Curr Drug Deliv [JOURNAL]
Sun
200 papers
Exploring Drug Repositioning: Enhanced Co-Delivery of Disulfiram and Celecoxib by Nanostructured Lipid Carriers for Breast Cancer Cells.
Seidu TA, Farooq MA, Wande MP … +4 more , Ghayas S, Kutoka PT, Alolga RN, Wang B
Curr Drug Deliv · 2025 Aug · PMID 40820450 · Publisher ↗
BACKGROUND: In the current era, the importance of pharmaceutical technology and research in innovating novel drugs and formulations is undeniable. OBJECTIVE: This study aimed to produce a nanoscale drug delivery system f...
BACKGROUND: In the current era, the importance of pharmaceutical technology and research in innovating novel drugs and formulations is undeniable. OBJECTIVE: This study aimed to produce a nanoscale drug delivery system for the simultaneous delivery of repurposed disulfiram (DSF) and celecoxib (CXB). METHODS: The co-formulation was prepared utilizing the emulsification ultrasonication technique to enhance the anti-cancer activity through NLCs. The surface morphology of the optimized NLCs was examined using TEM, while physicochemical characterization analyses employed FTIR, DSC, PXRD, and TGA. In-vitro cell uptake studies were conducted through MTT assay, confocal microscopy, and flow cytometry, respectively. RESULTS: The optimized DSF-CXB NLCs demonstrated a mean particle size of 144.2 nm, with a drug loading of 9.8% for DSF and 9.87% for CXB. The re-dispersibility index was measured at 103.26%, indicating effective dispersion. Stability analysis over 30 days confirmed the formulation's high stability. Transmission electron microscopy revealed spherical-shaped nanoparticles. Fourier transform infrared spectroscopy indicated no interaction between excipients and the formulation. Both DSC and PXRD techniques affirmed complete encapsulation of both drugs in the NLCs. In-vitro cytotoxicity of DSF-CXB NLCs exhibited a concentration-dependent increase compared to free DSF and CXB solutions in breast cancer cells. Confocal microscopy and flow cytometry studies demonstrated time-dependent internalization of the optimized formulation in 4T1 cancer cells. CONCLUSION: These results suggest that repurposing DSF and CXB NLCs holds promise as a co-delivery system for various cancers, potentially leading to improved therapeutic outcomes.
Formulation and Evaluation of Capecitabine-Loaded Microsponges for Colon Targeting.
Majumdar S, Dey S, Mahanti B … +3 more , Kar B, Nayak AK, Kar AK
Curr Drug Deliv · 2025 Aug · PMID 40798969 · Publisher ↗
INTRODUCTION: Capecitabine (CAP) is a chemotherapeutic drug used via oral administration for the management of metastatic cancers of the breast and colon. CAP is a prodrug of 5-fluorouracil, which inhibits DNA synthesis...
INTRODUCTION: Capecitabine (CAP) is a chemotherapeutic drug used via oral administration for the management of metastatic cancers of the breast and colon. CAP is a prodrug of 5-fluorouracil, which inhibits DNA synthesis and slows tumor growth. The objective of the current research was to develop colon-targeting CAP-loaded microsponges by using the quasi-emulsion solvent diffusion technique employing Hydroxypropyl Cellulose (HPC) and Ethyl Cellulose (EC) as constituent polymers at different ratios with varying stirring speeds (rpm). METHODS: In the present study, CAP-loaded microsponges were formulated by using the quasiemulsion solvent diffusion method with HPC and EC as polymers at different ratios with varying stirring speeds. The 32-factorial design was used to perform the statistical optimization of CAPloaded microsponges. The in vivo pharmacokinetic study of the optimized formulation of CAP-loaded microsponges was performed using Albino Wistar Rats. RESULTS: Based on the statistical optimization, the F1 formulation prepared using a 1:1 ratio of HPC and EC with 1000 rpm stirring speed was selected for its effective drug release (31.13 ± 1.73% after 8 hours and 69.57 ± 2.53% after 12 hours) and the highest drug entrapment efficiency (73.09 ± 3.54%). The high Cmax, low tmax, and 1.48-fold improvement in AUC0-∞ indicated that the optimized formulation of CAP-loaded microsponges, compared to an aqueous solution of CAP, revealed a significant (p<0.05) improvement in bioavailability of CAP when administered orally. DISCUSSION: These findings indicated the potential delivery of CAP by these CAP-loaded microsponges to the colon, enabling sustained delivery and improving the bioavailability of CAP. However, comparative evaluation with existing market formulation and stability studies is essential to validate its therapeutic implications. CONCLUSION: The developed CAP-loaded microsponges could serve as an effective carrier for the sustained release of CAP, thereby improving the oral bioavailability of CAP for the management of colon cancer.
Nanostructured Systems for Effective Transdermal Drug Delivery.
Kadian R
Curr Drug Deliv · 2026 · PMID 40765080 · Publisher ↗
INTRODUCTION: One of the least invasive, recognized potential routes for both local and systemic drug delivery and the most patient-friendly methods of administering therapeutic agents is transdermal drug delivery. It mi...
INTRODUCTION: One of the least invasive, recognized potential routes for both local and systemic drug delivery and the most patient-friendly methods of administering therapeutic agents is transdermal drug delivery. It minimizes gastrointestinal side effects, prevents hepatic first-pass metabolism, lowers dosage frequency, and boosts patient compliance. OBJECTIVE: This review aims to examine the nanostructured systems for transdermal drug delivery, focusing on their types, design, development and mechanism in enhancing drug permeation through the skin. METHODS: This review article synthesized findings from recent studies on nanostructured systems used in transdermal drug delivery systems. With a particular focus on offering a comprehensive understanding of transdermal drug delivery methods and augmentation strategies, the author examines current trends and potential uses of transdermal technologies. RESULTS: Nanostructured systems have shown increased drug penetration, improved bioavailability and controlled release profiles. CONCLUSION: Nanostructured systems offer a versatile and effective approach to overcoming the limitations of traditional transdermal drug delivery methods. Future research should focus on optimizing these systems for clinical applications, ensuring safety and regulatory compliance.
Advancements in Nanocarrier Production Techniques and Methods for Enhanced Targeted Delivery of Drug: A Comprehensive Review.
Kumar S Mundada A, Kothari LP, Vinchurkar K … +4 more , Yadav S, Malhan A, Guleria M, Singh S
Curr Drug Deliv · 2025 Jul · PMID 40754880 · Publisher ↗
Nanotechnology has transformed drug delivery systems, leading to the creation of various nanocarriers that offer significant advantages over traditional methods. This review explores key techniques and methods for produc...
Nanotechnology has transformed drug delivery systems, leading to the creation of various nanocarriers that offer significant advantages over traditional methods. This review explores key techniques and methods for producing nanocarriers like liposomes, niosomes, dendrimers, nanocapsules, carbon nanotubes, polymeric micelles, and solid lipid nanoparticles. Operating within the nanoscale range (1-100 nm), these nanocarriers enhance drug efficacy, reduce side effects, and improve bioavailability. Liposomes are generated using methods, such as the Bangham procedure, solvent injection, and microfluidic channels. Nanocarriers have become fundamental to sophisticated drug delivery systems, providing improved precision, regulated release, and targeted therapeutic administration. Innovative methods, such as microfluidics and nanoprecipitation, have enhanced the scalability and consistency of nanocarriers, while progress in surface engineering, including ligand conjugation and stimuli-responsive coatings, facilitates improved targeting and controlled drug release. The advancement of biocompatible and biodegradable nanomaterials, including polymeric nanoparticles, liposomes, and dendrimers, has broadened the clinical utility of nanocarriers, especially in oncology, neurology, and gene therapy. This review underscores the versatility and potential of these nanocarriers in advancing drug delivery, emphasizing their capacity for targeted, efficient, and controlled therapeutic interventions.
Applications of Biodegradable Polymeric Nanomaterials as Drug Delivery Systems.
Bao H, Wang N, Guo J … +1 more , Han X
Curr Drug Deliv · 2025 Jul · PMID 40754879 · Publisher ↗
There are a variety of biodegradable polymers, including natural polysaccharides, proteins, nucleic acids, etc., in animals and plants, as well as some polymers that are synthesized by microorganisms, such as poly(3-hydr...
There are a variety of biodegradable polymers, including natural polysaccharides, proteins, nucleic acids, etc., in animals and plants, as well as some polymers that are synthesized by microorganisms, such as poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). At present, the most common polymers are those that are artificially synthesized, such as polyethylene glycol, polylactic acid, and polycaprolactone. These polymers can degrade via hydrolytic and enzymatic processes in the body into low-molecular-weight products that are then reabsorbed or excreted, making them the most suitable materials for the synthesis of biodegradable nanoparticles. Biodegradable polymers can react with other substances to form nanocomposites, which have superior biocompatibility, degradability, and safety. Biodegradable polymer-based nanocomposites exhibit targeting capabilities, including passive (enhanced permeability and retention effect), active (ligand-receptor interactions), tumor microenvironment-responsive, and external stimulus-responsive (e.g., magnetic, electric, and lightdriven) targeting. In addition, synthesized biodegradable nanomaterials can alter the solubility of the loaded drug and improve its bioavailability. Thus, these materials have been widely used in drug delivery systems. This review aimed to summarize the recent advances in biodegradable polymeric nanomaterials for biomedical drug delivery, analyze their design advantages and clinical translation potential, and explore their future prospects and challenges in precision therapy and targeted delivery.
Cancer Cell-Coated PLGA Nanoparticles Loaded with Sorafenib and Spions for Hepatocellular Carcinoma Theranostics.
Lin Q, Wen Y, Peng Y … +5 more , Shi T, Liu K, Yu Q, Tian W, Meng Y
Curr Drug Deliv · 2025 Jul · PMID 40735995 · Publisher ↗
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common malignant cancer worldwide, but the chemotherapy drugs used in the treatment of HCC patients have limited efficacy and cause severe side effects. To i...
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common malignant cancer worldwide, but the chemotherapy drugs used in the treatment of HCC patients have limited efficacy and cause severe side effects. To improve HCC treatment outcomes, a cancer cell membrane (CCM)-coated biomimetic nanodelivery system was designed to achieve enhanced anti-HCC effects. METHODS: Poly (lactic-co-glycolic acid) (PLGA) was used to carry both sorafenib, which is used to treat advanced HCC, and superparamagnetic iron oxide nanoparticles (SPIONs). The prepared nanoparticles (NPs) were coated with Huh-7 cell membranes to obtain biomimetic nanoparticles (SFINPs@CCM). The physicochemical properties of SFINPS@CCM were then characterized, and the drug loading efficiency, release rate, transverse relaxation rate for MRI, fluorescence targeting ability, and anti-HCC ability were evaluated. RESULTS: The SFINPS@CCM were successfully prepared. The loading efficiency of sorafenib in the SFINPs was 88.24%. The cumulative amount of sorafenib released from the SFINPs@CCM at 72 h was 72.96%. In vitro magnetic resonance imaging (MRI) showed the transverse relaxation rate was 25.448 mM-1 s-1. Meanwhile, the fluorescent tracing verified the homologous targeting ability of SFINPs@CCM to Huh-7 cells. The cytotoxicity of SFINPS@CCM was 29.48±5.74%, which was significantly higher than that of the SFINPs. DISCUSSION: The study indicates that the SFINPs@CCM system achieves efficient drug delivery and enhances anti-HCC efficacy. While the results are encouraging, further research is needed to confirm broader applicability. CONCLUSION: The biomimetic nanodelivery system exhibits good targeting and excellent therapeutic effects, laying a technical foundation for preclinical studies.
Metformin-Embedded Hydrogels: A Promising Approach for Accelerating Healing in Diabetic Ulcers.
Zhou J, Liu X, Tang T … +7 more , Liang J, He H, Luo Y, Guo Y, Li P, Ban J, Zhang Y
Curr Drug Deliv · 2025 Jul · PMID 40734436 · Publisher ↗
INTRODUCTION: Difficulty in wound healing is a significant worldwide clinical challenge with serious health consequences and even life-threatening consequences. We designed an acrylic hydrogel loaded with metformin and i...
INTRODUCTION: Difficulty in wound healing is a significant worldwide clinical challenge with serious health consequences and even life-threatening consequences. We designed an acrylic hydrogel loaded with metformin and investigated its mechanism of action in promoting wound repair. METHODS: In this study, we obtained self-assembled metformin hydrogels (SAMHs) delivery system using acrylic acid (AA) as matrix and ammonium persulfate (APS) as initiator, and evaluated the appearance, water vapor transmission rate, swelling properties, mechanical properties, and bioactivities of the SAMHs, and finally assessed the potential of the SAMHs for the treatment of chronic wounds in a diabetic rat wound model. RESULTS: SAMHs were colorless and transparent in appearance, with a water vapor transmission rate of 3530 g·m-2·day-1, a dissolution rate of 504%, a Young's modulus of 34 Kpa, and an elongation at break of 595.7%.The drug loading capacity of SAMHs was 0.8±0.04 mg·g-1 and the cumulative release amounted to 71.67±2.03%. In vivo experiments showed that on day 14, the SAMHs group achieved a wound healing rate of 96.74%, with complete epithelialization, a collagen fiber content of 75.10%, elevated VEGF expression, and a TNF-α level of 162.62 pg·mL⁻¹, all of which exhibited significant differences compared to the control group. DISCUSSION: SAMHs exhibit excellent performance in several aspects, achieving slow drug release and promoting wound repair. In addition, SAMHs are simple and low-cost to prepare, which is expected to bring more cost-effective treatment options for diabetic patients. However, antimicrobial properties and clinical trial data are lacking in this study, and their applicability in complex wounds requires further validation. CONCLUSION: The hydrogel we prepared has excellent properties, is suitable for use in chronic wounds and promotes wound healing in diabetic rats and is an effective therapeutic strategy for chronic wounds.
Smart Nanofibers in Wound Healing: Exploring Novel Combinations and Applications.
Alotaibi BS, Khan M, Ibrahim NA … +3 more , Khan AK, Liaqat R, Ijaz M
Curr Drug Deliv · 2025 Jul · PMID 40605157 · Publisher ↗
Due to certain limitations of traditional therapies, millions of people all over the world suffering from chronic wounds are exploring new treatments. As single-layer nanofibers cannot meet different wound surface needs,...
Due to certain limitations of traditional therapies, millions of people all over the world suffering from chronic wounds are exploring new treatments. As single-layer nanofibers cannot meet different wound surface needs, multifunctional nanofibers with drug combinations surpass the limitation of conventional drug-polymer combinations. Traditional wound therapies have several limitations, prompting the search for more effective alternatives, particularly for chronic wounds. Singlelayer nanofibers often fail to meet diverse wound-healing needs, whereas multifunctional nanofibers, incorporating drug combinations, overcome these limitations. Polymers, widely used in nanofiber formulations, exhibit immunostimulatory, anti-inflammatory, and antimicrobial properties, enhancing the woundhealing process. However, due to a lack of certain biological properties, researchers have formed hybrid polymers, which are a combination of natural and synthetic polymers to meet wound healing requirements. Despite their advantages in biocompatibility and tunable mechanical properties, the clinical translation of polymer-based nanofibers faces challenges in regulatory approval and largescale production. Most studies are still limited to in vitro evaluations, and standardized in vivo models or human trials are necessary to validate their long-term efficacy. Additionally, to meet FDA and DRAP guidelines, these materials must undergo rigorous biodegradation and cytotoxicity assessments before clinical adoption. Owing to several bioactive components (e.g., vitamins, polyphenols) in structures of herbal extract, they have excellent anti-inflammatory, antimicrobial, and antioxidant properties. Nanofibrous scaffolds of herbal extracts are in prominence and can have a multi-target synergistic impact. Among several treatments for repairing wounds, growth factors have also been proven as an effective treatment for active healing. This review will provide the researchers with a holistic view of recently reported novel multifunctional nanofibers composed of different combinations of drugs, polymers, herbal extracts, growth factors, and biomolecules to promote wound healing. Although several multifunctional nanofibers have been prepared and shown excellent properties for wound healing therapy, still development of multifunctional nanofibers still needs to be focused on. In a nutshell, multifunctional nanofibers have become very famous in the wound healing process, and a better scale-up of these nanofibers in the coming era will result in commercialization, and products of these nanofibers will become more popular.
6D Printing and the Future of Personalized Medicine: A New Frontier in Drug Delivery.
Komal, Kurmi BD, Narang RK … +1 more , Singh A
Curr Drug Deliv · 2025 Jun · PMID 40588999 · Publisher ↗
Abstract loading — click title to view on PubMed.
Cefadroxil-Mupirocin Integrated Electrospun Nanofiber Films for Burn Wound Therapy.
Rashid S, Ijaz M, Rafique S … +6 more , Yasin H, Mushtaq M, Khan AK, Khan M, Nasir B, Murtaza G
Curr Drug Deliv · 2025 Jun · PMID 40539348 · Publisher ↗
OBJECTIVE: This study aims to fabricate dual drug-loaded nanofibrous films made from polyvinyl alcohol (PVA) and chitosan, incorporating cefadroxil and mupirocin to meet the critical needs of burn wound care. METHODS: El...
OBJECTIVE: This study aims to fabricate dual drug-loaded nanofibrous films made from polyvinyl alcohol (PVA) and chitosan, incorporating cefadroxil and mupirocin to meet the critical needs of burn wound care. METHODS: Electrospinning was utilized to fabricate cefadroxil- and mupirocin-loaded polyvinyl alcohol PVA/Chitosan nanofibers. Characterization of structural and morphological properties of these nanofibers was done through Fourier Transform IR Spectroscopy, Scanning Electron Microscopy, Thermal analysis by TGA, and XRD spectroscopy. The kinetic profiles of the drug release mechanisms were considered to determine the release of cefadroxil and mupirocin. Antibacterial activity was determined against the bacteria Staphylococcus aureus and Pseudomonas aeruginosa, while the wound healing efficacy was tested in a rabbit model using full-thickness wounds. RESULTS: SEM analysis demonstrated the formation of uniform and smooth nanofibers possessing a well-defined morphology. FTIR spectroscopy confirmed the successful incorporation of cefadroxil and mupirocin into the PVA/Chitosan matrix. TGA analysis indicated the thermal stability of the nanofibers, while XRD results suggested that the drugs were either molecularly dispersed or in an amorphous state within the biopolymeric blend. Drug release studies showed distinct profiles, with an initial burst release followed by sustained drug release. Over 80% of mupirocin was released within the first 2 hours, while cefadroxil exhibited a cumulative release exceeding 60%. Antibacterial assays showed significant inhibition zones, with the largest being 20 mm against Staphylococcus aureus. In vivo studies utilizing a full-thickness rabbit wound model revealed that the drug-loaded nanofibers accelerated wound contraction, achieving approximately 90% closure by day 17, compared to less than 70% for the control. CONCLUSION: The study demonstrates that cefadroxil-mupirocin nanofiber films provide superior antibacterial activity and faster wound healing rates, highlighting their potential in advanced burn wound management.
Brain Targeting Using Nanocolloids for the Management of Multiple Sclerosis.
Jain S, Raza K
Curr Drug Deliv · 2026 · PMID 40539347 · Publisher ↗
Multiple sclerosis (MS) causes sensory and motor deficiencies by breaking the myelin sheath, which inhibits electrical impulses from reaching affected neurons. The blood-brain barrier (BBB) and unanticipated side effects...
Multiple sclerosis (MS) causes sensory and motor deficiencies by breaking the myelin sheath, which inhibits electrical impulses from reaching affected neurons. The blood-brain barrier (BBB) and unanticipated side effects from inadequate targeting are major hurdles to MS treatment. Nanomedicines are being used to deliver therapeutic chemicals to lesions in order to address the limitations of existing MS therapy approaches. Nano-based therapies with deep BBB penetration and selective targeting have shown promising results, emerging as a possible therapy strategy for MS with improved therapeutic effects. This review will suggest the latest developments in nano-colloidsbased therapy for treating MS by evaluating their advantages and disadvantages.
Type IV Collagen-Targeting Nanoparticles for Efficient Delivery to the Renal Interstitium in Fibrotic Kidneys.
Nakamura Y, Togami K, Chono S
Curr Drug Deliv · 2025 May · PMID 40442906 · Publisher ↗
INTRODUCTION: Renal fibrosis is widely recognized as the final common pathway in chronic kidney disease (CKD) progression, culminating in end-stage renal failure, and is characterized by excessive extracellular matrix (E...
INTRODUCTION: Renal fibrosis is widely recognized as the final common pathway in chronic kidney disease (CKD) progression, culminating in end-stage renal failure, and is characterized by excessive extracellular matrix (ECM) accumulation by renal myofibroblasts within the renal interstitium, ultimately leading to functional decline. In this study, to establish an effective drug delivery system targeting fibrotic lesions in the renal interstitium, we developed nanoparticles modified with short-chain peptides that bind type IV collagen (Col IV), a distinct ECM component predominantly remodeled in fibrosis. METHODS: Col IV-targeting nanoparticles were intravenously administered to a unilateral ureteral obstruction (UUO) rat model of renal fibrosis. The distribution of these nanoparticles to the renal interstitium was examined via fluorescence-based ex vivo imaging and analysis of frozen kidney tissue sections. Additionally, we assessed cellular uptake in renal fibroblasts (NRK-49F), with or without transforming growth factor-beta 1 (TGF-β1) stimulation, using flow cytometry. RESULTS: Both Col IV-targeting and non-targeting nanoparticles exhibited increased distribution in the fibrotic renal interstitium compared to healthy renal tissue. Moreover, the Col IV-targeting nanoparticles localized more extensively in the fibrotic interstitium than their non-targeting counterparts. In vitro, Col IV-targeting nanoparticles also showed significantly higher accumulation in NRK-49F cells, irrespective of TGF-β1 stimulation, compared to non-targeting nanoparticles. CONCLUSION: We successfully fabricated and evaluated Col IV-targeting nanoparticles as a potential drug delivery platform. In a UUO-induced renal fibrosis model, these nanoparticles efficiently migrated to the fibrotic renal interstitium, and in vitro experiments using NRK-49F cells demonstrated enhanced uptake by renal fibroblasts and myofibroblasts, central mediators of ECM deposition in fibrotic progression. These findings suggest that Col IV-targeting nanoparticles may serve as an effective drug carrier for delivering antifibrotic therapies, potentially mitigating CKD progression.
Self-Assembly Peptide Hydrogel and its Application in the Biomedical Field.
Yuan L, Zhang Y, Shuai Y
Curr Drug Deliv · 2026 · PMID 40370234 · Publisher ↗
With the continuous development of material science, many new biomaterials have emerged. Peptides have a strong supramolecular self-assembly ability and can form hydrogels through a self-assembly process. These self-asse...
With the continuous development of material science, many new biomaterials have emerged. Peptides have a strong supramolecular self-assembly ability and can form hydrogels through a self-assembly process. These self-assembled peptide hydrogels have the advantages of excellent biocompatibility, tunability, and degradability, and are suitable for biomedical fields. This paper reviews the mechanisms and characteristics of peptide gel formation, outlines the various factors affecting peptide gelation, and the applications of peptide hydrogels in drug delivery, tissue engineering, and wound healing. Finally, challenges encountered in self-assembled peptide gels and prospects for their application are highlighted.
Materials Chemistry and Engineering for Drug Delivery.
Lai WF
Curr Drug Deliv · 2025 · PMID 40356396 · Publisher ↗
Abstract loading — click title to view on PubMed.
Electrospun Nanofiber Films Containing Hesperidin and Ofloxacin for the Inhibition of Inflammation and Psoriasis: A Potential Study.
Thirumal V, Jerad AS, Sujatha K … +3 more , Alan MP, Dhanush R, Sowmya C
Curr Drug Deliv · 2025 · PMID 40353404 · Publisher ↗
INTRODUCTION: Nanofiber (NF) films have emerged as a promising alternative for treating psoriasis. Based on their specific characteristics, they have distinguished themselves from other topical dosage forms, such as hydr...
INTRODUCTION: Nanofiber (NF) films have emerged as a promising alternative for treating psoriasis. Based on their specific characteristics, they have distinguished themselves from other topical dosage forms, such as hydrogels, foams, and sponges. This research looks at making biocompatible and biodegradable nanofibers out of polyvinyl alcohol (PVA) and gelatin and adding hesperidin (HPN) and ofloxacin (OFX) as medicine. METHODS: HPN-OFX-integrated nanofiber (HPN-OFXNF) films were prepared using electrospinning. Subsequently, the surface morphology, entrapment efficiency, in vitro drug diffusion, and antimicrobial, anti-inflammatory, and anti-psoriasis properties were investigated. RESULTS: Scanning electron microscopy (SEM) analysis revealed that the produced nanofibers exhibited smooth surfaces with diameters from 50.67 to 114.4 nm, entrapment efficiencies from 69.3 ± 1.8% for OFX and 45.63 ± 1.6% for HPN. At the end of 48 h, nanofibers showed 90.8 ± 2.4% of OFX and 97.3± 3.1% of HPN release. In vitro, antimicrobial testing of the films demonstrated 24.89 ± 3.2 and 42.46 ± 4.4 mm zones of inhibition against E. coli and S. aureus. The total antioxidant activity of HPN is 198.67±2.38 (μ mol AAE/mg HPN), and HPN-OFXNF is 271.12 ± 3.56 (μ mol AAE/mg HPN-OFXNF), and their IC50 values against HaCaT cell growth of 80.5 ± 2.5 and 64.6 ± 3.4 μg/ml, respectively. DISCUSSION: HPN-OFXNFs have been developed successfully by the electrospinning method with moderate entrapment efficiencies, showing a biphasic trend of an early burst trailed by a sustained pattern of drug release, depending on the surface area and diameter of the fibers. Enhanced zones of inhibition and anti-inflammatory efficacy of NFs in comparison with their pure counterparts have been demonstrated to be beneficial. Stronger antioxidant efficacy, inducing anti-proliferation and promoting apoptosis in human keratinocytes, has made them the best versions over pure drug compounds. CONCLUSION: This therapy, which includes a combined anti-inflammatory and antibacterial treatment strategy with an innovative drug delivery system, has proven to be a promising development in treating psoriasis.
Unlocking the Power of Electrospinning: A Review of Cutting-Edge Polymers and their Impact on Scaffold Design and Performance.
Ghosh T, Nemadea A, K VK … +3 more , N S, V S, C P
Curr Drug Deliv · 2025 Apr · PMID 40265425 · Publisher ↗
Electrospun scaffolds are pivotal in tissue engineering due to their ability to mimic the Extracellular Matrix (ECM). Despite their potential, challenges such as, two-dimensional structure, limited load bearing capacity,...
Electrospun scaffolds are pivotal in tissue engineering due to their ability to mimic the Extracellular Matrix (ECM). Despite their potential, challenges such as, two-dimensional structure, limited load bearing capacity, and low mechanical strength restrict their application. This review explores advancements in electrospinning techniques and materials, highlighting methods like coaxial electrospinning, which enables the encapsulation of therapeutic agents, and the integration with 3D printing to create hybrid scaffolds with improved cell infiltration. Characterization techniques assessed by different researchers, such as scaffold morphology, mechanical properties, and biocompatibility, show that scaffolds with high spatial interconnectivity and controlled alignment enhance cell orientation and migration. Innovations in smart polymers and stimuli-responsive materials have furthered scaffold functionality. While recent advancements address some limitations, issues with scalability and production uniformity remain. Future research should optimize fabrication parameters and explore novel materials to enhance scaffold performance, requiring collaborative efforts and technological innovations to expand their practical applications in tissue engineering and regenerative medicine.
Revolutionizing Personalized Medicine with 4D Printing in Drug Delivery.
Sharma N, Garg Y, Singh A
Curr Drug Deliv · 2026 · PMID 40257026 · Publisher ↗
4D printing is an improvement over the traditional 3D printing technique involving the application of dynamic materials that change with the environmental conditions, including temperature, humidity, and pH. This technol...
4D printing is an improvement over the traditional 3D printing technique involving the application of dynamic materials that change with the environmental conditions, including temperature, humidity, and pH. This technology holds great promise for drug development to create effective and personalized drug delivery systems. Different from conventional technologies, 4D printed systems can control the administration rate of drugs depending on the internal environment, thus enhancing the effectiveness of treatments and considering adverse effects at the same time effectively. 4D printing contributes to the creation of smart materials for use in vaccines, implants, and other devices that respond to body signals in real-time. However, several hurdles persist in the synthesis and fabrication of these materials as well as their regulatory approval. This technology represents the future of drug manufacturing, emphasizing patient-specific care and providing a more effective, efficient, and adaptive approach to therapeutic delivery.
Advances in Nanostructured Lipid Carriers for Colorectal Cancer Treatment: A Comprehensive Review.
Patel R, Shah S, Acharya S … +3 more , Patel G, Shah S, Prajapati BG
Curr Drug Deliv · 2025 Apr · PMID 40207826 · Publisher ↗
As colorectal cancer is the third most common cancer globally, this study aimed to improve colorectal cancer treatment using nanostructured lipid carriers (NLCs) for drug delivery by overcoming the current drawbacks, imp...
As colorectal cancer is the third most common cancer globally, this study aimed to improve colorectal cancer treatment using nanostructured lipid carriers (NLCs) for drug delivery by overcoming the current drawbacks, improving therapeutic effectiveness, achieving site-specific delivery, and implementing controlled drug administration to mitigate systemic side effects. Based on the literature, it has been observed that the optimal drug size and zeta potential range depend on the drug formulation's targets and features. These ranges are determined through optimization and characterization. The particle size ranges from 10 to 200 manometers, and the zeta potential values range from -30 mV to +30 mV. Optimal formulations should have uniform spherical morphology and compatibility with biological entities. This paper provides an in-depth analysis of nanocarrier research and findings. This article offers a thorough synopsis of the latest research and findings on nanocarriers, offering a valuable understanding of their development.
Kidneys Toxicity and Biodistribution of Albumin-Based Gold and Silver Nanoclusters.
Alhawari H, AlShelleh S, Abu Shahin N … +6 more , Alkawareek M, Abbasi R, El-Zubi MK, Mahafdeh R, Alzoubi KH, Alkilany AM
Curr Drug Deliv · 2025 Apr · PMID 40207825 · Publisher ↗
BACKGROUND: The interaction of the kidneys with nanoparticles is a fundamental issue that accelerates the proper design of efficient and safe nanotherapeutics. The present study aimed to establish the kidney toxicity and...
BACKGROUND: The interaction of the kidneys with nanoparticles is a fundamental issue that accelerates the proper design of efficient and safe nanotherapeutics. The present study aimed to establish the kidney toxicity and the biodistribution profile of novel gold and silver nanocluster formulations. METHODS: Gold and silver nanoclusters were synthesized in an albumin template to probe their kidney- nano interaction. The interaction was performed on healthy animals to unveil the toxicity of nanoclusters on kidney tissue. RESULTS: Albumin-based gold nanoclusters (BSA-AuNCs) and albumin-based silver nanoclusters (BSA-AgNCs), exhibited comparable core size (2.2±1.3 nm and 2.5±1.6 nm, respectively) and hydrodynamic diameter (11.3±2.1 nm for BSA-AuNC and 10.7±1.9 nm for BSA-AgNC) indicating similarity in their core and overall sizes. Zeta potential measurements demonstrated a comparable surface charge between BSA- AuNC (18.1±3.2 mV) and BSA- AgNC (20.1±3.6 mV), which closely resembled the surface charge of albumin in water (20.7±3.5 mV). Upon administration to rats via intravenous route, ICP-OES measurements showed a significant silver and gold nanocluster accumulation in various vital organs with unequal distribution patterns. BSA-AgNC exhibited higher concentrations in the liver and spleen, while BSA-AuNC showed predominant accumulation in the liver and kidneys. However, the administered BSA-AgNC induced more renal damage than BSA- AuNCs. CONCLUSION: The identified renal toxicity linked to BSA-AgNCs, despite their lower kidney accumulation than BSA-AuNCs, illuminates the intricate interplay between nanoparticle biodistribution and toxicity. This underscores the significance of considering the core metal type in nanoparticle design and evaluation. Further investigation is needed to clarify the underlying molecular mechanisms of the observed biodistribution and toxicity.
Combination of Luteolin and Silibinin Has Hepatoprotective Effects on Rats' Liver Fibrosis Induced by Thioacetamide.
Alamri ZZ, Aharthi RF, Melebary SJ
Curr Drug Deliv · 2025 · PMID 40207824 · Publisher ↗
INTRODUCTION: A serious public health condition called liver fibrosis can cause cirrhosis, cancer, and even patient death. METHOD: This study sought to determine if Luteolin (LUT) and Silibinin (SBN) could protect rats a...
INTRODUCTION: A serious public health condition called liver fibrosis can cause cirrhosis, cancer, and even patient death. METHOD: This study sought to determine if Luteolin (LUT) and Silibinin (SBN) could protect rats against oxidative stress and liver fibrosis caused by thioacetamide (TAA) over three weeks, as well as any potential mechanisms of action. There will be 49 adult Wistar albino rats utilized, split up into 7 groups: (G1) Negative control, (G2) Positive control, (G3) LUT+TAA, (G4) SBN+TAA, (G5) mix LUT+ SBN, (G6) LUT+SBN with TAA, (G7) LUT+SBN then TAA, and so. Liver function tests and oxidative stress markers were measured after the experiment. The liver underwent microscopic inspection. Rats given TAA treatment had significantly higher liver enzymes than control; yet, albumin (ALB), total protein (TP), superoxide dismutase (SOD), and reduced glutathione (GSH) significantly decreased. RESULTS: Following three weeks of TAA exposure, liver sections revealed hepatocytic damage and fibrosis. Oxidative stress, histological alterations, and alterations in liver function were all lessened in TAA rats administered with LUT, SBN, or both. CONCLUSION: The combined hepatoprotective benefits of LUT and SBN prevented TAA-induced biochemical and histological alterations in rat liver, acting in concert with each other.
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