Journal Of The American Academy Of Dermatology[JOURNAL]

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Genetic predisposition to malignancy confers different outcomes in malignant cutaneous melanoma: A retrospective cohort matched study using TriNetX.

Nassief G, Kaelber D, Nowacki AS … +1 more , Arbesman J

J Am Acad Dermatol · 2026 Jun · PMID 42314938 · Publisher ↗

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Allergic Contact Dermatitis to Personal Care Products: A Focus on Established and Emerging Allergens.

Smale NE, Karagounis TK, Milam EC … +2 more , Cohen DE, Flamm A

J Am Acad Dermatol · 2026 Jun · PMID 42309282 · Publisher ↗

Allergic contact dermatitis (ACD) to personal care products (PCPs) represents a significant and growing clinical challenge, with increasing use of diverse PCPs and their expanding range of ingredients. Common allergenic... Allergic contact dermatitis (ACD) to personal care products (PCPs) represents a significant and growing clinical challenge, with increasing use of diverse PCPs and their expanding range of ingredients. Common allergenic components include fragrances, botanicals, preservatives, surfactants, emollients, emulsifiers, vitamins, and ultraviolet (UV) filters. Patch testing remains the gold standard for diagnosing ACD and identifying causative allergens, but traditional panels often fail to capture emerging PCP-related allergens. This review highlights key established and emerging PCP allergens, such as limonene and linalool hydroperoxides, sodium benzoate, octocrylene, and benzophenone-4. Strategies are discussed to optimize diagnostic accuracy through targeted series and repeated open application tests. Patient education about PCP labeling is paramount when assisting patients with allergen avoidance. Clinicians must balance precise allergen identification with practical management knowledge to improve outcomes in PCP-related ACD.

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Hormone Replacement Therapy and Menopausal Skin Aging: Implications of Recent Regulatory Updates.

Haykal D

J Am Acad Dermatol · 2026 Jun · PMID 42309281 · Publisher ↗

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Dermatological Manifestations Associated with Fertility Treatments.

Shahrour N, Shahrour L, Rafeeqi Y … +1 more , Hussain A

J Am Acad Dermatol · 2026 Jun · PMID 42303160 · Publisher ↗

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Clinical utility of immune biomarker staining of skin biopsies in psoriasis and eczematous dermatitis: A single-center retrospective analysis.

Foroohar T, Sadlowski A, Cohen JM … +1 more , Damsky W

J Am Acad Dermatol · 2026 Jun · PMID 42303159 · Publisher ↗

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Progression of skin-limited pediatric-onset discoid lupus erythematosus to diagnosis of systemic lupus erythematosus: results of a multicenter, retrospective cohort study.

Arkin LM, Buhr KA, Ardoin SP … +17 more , Faith EF, Lee LW, von Scheven E, Brandling-Bennett JH, Castelo-Soccio L, Chiu YE, Diaz LZ, Garcia-Romero MT, Hunt RD, Oza VS, Schoch JJ, Paller AS, Vleugels RA, Chong BF, Werth VP, Ardalan K, CARRA-PeDRA Lupus Dermatology Work Groups

J Am Acad Dermatol · 2026 Jun · PMID 42297301 · Publisher ↗

BACKGROUND: Pediatric skin-limited discoid lupus erythematosus (DLE-only) is rare, with limited data on risk factors for progression to systemic lupus erythematosus (SLE). OBJECTIVE: To assess incidence, risk factors, an... BACKGROUND: Pediatric skin-limited discoid lupus erythematosus (DLE-only) is rare, with limited data on risk factors for progression to systemic lupus erythematosus (SLE). OBJECTIVE: To assess incidence, risk factors, and phenotype of pediatric DLE-only progression to SLE. METHODS: In this 17-site retrospective cohort of pediatric DLE, the primary outcome was time to SLE diagnosis (ACR classification criterion ≥4). Kaplan-Meier estimates for 1-, 2-, and 5-year progression to SLE were generated. Cox proportional hazards modeling identified baseline predictors of progression to SLE. RESULTS: The 1-year progression rate from DLE-only to SLE was 14.4% (95% CI: 9.6-18.9%). Progression to SLE was most strongly associated with baseline ANA positivity (HR 3.71) and older age (HR 1.11/yr). Antiphospholipid antibodies and cytopenias also predicted progression to SLE in multivariable analysis. The SLE phenotype was relatively mild, with most patients developing mucocutaneous and laboratory criteria (22/236, 9%) and few developing other end-organ disease (7/236, 3%). LIMITATIONS: Retrospective design, missing data. CONCLUSION: ANA-positive DLE-only patients warrant close monitoring for progression SLE, especially within the first year. Severe end-organ disease in DLE patients who progress to SLE is uncommon. Future studies should test whether early recognition and intervention in DLE-only slows progression to SLE.

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Geographic accessibility of dermatology care in the United States via walking and motorized transport: A quantitative analysis of population-weighted travel time distributions.

Woll JP, Sharma AN

J Am Acad Dermatol · 2026 Jun · PMID 42297300 · Publisher ↗

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JAAD Game Changer: Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study.

Brodell RT

J Am Acad Dermatol · 2026 Jun · PMID 42297299 · Publisher ↗

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JAAD Game Changer: "A phase 2 study of oral difelikefalin in subjects with chronic kidney disease and moderate-to-severe pruritus".

Brodell RT

J Am Acad Dermatol · 2026 Jun · PMID 42297298 · Publisher ↗

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JAAD Game Changers: "Outcomes of down-titration in patients with severe scalp alopecia areata initially treated with baricitinib 4 mg: week 152 data from BRAVE-AA2".

Lake E

J Am Acad Dermatol · 2026 Jun · PMID 42297297 · Publisher ↗

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JAAD Game Changers: "Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: a Danish nationwide population-based cohort study".

Lake E

J Am Acad Dermatol · 2026 Jun · PMID 42297296 · Publisher ↗

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JAAD Game Changer: "Pemphigus and hematologic malignancies: a population-based study of 11,859 patients".

Lake E

J Am Acad Dermatol · 2026 Jun · PMID 42297295 · Publisher ↗

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Response to Commentary: Aligning Dermatology Continuing Certification and Quality Outcomes Through Research.

Thapa M, Raheel O, Fleischer AB … +1 more , Feldman SR

J Am Acad Dermatol · 2026 Jun · PMID 42288218 · Publisher ↗

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A Novel Container for Liquid Nitrogen for Mohs Tissue Processing.

Keith Ht D, Ochoa S

J Am Acad Dermatol · 2026 Jun · PMID 42288217 · Publisher ↗

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Dermatologic manifestations of silent sinus syndrome: A retrospective cohort study of 135 patients.

Brown CR, Zappi I, Lo Sicco KI … +2 more , Eytan DF, Mazori DR

J Am Acad Dermatol · 2026 Jun · PMID 42288216 · Publisher ↗

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Aligning dermatology continuing certification and quality outcomes through research Commentary on JAAD-D-25-04225R2.

Stratman EJ

J Am Acad Dermatol · 2026 Jun · PMID 42288215 · Publisher ↗

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Considerations for commonly prescribed medications by dermatologists in patients on immune checkpoint inhibitors.

Rachofsky C, Liu MH, D'Aiello A … +3 more , Halmos B, McLellan BN, Deutsch A

J Am Acad Dermatol · 2026 Jun · PMID 42288214 · Publisher ↗

Immune checkpoint inhibitors (ICI) have revolutionized the treatment of many cancers. It is important for all members of the multidisciplinary teams supporting cancer patients to understand the impact of their clinical p... Immune checkpoint inhibitors (ICI) have revolutionized the treatment of many cancers. It is important for all members of the multidisciplinary teams supporting cancer patients to understand the impact of their clinical practice on immunotherapy response. Multiple medications have been implicated in altered ICI efficacy, of which many are first line treatments for common dermatologic conditions, including those arising as immune-related adverse events (irAEs). Cognizance of potential consequences associated with typical management strategies must be accounted for in this unique population. In this review, we hope to raise awareness of the potential impact that medications commonly prescribed by dermatologists may have on immunotherapy response. Specifically, we review the available evidence regarding the impact of antibiotics, systemic corticosteroids, Janus kinase inhibitors, biologics, and other immunomodulators. Improved understanding of these medication interactions will uphold informed management strategies for irAEs and coincidental dermatologic disorders in patients receiving ICIs, ultimately optimizing outcomes.

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AI-Powered Imaging for Objective Psoriasis Severity Assessment at Home: Feasibility and Reliability in a Randomized Clinical Trial.

Oliver M, Molnarova M, Bergmans M … +11 more , Ranjan R, Exadaktylos V, Niemeyer van der Kolk T, Seyger MMB, Wee L, Balak DMW, van Doorn MBA, Rissmann R, Schnidar H, Rousel J, Next Generation ImmunoDermatology Consortium (NGID)

J Am Acad Dermatol · 2026 Jun · PMID 42288213 · Publisher ↗

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Correction to Topical therapies for atopic dermatitis. Journal of the American Academy of Dermatology 2026 May;94(5S)S31-S34.

J Am Acad Dermatol · 2026 Jun · PMID 42287307 · Publisher ↗

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Prevalence, characterization, and clinical predictors of advanced systemic therapy-refractory palmoplantar pustulosis: A prospective real-world cohort study.

Du J, Xu Z, Chen W … +6 more , Xing X, Yang J, Yu C, Cao T, Wang G, Shao S

J Am Acad Dermatol · 2026 Jun · PMID 42285263 · Publisher ↗

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Journal Of The American Academy Of Dermatology[JOURNAL]

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