Zhonghua Er Bi Yan Hou Ke Za Zhi[JOURNAL]
Sun
200 papers
[Overexpression of thymosin beta4 in the cochlea of senescence-accelerated mouse].
Wang YS, Asamura K, Usami S
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Dec · PMID 15813012
OBJECTIVE: To develop gene expression profiles of young and old senescence-accelerated mouse (SAM) cochlea and identify genes responsible for aging-related hearing loss. METHODS: Gene micro-array slides containing 1101 m...
OBJECTIVE: To develop gene expression profiles of young and old senescence-accelerated mouse (SAM) cochlea and identify genes responsible for aging-related hearing loss. METHODS: Gene micro-array slides containing 1101 mouse genes were hybridized to cDNA micro-arrays (Atlas Glass Array Mouse 1.0) that were synthesized using total RNAs from the cochlea of 2 mounts and 12 mounts mouse. Hybridization signals were visualized with cyanine-3 fluorescent reporter molecules, and the fluorescence intensities of the images were analyzed. Real-time quantitative reverse transcription PCR (qRT-PCR) was performed to validate the micro-array results. Immunofluorescence was used to identify the located region of the protein encoding by the candidate gene in the cochlea. RESULTS: Expression of a majority of the 1101 genes represented on the micro-array slides was not altered during aging; nonetheless, changes in the expression of 3 genes were detected between young and old mouse cochlea. RT-PCR results confirmed the changes in expression of thymosin beta4 of 3 genes examined. Through the using of immunofluorescence, it was shown that thymosin beta4 was primarily located in the tectorial membrane and the supporting cells of outer hair cell. CONCLUSIONS: Using commercially available slide micro-arrays, the results show that aging of the mouse cochlea is associated with changes in patterns of gene expression. This analysis suggests that thymosin beta4 may play a role in aging-related hearing loss. These studies lay the foundation for future studies defining the genetic basis of aging-related hearing loss.
[Epidermal stem cells in the tympanic membrane].
Wang WQ, Wang ZM, Tian J
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Dec · PMID 15813011
OBJECTIVE: To investigate the distributions of epithelial stem cells in the tympanic membrane and the growth characteristics of cultured epithelial cells from different region of tympanic membrane, and to establish cultu...
OBJECTIVE: To investigate the distributions of epithelial stem cells in the tympanic membrane and the growth characteristics of cultured epithelial cells from different region of tympanic membrane, and to establish culture techniques of stem cells in tympanic membrane. METHODS: Four young rats and four adult SD rats were used to observe normal tympanic membrane. The other 28 rats were performed 2 mm size perforations in pars tensa. These animals were sacrificed at different periods after perforation. The tympanic membranes were cut in cryostat sections for immunohistochemistry of cytokeratin 19 and integrin beta1. Thirty tympanic membranes of rats were treated with Mitomycin C to damage the mucosal surface, then divided into two parts: the annulus region and center region of pars tensa, cultured in medium with high amount of epidermal growth factor and low amount of calcium. RESULTS: The immunostaining cells of cytokeratin 19 and integrin beta1 were displayed in both the handle of malleus and annular regions, but there were no staining positive cells in the intermediate region of pars tensa. The positive cells distribution had no significant difference between adult and infancy rats. In the pars flaccid, the positive cells scattered in the basal layer. The positive cells increased after perforation in the annulus and handle of malleus region, but no immunostaining cells were found at the edge of perforation. The redouble time of the culture cells from the annulus region was shorter than the center of pars tensa. The cells adherent within 1 hour formed larger and more colonies, and contained more positive cells. CONCLUSION: The epithelial stem cells in tympanic membrane were located in both the handle of malleus and annular regions, but no stem cells could be found in the intermediate region of pars tensa. The stem cells of tympanic membrane can be simply purified according to the adherent time.
[Protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats].
Kong WJ, Han YC, Wang Y … +3 more , Hu YJ, Liu J, Wang Q
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Dec · PMID 15813010
OBJECTIVE: To explore the protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats. METHODS: Forty-six Wistar rats were randomly divided into three groups. The r...
OBJECTIVE: To explore the protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats. METHODS: Forty-six Wistar rats were randomly divided into three groups. The rats of group A (18 rats) had admitted adriamycin 1 mg/kg by intraperitoneal injection twice a week and had taken vitamin E 50 mg/kg, coenzyme Q10 10 mg/kg orally everyday for three months. Group B (18 rats) was given the same dose of adriamycin as group A and saline instead of vitamin E and coenzyme Q10. Group C (10 rats) was given Saline only. The inner ear tissue was harvested and mitochondrial DNA was amplified to identify t he 4834 bp deletion mutation by nested-primer polymerase chain reaction (nested-PCR) technique. And the serum glutathione peroxidase (GSH-PX) activity was measured. RESULTS: The incidence of mitochondrial DNA 4834 bp deletion mutation of group A was 23.08% (3/13), group B was 68.75% (11/16), and group C was 0 (0/8). The mutation incidence of group A was significantly lower than group B (Fisher's exact test, 1-sided, P = 0.018) and there was no significant difference between group A and group C (Fisher's exact test, 1-sided, P = 0.215). The activity of serum glutathione peroxidase of group A was marked higher than that of group B (adjusted t' test, 1-sided, t' = 6.474, P < 0.01). And the difference of activity of serum glutathione peroxidase between group A and group C was not significantly (adjusted t' test, 2-sided, t' = 1.920, P > 0.05). CONCLUSION: The results suggested that vitamin E and coenzyme Q10 could improve the ability of free radicals cleaning and protect the mitochondrial DNA from 4834 bp deletion mutation.
[Advantages and disadvantages of image guidance system in sinus surgery].
Wang RG, Chen L, Yang WY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Dec · PMID 15813009
Abstract loading — click title to view on PubMed.
[Distributing and changes of NO and calcitonin gene-related peptide in pharyngeal tissues and plasma in obstructive sleep apnea and hypopnea syndrome].
Deng AC, Meng XG, Yang H … +1 more , Chan XM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696922
OBJECTIVE: To explore the distributing and changes of nitric oxide (NO) and calcitonin gene-related peptide (CGRP) in obstructive sleep apnea and hypopnea syndrome (OSAHS). METHODS: This study investigated the content of...
OBJECTIVE: To explore the distributing and changes of nitric oxide (NO) and calcitonin gene-related peptide (CGRP) in obstructive sleep apnea and hypopnea syndrome (OSAHS). METHODS: This study investigated the content of NO and CGRP in plasma and in pharyngeal tissues of OSAHS subjects. Moreover, the distribution of NOS and CGRP in pharyngeal tissues was researched using method of immunohistochemistry. RESULTS: (1) Plasma NO level in control group was higher than in mild OSAHS group and in serious OSAHS group, P < 0.001. There was a significant increase in plasma CGRP after UPPP (P < 0.001), and the plasma CGRP level in control group was as high as that in after UPPP group (P > 0.05) NO level in pharyngeal tissue of OSAHS increased significantly, P < 0.001), but CGRP level decreased markedly, P < 0.001. (2) Immunohistochemistry change about NOS: there was a feeble positive expression in mucosa squamous epithelium of OSAHS and powerful positive expression in some salivary glandular epithelium, striated muscle cells, vascular wall/small vascular wall and epithelium of glandular duct of OSAHS. (3) Immunohistochemistry change about CGRP: There were diffusible positive markings in striated muscle cells and most cilium columnar epithelium in OSAHS, and negative expressions in other sites. CONCLUSIONS: (1) Circulating NO and CGRP are suppressed in OSAHS, and reversible promptly after UPPP. Further more, The content of NO in pharyngeal tissues increases significantly and that of CGRP decreases markedly. (2) The distribution of NOS and CGRP in pharyngeal tissue changes apparently according to sites.
[Relationship between levels of intercellular adhesion molecule-1, interleukin-6 and airway hyperresponsiveness in patients with allergic rhinitis].
Zhang QG, Zheng DS, Yao YT … +3 more , Zhang XH, Yu HL, Liang DP
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696921
OBJECTIVE: To investigate the relation between levels of intercellular adhesion molecule-1, interleukin-6 and airway hyperresponsiveness in patients with allergic rhinitis. METHODS: Fifty-four patients with allergic rhin...
OBJECTIVE: To investigate the relation between levels of intercellular adhesion molecule-1, interleukin-6 and airway hyperresponsiveness in patients with allergic rhinitis. METHODS: Fifty-four patients with allergic rhinitis (AR) and 20 controls were included in the study. The levels of intercellular adhesion molecule-1 (ICAM-1) and interleukin-6 (IL-6) in nasal lavage fluid, gathered 1 hour after specific allergen nasal provocation test (SANPT), were detected by sandwich enzyme-linked immunosorbent assay (ELISA) technique. The pulmonary function (FEV1) and nonspecific bronchial provocation test were measured in 54 patients with AR, 36 patients with AR and bronchial asthma (BA) and 20 controls. At the same time, the correlation between levels of ICAM-1 and IL-6 in nasal lavage fluid and pulmonary function (FEV1) was studied. RESULTS: The levels of ICAM-1 and IL-6 in nasal lavage fluid from patients with AR were (272.75 +/- 32.25) pg/ml and (52.11 +/- 16.54) pg/ml, significantly higher than those the controls, which were (158.82 +/- 33.88) pg/ml and (25.64 +/- 10.14) pg/ml (P < 0.01). The pulmonary function (FEV1) in patients with AR and BA was (78.82 +/- 7.41)%. It was obviously lower than that in patients with AR [(83.90 +/- 4.87)%], much lower than that in normal controls [(90.25 +/- 4.69)%]. The difference among them was significant. In patients with AR, the positive percentage of bronchial provocation test was 64.81%, in patients with AR and BA, it was 83.33% in normal controls, it was 0. The differences among them had very significant meaning. The levels of ICAM-1 and IL-6 in nasal provocation fluid had closely negative correlation with pulmonary function (FEV1), r = -0.7071, -0.6248, P < 0.01. CONCLUSIONS: The close correlation was observed in upper and lower airway for allergic inflammation. The pulmonary function of patients with AR was lower, and 64. 8% of them had airway hyperresponsiveness, so that they had the potent possibility to have bronchial asthma.
[Experimental reconstruction of the canine trachea with shape-memory titanium-nickel alloy stent coupled with free jejunal graft].
Ma LG, Wang YJ, He FY … +2 more , Zhang JL, Zhou X
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696920
OBJECTIVE: To explore the reconstruction method of extensive circumferential tracheal defects longer than 6.0 cm and evaluate the influence on pulmonary function from jejunal secretion. METHODS: Jejunal secretion model w...
OBJECTIVE: To explore the reconstruction method of extensive circumferential tracheal defects longer than 6.0 cm and evaluate the influence on pulmonary function from jejunal secretion. METHODS: Jejunal secretion model without extraneous nerve were established. 10 mongrel dogs were randomly divided into two groups. In group A, the nude stent made by shape-memory titanium-nickel alloy (SMA stent) was placed in the interior of the intestinal lumen. In group B, the SMA stent with silicone membrane was placed in the interior of the intestinal lumen. The secretion and histological chance of these jejunal were observed regularly. The cervical tracheal segment (6.5 cm) was replaced by the intestinal graft. In group C (6 mongrel dogs), the nude stent made by SMA stent was placed in the interior of the intestinal lumen. In group D (6 mongrel dogs and 6 Beagle dogs), the SMA stent with silicone membrane was placed in the interior of the intestinal lumen, the nude "C-shaped" SMA stent was placed out of the intestinal lumen, and the silicone stent was removed the fourth week after operation. In group C and group D, endoscopic and histological examinations were performed between the first week and eighth month. RESULTS: The secretory peak of Jejunal secretion model without extraneous nerve ranged from the first day to seventh day after operation. The jejunal secretion reduced gradually from 7th days after operation. The jejunal secretion remained steady after postoperative two months. In group C, endoscopic examination showed heavy proliferation of granulation in the tracheo-intestinal anastomosis. 4 dogs died between seventh day to second month. In group D, one dog died from ileus third month after operation. The other all survived operation. Gentle pneumonia happened to some dogs during 1-2 months after operation by X-ray examination. No one died of pneumonia result from hypersecretion. CONCLUSIONS: Reconstruction of the canine trachea with SMA stent with silicone membrane placed in the interior of the intestinal lumen together with the nude "C-shaped" SMA stent placed out of the intestinal lumen achieve satisfactory effect, the reconstructed trachea remain unblocked and this method of tracheal reconstruction may be relatively perfect and be expected for clinical application in future. The jejunal secretion didn't have severe influence on pulmonary function of experimental canine and couldn't cause experimental canine death.
[Fabrication of laryngeal cartilage by means of tissue engineering technique].
Sun AK, Pei GX, Hu P … +5 more , Chen JR, Ren GH, Zhang Y, Hu BS, Qin Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696919
OBJECTIVE: To explore the method of fabricating tissue engineered laryngeal cartilage. METHODS: The rib and articular cartilage of infant New Zealand white rabbits were harvested in sterile condition. The chondrocytes we...
OBJECTIVE: To explore the method of fabricating tissue engineered laryngeal cartilage. METHODS: The rib and articular cartilage of infant New Zealand white rabbits were harvested in sterile condition. The chondrocytes were separated by collagenase digestion and cultured in vitro for 3 passage. Serial steps of solution casting, extrusion molding and particulate leaching were used to make larynx-shaped biomaterial models with poly(3-hydroxybutyrate-co-3-hydroxyhexanoate, PHBHH). The chondrocytes were seeded onto PHBHH scaffolds to form cell-PHBHH composites, which were subsequently in vitro for one week. After that, the measure of filling inner space of cell-PHBHH composites together with wrapping total composites using either greater omentum (n = 9) or fascia flap and muscle (also n = 9) in experimental groups was taken to implant the larynx-shaped biomaterial models seeded with chondrocytes into the belly and the back of adult New Zealand white rabbits. Control groups (every group n = 3) were the same measure as experimental groups but without chondrocyte on PHBHH scaffolds. Finally, morphological observation, HE staining & special staining and immunohistochemical test were conducted to assess cartilage regeneration and its shape at different period following implantation. RESULTS: The rate of viable cell in the final cell suspension was (93 +/- 2)% after well-controlled prolongation of digestion trypsin. Similar to that by traditional procedures (94 +/- 2)% (P > 0.05). The larynx-shaped PHBHH models with edges and corners of laryngeal cartilage made by us appeared to be hollow half-trumpet shape and its porosity was more than 90%. It showed that chondrocytes equally attached to the surface of porous PHBHH and filled within porousness with scanning electron microscopic examination. Tissue engineered larynx-shaped specimens could alternatively be harvested with the above mentioned two different implantation measures. The specimens presented to be similar to that before implantation in gross shape. It was demonstrated to be cartilaginous tissue through histological and immunohistochemical examination. Furthermore, There was nearly no difference between two kinds of tissue engineered laryngeal cartilage with two measures of implantation in morphology and histology. CONCLUSIONS: The regeneration of tissue engineered cartilage in vivo is not influenced by the chondrocytes harvested by improvement of well-controlled prolonged digestion with trypsin during in vitro cell culture. It seems that PHBHH may be used as scaffold in cartilage tissue engineering and wrapping together with filling method with either greater omentum or fascia flap and muscle is appropriate for fabricating tissue engineered laryngeal cartilage.
[Spontaneous healing of various types of rat tympanic membrane perforation].
Wang WQ, Wang ZM, Tian J
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696918
OBJECTIVE: To investigate the spontaneous healing process of various types of rat tympanic membrane perforation, study the perforation healing mechanism. METHODS: Fifty rats were divided into five groups in randomization...
OBJECTIVE: To investigate the spontaneous healing process of various types of rat tympanic membrane perforation, study the perforation healing mechanism. METHODS: Fifty rats were divided into five groups in randomization, and performed perforations phi = 2.5 mm, 1 mm, respectively in the center of tympanic membrane pars tensa, posterior marginal perforation (phi = 1.5 mm) in pars tensa, the handle of malleus cauterized with chromic acid after tympanic membrane 3/4 excision, and perforation (phi = 1.5 mm) in the center of pars flaccid, The histology of the perforations healing process was observed with light microscope. RESULTS: The epithelia retracted in the early stage after perforation. The epithelia near the annulus and manubrium showed hyperplasia. The epithelia hyperplasia also appeared the intact annulus region remote to the perforation. The middle connective tissue layer reacted later than the epithelial layer. The defects were closed first by the accumulation of the epithelial cells. The difference of healing time had no statistics significance between the big and small perforations. One ear perforated, but the other side intact ear appears no change. The epithelia didn't migrate into the tympanic cavity in the posterior marginal perforations. All the perforations healed after the manubriums of the malleus were damaged. Perforations in pars flaccid healed more quickly. CONCLUSIONS: The normal migration of the epithelia of the tympanic membrane played an important role in the healing of perforation. The generation center was located near tympanic annulus and manubrium of the malleus, so the protection of these two regions was very important in the middle-ear surgery.
[Cochlear reimplantation].
Yu LS, Chen F, Zheng HW … +1 more , Ma X
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696917
OBJECTIVE: To analyze retrospectively the outcome of 6 cases of cochlear reimplantation to summarize its experience. METHODS: The operation method of cochlear reimplantation was similar to routine cochlear implantation....
OBJECTIVE: To analyze retrospectively the outcome of 6 cases of cochlear reimplantation to summarize its experience. METHODS: The operation method of cochlear reimplantation was similar to routine cochlear implantation. A "H" incision for the muscle-periosteum was used to shorten the operation time. RESULTS: Of all the cases, the electrodes are successfully and totally inserted into the cochlea. The causes for revision are different. The electrode was found to be not in the proper situ of the cochlea after the first operation in one patient. The out part was ruptured because of trauma in another patient. The causes of the other four patients were unknown. CONCLUSIONS: The incision should not be too small. The control electrode should be put beneath the periosteum. The site used to fix up the out part need be burnished. Unabsorbable suture should do not be used. It is important to insert the new electrode quickly after drawing the old one out. The time to accommodate the new electrode often needs 3-4 weeks.
[Pre-operation evaluation and intra-operation management of cochlear implantation].
Zhang DX, Hu BH, Xiao YL … +1 more , Shi BN
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696916
OBJECTIVE: To summarize pre-operation evaluation experiences in cochlear implantation. METHODS: Performing auditory evaluation and image analysis seriously in 158 severe hearing loss or total deaf cases before cochlear i...
OBJECTIVE: To summarize pre-operation evaluation experiences in cochlear implantation. METHODS: Performing auditory evaluation and image analysis seriously in 158 severe hearing loss or total deaf cases before cochlear implantation, comparing their performance with the findings during and post operation. RESULTS: Among the total 158 cases, 116 cases with normal structure, 42 cases with the abnormal findings of the inner or middle ear. Stapedial gusher happened in 6 cases, 1 case was not predicted before operation. Except 1 case with serious malformation, the findings of other 157 cases in operation were consistent with the pre-operation evaluation. We helped all patients reconstruct auditory conduction with cochlear implantation, and the average hearing level up to 37.6 dB SPL. CONCLUSIONS: Performing image analysis seriously before operation and planning for operation according to HRCT can do great help to cochlear implantation. The operation under the HRCT instruction has less complications.
[Cochlear implantation in patients with inner ear malformations].
Han DM, Li YX, Zhao XT … +8 more , Chen XQ, Zheng J, Kong Y, Liu B, Liu S, Mo LY, Song Y, Wang L
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696915
OBJECTIVE: To describe clinical experiences with multi-channel cochlear implantation in patients with bilateral inner ear malformations. METHODS: Among 410 patients who received multi-channel cochlear implantations from...
OBJECTIVE: To describe clinical experiences with multi-channel cochlear implantation in patients with bilateral inner ear malformations. METHODS: Among 410 patients who received multi-channel cochlear implantations from 1996 to 2004 in Beijing Tongren Hospital, 82 patients were diagnosed with inner ear malformations and implanted. A retrospective analysis was performed about the surgical characteristics and mapping characteristics after implantation. RESULTS: (1) All patients had auditory sensations. (2) Gusher was more common than the normal cochlear implantation. (3) The electrodes were inserted in the "cochleostomy" in full length of 80 Patients, but 2 pairs of electrodes remained outside of "cochleostomy" in 2 patients. (4) No serious complications occurred after implantation. (5) The impedance of the electrodes, the T level and C level were similar with the normal cochlear implantation. The results had no significant difference in compare with normal cochlear group (P > 0. 05). (6) The abilities of speech discrimination and spoken language were improved through rehabilitation. CONCLUSIONS: The cochlear implantation can be performed safely in inner ear malformations. The outcome of hearing rehabilitation for patients with inner ear malformations are similar to those children with normal cochlear structure followed the multi-channel cochlear implantation.
[Rating evaluation of the effect of pre-lingual cochlear implanted's aural/oral rehabilitation by questionnaires].
Ji F, Xi X, Hong MD … +3 more , Han DY, Huang DL, Wu WM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696914
OBJECTIVE: To evaluate the effect of cochlear implanted's aural/oral rehabilitation using rating evaluation method by questionnaires, to analyze the relationship between rehabilitation effect and its possible influence f...
OBJECTIVE: To evaluate the effect of cochlear implanted's aural/oral rehabilitation using rating evaluation method by questionnaires, to analyze the relationship between rehabilitation effect and its possible influence factors including type of implant, age at surgery, pathology, etc, and to explore the rating questionnaire method for cochlear implanted's aural/oral rehabilitation effect evaluation. METHODS: Ninety-seven pre-lingual cochlear implanted's were involved in this investigation, all of which were severe or profound deafness before implantation. Interviewed the implanted's parents or teachers, asking them to rate the implanted's aural ability objectively from 1 to 8 according to Categories of Auditory Performance (CAP) and speech producing ability from 1 to 5 according to Speech Intelligibility Rating (SIR), then analyzed the relationship between effect of aural/oral rehabilitation represented by CAP/SIR rating results and its possible 9 influence factors including type of implant, age at surgery, pathology, duration of hearing loss, hearing aid wearing, inserting length of electrodes, implanted period, rehabilitation mode and financial conditions. Univariate test and multivariate stepwise logistic regression model were used for the analysis. RESULTS: In a univariate analysis, it was confirmed that 4 factors i.e. type of implant (P = 0.0439), implanted period (P = 0.0001), rehabilitation mode (P = 0.0460) and financial conditions (0.0140) were correlated to CAP; 2 factors i.e. implanted period (P = 0.0001), rehabilitation mode (P = 0.0271) were correlated to SIR. In a multivariate analysis using stepwise logistic regression model, the more significant influence factor for CAP was implanted period and financial conditions, and for SIR was implanted period. CONCLUSIONS: Cochlear implants will be more effective for aural/oral rehabilitation of implanted's with longer implanted period. Rehabilitation mode and method contribute to the effect of rehabilitation.
[Clinical review of cochlear implant in 533 cases].
Cao KL, Wei CG, Jin X … +2 more , Chen XW, Wang Y
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696913
OBJECTIVE: To summarize and analyze the etiology, surgical indications, operation methods and outcomes of cochlear implantation. METHODS: 533 cases (534 ears) with severe and profound hearing loss received cochlear impla...
OBJECTIVE: To summarize and analyze the etiology, surgical indications, operation methods and outcomes of cochlear implantation. METHODS: 533 cases (534 ears) with severe and profound hearing loss received cochlear implant, 489 were pre-lingual deafness and 38 cases were post-lingual deafness. Their ages at implant, 1 to approximately 3 were 167, approximately 5 were 77, approximately 7 were 73, approximately 14 were 136, approximately 17 were 28, >17 were 52. 76 cases (14. 3%) were found the middle and inner ear malformations. That included Mondini 26 in cases, Common cavity in 10 cases and Large vestibule aqueduct syndrome in 20 cases. The average pure tone threshold were 105.5 dB HL, ABR threshold were >95 dB nHL and 40 Hz threshold in 500 Hz were 101.7 dB. The devices they used were Nucleus 22M in 27 ears, 24M in 308 ears, 24R Contour in 131 ears and 24R ST in 21 ears; Med El C40+ in 44 ears; Clarion CI in 3 ears. Facial recess approach was performed in normal cases, and in Common cavity cases horizontal semicircular canal approach was used. Preoperative hearing and speech evaluations were done in most cases. RESULTS: In 26 Mondini case, gusher were happened in 20 cases. The insertion depth in normal cases: Nucleus were 30 bands, Med El were 31 mm. In Mondini cases, Nucleus were 28 bands. In Common cavity cases, Nucleus were 26 bands. Of 533 cases, The average of open set sentences discrimination of post-lingual deafness was 70%, the satisfaction rate of questionnaire for pre-lingual deafness under 17 years old was 94.7%. CONCLUSIONS: Cochlear implant is a useful method to restore the hearing of the patients with severe and profound hearing loss. It is important for the outcomes with proper preoperative assessment, surgery and postoperative speech and hearing evaluations.
[Concerning to issue of the cochlear implant].
Han DY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Oct · PMID 15696912
Abstract loading — click title to view on PubMed.
[Design and preliminary use of the device of subjective visual vertical].
Wu ZM, Zhang SZ, Zhao CJ … +2 more , Yang WY, Han DY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Sep · PMID 15606010
OBJECTIVE: The device of subjective visual vertical (SVV) was made to test the gravity orientation of subjects visual. METHODS: The normative value was established firstly in the right, left and both eyes respectively. T...
OBJECTIVE: The device of subjective visual vertical (SVV) was made to test the gravity orientation of subjects visual. METHODS: The normative value was established firstly in the right, left and both eyes respectively. Then the test was applied to evaluate the function of otolith function (utricular function) in normal adult subjects and examined the SVV in some patients suffered from acute unilateral vestibulopathy. RESULTS: The difference of the SVV among right, left and both eyes was not significant and the normative value was lower than +/- 2 degrees. No matter one eye or both eyes, SVV had the tendency to lateraliseze to the right. CONCLUSIONS: The SVV is a reliable choice to test the otolith vestibulopathy, which is at least suitable for acute phase. The bilateral eyes open mode is recommended to test the subjects suspected of utricuar dysfunction.
[Clinical analysis of 57 patients with poorly differentiated carcinomas of the supraglottic larynx].
Liu WS, Tang PZ, Qi YF … +2 more , Xu ZG, Li ZJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Sep · PMID 15606009
OBJECTIVE: To investigate the clinical characteristics, treatment and prognosis for poorly differentiated supraglottic carcinomas. METHODS: A retrospective study was conducted in 57 cases of poorly differentiated supragl...
OBJECTIVE: To investigate the clinical characteristics, treatment and prognosis for poorly differentiated supraglottic carcinomas. METHODS: A retrospective study was conducted in 57 cases of poorly differentiated supraglottic carcinomas treated in our hospital from 1980 to 1998. The distribution of the patients according to UICC in 1997 was as follows: stage I 4, stage II 15, stage III 18, stage IV 30. Of the 57 patients, 25 were treated with surgery alone, 9 with irradiation alone, 14 with surgery following preoperative radiation, 7 with postoperative radiation following surgery and 2 with surgery following preoperative chemotherapy. Total laryngectomy was performed on 23 patients and partial laryngectomy on 25 patients. The concurrent neck dissections were undergone for 31 cases (17 unilateral side, 14 bilateral side) and the upper neck dissections for 12 cases. RESULTS: The overall 5-year survival rate, accumulated cervical metastasis rate, metastasis rate of bilateral side of neck, distant metastasis rate, cervical recurrent rate and locally recurrent rate were 47.4% (27/57), 63.2% (36/57), 24.6% (14/57), 21.1% (12/57), 28.1% (16/57) and 10.5% (6/57), respectively. In addition, the local recurrent rate for partial laryngectomy was 12% (3/25). 5-year survival rate for each TNM staging decreases gradually. The difference in 5-year survival rate between T1 + T2 and T3 + T4 and the difference between N0 + N1 and N2 + N3 were statistically significant (chi2 = 4.942, P = 0.026; chi2 = 4.306, P = 0.038). No evidence in our analysis was found about the difference in 5-year survival rate between surgery alone and surgery combined with radiotherapy. The effect of surgery combined with radiotherapy on patients at N2 and N3 was relatively superior to that of surgery alone. CONCLUSIONS: Poorly differentiated carcinomas of the supraglottic larynx had characteristics of the advanced stage in terms of earlier lymph node metastasis and a relatively high rate of cervical and distant metastasis. Surgery was still the primary treatment for this disease and it was feasible to perform partial laryngectomy on certain patients. For patients with T3 who need partial laryngectomy and patients with advanced N stage, the combination of surgery with radiotherapy was supposed to be a priority.
[Diagnosis and treatment on osteoradionecrosis of skull base after radiotherapy for nasopharyngeal carcinoma].
Huang XM, Zheng YQ, Mai HQ … +5 more , Zhou H, Liu X, Deng MQ, Mi HQ, Xu G
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Sep · PMID 15606008
OBJECTIVE: To investigate the diagnosis and management on osteoradionecrosis (ORN) of skull base in the patients with nasopharyngeal carcinoma (NPC) after radiotherapy. METHODS: All patients (n = 15) diagnosed as NPC and...
OBJECTIVE: To investigate the diagnosis and management on osteoradionecrosis (ORN) of skull base in the patients with nasopharyngeal carcinoma (NPC) after radiotherapy. METHODS: All patients (n = 15) diagnosed as NPC and ORN of skull base were studied on the clinical data, diagnosis and therapy. RESULTS: All the patients were found with foul odor, headache, bleeding and exposed necrotic bone. 9 patients were treated by surgery, among them 2 patients died of temporal lobe radionecrosis, and the survival time of remaining 7 patients was 2 to 7 years. 5 patients with extensive ORN and 1 patient with local ORN were treated by conservative methods, among them 3 died of nasopharyngeal bleeding and 1 died of respiratory and heart failure, survival time of the remaining 2 patients was 3 to 5 years. CONCLUSIONS: ORN can be diagnosed by clinical characteristics, CT or MR, and endoscopic findings. Surgery is the best choice for ORN. The patients with extensive ORN or radiation-induced cranial neuropathy had poor prognosis. The most common causes of death were nasopharyngeal bleeding and exhaustion.
[Glottic measurement and vocal evaluation before and after adult arytenoidectomy].
Huang YD, Zhou SM, Zheng HL … +4 more , Li ZJ, Wen W, Zhang SQ, Geng LP
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Sep · PMID 15606007
OBJECTIVE: To study minimal glottic area which can acquire sufficient airway for decannulation and maximal glottic area which can maintain preoperative vocal function on adult bilateral vocal cord paralysis with unilater...
OBJECTIVE: To study minimal glottic area which can acquire sufficient airway for decannulation and maximal glottic area which can maintain preoperative vocal function on adult bilateral vocal cord paralysis with unilateral arytenoidectomy. METHODS: Sixteen adult received microscopic right arytenoidectomy with Diomed-25 laser under general anaesthesia and sustained laryngoscope from September 1998 to February 2003. The pre-postoperative glottic measurement and vocal acoustic parameters were analyzed. RESULTS: The postoperative maximal glottic area, maximal posterior glottic width and maximal opening angle between bilateral vocal cords of the 15 decannulated cases were (45.93 +/- 6.56) mm2, (4.97 +/- 0.73) mm and (24.34 +/- 4.74) degrees respectively. Compared with preoperative period, there were significant difference. Pre-postoperative acoustic parameters (Jitter, Shimmer, harmonics-noise ratio) were analyzed and no significant difference were found (P > 0.05, but there are significant difference in NNE (normalized noise energy) and MPT (maximum phonation time) (P < 0.05). Except for three cases whose postoperative glottic area were more than 50. 1 mm2, there were no significant difference in pre and postoperative NNE (P > 0.05). The minimal glottic area decannulated was 38.0 mm2. The more opening maximal glottic area, the greater of NNE because of bigger closing gap. Noticeable increase of NNE was observed when maximal opening glottic area was up to 50.1 mm2. CONCLUSIONS: The minimal glottic area for decannulation should be 38.0 mm2, and the maximal glottic area for maintaining preoperation vocal function should be 50.1 mm2 on adult bilateral voca cord paralysis with laser aryntenoidectomy.
[A clinical trial to evaluate the efficacy and safety of compound pseudoephedrine hydrochloride sustained release capsule in patients with seasonal allergic rhinitis].
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Sep · PMID 15606006
OBJECTIVE: To evaluate the efficacy and safety of compound pseudoephedrine hydrochloride sustained release capsule (Contac NT) in the relief of symptoms (such as nasal congestion, runny nose, nasal itching, sneezing, wat...
OBJECTIVE: To evaluate the efficacy and safety of compound pseudoephedrine hydrochloride sustained release capsule (Contac NT) in the relief of symptoms (such as nasal congestion, runny nose, nasal itching, sneezing, watery eyes, ocular itching and ear/palate itching) and signs (such as congested nasal mucosa and conchae, red eyes) in patients with Seasonal Allergic Rhinitis (SAR). METHODS: An open, multi-centre clinical trial was conducted. Contac NT (one capsule, twice a day, with an interval of 12 hours, successively for 7 days) was given to patients with seasonal allergic rhinitis. RESULTS: A total of 370 patients were eligible for efficacy analysis, 371 patients were eligible for safety analysis. The symptoms and signs improved significantly after medication, improvement of Day 1 to Day 7 in individual symptom and sign scores was highly statistically significant (P < 0.001). These results were clinically meaningful given that symptoms and signs were "much improved" in 70% and 68% of patients, respectively, "Total improved" rates for symptoms and signs were 89% and 80% respectively. There were 54 patients who reported 61 adverse events. The most frequent were mild to moderate drowsiness and dry mouth. There were no serious adverse events during the study. CONCLUSION: Compound pseudoephedrine hydrochloride sustained release capsule (Contac NT) was effective in controlling SAR symptoms and signs and well tolerated.
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