Endocrine Research[JOURNAL]
Sun
200 papers
MMRN1 suppresses thyroid cancer progression via activation of the Hippo signaling pathway.
Zhang M, Guo J, Sun J … +2 more , Gao X, Lv Y
Endocr Res · 2026 Jun · PMID 42381366 · Publisher ↗
INTRODUCTION: Thyroid cancer (TC) represents the most frequently diagnosed malignancy of the endocrine system, with its incidence continuing to increase worldwide. Multimerin 1 (MMRN1), a glycoprotein implicated in vario...
INTRODUCTION: Thyroid cancer (TC) represents the most frequently diagnosed malignancy of the endocrine system, with its incidence continuing to increase worldwide. Multimerin 1 (MMRN1), a glycoprotein implicated in various cancers, exhibits context-dependent roles, but its function in TC remains unexplored. The Hippo pathway, a key regulator of cell proliferation and apoptosis, is frequently dysregulated in TC. We hypothesized that MMRN1 inhibits TC progression by activating the Hippo signaling pathway. METHODS: Bioinformatics analysis of GSE33630 identified differentially expressed genes (DEGs) in TC. MMRN1 expression was validated in TC cell lines (BCPAP, TPC-1, IHH-4, HTH83) and normal thyroid cells (NTHY-ORI3.1) via RT-qPCR and Western blot. Functional assays assessed proliferation, migration, and invasion. Hippo pathway activity was evaluated after MMRN1 modulation. Oxidative stress and ferroptosis markers (ROS, SOD, CAT, GSH, MDA, GPX4, TF, TFR1) were analyzed. RESULTS: MMRN1 was downregulated in TC tissues and cell lines. Overexpression of MMRN1 suppressed TC cell proliferation, migration, and invasion while promoting apoptosis. Mechanistically, MMRN1 activated Hippo signaling, increasing p-MST1/2, p-LATS1/2, and p-YAP levels. Verteporfin reversed these effects. Additionally, MMRN1 modulated oxidative stress markers (including ROS and the indirect lipid peroxidation marker MDA) and altered GPX4 activity and iron metabolism, suggesting enhanced ferroptosis sensitivity. CONCLUSION: MMRN1 acts as a tumor suppressor in TC by activating the Hippo pathway and modulating oxidative stress and ferroptosis. These findings highlight MMRN1 as a potential therapeutic target for TC treatment.
Body composition and cardiometabolic changes during gender-affirming hormone therapy: 12-month longitudinal study.
Korkmaz ES, Kalkan AT, Akalın A … +3 more , Kebapçı MN, Çolak E, Yorulmaz G
Endocr Res · 2026 Jun · PMID 42358111 · Publisher ↗
BACKGROUND: Testosterone therapy induces well-known changes in body composition in transgender men; however, its short-term cardiometabolic effects remain incompletely characterized. This study aimed to evaluate body com...
BACKGROUND: Testosterone therapy induces well-known changes in body composition in transgender men; however, its short-term cardiometabolic effects remain incompletely characterized. This study aimed to evaluate body composition and cardiometabolic changes during testosterone therapy over a 12-month period. METHODS: This retrospective observational study included 15 transgender men initiating intramuscular testosterone therapy who were followed for 12 months. Anthropometric measurements, body composition, blood pressure, and laboratory parameters including lipid profile, fasting glucose, HbA1c, plasma atherogenic index (PAI), and triglyceride-glucose (TyG) index were assessed at baseline and at 12 months. All participants initiated intramuscular depot testosterone therapy administered every 28 days. None of the participants underwent oophorectomy during the study period. RESULTS: Total testosterone levels increased significantly from 40.82 ± 19.46 ng/dL to 338.06 ± 205.02 ng/dL ( < 0.001), while estradiol levels remained stable. Systolic blood pressure and mean arterial pressure showed mild but non-significant increases during follow-up. Body weight, body mass index, and fat-free mass increased significantly, while body fat percentage decreased. HDL cholesterol levels decreased (59.7 ± 11.2 to 52.3 ± 13.2 mg/dL, = 0.019), and triglyceride levels showed a non-significant upward trend. The PAI increased from 0.08 ± 0.24 to 0.23 ± 0.25 ( = 0.017), and the TyG index rose from 8.02 ± 0.43 to 8.21 ± 0.39 ( = 0.016). Blood pressure parameters did not change significantly. CONCLUSIONS: In transgender men without oophorectomy, testosterone therapy was associated with favorable changes in body composition alongside modest shifts in cardiometabolic indices over a 12-month period. These findings suggest that simple indices such as PAI and TyG may be useful for monitoring early cardiometabolic changes attributable to exogenous testosterone therapy. Larger prospective studies are warranted to confirm these observations.
Epigenetic analysis reveals aberrant aging in thyroid cancer.
Hou Y, Luo C, Yao Y … +1 more , Luo Y
Endocr Res · 2026 Jun · PMID 42340814 · Publisher ↗
BACKGROUND: Thyroid cancer (TC), the most common endocrine malignancy, is closely linked to aging. In this study, we estimated DNA methylation (DNAm) age in TC tissues versus adjacent non-cancerous thyroid tissues using...
BACKGROUND: Thyroid cancer (TC), the most common endocrine malignancy, is closely linked to aging. In this study, we estimated DNA methylation (DNAm) age in TC tissues versus adjacent non-cancerous thyroid tissues using TCGA and GSE97466 datasets. METHODS: We employed multi-tissue DNAm age estimators, specifically Horvath's clock and the Bayesian Neural Network (BNN) clock, to quantify epigenetic aging in TC and adjacent normal tissues from the TCGA and GSE97466 cohorts. We further integrated genomic, transcriptomic, and mutational analyses, including assessments of senescence-associated secretory phenotype (SASP), immune cell infiltration, and thyroid differentiation, to elucidate the associations between DNAm age acceleration and various cancer-related features. RESULTS: Our results revealed marked DNAm age acceleration in TC tissues relative to controls, with both models yielding significantly higher DNAm age estimates in tumors. Although DNAm age correlated strongly with chronological age in control tissues ( ≈ 0.94), this association was notably diminished in TC tissues ( ≈ 0.62). Moreover, TC tissues with accelerated DNAm age exhibited higher telomerase-associated gene expression score, heightened SASP signaling, and distinct immune profiles characterized by elevated M2 macrophages and reduced activated NK cells. Genomic analysis further showed a higher prevalence of BRAF mutations and lower thyroid differentiation scores (TDS) in the accelerated subgroup. No significant associations were detected between DNAm age and clinicopathological parameters or overall survival. CONCLUSIONS: Our findings provide valuable insights into the complex interplay between epigenetic regulation, immune dysfunction, and genomic instability in thyroid cancer, highlighting promising avenues for future research and therapeutic intervention.
gene functional domains and their role in clinical severity in androgen insensitivity syndrome: a single-center cohort from Turkey.
Celebi ST, Turan I, Kotan LD … +5 more , Cay M, Cimen AM, Celiloğlu C, Mengen E, Yuksel B
Endocr Res · 2026 Jun · PMID 42285972 · Publisher ↗
INTRODUCTION: Androgen receptor () gene mutations are a common cause of 46, XY disorders of sex development (DSD), resulting in varying degrees of androgen insensitivity. This study aims to comprehensively evaluate the c...
INTRODUCTION: Androgen receptor () gene mutations are a common cause of 46, XY disorders of sex development (DSD), resulting in varying degrees of androgen insensitivity. This study aims to comprehensively evaluate the clinical features, hormone profiles, and gene variants of patients diagnosed with Androgen Insensitivity Syndrome (AIS), and to analyze the distribution of these variants across different functional domains. MATERIALS AND METHODS: This retrospective, single-center study analyzed 16 cases of 46, XY DSD, all of whom were found to have variants from a single tertiary center in Turkey. Patients were evaluated based on their complaints, hormonal measurements, clinical features, and genetic diagnoses. Patients were classified as having Complete, Partial, or Mild AIS. The variants were categorized based on their location within the functional domains: The Ligand Binding Domain (LBD) and the N-terminal Domain (NTD). RESULTS: Patients were classified as having CAIS (8/16), PAIS (6/16), MAIS (1/16), and suspected diagnosis (1/16). The most common clinical finding was cryptorchidism (11/16). Ten different variants were detected: eight missense (p.Pro392Ser, p.Ala749Val, p.Val890Met, p.Asp733Asn, p.Arg856His, p.Arg856Cys, p.Glu494Ala, and p.Glu710Lys), one nonsense (p.Lys659Ter), and with p.Lys659Ter, p.Glu494Ala and being novel. A CAIS associated with p.Pro392Ser has been reported, and intrafamily variability has been documented in variants such as p.Arg856His and p.Pro392Ser. Most variants (10/16 patients) localized to the LBD. Individuals harboring LBD variants demonstrated lower external genital scores and shorter phallus lengths compared to those with NTD variants. T/DHT ratio was available in 11 patients and did not yield false-positive AIS diagnoses. Marked intrafamilial phenotypic variability was observed. CONCLUSION: This study expands the variant spectrum in AIS and represents one of the more comprehensively characterized cohorts from our country. While LBD variants were more often associated with severe phenotypes and NTD variants with milder presentations, marked phenotypic variability was observed. Nevertheless, considerable phenotypic variability, including marked intrafamilial heterogeneity, was evident. The T/DHT ratio provided supportive biochemical information but did not replace the need for molecular confirmation. Molecular confirmation remains essential, and multidisciplinary, patient-centered management is warranted.
Nocturnal tissue glycemia is associated with cortisol rise in the morning in young but not in older healthy adults.
Köhlmoos A, Dittmar M
Endocr Res · 2026 Apr · PMID 42048113 · Publisher ↗
Cortisol and vitamin D are known to influence plasma glucose, but their relationship with glycemia, assessed by continuous glucose monitoring, remains unclear for healthy adults. This study compared these relationships b...
Cortisol and vitamin D are known to influence plasma glucose, but their relationship with glycemia, assessed by continuous glucose monitoring, remains unclear for healthy adults. This study compared these relationships between 32 young (26.0 ± 4.8 years) and 25 older (67.3 ± 4.8 years) healthy volunteers. Cortisol was determined at bedtime, awakening, and 30 min (T30) and 60 min (T60) post-awakening. Older adults had higher fasting glucose but lower cortisol concentration at T30 than young adults. In young adults, night- and daytime mean glucose and fasting glucose correlated negatively with cortisol at T30, while glycemic variability correlated positively with cortisol at T60. Vitamin D correlated negatively with nighttime mean glucose in the young group. In conclusion, glucose concentration and glycemic variability are associated with the cortisol response the following morning. The lack of these associations in older adults could be explained by their higher fasting glucose concentrations resulting in a lower morning cortisol response.
Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes.
Athinarayanan SJ, Phinney SD, Adams RN … +7 more , Volek JS, Thurmond DC, McKenzie AL, Roberts CGP, Ratner RE, Krauss RM, Fonseca VA
Endocr Res · 2026 May · PMID 41994946 · Publisher ↗
BACKGROUND: Chronic low-grade inflammation contributes to the development and complications of type 2 diabetes (T2D). Nutritional ketosis improves glycemic control and weight, but its broader immunomodulatory effects are...
BACKGROUND: Chronic low-grade inflammation contributes to the development and complications of type 2 diabetes (T2D). Nutritional ketosis improves glycemic control and weight, but its broader immunomodulatory effects are less well defined. METHODS: In this post-hoc analysis, adults with T2D ( = 195) or prediabetes ( = 89) in a two-year continuous care intervention (CCI) with individualized carbohydrate reduction emphasizing nutritional ketosis were compared with T2D participants receiving usual care (UC, = 63). Serum was collected at baseline, 1, and 2 years for high-sensitivity CRP, 15 cytokines/adhesion molecules, and comprehensive blood count (CBC)-derived indices. Linear mixed-effects models evaluated longitudinal changes, while regression (including least absolute shrinkage and selection operator, LASSO) examined associations with mean β-hydroxybutyrate (BHB), weight change, HbA1c, and HOMA-IR. RESULTS: Nineteen of 21 markers declined at 1 year in CCI, largely sustained at 2 years; UC showed no changes. Higher BHB predicted reductions in WBC, ICAM-1, VEGF-A, and systemic immune-inflammation index (SII), while weight loss correlated with IL-6, IL-18, IL-1β, and TNF-α. CONCLUSION: CCI induced broad, durable anti-inflammatory effects, supporting its role in lowering systemic inflammation and cardiometabolic risk.
Chemical chaperone TUDCA rescues Insulin-mediated vascular relaxation via ER stress inhibition in diabetic rat model.
Mustapha S, Azemi AK, Rasool AHG … +1 more , Mokhtar SS
Endocr Res · 2026 Apr · PMID 41987660 · Publisher ↗
BACKGROUND: Tauroursodeoxycholic acid (TUDCA) has been shown to improve endothelial dysfunction in type 2 diabetes mellitus (T2DM). However, its role in attenuating endothelial insulin resistance in diabetes is not well...
BACKGROUND: Tauroursodeoxycholic acid (TUDCA) has been shown to improve endothelial dysfunction in type 2 diabetes mellitus (T2DM). However, its role in attenuating endothelial insulin resistance in diabetes is not well understood. OBJECTIVES: This study aimed to investigate TUDCA's potential therapeutic effect on endothelial insulin resistance and its underlying mechanisms. METHODS: Twenty-seven male Sprague Dawley rats were categorized into control (CON, = 9), diabetes (DM, = 9), and diabetes treated with TUDCA (DMT, = 9). Diabetes was induced using a high-fat diet and low-dose streptozotocin. TUDCA (150 mg/kg) was administered to the DMT group during the last two weeks of a 15-week study. Aortic tissues were analyzed for insulin-mediated relaxation, endoplasmic reticulum (ER) stress markers [inositol-requiring kinase 1 (IRE-1), protein kinase-like ER kinase (PERK), and binding immunoglobulin protein (BIP)], end othelial function markers [endothelial nitric oxide synthase (eNOS), protein kinase B (Akt), and insulinreceptor substrate-1 (IRS-1)], oxidative stress [superoxide dismutase activity (SOD) and malondialdehyde level (MDA)] and inflammation [tumor necrosis factor-alpha (TNF-a)] markers. RESULTS: Insulin-mediated relaxation was impaired in diabetic rats (-56.7%) compared to controls (0%), accompanied by elevated ER stress markers and reduced eNOS, Akt, and IRS-1 expression. TUDCA treatment improved relaxation responses (-6.2%) significantly reduced ER stress markers and restored the expression of endothelial markers.
Correction.
Endocr Res · 2026 May · PMID 41765381 · Publisher ↗
Abstract loading — click title to view on PubMed.
ETV4 transcriptionally activates STAT6 to inhibit ferroptosis and promote immune escape in thyroid cancer.
Zong W, Wang Y, Xu B
Endocr Res · 2026 May · PMID 41759995 · Publisher ↗
BACKGROUND: Thyroid cancer (THCA) is one of the most common endocrine malignancies, with a significant increase in incidence over the past few decades. ETS variant transcription factor 4 (ETV4) is a member of the ETS fam...
BACKGROUND: Thyroid cancer (THCA) is one of the most common endocrine malignancies, with a significant increase in incidence over the past few decades. ETS variant transcription factor 4 (ETV4) is a member of the ETS family of transcription factors, which play crucial roles in tumorigenesis. However, the precise mechanisms by which ETV4 contributes to THCA progression remain largely unexplored. METHODS: The expression levels of ETV4, programmed death-ligand 1 (PD-L1), signal transducer and activator of transcription 6 (STAT6), and solute carrier family 7 member 11 (SLC7A11) were analyzed using quantitative reverse transcription PCR (qRT-PCR) and western blotting assays. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay. Reactive oxygen species (ROS) levels and apoptosis were evaluated by flow cytometry. Colorimetric assays were employed to measure malondialdehyde (MDA) levels, glutathione (GSH) levels, iron (Fe) levels, and lactate dehydrogenase (LDH) cytotoxicity. Enzyme-linked immunosorbent assay (ELISA) was used to quantify interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-2 (IL-2) levels. The interaction between ETV4 and STAT6 was confirmed using a dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay. RESULTS: ETV4 expression was upregulated in THCA tissues and cells. Its knockdown increased ROS, MDA, and Fe, decreased GSH and SLC7A11, and reduced PD-L1 expression. Silencing ETV4 enhanced CD8 T cell cytotoxicity and elevated secretion of IFN-γ, TNF-α, and IL-2, while promoting apoptosis. STAT6 expression was upregulated in THCA tissues and positively correlated with ETV4 expression. Mechanistically, ETV4 transcriptionally activated STAT6 in FTC-133 cells, and STAT6 overexpression inhibited ferroptosis and promoted immune escape by interacting with ETV4. CONCLUSION: ETV4 transcriptionally activated STAT6 to inhibit ferroptosis and promote immune escape in THCA. Targeting the ETV4-STAT6 axis may offer a novel therapeutic strategy, potentially inhibiting ferroptosis and enhancing immune response in THCA patients.
Diabetic ketoacidosis and hyperosmolar hyperglycemic state in patients with end-stage renal disease on dialysis: a review.
Aoun L, Itani H, Kaspar C … +13 more , Al Achkar M, Saliba F, Al Mardini S, Abidor E, Aldalahmeh M, Khamis Z, Habib T, Haddadin F, Azam W, Dankar R, Barakat S, Pannala SSS, Zaidan J
Endocr Res · 2026 May · PMID 41716038 · Publisher ↗
PURPOSE: This review aims to discuss the prevalence, risk factors, and management of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) in patients with end-stage renal disease (ESRD) on hemodialysis....
PURPOSE: This review aims to discuss the prevalence, risk factors, and management of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) in patients with end-stage renal disease (ESRD) on hemodialysis. METHODS: A comprehensive literature review of retrospective studies, case reports, and clinical guidelines was conducted. RESULTS: DKA and HHS incidence is lower in ESRD patients due to delayed insulin clearance and regular dialysis. Management requires cautious fluid administration, reduced insulin infusion rates, conservative potassium replacement, and gradual correction of hyperosmolarity. Emergency hemodialysis may be necessary for severe acidosis or hyperkalemia. CONCLUSION: Treatment must be individualized. Emerging strategies, including extended dialysis sessions and closed-loop insulin delivery, require further validation.
Role of the trigeminal system in pancreatic innervation: new concept and challenge - a narrative review.
Bou Malhab FM, Jabbour SA, Defronzo R … +1 more , Nemr R
Endocr Res · 2026 May · PMID 41701512 · Publisher ↗
INTRODUCTION: The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may...
INTRODUCTION: The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may also contribute to pancreatic innervation. METHODS: This review explores the hypothesis that the trigeminal system, via sensory neuropeptides such as calcitonin gene-related peptide and substance P, plays a role in pancreatic sensory innervation. Several hypotheses are proposed to explain this potential role, including embryological development, antidromic activity, and neurotransmitter actions. RESULTS: Neuropeptides, found in pancreatic tissues, may influence blood flow, inflammation, and pain perception, as well as modulate pancreatic functions such as enzyme secretion and insulin release. Understanding the interplay between the trigeminal system and the pancreas could provide insights into the pathophysiology of conditions like pancreatitis and diabetes. DISCUSSION: Targeting these pathways might offer new therapeutic strategies for managing pancreatic disorders, especially pain control and inflammation.
Risk of obstructive sleep apnea and diabetes in Korean adults.
Han MA
Endocr Res · 2026 May · PMID 41676969 · Publisher ↗
OBJECTIVE: We aimed to determine the relationship between obstructive sleep apnea (OSA) and diabetes in Korean adults. METHODS: This study used data from the 8th Korea National Health and Nutrition Examination Survey (20...
OBJECTIVE: We aimed to determine the relationship between obstructive sleep apnea (OSA) and diabetes in Korean adults. METHODS: This study used data from the 8th Korea National Health and Nutrition Examination Survey (2019-2021). A total of 11,439 adults aged ≥40 years were included. The obstructive sleep apnea was evaluated using the Snoring, Tiredness during the daytime, Observed apnea, high blood Pressure, Body mass index, Age, Neck circumference, and Gender (STOP-BANG) criteria. RESULTS: The prevalence of diabetes was 18.3% and a high risk for OSA was 7.3%. The prevalence of diabetes differed depending on the OSA risk, with the high-risk group demonstrating a significantly higher adjusted odds ratio for diabetes (2.78, 95% confidence interval = 2.24-3.44) compared with the low-risk group for OSA. Additionally, we identified a dose-response relationship, where the risk of diabetes increased as the number of risk factors for OSA increased ( < 0.001). CONCLUSION: People at high risk for OSA had a higher prevalence of diabetes than those who were not at risk. Given the increasing burden of diabetes and the potential association of OSA with other essential health conditions, further research is needed to evaluate the benefits of diabetes prevention or blood glucose testing in patients with OSA.
Early treatment responses in childhood Graves' disease: factors affecting the normalization period of thyroid hormones.
Erbaş İM, Çelik E, Kırkgöz T … +3 more , Nalbantoğlu Ö, Korkmaz HA, Özkan B
Endocr Res · 2026 Feb · PMID 41572819 · Publisher ↗
OBJECTIVE: Herein, we aimed to reveal the factors affecting the early treatment responses and the normalization process of thyroid hormone levels in childhood Graves' disease.. METHODS: This retrospective study included...
OBJECTIVE: Herein, we aimed to reveal the factors affecting the early treatment responses and the normalization process of thyroid hormone levels in childhood Graves' disease.. METHODS: This retrospective study included 46 pediatric patients who were diagnosed with Graves' disease and started treatment during a period of 10 years, and whose at least one of their free T3 (fT3) or free T4 (fT4) levels decreased to the reference range during follow-up. RESULTS: The normalization time of fT3 and fT4 were 5 (3-8) and 3.5 (2-7) weeks after the treatment initiation, respectively. Gender, age, pubertal status, presence of goiter, ophthalmopathy or tachycardia, basal thyroid hormone levels, initial dose of methimazole, and addition of beta-blockers did not show an effect on the normalization time of either fT3 or fT4 ( > 0.05). In those under the age of 12 ( = 15) with a high TRAb titer (>10 IU/L), the time for normalization of fT3 was longer ( = 0.024), and in those with ophthalmopathy, this process was longer for fT4 ( = 0.017). CONCLUSIONS: By these results, we showed that early treatment response and the normalization period of thyroid hormones were not related to the initial treatment dose.
Investigation of serum orexin-A levels in women with polycystic ovary syndrome.
Ağlıç Y, Kale İ
Endocr Res · 2026 Feb · PMID 41486094 · Publisher ↗
OBJECTIVE: Orexin-A (OXA) is a hypothalamic neuropeptide implicated in glucose regulation and insulin sensitivity. Given the central role of insulin resistance in polycystic ovary syndrome (PCOS), this study evaluated se...
OBJECTIVE: Orexin-A (OXA) is a hypothalamic neuropeptide implicated in glucose regulation and insulin sensitivity. Given the central role of insulin resistance in polycystic ovary syndrome (PCOS), this study evaluated serum OXA levels in women with PCOS. METHODS: This cross-sectional case-control study included 88 women with PCOS and 88 age- and body mass index-matched controls. Serum OXA levels were quantified using a commercial ELISA kit. RESULTS: Serum OXA levels were significantly lower in women with PCOS than in controls (321.53 ng/L vs. 385.06 ng/L, = 0.012). A significant negative correlation was observed between the modified Ferriman-Gallwey score and serum OXA level. In the ROC analysis, a serum OXA level of 369.55 ng/L yielded a sensitivity of 55.7% and a specificity of 55.7% (AUC: 0.610) for detecting PCOS. CONCLUSIONS: Serum OXA concentrations were reduced in women with PCOS. Whether this reduction contributes to PCOS pathogenesis or reflects a secondary alteration remains uncertain.
Change in apnea hypopnea index and sleep quality following treatment in acromegaly.
Kadian K, Gupta R, Arora R … +1 more , Sridharan K
Endocr Res · 2026 Feb · PMID 41436192 · Publisher ↗
BACKGROUND: Sleep Apnea Syndrome (SAS) is a common problem in acromegaly. This study examines changes in apnea hypopnea index (AHI) and sleep quality following treatment for acromegaly. METHODS: Subjects with active acro...
BACKGROUND: Sleep Apnea Syndrome (SAS) is a common problem in acromegaly. This study examines changes in apnea hypopnea index (AHI) and sleep quality following treatment for acromegaly. METHODS: Subjects with active acromegaly underwent polysomnography to identify SAS and Pittsburgh Sleep Quality Index (PSI) questionnaire for the assessment of subjective sleep quality at baseline, which were repeated after treatment. RESULTS: Twenty patients were recruited. Obstructive SAS was present in 85% and poor sleep quality was reported in 65% patients. AHI positively correlated with age, duration of disease, male gender, and PSQI score. After treatment, there was a significant decrease in tumor volume (72%) and insulin-like growth hormone (IGF-1) levels (44%), although IGF-1 normalization was seen in only 34% subjects. There was a significant reduction in mean AHI (35 ± 20 vs 23 ± 19; p = 0.008) and mean PSQI (7.8 ± 3.9 vs 5.6 ± 3.6; p = 0.002) after treatment. CONCLUSION: Mean AHI and mean PSQI improved significantly after treatment, although normalization of IGF-1 was seen in only one-third of patients.
Sex-specific impact of serum testosterone on the risk of atherosclerotic cardiovascular disease.
Peng X, Yang G, Chen X … +4 more , Xue Y, Guo R, Cao Y, Dong C
Endocr Res · 2026 Feb · PMID 41436183 · Publisher ↗
BACKGROUND: Testosterone plays multifaceted roles in cardiovascular health. However, the prospective sex-specific impact of serum testosterone on atherosclerotic cardiovascular disease (ASCVD) risk remains unclear. METHO...
BACKGROUND: Testosterone plays multifaceted roles in cardiovascular health. However, the prospective sex-specific impact of serum testosterone on atherosclerotic cardiovascular disease (ASCVD) risk remains unclear. METHODS: This prospective study included 2978 participants (1184 men and 1794 women) with a followed-up 10.66 years. The Cox proportional hazards model was employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for ASCVD events according to testosterone tertiles. Additionally, structural equation modeling was used to investigate whether hypertension and metabolic factors mediate the association between serum testosterone levels and ASCVD risk. RESULTS: During follow-up, 142 and 203 ASCVD events occurred in men and women, respectively. Compared with participants in the lowest serum testosterone tertile, men in the highest tertile exhibited a reduced ASCVD risk (HR: 0.59, 95% CI: 0.38-0.90), while women in the highest tertile showed an increased risk of ASCVD (HR: 1.79, 95% CI:1.26-2.55). Structural equation modeling revealed that in men, the association between testosterone and ASCVD risk was indirectly mediated by metabolic factors (β = -0.119). Among women, the results indicated a total effect of testosterone on ASCVD risk (β = 0.051), comprising a significant direct positive effect (β = 0.056) and a negative indirect effect mediated by hypertension and metabolic factors (β = -0.005). CONCLUSIONS: Elevated serum testosterone levels are associated with a reduced risk of ASCVD in men but an increased risk in women.
Overcoming underutilization of continuous glucose monitoring devices with diabetes among disparate populations.
Nasser SA, Lovre D, Zahedi Tajrishi F … +1 more , Ferdinand KC
Endocr Res · 2026 Feb · PMID 41134714 · Publisher ↗
INTRODUCTION: Continuous glucose monitoring (CGM) demonstrates significant benefits in glycemic control for both type 1 and type 2 diabetes, including reductions in HbA1c, increased time-in-range, and decreased hypoglyce...
INTRODUCTION: Continuous glucose monitoring (CGM) demonstrates significant benefits in glycemic control for both type 1 and type 2 diabetes, including reductions in HbA1c, increased time-in-range, and decreased hypoglycemia. METHODS: In this article, we review the recent American Diabetes Association guidelines recommending real-time CGM for adults with type 2 diabetes, including those not using insulin. RESULTS: While acknowledging the documented advantages, CGM remains underutilized, with many barriers, particularly in primary care settings and among racially diverse or lower socioeconomic populations. DISCUSSION: This review outlines positive strategies to address barriers to CGM-adoption, optimize glycemic control and thereby potentially reduce cardiovascular-kidney-metabolic complications.
Autoimmune Thyroid Disease in Pregnancy: Clinical Implications for Miscarriage Risk.
Shibi Anilkumar A, Mariam Thomas S, Veerabathiran R
Endocr Res · 2026 Feb · PMID 41084186 · Publisher ↗
INTRODUCTION: A leading endocrine illness affecting women of reproductive age is autoimmune thyroid disease (AITD), which can have a significant impact on the course of a pregnancy. Thyroid dysfunction is more likely to...
INTRODUCTION: A leading endocrine illness affecting women of reproductive age is autoimmune thyroid disease (AITD), which can have a significant impact on the course of a pregnancy. Thyroid dysfunction is more likely to occur during pregnancy due to hormonal and immunological changes. Women are more susceptible to thyroid dysfunction during pregnancy because of physiological changes that increase the need for thyroid hormones. METHODS: This review summarizes the most recent research on alterations in thyroid function during pregnancy, investigates the mechanisms underlying autoimmune thyroid imbalance and its effects on reproduction, and emphasizes the importance of early detection and specialized clinical management. RESULTS: Infertility, miscarriage, preterm birth, and decreased fetal development are among the negative reproductive consequences that can result from AITD, which affects up to 2-5% of pregnant women and is frequently asymptomatic and undetected. DISCUSSION: To maximize outcomes for both the mother and the fetus, early detection and specialized clinical management are essential, particularly because AITD is often asymptomatic and can go undetected during pregnancy.
Polymorphism as Biomarker Analysis of Genes , and in Hypothyroidism Patients.
Bashir K
Endocr Res · 2025 Nov · PMID 40963443 · Publisher ↗
OBJECTIVE: The present research was done to explore the possible association of (rs1991517, rs12050077), (rs2235544), (rs925489), and (rs10917469) gene variants in hypothyroidism patients. DESIGN & METHODS: This stud...
OBJECTIVE: The present research was done to explore the possible association of (rs1991517, rs12050077), (rs2235544), (rs925489), and (rs10917469) gene variants in hypothyroidism patients. DESIGN & METHODS: This study included 600 participants with hypothyroidism and a control. Genomic DNA was extracted from whole blood and amplified using polymerase chain reaction (PCR). RESULTS: The Homozygous genotype (CC) of SNP rs1991517 of the gene exhibited a significant association with hypothyroidism by 2-fold more risk of hypothyroidism. In comparison, in the combined genotype model, similar results were obtained with 2-fold more risk of hypothyroidism. In the rs12050077 variant of gene, statistically significant results were observed with a 2-fold higher risk of hypothyroidism by homozygous mutant (AA), while a significant association with decreased risk of hypothyroidism was observed in heterozygous (GA). Its joint genotype model (GA+AA) showed a substantial decrease in the risk and played a protective role. In gene, a heterozygous mutant genotype (AC) of variant rs2235544, a significant association with 3-fold increased the risk of hypothyroidism was observed, and homozygous mutant genotype (CC) of the same SNP rs2235544 also showed significant association by decreasing the risk of hypothyroidism. In SNP rs925489 of gene , heterozygous (CT) showed a significant association with hypothyroidism. joint genotype model of rs925489 showed a crucial significant association with hypothyroidism. In rs10917469 SNP of gene in heterozygous mutant (AG), a significant association was observed but with a decreased risk of hypothyroidism. The joint genotype model of rs10917469 shows a significant association with hypothyroidism. CONCLUSIONS: Association study of polymorphism (rs1991517, rs12050077), polymorphism rs2235544, polymorphism rs925489, and polymorphism rs10917469 with hypothyroidism showed that rs2235544 of gene are associated with increasing risk of hypothyroidism.
Development of painless thyroiditis after thyroid lobectomy in patients with Hashimoto's thyroiditis.
Sato S, Nagayama Y, Shindo H … +7 more , Katsuyama K, Tatsushima D, Mori Y, Takahashi H, Tachibana S, Fukuda T, Yamashita H
Endocr Res · 2025 Nov · PMID 40931783 · Publisher ↗
OBJECTIVE: Postoperative hypothyroidism, a complication of thyroid lobectomy, occurs frequently. Unique cases of post-lobectomy painless thyroiditis, a pathology not previously reported, were recently observed in our pra...
OBJECTIVE: Postoperative hypothyroidism, a complication of thyroid lobectomy, occurs frequently. Unique cases of post-lobectomy painless thyroiditis, a pathology not previously reported, were recently observed in our practice. In this study, we aimed to retrospectively investigate the frequency and characteristics of thyroid dysfunction after lobectomy, focusing on painless thyroiditis. METHODS: A total of 193 patients with thyroid tumors, including 66 with Hashimoto's thyroiditis and 127 without Hashimoto's thyroiditis, underwent thyroid lobectomy. These patients were followed up for 49.6 (12-118) months. RESULTS: Thyroid dysfunction occurred in 20.7% of patients, including 31.8% (21/66) and 14.9% (19/127) of those with and without Hashimoto's thyroiditis, respectively. The types of thyroid dysfunction included thyrotoxicosis (10.0%), subclinical hypothyroidism (47.5%), and overt hypothyroidism (42.5%). Nine of 21 patients with Hashimoto's thyroiditis who developed thyroid dysfunction 1-4 months after lobectomy were diagnosed with painless thyroiditis, based on the characteristic transient hypoechogenic pattern on ultrasonography during hormonal fluctuations. Four patients developed thyrotoxicosis, one of whom subsequently become hypothyroid. Thyroid function returned to normal in all four patients. Two patients tested negative for TSH receptor antibody during the thyrotoxic period. The remaining five patients developed hypothyroidism, which was transient in three patients. CONCLUSION: Painless thyroiditis develops as post-lobectomy thyroid dysfunction in patients with Hashimoto's thyroiditis. We propose naming this condition "post-lobectomy thyroiditis," as it is believed to be triggered by surgical manipulation of the thyroid gland in individuals with underlying subclinical thyroid autoimmunity. Given its transient nature in most cases, distinguishing this condition from postoperative permanent hypothyroidism is essential.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe