 1999. RESULTS: Twenty cases recovered normal swallow function in 20 days post-operation as well as the entire function of larynx was recovered, and the rate of decannulation was 90.9% (20/22). One case with pharyngeal fistula recovered a month later, but the other case recovered to normal diet by operation repaired. All the patients pronounced clearly and were able to keep the characteristics of their own voice. The fibred laryngoscope examination showed that the sphincter valves were formed at the larynx atrium in all postoperative cases. The rate of 3-year survival for T2 and T3 stages was 100% (9/9) and 92.3% (12/13), respectively. CONCLUSION: The laryngeal cavity could be enlarged and the laryngeal atrium was reconstructed by employing epiglottis ifraplacement and cervical anterior muscle to reduce the tension of epiglottis and minimize the injury of the membrane as well as to overcome the shortcomings of insufficient material if mere employing epiglottis. The application of combined methods to reconstruct the laryngeal cavity is a practical way to restore the larynx function and improve the life quality.
[Lateral neck dissection vs radical neck dissection in the management of supraglottic carcinoma with pathologically negative nodes].
Zhang B, Xu ZG, Tang PZ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040103
OBJECTIVE: To compare the effectiveness of lateral neck dissection (LND) with radical or modified radical neck dissection (RND) for the management of supraglottic carcinoma with pathologically negative nodes (pNO). METHO...
OBJECTIVE: To compare the effectiveness of lateral neck dissection (LND) with radical or modified radical neck dissection (RND) for the management of supraglottic carcinoma with pathologically negative nodes (pNO). METHODS: Two treatment groups with pNO supraglottic carcinoma were retrospectively compared: 39 patients who were treated with RND between March of 1980 and December of 1996, and 54 patients who were treated with LND between January 1997 and December 2001. RESULTS: The neck recurrent for LND population was 2.3%, which was not statistically different from the neck recurrent in the RND population (0.0%). Also, the 5-year survival rates were no statistic difference between LND and RND groups (97% vs 94%). Complications and period of hospitalization were both decreased in LND group comparison of RND group (6.7% vs 38.5%; 28 days vs 39 days). CONCLUSION: Comparing to the radical or modified neck dissection, the LND offers less invasive surgery and less morbidity without oncologic compromise for patients with pNO supraglottic carcinoma.
[Diagnosis and treatment of juvenile recurrent laryngeal papillomatosis].
Wang HG, Lin XQ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040102
OBJECTIVE: To evaluate some perplexing problems in the diagnosis and treatment of juvenil recurrent laryngeal papillomatosis (JRLP) and the relationship between juvenile onset recurrent respiratory papillomatosis(JORRP)...
OBJECTIVE: To evaluate some perplexing problems in the diagnosis and treatment of juvenil recurrent laryngeal papillomatosis (JRLP) and the relationship between juvenile onset recurrent respiratory papillomatosis(JORRP) and infantile laryngeal condyloma accuminatum (ILCA). METHODS: A group of 44 cases with JRLP were analyzed retrospectively from March, 1994 to March, 2002 in the light of literature review. RESULTS: The average age of first visit was 1.6 years. Average 5.3 operations had been performed per patient. There was an interval of average 2.4 months between two surgical excisions. Of 233 operations, the total incidence rate of all the complications was 3.9%. At present, the laryngeal lesion of 18 cases have withered away for over 1 year. 11 cases have being followed up. 10 cases have lost follow-up and 5 cases have died (11.4%). Combined laryngeal lesion excision with tracheotomy aiming at prolonging operative interval or Chinese traditional medicine has received more satisfactory effect than other therapies. There is an extensive similarity between JORRP and ILCA. CONCLUSIONS: To demondrate further whether JORRP and ILCA are the same identical disease has important significance in both theoretical study and clinic practice. The treatment for JRLP is still difficult. The tracheotomy for laryngeal obstruction resulted from the laryngeal lesion of JRLP should be avoided as far as possible. Combined laryngeal lesion excision with tracheotomy aiming at prolonging opertive interval or Chinese traditional medicine shows optimistic prospect.
[The detection and significance of human papilloma virus 11b virus like particles and its serum antibody in juvenile larynx papilloma].
Chen BB, Zhao KN, Liu XS … +3 more , Xu Y, Chen XF, Wang XD
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040101
OBJECTIVE: To study the relationship between human papilloma virus 11b virus like particles (HPV11bVLPS) serum antibody and the development and prognosis of juvenile larynx papilloma (JLP). METHODS: Enzyme linked immunos...
OBJECTIVE: To study the relationship between human papilloma virus 11b virus like particles (HPV11bVLPS) serum antibody and the development and prognosis of juvenile larynx papilloma (JLP). METHODS: Enzyme linked immunosorbent assay (ELISA) was used to detect the serum HPV11bVLP antibody (Ab) of 46 JLP's samples in different stage and 20 controls using HPV11bVLPS which was produced by recombinant bacilovirus in insect cells. Grouping: A: control group (n = 20); B: the time of onset was 1 years (n = 15); C: the time of onset was 2 years (n = 15); the patients were followed-up 1 year without recurrence (n = 8); E: The patients were followed-up 2 years without recurrence (n = 8). RESULTS: A value of HPV11bVLP Ab among A, B, C, D, E. group were: (0.073 +/- 0.035); (0.120 +/- 0.049); (0.137 +/- 0.057); (0.518 +/- 0.122); (0.557 +/- 0.144). There was a significant difference between JLP patients and the control group (P < 0.05). The level of HPV11bVLP Ab in (D + E) group (0.534 +/- 0.132) was higher than (B + C) group (0.128 +/- 0.053) (t = 14.90, P < 0.001). CONCLUSION: The results suggested that HPV serum antibody was produced in JLP with HPV infection. There is close relationship between the development and prognosis of the disease and the level of HPV11Ab in serum. The assay of serum HPV11bVLPAb and HPV-VLP could be used as immunological study of HPV11-infection associated disease.
[Study on the expression of the metastasis suppressor gene KAI1 in laryngeal squamous cell carcinoma].
Wu ZL, Wu ZH, Guo X
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040100
OBJECTIVE: To investigate the expression of the metastasis suppressor gene KAI1 in laryngeal squamous cell carcinoma and the relationship between expression of KAI1 and it's role in tumorgenesis and development. METHODS:...
OBJECTIVE: To investigate the expression of the metastasis suppressor gene KAI1 in laryngeal squamous cell carcinoma and the relationship between expression of KAI1 and it's role in tumorgenesis and development. METHODS: The sections of 84 samples of primary laryngeal squamous cell carcinoma (PLSCC), 27 samples of laryngeal precancerous lesion (LPL), 10 samples of vocal cords polyp (VCP) and 10 samples of normal laryngeal tissues (NLT) were examined by in situ hybridization for KAI1mRNA. RESULTS: It was found that 10 samples of NLT and 10 samples of VCP showed strong expression of KAI1, the Integrated A Total of KIA1 in these two types of tissues were 136,206.8 +/- 36,675.536 and 133,674.505 +/- 42,858.456, respectively, with no statistically significant difference between them, and high prevalence of decreased expression of KAI1 in LPL and PLSCC compared with that in VCP and in NLT (P < 0.01). There was a significant relationship between down-regulation of KAI1 expression with pathological grade, lymph node metastases, T stage and clinical stage (P < 0.01) and did not correlate with gender. CONCLUSION: KAI1 may play an important role on tumor genesis, development, invasion and metastasis of PLSCC, and become one of the molecular markers for early diagnosis and predicting of aggressive and metastasis potential to assess the clinical stage of PLSCC.
[Effects of E1A gene on the growth and chemosensitivity of transplantation tumor of nude mice].
Wang XL, Qian XL, Zhao QZ … +2 more , Xu ZG, Tang PZ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040099
OBJECTIVE: To study the effects of E1A gene on the growth and chemosensitivity of transplantation tumor of nude mice of lymph node metastasis cell line (686LN-1) of human tongue squamous cell carcinoma. METHODS: 686LN-1,...
OBJECTIVE: To study the effects of E1A gene on the growth and chemosensitivity of transplantation tumor of nude mice of lymph node metastasis cell line (686LN-1) of human tongue squamous cell carcinoma. METHODS: 686LN-1, 686LN-1-vect and 686LN-1-E1A cells were transplanted into nude mice, then the time of tumor formation, growth rates and weight of tumor were observed. To study the effects of the E1A gene on bleomycin sensitivity in vivo, 686LN-1 cells were injected into nude mice. After tumor formed, bleomycin, E1A gene and E1A gene + bleomycin were given respectively as therapy. The tumor volume was calculated, and growth curve was plotted. Representative histological sections were taken from mice bearing transplantation tumor either treated or control groups, and expression of HER-2/neu was detected. RESULTS: In nude mice, the expression of E1A gene significantly suppressed the growth rates and elongated the time of tumor formation. Bleomycin or E1A Gene and E1A gene + bleomycin can suppress the growth rates of transplantation tumor of nude mice, the suppressed rates of tumor growth was 53.13%, 76.83% and 96.65%, respectively. The expression of E1A gene can significantly suppressed the expression of HER-2/neu gene in 686LN-1-E1A cells. CONCLUSION: E1A is able to significantly inhibit the growth rate of transplantation tumor of nude mice of lymph node metastasis cell line (686LN-1) of human tongue squamous cell carcinoma, and dramatically enhance the sensitivity of the cells to cytotoxic agents in vivo. Above of all functions of E1A gene may be related to that it suppressed the expression of HER-2/neu gene.
[Preliminary study on the correlation factors of cervical lymphatic metastasis of glottic carcinoma].
Li W, Ji WY, Liu R
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743645
OBJECTIVE: To investigate the incidence of occult nodal in glottic carcinoma and access the correlation between the cervical lymph nodes metastases and originals of tumor. METHODS: A retrospective review was made on 452...
OBJECTIVE: To investigate the incidence of occult nodal in glottic carcinoma and access the correlation between the cervical lymph nodes metastases and originals of tumor. METHODS: A retrospective review was made on 452 patients from January 1983 to May 1998. 413 patients were male and 39 were female. The age ranged from 42 to 79 years with a mean of 59.3 years. RESULTS: The incidence of occult nodal in glottic carcinoma was low (3.54%), and 0.29% in early stage (T1-T2), 13.39% in late stage (T3-T4), respectively. The number of metastasis lymph nodes was 7 in level II (43.75%), 7 in level III (43.75%) and 2 in level IV (12.5%). CONCLUSION: According to the multivariate analysis, none of the factors such as histopathologic differentiation and invasion of peripheral tissue significantly affect on cervical metastases. The incidence of cervical lymph nodes metastases in glottic carcinoma is low. Selective neck resection should not be undertaken even for the advanced stage that don't exist metastases.
[Clinical analysis of relevant factors causing laryngeal cancer postoperative recurrence].
Guo R, Huang DL, Li H … +2 more , Yang WY, Han DY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743644
OBJECTIVE: To investigate the clinical relevant factors causing laryngeal cancer postoperative recurrence and analysis the reasons of treatment failure. METHODS: Totally, 574 cases of laryngeal cancer from 1958 to 1999 t...
OBJECTIVE: To investigate the clinical relevant factors causing laryngeal cancer postoperative recurrence and analysis the reasons of treatment failure. METHODS: Totally, 574 cases of laryngeal cancer from 1958 to 1999 treated in ENT department of PLA general hospital were retrospectively reviewed. All the patients were observed for 3 years postoperatively, and finally 56 cases of the recurrence were diagnosed. We analyzed the factors possibly causing the recurrence including age, sex, history, time in hospital, smoke, grade of pathology, combination, tumor stage, transfusion, radiotherapy, operation manners and cervical lymph metastasis node grade. RESULTS: By statistic analysis, tumor grade (P = 0.0002), operation (P = 0.0017), transfusion (P = 0.0001), radiotherapy (P = 0.0001) and cervical lymphatic metastasis node grade(P = 0.0228) have significant meaning with laryngeal cancer postoperative recurrence. CONCLUSION: Tumor grade, transfusion, radiotherapy, operation and cervical lymph metastasis node grade are main factors which may cause neoplasm postoperative recurring.
[Surgical management of hypopharyngeal cancer].
Yu F, Dong YL, Zu ZJ … +8 more , Zhan XD, Shu JH, Yang JS, Han GS, Lu LC, Zhang K, Sun HJ, Ren KJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743643
OBJECTIVE: To investigate the preservation of laryngeal function for the patients with hypopharyngeal cancer. METHODS: Two hundred and ninety-three cases of hypopharyngeal cancer with surgical management were reviewed re...
OBJECTIVE: To investigate the preservation of laryngeal function for the patients with hypopharyngeal cancer. METHODS: Two hundred and ninety-three cases of hypopharyngeal cancer with surgical management were reviewed retrospectively, and 222 cases were originated from pyriform sinus, 13 from post-cricoid, and 21 from posterior pharyngeal wall. Radiotherapy (37 cases), operation only (56 cases) and the combined treatment (operation plus radiation or chemotherapy, 200 cases) were adopted. 159 cases were treated with function preserved laryngectomy and 97 with total laryngectomy. RESULTS: The 5 year survival rates of patient with laryngeal function preserved and no laryngeal function preserved were 51.3%, 47.6% (for stage III); 40.4%, 43.3% (for stage IV), respectively. There were no significant differences in 5-year survival between the functionally preserved group and no functioned group (P > 0.05). The analysis of survival rates revealed a significant difference between combined therapy and radiotherapy. CONCLUSION: There is no significant difference between the survive rates of function preserved and non-preserved groups. Conservation laryngectomy improves the quality of patient's life, and combined therapy is the best choice for hypopharyngeal cancer.
[CO2 laser endoscopic subtotal arytenoidectomy for bilateral median vocal cord paralysis].
Qin Y, Xiao SF, Wang QG … +2 more , Li ZG, Guo M
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743642
OBJECTIVE: To delineate the surgical procedures and correlated techniques for endoscopic subtotal arytenoidectomy, as well as to discuss their applications and clinical outcomes. METHODS: CO2 Laser endoscopic unilateral...
OBJECTIVE: To delineate the surgical procedures and correlated techniques for endoscopic subtotal arytenoidectomy, as well as to discuss their applications and clinical outcomes. METHODS: CO2 Laser endoscopic unilateral arytenoidectomy was performed in eight cases of bilateral median vocal cord paralysis combined with one stage of mucosal micro-anastomosis. All patients suffered from dyspnea in some extent, of which 5 had the history of thyroidectomy and 2 had traumatic causes following esophagectomy and tracheal surgery respectively. One of patient had unknown cause. Six patients had undergone tracheotomy prior to operation or before their referral to our hospital. The airway was evaluated via fibro-optic laryngoscopy, and the voice quality was assessed subjectively by the patients and the surgeon before and after surgery. RESULTS: Following 5-43 months after the surgery, in all cases the function of airway as well as the acceptable voice quality was successfully restored. The tracheotomy done before operation in six patients was decannulated within the mean time of 44.2 days post-operation. CONCLUSION: The endoscopic approach for CO2 laser unilateral arytenoidectomy may lead to better restoration of an adequate airway and satisfying phonation without postoperative aspiration. Mucosal micro-anastomosis can prevent the formation of granulation or scar tissue thus promotes the healing processes. This procedure is simpler than other ordinary surgical methods, and could be a satisfactory alternation of treatment for bilateral median vocal cord paralysis.
[Application of bi-pedicel and bi-muscle flaps for the expanded partial laryngectomy in the patients with T3T4 laryngeal cancer].
Wu NW, Wu YL, Zhang DX
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743641
OBJECTIVE: To evaluate the application of bi-pedicel and bi-muscle flaps for the expanded partial laryngectomy in the patients with T3T4 larynx cancer. METHODS: From 1990 to 1997, 386 patients of laryngeal cancer were tr...
OBJECTIVE: To evaluate the application of bi-pedicel and bi-muscle flaps for the expanded partial laryngectomy in the patients with T3T4 larynx cancer. METHODS: From 1990 to 1997, 386 patients of laryngeal cancer were treated by expanded partial laryngectomy and repaired with unilateral or bilateral bi-pedicel and bi-muscle flaps. 322 patients were male and 64 were female. The age ranged from 30 to 84 years old. All the patients were in the stage T3 or T4 of cancer. The operation included expanded horizontal supraglottic laryngectomy, vertical partial laryngectomy, 3/4 laryngectomy and sub-total laryngectomy. RESULTS: After operation, the speech function was still good in all cases. The swallow function recovered in 8 to 12 days post-operation. The extraction rate of tracheal tube was 50.3% (194/386), and the 5-years survival rate was 55.2% (213/386) while the local recurrence rate was 16.6% (64/386). CONCLUSION: With the application of bi-pedicel and bi-muscle flaps, the patients, if treated by total laryngectomy as traditional technique, could be treated by partial laryngectomy. This method could expand the indication of partial laryngectomy and improve the life quality and survival rate.
[Effects of pingyangmycin on mucous membrane of respiratory tract and its prevention].
Chen F, Lin SZ, Gong ZP
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743640
OBJECTIVE: To observe the effects of pingyangmycin(PYM) on the histomorphology and ultrastructure of airway mucosa from the healthy Wistar rats and explore the intervenient role of Vitamin E and Composite Salvia Miltiorr...
OBJECTIVE: To observe the effects of pingyangmycin(PYM) on the histomorphology and ultrastructure of airway mucosa from the healthy Wistar rats and explore the intervenient role of Vitamin E and Composite Salvia Miltiorrhiza (CSM) on these effects. METHODS: Thirty Wistar rats were divided randomly into four groups: Group A as control group (injection of N. S into peritoneal cavity); Group B received intracavitary injection of PYM; Group C received both intracavitary injection of PYM and tube feeding of Vitamin E; Group D received intracavitary injection of PYM and CSM. The nasal and tracheal mucosa were taken for light microscopy(LM), transmission electron microscopy(TEM) and scanning electron microscopy(SEM) at the 1st, 2nd, 4th and 6th week of the experiment. RESULTS: Edema and degeneration of epithelial cells manifested as expansion of endoplasmic reticula, swelling of mitochondria, disarrangement of mitochondrial crista, vesicula formation of mitochondria, reduction of mitochondria in part cells, mild expansion of perinuclear space and slight peripheral accumulation of nuclear chromatin could be seen in Group B at the end of the 1st week without necrosis or detachment of the cells. At the 2nd week, there were necrosis and exfoliation of epithelial cells, rupture of cell membrane, phenomena of outflow of mitochondria and endoplasmic reticula. The degree of cell damage became more seriously at the 4th week and was not recovered to normal condition even 2 weeks after stopping administration of PYM. The cell damages in Group C and D were significantly lighter than that in Group B and its occurrence were significantly postponed. The injured cells recovered definitely after stopping PYM administration and continuous application of Vitamin and CSM for another 2 weeks. CONCLUSIONS: (1) The nasal and tracheal mucosa of Wistar rats can be damaged by injection of PYM and the degree of damage which become more serious with the increase of dose. (2) Vitamin E and CSM can alleviate the damages of the respiratory mucosa from Wistar rats caused by PYM. Both drugs could be used to prevent respiratory tract mucosa from the damages induced by PYM in clinical.
[Malignant fibrous histiocytomas of larynx].
Wu HT, Li C, Wu YF … +1 more , Wang W
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743639
OBJECTIVE: To explore the histopathology, diagnosis and treatment of malignant fibrous histiocytomas (MFH) of larynx. METHODS: The clinical and pathologic features of 9 cases with MFH of larynx were reviewed retrospectiv...
OBJECTIVE: To explore the histopathology, diagnosis and treatment of malignant fibrous histiocytomas (MFH) of larynx. METHODS: The clinical and pathologic features of 9 cases with MFH of larynx were reviewed retrospectively. RESULTS: All the 9 cases with MFH of larynx were adults (the age ranged from 43 to 87 years; average 56 years); 8 were men and 1 woman. The tumor of eight cases originated in glottic area and 1 case occurred in supraglottic area. The histological diagnosis was difficult, so the immunohistochemical studies in 5 cases were examined. Because surgical resection was a mainly treatment, seven patients underwent total laryngectomy and 2 cases underwent frontal partial laryngectomy. Six patients were followed up for more than 3 years and no patient died of MFH after surgical resection. CONCLUSION: The diagnosis of MFH of larynx was sometimes difficult and immunohistochemistry could be helpful. The mainly treatment of MFH of larynx was surgical resection by total laryngectomy or partial laryngectomy.
[Pneumatization of perpendicular plate of the ethmoid bone and mucocele].
Wang RG, Zou YH, Han DY … +1 more , Zhang W
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743638
OBJECTIVE: To find out the prevalence of pneumatization of perpendicular plate of the ethmoid bone, and to discuss the diagnosis and management of perpendicular plate mucocele (nasal septal mucocele). METHODS: The CT dat...
OBJECTIVE: To find out the prevalence of pneumatization of perpendicular plate of the ethmoid bone, and to discuss the diagnosis and management of perpendicular plate mucocele (nasal septal mucocele). METHODS: The CT data from 32 patients with septal deviation were reviewed, and an unusual case of perpendicular plate mucocele was reported. RESULTS: Six cases (6/32, 18%) were found to have pneumatization of perpendicular plate of the ethmoid bone, with 2 located in the anterior portion (frontal-septal pneumatization), and 4 located in the posterior portion (spheno-septal pneumatization). A patient with perpendicular plate mucocele was treated by the technique of marsupialization under nasal endoscope. This patient was followed-up for 10 months without recurrence. CONCLUSION: As a kind of variation of nasal septum, the clinical significance of pneumatization of perpendicular plate should be emphasized. We reported the first case of perpendicular plate mucocele, originated possibly from the pneumatization of perpendicular plate of the ethmoid bone. Marsupialization under endoscope was considered to be the initial management for this unusual disease.
[Analysis of growth model in vestibular aqueduct during human fetal development].
Lei L, Han DM, Yu ZK … +4 more , Zhu XN, Liu S, Chen SB, Fan EZ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 14743637
OBJECTIVE: To characterize the growth of the developing vestibular aqueduct in order to gain a better understanding of the possible origins of enlarged vestibular aqueduct. METHODS: Serial sections from 32 temporal bones...
OBJECTIVE: To characterize the growth of the developing vestibular aqueduct in order to gain a better understanding of the possible origins of enlarged vestibular aqueduct. METHODS: Serial sections from 32 temporal bones for every other week from human embryos ranging in age from 6 to 38 weeks were studied with 3DMed medical image analysis software. The internal, external aperture, midpoint diameter and length vestibular aqueduct were analyzed with regression analysis to obtain a growth curve. RESULTS: The internal aperture of vestibular aqueduct was began to form at 6 weeks' gestation. It grew to reach the posterior surface of the petrous bone in the posterior cranial fossa by 10 weeks' gestation. All width parameter mean value in our embryos nerve reached the maximum average width in the adult. Statistical analysis showed that the vestibular aqueduct grew in a nonlinear continuous fashion and instability trend throughout embryonic life, except length parameter. CONCLUSION: The vestibular aqueduct grows in a nonlinear fashion throughout embryonic life. The widest aqueduct measured in embryonic life does not reach the maximum average width in the adult. These results suggest that it would be possible for vestibular aqueduct to develop postnatally.
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