Cesk Slov Oftalmol [JOURNAL]
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200 papers
Clinical Outcomes of Preserflo MicroShunt versus Trabeculectomy: A Retrospective 6-Month Study.
Majtánová N, Takáčová A, Herdová L … +5 more , Kurilová V, Majtán J, Fellner Z, Cholevík D, Kolář P
Cesk Slov Oftalmol · 2026 · PMID 40843645 · Publisher ↗
OBJECTIVE: To characterize and compare the efficacy and safety of trabeculectomy and Preserflo microshunt (PMS) implantation in patients with openangle glaucoma. MATERIAL AND METHODS: This retrospective 6-month study inc...
OBJECTIVE: To characterize and compare the efficacy and safety of trabeculectomy and Preserflo microshunt (PMS) implantation in patients with openangle glaucoma. MATERIAL AND METHODS: This retrospective 6-month study included 100 eyes (100 patients). The 100 patients were divided into two groups of 50 patients, who were randomly assigned to either trabeculectomy or PMS implantation with mmC (0.4 mg/ml) applied using saturated sponges. The patients attended follow-up checks at 1, 8, 30, and 90 days postoperatively and at 6 months postoperatively. Endothelial cells were assessed at 3 and 6 months respectively. The main observed parameters were intraocular pressure (IOP), best corrected visual acuity (BCVA), anterior chamber depth (ACD), corneal hysteresis (CH), corneal endothelial cell density (CECD), coefficient of variation (CV), and antiglaucoma treatment. RESULTS: In patients after trabeculectomy and after PMS implantation a comparable reduction in mean IOP values of 40.2% and 45.8% respectively was recorded for both surgical approaches in comparison with the preoperative mean IOP values. In all the studied patients, regardless of the type of surgical procedure, a significant reduction of CECD values was recorded 6 months after surgery. However, PMS implantation led to a greater reduction in antiglaucoma treatment postoperatively compared to trabeculectomy. Qualified success was almost identical in the case of both operations throughout the entire course, complete success was higher in favor of PMS at the beginning of the observation, but their values converged or met from approximately day 90 to month 6. CONCLUSION: The performed clinical evaluation of the efficacy and safety of PMS implantation compared to the classical surgical approach using trabeculectomy showed positive results related primarily to the reduction of postoperative complications, while maintaining the effectiveness of the surgical procedure. However, further clinical studies with a longer follow-up period are needed in order to provide long-term evidence of clinical efficacy.
The Frequency of Postoperative Complications in Current Types of Hydrophobic and Hydrophilic Intraocular Lenses. A Systematic Review.
Studený P, Hložánek M, Marešová K
Cesk Slov Oftalmol · 2025 · PMID 40705540 · Publisher ↗
OBJECTIVE: To compare the incidence of postoperative complications after cataract surgery in current types of acrylic intraocular lenses (IOLs) in relation to the material used to manufacture the implant, published in th...
OBJECTIVE: To compare the incidence of postoperative complications after cataract surgery in current types of acrylic intraocular lenses (IOLs) in relation to the material used to manufacture the implant, published in the scientific literature. METHODOLOGY: Search for publications in the Pubmed database, published in 2015-2024 (inclusive), without language restrictions, featuring the keywords Hydrophobic, Hydrophilic, Intraocular lens. Reviewing all abstracts and excluding publications that do not match the specified topic. RESULTS: A total of 220 works were published in the last 10 years that met the specified keywords. Of these, 92 publications were dedicated to the comparison of both types of IOLs. These were 4 meta-analyses, 10 reviews and 47 clinical studies, 21 laboratory and experimental studies and 10 studies of a different nature (editorials, considerations, chapters in textbooks). CONCLUSION: Current types of soft acrylic intraocular lenses achieve excellent refractive results and high subjective patient satisfaction. This applies to lenses made of both hydrophilic and hydrophobic materials. The main disadvantage of hydrophilic implants is the higher risk of opacification of the posterior capsule of the lens, as well as the risk of opacification of the implant itself. Especially in patients who are expected to undergo subsequent surgery (corneal endothelial dystrophy, retinal pathology), as well as in patients with a higher risk of complications after Nd:YAG laser capsulotomy (patients with myopia, chronic uveitis or glaucoma), the use of hydrophobic material should be considered as a priority.
Subretinal Triamcinolone Acetonide and Transpupillary Thermotherapy in Circumscribed Choroidal Hemangioma. A Case Report.
Umanets M, Kustryn T, Pasyechnikova N
Cesk Slov Oftalmol · 2026 · PMID 40705538 · Publisher ↗
PURPOSE: To evaluate the potential use of a combination of subretinal triamcinolone acetonide (TA) injection with transpupillary thermotherapy (TTT) in the treatment of circumscribed choroidal hemangioma (CCH) with exuda...
PURPOSE: To evaluate the potential use of a combination of subretinal triamcinolone acetonide (TA) injection with transpupillary thermotherapy (TTT) in the treatment of circumscribed choroidal hemangioma (CCH) with exudative retinal detachment. CASE REPORT: The clinical case of a 27-year-old patient demonstrates the treatment of CCH with exudative retinal detachment. We used a combination of subretinal injection of 4 mg preservative-free TA with the simultaneous partial aspiration of subretinal fluid in the first stage. After one week, when the retina was fully attached, TTT of CCH was used in the second stage. At Month 12, visual acuity in the left eye increased from light perception with projection to 20/400. Ultrasonography did not reveal any signs of choroidal masses or retinal detachment. During the follow-up period, 3 sessions of TTT were performed. CONCLUSION: A combination of subretinal TA injection with TTT can be an alternative treatment for CCH with exudative retinal detachment.
Evaluation of Morphological Changes in the Retina Using OCTA in Patients with Diabetic Macular Edema Treated with anti-VEGF Using ImageJ Software.
Beran D, Hejsek L, Studnička J
Cesk Slov Oftalmol · 2026 · PMID 40705537 · Publisher ↗
AIM: To evaluate changes in the vascular density of the deep and superficial capillary plexus of the retina, the area of the foveal avascular zone, central retinal thickness, and best corrected visual acuity in patients...
AIM: To evaluate changes in the vascular density of the deep and superficial capillary plexus of the retina, the area of the foveal avascular zone, central retinal thickness, and best corrected visual acuity in patients with diabetic macular edema treated with anti-VEGF agents. MATERIAL AND METHODS: In a prospective study at the Ophthalmology Clinic of FNHK, we evaluated a group of 41 eyes of 30 patients (19 men and 11 women) with diabetic macular edema treated with Lucentis or Eylea. The average age of the patients was 61.7 ±11.3 years. Average initial visual acuity was 64.4 ±9.1 letters on ETDRS optotypes. During the one-year follow-up period we monitored the density of the deep and superficial retinal capillary plexus using OCTA. We evaluated OCTA scans with the ImageJ program at 3, 6, 9, and 12 months. Additionally, the area of the foveal avascular zone, central retinal thickness, and best-corrected visual acuity were measured. RESULTS: During the one-year follow-up period there was a statistically significant change in both retinal capillary plexuses, with the density of the deep capillary plexus increasing (p.
Punctate Inner Pachychoroidopathy Associated with Choroidal Neovascularization. A Case Report.
Orrego-Vélez AM, Quintero-Lizcano K, Turizo S … +1 more , Arango M
Cesk Slov Oftalmol · 2026 · PMID 40705536 · Publisher ↗
AIMS: To report a case of punctate inner choroidopathy (PIC) with pachychoroid disease features and active choroidal neovascular membrane. MATERIALS AND METHODS: Case report Results: A 33-year-old female patient with a h...
AIMS: To report a case of punctate inner choroidopathy (PIC) with pachychoroid disease features and active choroidal neovascular membrane. MATERIALS AND METHODS: Case report Results: A 33-year-old female patient with a history of myopic neovascular membrane in the right eye (OD), who had received multiple doses of intravitreal Aflibercept, consulted our retina service. Best-corrected visual acuity was 20/40 in OD. Fundus examination revealed small, well-defined, yellow-gray spots with subretinal fluid limited to the posterior pole. Optical coherence tomography scans from the OD showed subretinal fluid and a hyperreflective material between the epithelium/Bruch membrane (RPE/ BrM) complex, associated with loss of normal choroidal architecture and focal conformational choroidal excavation. There was also diffuse choroidal thickening in the macula, with pachyvessels compressing the inner choroid. Fundus autofluorescence showed active PIC lesions. With these findings, the diagnosis of punctate inner pachychoroidopathy associated with active choroidal neovascular membrane was made and Aflibercept therapy was restarted. CONCLUSIONS: A subset of patients with PIC exhibits features associated with pachychoroid disease. This subtype of PIC is determined by unique demographics, multimodal image findings, and complications that differ from classic PIC, due to the potential influence of choroidal venous insufficiency on PIC manifestations and secondary complications.
Use of Imaging Modalities in Vogt-Koyanagi-Harada Disease: An Overview.
Karti O, Ayhan Z, Saatci OA
Cesk Slov Oftalmol · 2025 · PMID 40705535 · Publisher ↗
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting multiple systems and characterized by bilateral granulomatous uveitis, frequently together with neurological, auditory, and integumentary manifestati...
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting multiple systems and characterized by bilateral granulomatous uveitis, frequently together with neurological, auditory, and integumentary manifestations. Prompt diagnosis and intervention are a must to prevent irreversible vision loss and possible systemic complications. Fundus imaging plays a pivotal role in the management of VKH, not only to reach the diagnosis but also to monitor disease activity and response to treatment. Fundus photography, fundus autofluorescence imaging, fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT) are among the imaging modalities. These methods provide invaluable insights into the different phases of the disease. In addition, OCT angiography enables clinicians to visualize associated retinal and choroidal microvascular changes. Continuous advances in imaging technology assist ophthalmologists to comprehend the VKH pathophysiology and to facilitate its differential diagnosis. Thus, clinical outcomes are improving with timely interventions and personalized treatment approaches. This mini-review provides an overview of VKH disease, with a particular focus on the fundus imaging techniques utilized in its management.
Clinical Results Following the Implantation of a New Toric Intraocular Lens with Extended Depth of Focus.
Jančárová S, Němcová M, Rozsíval P … +1 more , Nováček VL
Cesk Slov Oftalmol · 2026 · PMID 40705534 · Publisher ↗
PURPOSE: To evaluate the clinical outcomes following the implantation of a new toric intraocular lens (TIOL) with extended depth of focus (EDOF) Bi-Flex ELON Toric POB-MA 877PETY (Elon®, Medicontur Medical Engineering Lt...
PURPOSE: To evaluate the clinical outcomes following the implantation of a new toric intraocular lens (TIOL) with extended depth of focus (EDOF) Bi-Flex ELON Toric POB-MA 877PETY (Elon®, Medicontur Medical Engineering Ltd., Zsámbék, Hungary), including analysis of lens rotational stability and assessment of patient satisfaction. MATERIAL AND METHODS: In a retrospective, monocentric clinical study, 29 eyes of 18 patients (11 men and 7 women) with presbyopia, cataracts, and corneal astigmatism were evaluated. These patients underwent uncomplicated cataract surgery with Bi-Flex ELON Toric TIOL implantation. Postoperative assessments included measurements of monocular uncorrected and corrected distance visual acuity (UDVA, CDVA) and near visual acuity (UNVA, CNVA), rotational stability of the TIOL, and subjective evaluation of visual quality using a questionnaire. Follow-up examinations were conducted 6 months postoperatively (ranging from 3 to 9 months). RESULTS: The mean postoperative monocular UDVA improved from 0.4 ±0.2 to 0.90 ±0.1 (p.
New Features in Screening of Retinopathy of Prematurity. Our Experience with New Recommendations for Retinopathy of Prematurity Screening.
Tomčíková D, Prepiaková Z, Bušányová B … +1 more , Kostolná B
Cesk Slov Oftalmol · 2025 · PMID 40553639 · Publisher ↗
Retinopathy of prematurity (ROP) is always a serious and sight-threatening condition, and its treatable stages require early detection and adequate treatment. It is necessary to focus on the principles of screening of RO...
Retinopathy of prematurity (ROP) is always a serious and sight-threatening condition, and its treatable stages require early detection and adequate treatment. It is necessary to focus on the principles of screening of ROP and recurrences thereof, which occur more often with the onset of intravitreal treatment using anti-vascular endothelial growth factor (anti-VEGF) agents. In this study, we evaluate the recurrence of ROP after primary treatment with intravitreally administered bevacizumab or ranibizumab, its frequency and timing of occurrence. Also discussed are the rules for screening of ROP, its recurrence and the need for long-term follow-up monitoring of children with any form of ROP.
Calculation of Intraocular Lens in Patients after Previous Laser Refractive Surgery.
Maláková E, Janeková A
Cesk Slov Oftalmol · 2025 · PMID 40553638 · Publisher ↗
AIM: The incidence of cataract surgery in patients after previous laser refractive surgery is increasing worldwide. However, the resulting uncorrected distance visual acuity (UDVA) after cataract surgery in these patient...
AIM: The incidence of cataract surgery in patients after previous laser refractive surgery is increasing worldwide. However, the resulting uncorrected distance visual acuity (UDVA) after cataract surgery in these patients is less frequently satisfactory. The aim of this article is to present the results of cataract surgery in a group of patients who had undergone previous laser refractive surgery, in whom the IOL power was calculated only according to the currently measured values, and to compare them with the results from other workplaces. MATERIAL AND METHODS: Our group incorporates 69 eyes of 43 patients. The data collection took place over a period of 33 months. The group included patients who attended at least one follow-up examination in the postoperative period. The resulting postoperative vision was considered to be vision determined at least 1 month after cataract surgery. Data were collected retrospectively. RESULTS: The resulting postoperative average monocular best corrected distance visual acuity (BCDVA) in the patients from our cohort was 0.024 LogMAR in the group of initially myopic patients and 0.030 LogMAR in the group of initially hypermetropic patients. Thus, BCDVA in myopic was better than in hypermetropic patients, without a statistically significant difference. Conversely, the resulting mean manifest spherical equivalent (MSE) was higher for myopic patients (-0.844) than for hypermetropic patients (-0.658), and this difference was evaluated as statistically significant. A refractive result above ±0.5 Dsf was present in 14 eyes, above ±1.0 Dsf in 6 eyes. CONCLUSION: In 90% of patients we achieved an average MSE up to ±1.0 Dsf postoperatively. The results from our report regarding postoperative monocular BCDVA, BCNVA, mean SE and MSE are consistent with those from other reports dealing with this issue, although our cohort included a much smaller group of patients.
Failure of Primary Posterior Continuous Curvilinear Capsulorhexis? A Case Report.
Novák J, Otrošinová M, Kubíková L … +1 more , Krásnik V
Cesk Slov Oftalmol · 2025 · PMID 40553637 · Publisher ↗
The aim of the study is to present the possible development of proliferative secondary cataracts in the unique case of a patient having undergone premium cataract surgery with preventive primary posterior continuous curv...
The aim of the study is to present the possible development of proliferative secondary cataracts in the unique case of a patient having undergone premium cataract surgery with preventive primary posterior continuous curvilinear capsulorhexis (PCCC). Due to the negative effect on visual functions, it was decided to treat the patient with an Nd:YAG laser, which was successful with minimal energy but resulted in damage to the anterior hyaloid membrane. Case report In 2020, a 65-year-old man underwent uncomplicated cataract surgery in both eyes at our clinic bilaterally with primary PCCC with implantation of a tension ring and an artificial intraocular lens into the capsule. In February 2023, on the recommendation of the area ophthalmologist, he was examined at our outpatient clinic due to a decrease of visual acuity in the right eye. Blurred vision predominated. A diagnosis of proliferative form of secondary cataract was confirmed and documented using a photo of the anterior segment in retroillumination and anterior segment OCT (Optovue, Avanti RTVue XR). The patient was indicated for Nd:YAG laser disruption by proliferation in the PCCC space in the right eye. The return of visual acuity to its original state confirmed the correct diagnosis. The literature review and discussion summarize the current issue of secondary cataracts and the use of primary PCCC. Conclusion: Secondary cataract is the main long-term complication of modern cataract surgery. One of the possible solutions is the preventive implementation of a simple PCCC, which may be accompanied by isolated failure.
Recurrent Congenital Cytomegalovirus Chorioretinitis in a Newborn. A Case Report.
Kašpráková M, Timkovič J, Širůček P … +2 more , Matyáštíková I, Němčanský J
Cesk Slov Oftalmol · 2025 · PMID 40553636 · Publisher ↗
PURPOSE: To describe the clinical course, treatment, and subsequent care of a full-term newborn with atypical, unilateral, recurrent cytomegalovirus chorioretinitis. CASE REPORT: The perinatal period of a full-term newbo...
PURPOSE: To describe the clinical course, treatment, and subsequent care of a full-term newborn with atypical, unilateral, recurrent cytomegalovirus chorioretinitis. CASE REPORT: The perinatal period of a full-term newborn girl was complicated by the development of petechiae on the skin. The initial laboratory findings were notable for thrombocytopenia, hyperbilirubinemia, and polycythemia. An ultrasound of the brain revealed cystic changes in the area of the lateral ventricles. MRI confirmed pseudocystic periventricular changes with periventricular calcifications. PCR testing confirmed CMV positivity, and the condition was diagnosed as congenital CMV infection requiring systemic treatment with ganciclovir. Indirect ophthalmoscopy revealed nonspecific lucency in the central area of the right eye, with several small hemorrhages on the retinal periphery. Although systemic therapy was initiated promptly, the original lesion reactivated multiple times on its periphery over the following months. The lesions were gradually healed, with pigmented scarring limiting the visual function of the affected eye. CONCLUSION: In contrast with the focal changes in the peripheral retina observed in adults, congenital CMV infection affecting children is characterized by macular involvement. The degree of visual impairment is directly proportional to the extent of reparative scarring affecting the central retina. From the perspective of prognosis and prevention of potential late retinal complications, screening and regular ophthalmological examinations are essential.
Idiopathic Corneal Thinning and Spontaneous Perforation at Early Adulthood. A Case Report.
Lukács MÁ, Módis L
Cesk Slov Oftalmol · 2025 · PMID 40357859 · Publisher ↗
AIM: To report a case of progressive corneal thinning and spontaneous corneal perforation in the setting of recurrent keratoconjunctivitis of undetermined etiology in a 20-year-old female patient. MATERIAL AND METHODS: L...
AIM: To report a case of progressive corneal thinning and spontaneous corneal perforation in the setting of recurrent keratoconjunctivitis of undetermined etiology in a 20-year-old female patient. MATERIAL AND METHODS: Longitudinal follow-up of the reported case was performed with regular slit-lamp examination, anterior segment optical coherence tomography, and laboratory evaluation. Relevant scientific literature was reviewed to discover potential etiologies and causes of the reported case. CASE REPORT: Recurrent bilateral keratoconjunctivitis was detected and followed up in a 20-year-old female patient. Long-standing blepharitis and several ocular inflammatory episodes were observed involving the conjunctiva and cornea causing corneal thinning and irregular astigmatism on both eyes. Patient's history, physical and laboratory examination did not reveal any systemic inflammatory or dermatological disorder. After 4 years from the onset of symptoms, spontaneous corneal perforation was observed on the right eye and treated with amniotic membrane transplantation. At that time, eyelid margin culture was positive for Streptococcus mitis. The graft healed completely with paracentral stromal scarring. Best spectacle corrected visual acuity was 20/25 OD and 20/40 OS a month after the procedure. CONCLUSION: Corneal and ocular surface inflammation is a potential multifactorial disease. Bacterial hypersensitivity, atopy and dermatological disorders such as atopic dermatitis and rosacea may play a role in recurrent keratitis, corneal thinning and eventually corneal perforation. Frequent and regular follow-ups are required to detect complications early as well as to discover all possible local and systemic contributing factors of keratoconjunctivitis.
Uveitis associated with juvenile idiopathic arthritis (JIA) and JIA-like uveitis in pediatric patients.
Bártková D, Timkovič J, Kolarčíková V … +3 more , Pískovský T, Polách O, Němčanský J
Cesk Slov Oftalmol · 2025 · PMID 40357858 · Publisher ↗
AIMS: To evaluate the prevalence of uveitis and ocular complications in children with juvenile idiopathic arthritis (JIA) and "JIA-like" form. To determine the onset of ocular symptoms in relation to the diagnosis of the...
AIMS: To evaluate the prevalence of uveitis and ocular complications in children with juvenile idiopathic arthritis (JIA) and "JIA-like" form. To determine the onset of ocular symptoms in relation to the diagnosis of the underlying disease and identify the most common predictive factor preceding the onset of uveitis. MATERIALS AND METHODS: Retrospective analysis of medical records of children with JIA and JIA-like uveitis monitored at the Pediatric Rheumatology and Ophthalmology Clinic at the University Hospital Ostrava between 2016-2024. Observed parameters included the child's age at the time of diagnosis of JIA or JIA-like uveitis, laboratory tests, ocular findings, age at the onset of uveitis symptoms, time correlation with the diagnosis of the underlying disease, ocular complications of recurrent uveitis attacks and overall treatment of the underlying disease. RESULTS: There were 27 children in the group with confirmed JIA, with an average age of 5 years. Ten patients were diagnosed with anterior or posterior uveitis. The average age at the time of JIA diagnosis was 6 years. The mean time interval from JIA diagnosis to the appearance of pathological ocular findings was 38 months. Ocular complications were recorded in 50% of children, most commonly cataracts (40%). All children with uveitis were laboratory positive for ANA antibodies. There were 8 patients with JIA-like uveitis, with an average age of 9 years. All children showed signs of anterior or posterior uveitis, which was manifested on average at 8.5 years of age. Exclusion of JIA diagnosis was established on average 6 months after the appearance of ocular pathology. Ocular complications were observed in 88% of children, most frequently posterior synechiae (63%). Laboratory findings showed ANA antibody positivity in 88% of children with uveitis. CONCLUSION: Regular ophthalmological examinations in JIA patients are essential due to the potential occurrence of complications, which are more frequent in young females with JIA-like uveitis and ANA antibody positivity.
Effect of Myopia and Glare on Mesopic Contrast Sensitivity.
Junker J, Pluháček F
Cesk Slov Oftalmol · 2025 · PMID 40357857 · Publisher ↗
AIM: The aim of the study is to evaluate the simultaneous effect of mild myopia and glare on contrast sensitivity under mesopic conditions corresponding to the conditions of night driving. MATERIAL AND METHODS: The study...
AIM: The aim of the study is to evaluate the simultaneous effect of mild myopia and glare on contrast sensitivity under mesopic conditions corresponding to the conditions of night driving. MATERIAL AND METHODS: The study included 22 volunteers (11 women and 11 men) aged between 20 and 42 years (mean age 26.5 years, standard deviation 5.2 years) with normal or corrected to normal binocular and monocular vision acuity and normal healthy eyes. The study was designed as a prospective study. After adaptation to mesopic conditions, three series of contrast sensitivity measurements (with fully corrected refractive error, with induced myopia -0.50 D and -1.0 D) were performed in random order using the Mesotest II device. In each series, measurements were performed with and without glare. All measurements were performed twice, and their average was considered as the result. The effect of induced myopia and glare was assessed using the analysis of variance method for repeated measures. RESULTS: Significant effects of myopia (p.
OCT in the Differential Diagnosis of Optic Neuropathies. A Review.
Kecer F, Tomčíková D
Cesk Slov Oftalmol · 2025 · PMID 40135703 · Publisher ↗
Optical coherence tomography (OCT) has become a key tool in the differential diagnosis of optic neuropathies (ON), particularly in differentiating between glaucomatous and non-glaucomatous ON. Correct diagnosis is an ess...
Optical coherence tomography (OCT) has become a key tool in the differential diagnosis of optic neuropathies (ON), particularly in differentiating between glaucomatous and non-glaucomatous ON. Correct diagnosis is an essential factor for effective treatment management and prevention of progressive loss of vision. While glaucomatous ON is characterized by specific structural changes in the optic nerve head and retinal layers, non-glaucomatous neuropathies can be caused by a wide range of other causes, including inflammatory, ischemic or compressive processes. OCT allows visualization of the fine anatomical details of the optic nerve head and retina, providing valuable information for differential diagnosis. The importance lies in the physician's ability to correctly interpret these images and integrate them into the patient's overall clinical picture. This review focuses on the key features of glaucomatous and non-glaucomatous ON that can be detected early with OCT and highlights the importance of using this technique in everyday clinical practice.
Mitochondrial Retinopathy Due to MT-TL1 Mutation: The Role of Heteroplasmy. A Case Report.
Arango M, Restrepo S, Orrego AM … +2 more , Turizo S, Quintero-Lizcano K
Cesk Slov Oftalmol · 2025 · PMID 40125788 · Publisher ↗
OBJECTIVE: To report a case of mitochondrial retinopathy, highlighting its clinical and imaging findings, the importance of genetic confirmation, and the possible implications of heteroplasmy in this disease. MATERIAL AN...
OBJECTIVE: To report a case of mitochondrial retinopathy, highlighting its clinical and imaging findings, the importance of genetic confirmation, and the possible implications of heteroplasmy in this disease. MATERIAL AND METHODS: Case report of a mitochondrial retinopathy secondary to m.3243A>G mutation in the MT-TL1 gene. RESULTS: A 32-year-old woman presented with bilateral vision loss, photophobia, and sensorineural hearing loss for more than 3 years. Best corrected visual acuity (BCVA) was 20/60 in the right eye (OD) and 20/25 in the left eye (OS). Fundus examination revealed multiple macular subretinal yellow-white deposits and central chorioretinal atrophy, without edema, hemorrhage, or subretinal fluid in the RE, and juxtafoveal atrophy with retinal pigment epithelium (RPE) metaplasia in the OS. Multimodal imaging raised suspicion of retinal dystrophy, and genetic testing confirmed a mitochondrial retinopathy secondary to the m.3243A>G mutation in the MT-TL1 gene. CONCLUSIONS: Bilateral and symmetric RPE atrophic changes in young individuals, especially when associated with systemic symptoms, should prompt a comprehensive evaluation, including multimodal imaging and genetic testing. Identifying causative mutations and understanding the dynamics of mitochondrial DNA in the pathogenesis of these diseases is crucial for improving diagnosis and suggesting potential therapeutic strategies, including gene therapy.
Two-year results of Preserflo Microshunt use in Open-angle Glaucoma Surgery.
Fialová V, Váša M, Rozsíval P … +2 more , Kalinová J, Studnička J
Cesk Slov Oftalmol · 2025 · PMID 40125787 · Publisher ↗
AIM: To evaluate the safety and efficacy outcomes of PRESERFLO™ MicroShunt implantation in patients with primary open-angle glaucoma. MATERIAL AND METHODS: Retrospective data analysis of 19 eyes of 12 patients, comprisin...
AIM: To evaluate the safety and efficacy outcomes of PRESERFLO™ MicroShunt implantation in patients with primary open-angle glaucoma. MATERIAL AND METHODS: Retrospective data analysis of 19 eyes of 12 patients, comprising 5 females and 7 males. The patients underwent surgery between August 2020 and February 2022. The follow-up period was 24 months after surgery. During the follow-up period, intraocular pressure (IOP), the need to apply topical antiglaucoma medication and its spectrum, visual field status, optic nerve target findings and postoperative complications were recorded. The indication for PRESERFLO™ MicroShunt implantation was primary open angle glaucoma (POAG), poorly controlled with maximum tolerated medical therapy. RESULTS: Average IOP was reduced from 19.05 ±5.58 mmHg preoperatively to 11.47 ±2.48 mmHg at 3 months postoperatively, 12.26 ±2.48 mmHg at 6 months postoperatively, 14.0 ±2.43 mmHg at 12 months postoperatively, 11.78 ±2.37 mmHg at 18 months postoperatively, and 12.73 ±2.51 mmHg at 24 months postoperatively (p.
Presentation of a New Method for Quantitative Determination of Trifocal Intraocular Lens Decentration.
Moreno JJ, Galvis V, Salazar M … +3 more , Villamizar SJ, Leal N, Tello A
Cesk Slov Oftalmol · 2025 · PMID 40125786 · Publisher ↗
AIMS: This pilot study aims to present a novel method for quantitatively assessing the decentration of a trifocal intraocular lens (IOL) (Acrysof IQ PanOptix®) relative to three ocular reference points: the visual axis (...
AIMS: This pilot study aims to present a novel method for quantitatively assessing the decentration of a trifocal intraocular lens (IOL) (Acrysof IQ PanOptix®) relative to three ocular reference points: the visual axis (first Purkinje reflex), the photopic pupil center, and, for the first time, the corneal geometric center. Additionally, the study evaluates the influence of postoperative chord mu, chord alpha, and the distances of the IOL from these reference points on visual outcomes. MATERIALS AND METHODS: This retrospective, observational study included 18 eyes from 12 patients who underwent cataract surgery with PanOptix® IOL implantation. Postoperative IOL positioning was assessed using OPD-Scan III images, applying a novel approach that combines diffuse frontal and retroillumination views. Distances between the IOL center and three ocular reference points, including the corneal geometric center, were measured, and postoperative patient satisfaction was evaluated using the Catquest-9SF survey. Statistical analyses were performed to assess correlations among reference distances, chord measurements, and visual performance. RESULTS: The study found that in 72.2% of cases, the IOL center was closer to the visual axis than to the corneal geometric center. A greater distance between the IOL and the corneal geometric center was associated with an improved near-vision area under the visual acuity defocus curve. However, no significant correlations were found between chord mu or chord alpha and visual outcomes, patient symptoms, or satisfaction. CONCLUSION: This new approach to determining IOL centration proved practical, showing that the PanOptix® IOL tends to remain close to the visual axis over time, aligning with the surgeon's initial placement. No clear associations were found between chord mu, chord alpha, or most IOL distances (except the distance to the corneal geometric center) and visual quality or patient satisfaction. Further studies are needed to confirm these findings and to refine selection criteria for multifocal IOLs to enhance patient satisfaction and visual outcomes.
Treatment of Patients with Central Serous Chorioretinopathy using Navigated Laser Photocoagulation.
Tesař J, Šín M
Cesk Slov Oftalmol · 2025 · PMID 40125785 · Publisher ↗
AIM: To report the results of treatment of patients with central serous chorioretinopathy treated with a Navilas laser. MATERIAL AND METHODS: We retrospectively evaluated the results of the treatment of 39 eyes of 37 pat...
AIM: To report the results of treatment of patients with central serous chorioretinopathy treated with a Navilas laser. MATERIAL AND METHODS: We retrospectively evaluated the results of the treatment of 39 eyes of 37 patients with acute form of central serous chorioretinopathy, who did not respond to conventional treatment. In these patients we performed focal laser treatment at the point of leakage (hotspot) using a Navilas guided laser. RESULTS: 3 patients did not report for the check-up, of the remaining 36 eyes, complete liquid absorption was achieved in 32. Retreatment was necessary in 2 patients, choroidal neovascularization developed in one patient, and in one patient fluid absorption was not achieved even after retreatment. CONCLUSION: Focal laser treatment of hotspots in patients with central serous chorioretinopathy is still a very effective treatment method. Juxtafoveolar lesions can also be treated with a high degree of safety using a Navilas navigation laser.
Focusing on the Future: Patient-Centered Insights into Trifocal Intraocular Lens Adoption.
Yılmaz İE, Berhuni M, Öztürkmen C … +1 more , Reyhan HA
Cesk Slov Oftalmol · 2025 · PMID 40125784 · Publisher ↗
AIMS: To analyze determinants affecting the selection of trifocal intraocular lenses (IOLs) and to evaluate patient satisfaction and adaptation patterns post-implantation in a Turkish cohort. MATERIAL AND METHODS: A cros...
AIMS: To analyze determinants affecting the selection of trifocal intraocular lenses (IOLs) and to evaluate patient satisfaction and adaptation patterns post-implantation in a Turkish cohort. MATERIAL AND METHODS: A cross-sectional study was conducted using a 17-item questionnaire administered to 96 patients who underwent phacoemulsification with PanOptix trifocal IOL implantation. Demographics, IOL selection factors, surgeon trust, visual adaptation, and satisfaction metrics were analyzed across various patient subgroups. RESULTS: The cohort (mean age 60.62 ±11.94 years; 58.3% male) demonstrated 96.9% overall satisfaction post-implantation. Significant findings included higher satisfaction rates among patients under 65 years (98.3% vs 94.7%, p = 0.042), among tertiary-educated patients (98% vs 75%, p = 0.03), and 82.3% complete spectacle independence. Visual phenomena were reported at contemporary rates (glare: 18.8%, halos: 22.9%). Ninety-one percent of patients achieved visual adaptation within three months. Preoperative counseling participation (86.7% vs 71.4%, p = 0.035) and consistent follow-up attendance (88.9% vs 73.3%, p = 0.028) emerged as significant predictors of satisfaction. CONCLUSION: Patient satisfaction with trifocal IOLs correlates significantly with age, educational background, and engagement in the treatment process. While overall satisfaction rates are high, outcomes appear influenced by demographic factors and healthcare engagement patterns. These findings emphasize the importance of comprehensive preoperative assessment, patient education, and tailored follow-up protocols in optimizing trifocal IOL outcomes across diverse population segments.
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