Zhonghua Er Bi Yan Hou Ke Za Zhi[JOURNAL]
Sun
200 papers
[Diagnoses and surgery of chronic sinusitis in children].
Xu G, Li Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Aug · PMID 15129693
Abstract loading — click title to view on PubMed.
[Peri-uvulopalatopharyng oplasty otoacoustic emissions in patients with obstructive sleep apnea-hypopnea syndrome].
She WD, Zhang Q, Chen F … +2 more , Jiang P, Wang J
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127570
OBJECTIVE: To study the cochlear function of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: Transiently evoked otoacoustic emissions (TEOAEs) and Distortion-product otoacoustic emissions(DPOAEs...
OBJECTIVE: To study the cochlear function of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: Transiently evoked otoacoustic emissions (TEOAEs) and Distortion-product otoacoustic emissions(DPOAEs) of 28 patients with OSAHS were measured one week before uvulopalatopharyngoplasty (UPPP) and six months after UPPP. RESULTS: In these patients the prevalence of TEOAEs was 64.3%, its spectral energy was mainly distributed between 0.5-2 kHz, the amplitudes of DPOAEs between 0.5-8 kHz were reduced significantly, the prevalences of DPOAEs at 0.5-8 kHz were between 46.4%-89.3%. After UPPP, the prevalences of TEOAEs and DPOAEs were increased, the amplitudes of DPOAEs were in turn (22.50 +/- 16.70) dB SPL, (5.83 +/- 2.69) dB SPL, (0.69 +/- 3.83) dB SPL, (-2.50 +/- 2.45) dB SPL, (4.95 +/- 2.65) dB SPL, (4.48 +/- 3.07) dB SPL from 0.5 kHz to 8 kHz, the amplitudes of DPOAEs were significantly increased at 1 kHz, 2 kHz, 4 kHz, 6 kHz, 8 kHz. CONCLUSION: OSAHS can affect the cochlear function of the patients with OSAHS, UPPP can improve the cochlear function.
[Videomimicography: a new objective evaluation of facial motor function].
Wang DS, Dulguerov P, Lehmann W
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127569
OBJECTIVE: To develop a new method, videomimicography (VMG), to evaluate facial motor function. METHODS: During VMG, 11 landmarks were placed on the face, and 5 movements (forehead lifting, eye closure, nose wrinkling, l...
OBJECTIVE: To develop a new method, videomimicography (VMG), to evaluate facial motor function. METHODS: During VMG, 11 landmarks were placed on the face, and 5 movements (forehead lifting, eye closure, nose wrinkling, lip puckering and smiling) with maximal contraction were requested. A digital video film was recorded then fed in a computer to be analyzed. Ten normal subjects were used as normal control. RESULTS: Area measures were found better than distance measures in evaluating facial movements. The best measure for each movement was determined. Then a global index of facial motor function was derived from these measures. This index was found well correlated with the facial paralysis House-Brackmann grade in 48 patients with facial paralysis (r = -0.928). CONCLUSION: VMG is an objective, quantitative, relative simple method. It has good reproducibility. So it can be used in clinic for evaluating facial motor function.
[Operative therapy of the adhesive otitis media].
Yu LS, Qi ZM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127568
OBJECTIVE: To study the operative indications and treatment for adhesive otitis media (AOM). METHODS: Sixty-nine cases of AOM were undergone tympanoplasty between 1995 to 2000. Preoperative average air-bone gap(A-B gap)...
OBJECTIVE: To study the operative indications and treatment for adhesive otitis media (AOM). METHODS: Sixty-nine cases of AOM were undergone tympanoplasty between 1995 to 2000. Preoperative average air-bone gap(A-B gap) were (43.7 +/- 3.9) dB. Forty-one cases could be postoperative followed up for more than one year. Preoperative average A-B gap of this group were (43.8 +/- 4.2) dB. The adhesive ear drum and the other processes in middle ear were inserted and reconstructed with cartilage. RESULTS: The postoperative average A-B gap after one month(69 cases) and one year(41 cases) were (23.7 +/- 8.6) dB and (27.9 +/- 10.7) dB. In the long-time follow-up group, the A-B gap of 18 cases (43.9%) were less than 20 dB. Twenty-four cases (58.5%) become a nearly normal tympanum. CONCLUSION: The AOM can treatment with tympanoplasty. But the indication must be carefully selected. The cartilage was a good material for reconstruction of the ear drum to treatment the AOM. The influence factor were analyzed.
[Electrically stimulated olfactory evoked potential in olfactory-lesioned rabbit].
Wei YX, Han DM, Cai Z … +4 more , Yang-Ling, Liu XC, Xian M, Zhang XB
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127567
OBJECTIVE: To develop olfactory dysfunctioned animal model by injuring olfactory blub(s) and to investigate the characteristics of olfactory evoked potential. METHODS: The changes of OEP in rabbits were observed at 24 h,...
OBJECTIVE: To develop olfactory dysfunctioned animal model by injuring olfactory blub(s) and to investigate the characteristics of olfactory evoked potential. METHODS: The changes of OEP in rabbits were observed at 24 h, 48 h and 1 w after olfactory bulb(s) were electrolytically injured. The pathological and ultrastructural changes of olfactory mucosa and olfactory bulb were also observed. RESULTS: When unilateral olfactory bulb was damaged, N2 vanished with elongated latencies and lowered amplitudes of N1 and P1. When both olfactory bulbs were damaged, N1 and N2 were absent, only P1 could be recorded. The latency was extended obviously and the amplitude had a big change. Histopathology and ultrastructure showed that there were a lot of inflammatory cells and degenerated neurons scattered around OB 24 hours to 48 hours after injure. It was observed that the olfactory cilia had distraction perversion and colliquefaction changes. CONCLUSION: Different degree of olfactory bulb injury caused different effect on OEPs. These changes of potential were based on the histopathology and ultrastructure.
[Quantification of endolymphatic hydrops in experimental animal model].
Liang Q, Chi FL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127566
OBJECTIVE: To investigate a method of quantification of the endolymphatic hydrops in experimental animal model. METHODS: Thirty guinea pigs were divided into three groups at random. In control group, there were ten guine...
OBJECTIVE: To investigate a method of quantification of the endolymphatic hydrops in experimental animal model. METHODS: Thirty guinea pigs were divided into three groups at random. In control group, there were ten guinea pigs without operation on both ears. Endolymphatic hydrops was induced by endolymphatic sac obliteration through extradural posterior cranial fossa approach in right ear, including 4-week postoperative group(n = 10) and 8-week postoperative group(n = 10). The area of scala vestibuli (SV) and scala media(SM) of each turn on both cochlear midmodiolar sections was measured, respectively, using auto computer aided design(AutoCAD R14) software combined with digital camera, and then the maximum scala media area(SMA) ratio was calculated and compared. RESULTS: No endolymphatic hydrops was observed in all non-operated ears, however, variety degree of hydrops was present in all operated ears. The average maximum SMA ratio in the 4-week group (2.2231 +/- 0.1996) was greater than that in the control group (1.0971 +/- 0.0644). The average maximum SMA ratio of the 8-week group (4.0142 +/- 0.5218) was greater than that in the 4-weekgroup. There was significant difference between the two groups(P < 0.05). CONCLUSION: It is convenience and reliable to be used to quantify the experimental endolymphatic hydrops with the present method. This study provides a reliable methodological base for the experimental study of Meniere's disease.
[Functional evaluation of the selective neck dissection in patients with carcinoma of head and neck].
Zhang B, Tang PZ, Xu ZG … +2 more , Qi YF, Wang XL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127565
OBJECTIVE: To investigate comparatively the shoulder function, sensory and cosmetic changes after selective neck dissection (SND), modified neck dissection (MND) or radical neck dissection (RND). METHODS: 157 questionnai...
OBJECTIVE: To investigate comparatively the shoulder function, sensory and cosmetic changes after selective neck dissection (SND), modified neck dissection (MND) or radical neck dissection (RND). METHODS: 157 questionnaires, which involving shoulder function, skin numbness and cosmetic changes were sent to patients with SCC of head and neck who were treated with SND, MND or RND between January 1997 and May 2001. 32 eligible questionnaires were collected which included 32 patients had 43 neck dissection. Among them, SNDs were performed in 23 necks, MNDs in 11 necks and RNDs in 9 necks. RESULTS: The shoulder disability was least in SND necks (13.0%), followed by MND necks (36.6%) and RND necks (66.7%). Similarly, permanent neck anesthetic were found in 17.4% of SND necks, 36.6% of MND necks, and 88.9% of RND necks. Last, only 17.4% of SND necks had cosmetic changes after surgery, while 90.9% of MND necks and 100% of RND necks had cosmetic changes after surgery. CONCLUSION: Patients underwent selective neck dissection had the least damage to the shoulder function, skin sensory and cosmetic.
[Cervical metastasis in patients with T2-4 cN0 laryngeal carcinoma].
Jia SS, He HJ, Xiang C … +1 more , Liu WS
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127564
OBJECTIVE: To study the characteristics of the cervical lymph node metastasis in clinical N0 (cN0) patients with laryngeal carcinoma and its implication in clinical treatment. METHODS: 76 patients with laryngeal carcinom...
OBJECTIVE: To study the characteristics of the cervical lymph node metastasis in clinical N0 (cN0) patients with laryngeal carcinoma and its implication in clinical treatment. METHODS: 76 patients with laryngeal carcinomas of T2-4cN0 category were divided into two groups in random: 21(22 sides) radical neck dissection(RND) and 55(60 sides) functional neck dissection(FND) were performed. Lymph nodes were studied histologically according to the levels. RESULTS: On an average, 29.6 lymph nodes were obtained in one side of neck in RND group, and 24.7 in FND group(F = 3.145, P = 0.068). The occult metastasis rates were 33.3% (7/21) in RND group and 34.5% (19/55) in FND group. 25 of 26 patients (96.2%) who had positive nodes involved only the levels II and III. 2130 lymph nodes were obtained in all samples, 59 of 60 positive nodes(98.3%) were located in the level II and III. The 5 and 10-year survival rates of the two groups were 71.4% (15/21), 76.4% (42/55) and 61.9% (13/21), 68.9% (31/45), respectively with no statistical difference(chi 2 = 0.2394, P > 0.5; chi 2 = 0.3143, P > 0.05). Ipsilateral cervical recurrence rates in two groups were 9.5% (2/21) and 7.3% (4/55), respectively with no statistical difference (chi 2 = 0.1059, P > 0.900). 10-year mortalities with negative and positive cervical lymph nodes were 16.7% (7/42) and 62.5% (15/24) respectively, which had statistically difference (chi 2 = 14.4375, P < 0.005). CONCLUSION: The lateral neck (level II, III and IV) dissection may be suitable for the treatment laryngeal carcinoma patients with T2-4cN0.
[Combined treatment for advanced laryngeal carcinoma].
Ge JH, Zhao RL, Hu JL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127563
OBJECTIVE: To assess the efficacy of the combined therapy for advanced laryngeal carcinoma. METHODS: 204 cases of advanced laryngeal carcinoma were treated in this department from 1984 to 1997. Patients were treated by s...
OBJECTIVE: To assess the efficacy of the combined therapy for advanced laryngeal carcinoma. METHODS: 204 cases of advanced laryngeal carcinoma were treated in this department from 1984 to 1997. Patients were treated by surgery alone or combined therapy including of surgery, radiotherapy and chemotherapy. RESULTS: The overall 3 and 5 year survival were 70.1% (143/204) and 61.8% (126/204) respectively. 5-year survival rate of the combined therapy group was 68.2% (90/132), whereas, 5-year survival was only 50.0% (36/72) for surgery alone group (P < 0.05). There was no statistical differences between surgery alone group and the combined therapy group in the local recurrences (P > 0.05) but distant metastases (P < 0.05). There were also no statistical differences between the preoperative radiotherapy group and the non-preoperative radiotherapy group in the terms of infection and fistula (P > 0.05). CONCLUSION: The results suggest that the combined therapy was more effective than surgery alone for the treatment of the advanced laryngeal carcinoma. Preoperative radiotherapy did not increase the incidences of infection and fistula.
[Survival analysis of 1115 patients with laryngeal carcinoma].
Ji WY, Du Q, Guan C … +1 more , Wang DG
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127562
OBJECTIVE: To study the long-term result of patients with laryngeal carcinoma treated by surgery and the prognostic factors. METHODS: The survival status of 1115 patients with laryngeal carcinoma which were treated in th...
OBJECTIVE: To study the long-term result of patients with laryngeal carcinoma treated by surgery and the prognostic factors. METHODS: The survival status of 1115 patients with laryngeal carcinoma which were treated in this department between 1983 and 1996 were retrospectively investigated. RESULTS: Overall 5-year survival rate was 77%. Among them, 5-year survival rate for patients of stage I was 94%, stage II 89%, stage III 82%, stage IV 66%. Patients with glottic cancer had the best prognosis, followed by supraglottic, subglottic and transglottic cancer. Five years survival rate for patients with partial laryngectomy was 85%, whereas, for total laryngectomy was 68%. The causes of failure were local recurrence and metastasis(70%). 14% of dead was not clear. CONCLUSION: Early diagnosis was the key for both larynx preservation and survival rates. Causes of dead were laryngeal recurrence and metastasis.
[Detection of mutation in exon 5 and exon 8 of PTEN in laryngeal squamous cell carcinoma].
Bai WL, Gao H, Ren Z … +1 more , Pan ZM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127561
OBJECTIVE: To detect mutations of exon 5 and exon 8 of phosphatase and tensin homology deleted on chromosome10/mutated in multiple advanced cancer1/TGF-beta regulated and epithelial cell-enriched phosphatase (PTEN/MMAC1/...
OBJECTIVE: To detect mutations of exon 5 and exon 8 of phosphatase and tensin homology deleted on chromosome10/mutated in multiple advanced cancer1/TGF-beta regulated and epithelial cell-enriched phosphatase (PTEN/MMAC1/TEP1 for short PTEN) gene in laryngeal squamous cell carcinoma (LSCC) and analyze the relationship between the mutation and LSCC. METHODS: Fresh tumor samples from 40 LSCC patients were examined using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct DNA sequencing. RESULTS: The mutation of exon 5 and exon 8 occurred in supra-glottic laryngeal carcinoma and no mutation in the glottic laryngeal carcinoma was found. There were 6 cases of mutation for exon 5, and the mutation rate was 15%. In 2 cases, 1 base pair insertion TT-->TAT in codon 85, while in other two cases, 1 base pair deletion GCA-->GC in codon 86, and the two type mutation may result in frame shift mutation. One case had the above two type mutation simultaneously, which may result in missense mutation; 1 case had 1 base pair insertion TT-->TAT in 85 codon and 1 base pair deletion GCA-->GA, which may result in nonsense mutation. The pathology of 3/6 (50%) cases was low differentiation, and the others (3/6, 50%) were middle differentiation. Five cases had lymphatic metastasis, and the rate of which was 83.3%; the other one had no lymphatic metastasis, and the rate of which was 16.7%. There was only 1 case mutation for exon 8, and the mutation rate was 2.5%. One base pair deletion AAA-->AA in 276 codon as well as 1 base pair insertion CT-->CCT between the 336 codon and 337 codon may result in frame shift mutation. The pathology of the case was low differentiation. CONCLUSION: The codon 85,86 of PTEN gene in exon 5 may be "hot spots" in LSCC and the mutation of PTEN gene may be related with the lymphatic metastasis and middle or low differentiation.
[Human antisense-vascular endothelial growth factor gene therapy for laryngeal tumor by cationic liposome-mediated transfection].
Deng ZH, Jin M, Huang WG … +3 more , Qiu JH, Liu SL, Wang JL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127560
OBJECTIVE: To observe the effect of cationic liposome mediated antisense-vascular endothelial growth factor (VEGF) gene transfection on the growth of laryngeal cancer Hep-2 cells in the nude mice. METHODS: The VEGF-cDNA...
OBJECTIVE: To observe the effect of cationic liposome mediated antisense-vascular endothelial growth factor (VEGF) gene transfection on the growth of laryngeal cancer Hep-2 cells in the nude mice. METHODS: The VEGF-cDNA gene was cloned by reverse transcriptase polymerase chain reaction (RT-PCR) from human laryngeal cancer, and its eukaryotic expression vector pcDNA3-VEGF (-) with antisense-VEGF gene was constructed and identified by PCR and double-enzyme digestion. The pcDNA3-VEGF (-) was transfected into laryngeal cancer Hep-2 cell line by using cationic liposome (LP 2000). Then, the transfected Hep-2 cells were injected into nude mice and the size of tumor from different groups was observed while establishing laryngeal cancer xenografts in nude mice, and then treating the tumor-bearing mice with liposome-plasmid complex, observing the size of tumor from different groups. The expression of VEGF mRNA in different groups was observed by RT-PCR. The transfected cell ultranstructure was observed by transmission electron microscopy. RESULTS: The human VEGF-cDNA was successfully cloned and its eukaryotic expression vector with antisense-VEGF pcDNA3-VEGF (-) was constructed. The antisense-VEGF gene was transfected into Hep-2 cell line by using cationic liposome (LP2000). The size of tumor transfected with pcDNA3-VEGF (-) was significantly smaller than that of control groups. While the size of tumor treated with liposome-pcDNA3-VEGF (-) complex was significantly smaller than that of control groups. Many apoptic tumor cells were observed by transmission electron microscopy and the structure of microvessel was also changed. The expression of VEGF mRNA was evidently weaker than that of the control groups. CONCLUSION: The growth of Hep-2 cells could be inhibited significantly by antisense-VEGF gene transfection.
[Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1].
Li L, Lin P, Deng YF … +2 more , Zhu ZL, Lu HH
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Jan · PMID 15127559
OBJECTIVE: To investigate the relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 GSTM1. METHODS: The genetic polymorphisms of CYP1A1 exon-7 and GSTM1 were analyzed b...
OBJECTIVE: To investigate the relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 GSTM1. METHODS: The genetic polymorphisms of CYP1A1 exon-7 and GSTM1 were analyzed by polymorphism-polymerase chain reaction (PCR) technique in peripheral blood leukocytes of 89 laryngeal cancer cases and 164 non-cancer controls. RESULTS: Either in the frequency of CYP1A1 (W, MW, M) and GSTM1 negative individual of laryngeal cancer were significantly higher than that in the controls(P < 0.05). Combined genetype of CYP1A1 and GSTM1, that is CYP1A1 W/GSTM1 (-), CYP1A1 MW/GSTM1 (-), CYP1A1 M/GSTM1 (+), CYP1A1 M/GSTM1 (-) had higher risk than those combined genotypes, which ratios were 1.42 (0.62-3.22), 1.67 (0.7-4.03), 2.55 (1.0-6.54) and 4.02 (1.65-9.79), respectively. Statistic analysis suggested an interaction between smoking and CYP1A1 M/GSTM1 (-) genotypes polymorphisms which increase risk of laryngeal cancer. There was no significant difference in the frequency of CYP1A1, GSTM1 individual with the development and prognosis of laryngeal cancer. CONCLUSION: The present datas suggested that genetic polymorphisms of CYP1A1 and GSTM1 were susceptible to laryngeal cancer. Individuals with CYP1A1 M or GSTM1 (-) had increased risk of developing laryngeal cancer, but individuals with combined CYP1A1 M/GSTM1 (-) and smoking were more susceptible. Genetic polymorphisms of CYP1A1 and GSTM1 are not related with clinic process of laryngeal cancer.
[Clinical characteristics of sleep apnea-hypopnea syndrome in women].
Ye JY, Wang XY, Han DM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040116
OBJECTIVE: To realize the characteristics of symptoms and polysomnography in women with sleep apnea-hypopnea syndrome (SAHS) compared with that of male patients. METHODS: The symptoms and polysomnography were compared be...
OBJECTIVE: To realize the characteristics of symptoms and polysomnography in women with sleep apnea-hypopnea syndrome (SAHS) compared with that of male patients. METHODS: The symptoms and polysomnography were compared between men and women with SAHS and among mild (5 to 19 events/h), moderate (20 to 39 events/h), severe (> or = 40 events/h) of female patients. RESULTS: Female patients were older than that of male(51.1 +/- 11.2 yr versus 43.9 +/- 10.1 yr). The mean body mass index(BMI) for women was (27.8 +/- 3.9) kg/m2 and (28.1 +/- 3.8) kg/m2 for men. Women with higher AHI snored more severely, and female had a lower apnea hypopnea index (AHI) and apnea index (AI) but higher hypopnea index (HI) than did male. In addition, the respiratory events during non-rapid eye movement for men were significantly higher than that for women. CONCLUSION: Female patients are older than male but not more adipose. SAHS and respiratory events during NREM sleep are less severe in women.
[Expression of cell cycle regulators in squamous cell carcinoma of maxillary sinus and their significance].
Wang JB, Wang Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040115
OBJECTIVE: To investigate the clinicopathlogical significance of cyclinE, cyclinD1, P21WAF1/CIP1 and P27KIP1 expression in squamous cell carcinoma of maxillary sinus. METHODS: The expression of cyclinE, cyclinD1, P21WAF1...
OBJECTIVE: To investigate the clinicopathlogical significance of cyclinE, cyclinD1, P21WAF1/CIP1 and P27KIP1 expression in squamous cell carcinoma of maxillary sinus. METHODS: The expression of cyclinE, cyclinD1, P21WAF1/CIP1 and P27KIP1 was examined by the method of immunohistochemistry in inflammatory mucosa of maxillary sinus(10), inverting papilloma of maxillary sinus(20) and squamous cell carcinoma of maxillary sinus (50). RESULTS: (1) In inflammatory mucosa, inverting papilloma and squamous cell carcinoma, the positive immunostaining rates of cyclinD1 protein were 10.0%, 25.0%, 48.0% respectively (P < 0.05); cyclinE protein was 20.0%, 35.0%, 58.0% respectively (P < 0.05); P21WAF1/CIP1 protein was 80.0%, 65.0%, 40.0% respectively (P < 0.05) and P27KIP1 protein was 70.0%, 75.0%, 40.0% respectively (P < 0.05). (2) There was no significance between the clinical type, T stage and clinical stage of carcinoma of maxillary sinus and the expression of cyclinD1, cyclinE, P21WAF1/CIP1 and P27KIP1 (P > 0.05). (3) P21WAF1/CIP1 positive expression in highly, moderately and poorly differtiated carcinomas were 73.2% (11/15), 58.9% (11/19), 25.0% (4/16) respectively (P < 0.05). CONCLUSION: (1) With the development of the lesion, the positive immunostaining rate of cyclinE and cyclinD1 protein increases, while the rate of P21WAF1/CIP1 and P27KIP1 protein decreases. (2) P21WAF1/CIP1 expression is associated with tumour cell differentiation. (3) The mutual mechenism of cell cycle regulators plays an important role in the squamous cell carcinoma of maxillary sinus. The quantity and the frequency of four kinds of gene expression increase with the progression of maxillary sinus carcinogenesis.
[Surgery of ossifying fibroma of the sinuses].
Cui SJ, Zhou B, Han DM … +6 more , Liu M, Liu HC, Huang Q, Zhang L, Ge WT, Zhao XT
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040114
OBJECTIVE: To explore the different surgical choices for treating the ossifying fibroma of the sinuses. To summarize the management and characteristics of each surgical operation. METHODS: A retrospective evaluation of t...
OBJECTIVE: To explore the different surgical choices for treating the ossifying fibroma of the sinuses. To summarize the management and characteristics of each surgical operation. METHODS: A retrospective evaluation of thirty-five patients with ossifying fibroma of the sinuses from August 1994 to July 2001 was presented. RESULTS: Among 22 patients operated by nasal endoscopic management, complete ossifying fibroma removed was achieved in 8 cases, and the majority part of tumor removed in 14 cases. Six patients were operated through a lateral rhinotomy with radical operation in 4 cases. Five ossifying fibromas were removed with a coronal incision. Two cases underwent Caldwell-Luc' surgery. The clinical symptoms, location of ossifying fibroma, and surgical procedures were analyzed. All patients outcomes were successful, no serious complication from the surgical technique occurred. Thirty-three cases were followed-up for 1 to 8 years with an average of three and half years. Fourteen patients had no recurrence, fourteen cases lived with the remains of ossifying fibroma, and five cases recurred. CONCLUSIONS: The choice of surgical operations on ossifying fibroma of the sinuses was mainly decided by the location of ossifying fibroma, in the meanwhile, the organ function, the cosmetology, the surgical degree of difficulty, and the doctor's experience were taken into account.
[The use of muscle autograft denatured by microwave for repair of gaps in removal of facial neuromas].
Gao ZQ, Zhang LS, Ge PJ … +4 more , Li YL, Wang H, Liu W, Li FR
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040113
OBJECTIVE: To study the clinical value of muscle autograft denatured by microwave for repair of gaps in removal of facial neuromas. METHODS: Two cases of patients with facial nerve Schwann cell neuromas were reported. Th...
OBJECTIVE: To study the clinical value of muscle autograft denatured by microwave for repair of gaps in removal of facial neuromas. METHODS: Two cases of patients with facial nerve Schwann cell neuromas were reported. The operations for removal of facial neuromas were completed, and the gaps of the nerves were repaired with muscle autograft denatured by microwave of 250 W for 120 sec. RESULTS: The patients were followed up for two years, and the recovery of facial function on the affected sides were satisfactory. CONCLUSION: Muscle autograft denatured by microwave technique is convenient, highly efficient for repairing facial nerve gap after removal of facial neuroma.
[Phanerogenetic retrocochlear low frequency hearing loss].
Han WJ, Gu R, Yu LM … +4 more , Zheng JF, Zhou N, Cao JY, Wang L
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040112
OBJECTIVE: To study the pathogenisis of retrocochlear low frequency hearing loss. METHODS: Clinical and audiologic findings [auditory brainstem response (ABR), evoked otoacoustic emission (EOAE), et al] of 29 cases with...
OBJECTIVE: To study the pathogenisis of retrocochlear low frequency hearing loss. METHODS: Clinical and audiologic findings [auditory brainstem response (ABR), evoked otoacoustic emission (EOAE), et al] of 29 cases with retrocochlear low frequency hearing loss were studied. RESULTS: The head injury, acoustic neuroma, peripheral neurophathy, hereditary hear loss, multiple sclerosis and brainstem disease can cause retrocochlear low frequency hearing loss. The typical clinical manifestations of retrocochlear low frequency hearing loss were normal EOAE which cannot be suppressed by contralateral white noise, but with abnormal ABR as well as with no acoustic reflex and -SP/AP > 0.44. CONCLUSIONS: The results suggest that phanerogenetic retrocochlear low frequency hearing loss should be a syndrome rather than a disease called "auditory neuropathy". The main lesions of the disease are brainstem, cochlear nuclei and auditory nerve.
[Expression of nuclear factor-kappa B mRNA, inducible nitric oxide synthase and interleukin-6 in nasal polyp and its role].
Zhang H, Su SW, Zheng Y … +2 more , Wang L, Ma XD
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040111
OBJECTIVE: To evaluate the expression and significance of nuclear factor-kappa B (NF-kappa B) mRNA, inducible nitric oxide synthase(iNOS) and interleukin-6 (IL-6) in the pathophysiology of nasal polyp(NP). METHODS: The s...
OBJECTIVE: To evaluate the expression and significance of nuclear factor-kappa B (NF-kappa B) mRNA, inducible nitric oxide synthase(iNOS) and interleukin-6 (IL-6) in the pathophysiology of nasal polyp(NP). METHODS: The specimens from 59 nasal polyps (NP) and 20 inferior turbinates (IT) were studied by in situ hybridization for NF-kappa B mRNA, and by immunohistochemistry for iNOS and IL-6. Tissue sections were observed under optical microscope. RESULTS: NF-kappa B mRNA, iNOS and IL-6 overexpressions were localized mainly to the nasal polyp epithelium, the various inflammatory cells, in submucosal endothelial cells around the vessel and in submucosal glands. The positive frequency of activation of NF-kappa B mRNA was higher in NP (54.24%) than in IT (P < 0.01), whereas the positive frequency of iNOS and IL-6 overexpression were higher in NP (62.71% and 64.41%) than in IT (P < 0.01). Eosinophils and neutrophils in NP were higher than in IT (P < 0.01). CONCLUSION: These results suggest that NF-kappa B, iNOS and IL-6 are strongly correlated with the formation of NP. NF-kappa B, iNOS and IL-6 may act as anti-apoptotic molecules in eosinophils and neutrophils that may be responsible for the recruitment of inflammatory cells, particularly eosinophils, through the initiation of the transcriptional pathway of the related cytokines. NF-kappa B might play a key role in the pathogenesis of NP process and therefore is a potential target for medical treatment and new therapeutic intervention.
[Effect of erythromycin on the expression of apoptotic gene on eosinophils in nasal polyps in vitro].
Tang J, Li Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2003 Dec · PMID 15040110
OBJECTIVE: To study the expression of apoptotic gene in nasal polyps and the possible effect of erythromycin on it. METHODS: Total 40 nasal polyps biopsies were detected the expression of Bcl-2, Bax, Bcl-xL as well as Fa...
OBJECTIVE: To study the expression of apoptotic gene in nasal polyps and the possible effect of erythromycin on it. METHODS: Total 40 nasal polyps biopsies were detected the expression of Bcl-2, Bax, Bcl-xL as well as Fas protein on eosinophils by immunohistochemistry. The expression of Bax, Bcl-xL, Fas on eosinophils in 15 nasal polyps explants which cultured with or without erythromycin were detected also. RESULTS: In nasal polyps, the expression of Bcl-2, Bax, Bcl-xL and Fas protein on eosinophils are 5% (2/10), 65% (26/40), 40% (16/40) and 90% (36/40) respectively. As compared with inferior turbinate, there were significant difference in expression of Bax and Fas protein between two tissues (P < 0.05). After cultured with erythromycin, the expression of Bax protein increased (P < 0.05), but the expression of Bcl-xL and Fas protein had not changed. CONCLUSION: Bax may be the most significant gene which control the apoptosis of eosinophils in nasal polyps. And a possible mechaism which erythromycin promote the apoptosis of eosinophils is increase the expression of Bax.
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