Recent Patents On Biotechnology[JOURNAL]
Sun
200 papers
Phytochemical Analysis and Antimicrobial Potential of and .
Firdaus A, Izhar SK, Qamar S … +2 more , Siddiqui A, Afaq U
Recent Pat Biotechnol · 2025 · PMID 39253933 · Publisher ↗
BACKGROUND: and are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from and . Fo...
BACKGROUND: and are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from and . For instance, patent extracts from these plants have been utilized in the formulation of pharmaceutical drugs, herbal supplements, cosmeceuticals, and agricultural products. , commonly known as Santa Maria feverfew or Congress grass, contains various bioactive compounds like terpenoids, flavonoids, phenolics, and alkaloids.These compounds are the key to its medicinal properties, particularly its antimicrobial activity. On the other hand, , often referred to as wild sage, is rich in phytochemicals such as terpenoids, flavonoids, and alkaloid glycosides. METHODS: and plants selected and checking their antimicrobial activity by agar well diffusion method. RESULTS: In our study, we found that the leaf extract of exhibited the most potent antibacterial activity against exhibited the most potent antifungal activity against and , with a diameter of inhibition zone measuring 12 mm, followed by and . In case of L. camara, the inhibitory zone ranging from 14 to 18 mm was detected against , and . The leaf extract of the maximum zone of inhibition in case of was shown by (12 mm). CONCLUSION: The present study suggests that these two weeds could be useful in the development of bactericides and fungicides.
Exploration of Developmental Variants of Predatory Ladybird, L. (Coleoptera: Coccinellidae) on an Artificial Diet.
Siddiqui A, Shaizee, Khan D
Recent Pat Biotechnol · 2025 · PMID 39171591 · Publisher ↗
INTRODUCTION: This study aimed to focus on the identification, rearing, and exploration of developmental variants of the predatory ladybird, L., renowned for its efficacy as a biological control agent and its predation...
INTRODUCTION: This study aimed to focus on the identification, rearing, and exploration of developmental variants of the predatory ladybird, L., renowned for its efficacy as a biological control agent and its predation on agricultural pests. However, comprehensive knowledge concerning the occurrence and characteristics of developmental variants in this species remains limited. METHODS: In this study, through meticulous monitoring and exploration, we identified developmental variants exhibiting distinct sexual attributes, as well as survival rates. RESULTS: The research outcomes enhance our understanding of the developmental variations within an egg batch of . CONCLUSION: Moreover, the findings hold practical implications for the implementation of biological control strategies in agriculture, as specific variants may possess unique characteristics that enhance their effectiveness as natural enemies against pests. Furthermore, the increasing competitiveness in the artificial diet space for scientific models raises questions about intellectual property rights (IPR), patents, and strategies. This overview looks at recent developments and advanced protection strategies in this field to help understand the present state of IPR and patents in an artificial food for insects.
Unveiling Anthraquinones: Diverse Health Benefits of an Essential Secondary Metabolite.
Khatoon M, Dubey A, Janhvi K
Recent Pat Biotechnol · 2025 · PMID 38967073 · Publisher ↗
Since ancient times, plants have been used as a remedy for numerous diseases. The pharmacological properties of plants are due to the presence of secondary metabolites like terpenoids, flavonoids, alkaloids, etc. Anthraq...
Since ancient times, plants have been used as a remedy for numerous diseases. The pharmacological properties of plants are due to the presence of secondary metabolites like terpenoids, flavonoids, alkaloids, etc. Anthraquinones represent a group of naturally occurring quinones found generously across various plant species. Anthraquinones attract a significant amount of attention due to their reported efficacy in treating a wide range of diseases. Their complex chemical structures, combined with inherent medicinal properties, underscore their potential as agents for therapy. They demonstrate several therapeutic properties such as laxative, antitumor, antimalarial, antibacterial, antifungal, antioxidant, etc. Anthraquinones are found in different forms (derivatives) in plants, and they exhibit various medicinal properties due to their structure and chemical nature. The precursors for the biosynthesis of anthraquinones in higher plants are provided by different pathways such as plastidic hemiterpenoid 2-C-methyl-D-erthriol4-phosphate (MEP), mevalonate (MVA), isochorismate synthase and polyketide. Anthraquinones possess several medicinal properties and a complex biosynthetic pathway, making them good candidates for patenting new products, synthesis methods, and biotechnological production advancements. By conducting a thorough analysis of scientific literature, this review provides insights into the intricate interplay between anthraquinone biosynthesis and its broad-ranging contributions to human health.
Emerging Methods in the Identification of Bacterial Respiratory Tract Pathogens.
Kiaghobadi F, Dehshahri A, Ghasemi Y … +1 more , Morowvat MH
Recent Pat Biotechnol · 2025 · PMID 38967072 · Publisher ↗
AIMS: Here, we will review different bacterial causes of respiratory tract infections and discuss the available diagnostic methods. Moreover, we will provide some recently published patents and newer techniques, such as...
AIMS: Here, we will review different bacterial causes of respiratory tract infections and discuss the available diagnostic methods. Moreover, we will provide some recently published patents and newer techniques, such as respiratory panels and omics approaches, and express the challenges in this path. BACKGROUND: Respiratory tract infections (RTIs) include those infections that can lead to the involvement of different respiratory parts, including the sinuses, throat, airways, and lungs. Acute respiratory tract infection is the leading cause of death from infectious illnesses worldwide. According to the World Health Organization, 1.6 to 2.2 million deaths have occurred due to acute respiratory infections in children under five years of age. About 4 million people die annually from respiratory infections, 98% of which are caused by lower respiratory infections. RESULTS: Depending on the type of pathogen, the severity of the infection can vary from mild to severe and even cause death. The most important pathogens involved in respiratory tract infections include , and . The symptoms are often similar, but the treatment can vary greatly. Therefore, correct diagnosis is so important. There are several methods for diagnosing respiratory infections. Traditional tests include the culture of respiratory samples, considered the primary tool for diagnosing respiratory infections in laboratories, and less common standard tests include rapid and antigenic tests. It is essential to think that the culture method is reliable. In the original method of diagnosing respiratory infections, some bacteria were challenging to grow successfully, and many clinical laboratories needed to be equipped for viral cultures. Another issue is the time to get the results, which may take up to 7 days. Rapid and antigenic tests are faster but need to be more accurate. CONCLUSION: The clinical laboratories are trying to be equipped with molecular methods for detecting respiratory pathogens and identifying the genetic material of the infectious agent in these new methods as the primary method in their agenda.
Application of Linn in Traditional Medicine.
Nannar AR
Recent Pat Biotechnol · 2025 · PMID 38918980 · Publisher ↗
This patent article offers a thorough analysis of the contemporary application of Linn, or sapodilla, in conventional medicine. Tropical fruit-bearing Linn has long been used in many traditional medical systems. The st...
This patent article offers a thorough analysis of the contemporary application of Linn, or sapodilla, in conventional medicine. Tropical fruit-bearing Linn has long been used in many traditional medical systems. The study examines Linn's phytochemical makeup and pharmacological characteristics with an emphasis on the plant's possible medical uses in the treatment of a range of illnesses. Moreover, it highlights the safety and efficacy characteristics of Linn and talks about new research and clinical trials that back up its traditional applications. This study also discusses obstacles and potential avenues for further research and application of Linn in contemporary medicine. All things considered, it emphasizes how important Linn is to traditional medicine as a therapeutic resource.
Open Innovation or Traditional Patenting Strategies to Efficiently Address Health Emergencies: How Patent Information was used Towards Effective Treatments for COVID-19.
de Almeida TDME, Cordeiro DS
Recent Pat Biotechnol · 2025 · PMID 38910270 · Publisher ↗
INTRODUCTION/OBJECTIVE: During the 1150 days of COVID-19 pandemic there were great efforts to develop efficient treatments for the disease. After this long time, some drugs emerged as treatment for COVID-19. Some of them...
INTRODUCTION/OBJECTIVE: During the 1150 days of COVID-19 pandemic there were great efforts to develop efficient treatments for the disease. After this long time, some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of them, known drugs. These developments were triggered by information already available in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations and trials in order to deliver to the world a reasonable treatment that could reach the majority of its population. However, it is not immediately clear how companies operated to reach their goals. The ability of open innovation to achieve results assertively and faster than closed innovation strategies is questioned and therefore, it is questioned whether pharmaceutical companies use open innovation to face COVID-19. METHODS: In this work, data available on patent databases were mined to inform about the scientific and technological panorama of selected drugs tested for COVID-19 treatment and to understand the perspectives of such developments during the pandemic. RESULTS: This study evidenced that most treatments were based on known drugs, that some of the initially promising drugs were abandoned during the pandemic, and that it was able to inform if open innovation and collaborations were explored strategies. CONCLUSION: This study evidenced that the developments during COVID-19 were not based on open innovation by revealing a patent race towards the treatment development, but with practically no collaborations or information exchange between companies, universities, and research facilities.
Designing a Secretory form of RTX-A as an Anticancer Toxin: An Approach.
Taheri-Anganeh M, Nezafat N, Gharibi S … +7 more , Khatami SH, Vahedi F, Shabaninejad Z, Asadi M, Savardashtaki A, Movahedpour A, Ghasemi H
Recent Pat Biotechnol · 2024 · PMID 38817010 · Publisher ↗
BACKGROUND: Cancer is a leading cause of death and a significant public health issue worldwide. Standard treatment methods such as chemotherapy, radiotherapy, and surgery are only sometimes effective. Therefore, new ther...
BACKGROUND: Cancer is a leading cause of death and a significant public health issue worldwide. Standard treatment methods such as chemotherapy, radiotherapy, and surgery are only sometimes effective. Therefore, new therapeutic approaches are needed for cancer treatment. Sea anemone actinoporins are pore-forming toxins (PFTs) with membranolytic activities. RTX-A is a type of PFT that interacts with membrane phospholipids, resulting in pore formation. The synthesis of recombinant proteins in a secretory form has several advantages, including protein solubility and easy purification. In this study, we aimed to discover suitable signal peptides for producing RTX-A in Bacillus subtilis in a secretory form. METHODS: Signal peptides were selected from the Signal Peptide Web Server. The probability and secretion pathways of the selected signal peptides were evaluated using the SignalP server. ProtParam and Protein-sol were used to predict the physico-chemical properties and solubility. AlgPred was used to predict the allergenicity of RTX-A linked to suitable signal peptides. Non-allergenic, stable, and soluble signal peptides fused to proteins were chosen, and their secondary and tertiary structures were predicted using GOR IV and I-TASSER, respectively. The PROCHECK server performed the validation of 3D structures. RESULTS: According to bioinformatics analysis, the fusion forms of OSMY_ECOLI and MALE_ECOLI linked to RTX-A were identified as suitable signal peptides. The final proteins with signal peptides were stable, soluble, and non-allergenic for the human body. Moreover, they had appropriate secondary and tertiary structures. CONCLUSION: The signal above peptides appears ideal for rationalizing secretory and soluble RTX-A. Therefore, the signal peptides found in this study should be further investigated through experimental researches and patents.
The Inhibitory Effects of the Herbals Secondary Metabolites (7α-acetoxyroyleanone, Curzerene, Incensole, Harmaline, and Cannabidiol) on COVID-19: A Molecular Docking Study.
Zargari F, Mohammadi M, Nowroozi A … +3 more , Morowvat MH, Nakhaei E, Rezagholi F
Recent Pat Biotechnol · 2024 · PMID 38817009 · Publisher ↗
BACKGROUND: Since the COVID-19 outbreak in early 2020, researchers and studies are continuing to find drugs and/or vaccines against the disease. As shown before, medicinal plants can be very good sources against viruses...
BACKGROUND: Since the COVID-19 outbreak in early 2020, researchers and studies are continuing to find drugs and/or vaccines against the disease. As shown before, medicinal plants can be very good sources against viruses because of their secondary compounds which may cure diseases and help in survival of patients. There is a growing trend in the filed patents in this field. AIMS: In the present study, we test and suggest the inhibitory potential of five herbal based extracts including 7α-acetoxyroyleanone, Curzerene, Incensole, Harmaline, and Cannabidiol with antivirus activity on the models of the significant antiviral targets for COVID-19 like spike glycoprotein, Papain-like protease (PLpro), non-structural protein 15 (NSP15), RNA-dependent RNA polymerase and core protease by molecular docking study. METHODS: The root was extracted, dried, and pulverized by a milling machine. The aqueous phase and the dichloromethane phase of the root extractive were separated by two-phase extraction using a separatory funnel. The separation was performed using the column chromatography method. The model of the important antivirus drug target of COVID-19 was obtained from the Protein Data Bank (PDB) and modified. TO study the binding difference between the studied molecules, the docking study was performed. RESULTS: These herbal compounds are extracted from , and , respectively. The binding energies of all compounds on COVID-19 main targets are located in the limited area of 2.22-5.30 kcal/mol. This range of binding energies can support our hypothesis for the presence of the inhibitory effects of the secondary metabolites of mentioned structures on COVID-19. Generally, among the investigated herbal structures, Cannabidiol and 7α- acetoxyroyleanone compounds with the highest binding energy have the most inhibitory potential. The least inhibitory effects are related to the Curzerene and Incensole structures by the lowest binding affinity. CONCLUSION: The general arrangement of the basis of the potential barrier of binding energies is in the order below: Cannabidiol > 7α-acetoxyroyleanone > Harmaline> Incensole > Curzerene. Finally, the range of docking scores for investigated herbal compounds on the mentioned targets indicates that the probably inhibitory effects on these targets obey the following order: main protease> RNA-dependent RNA polymerase> PLpro> NSP15> spike glycoprotein.
Bioprospecting of Metabolites from Actinomycetes and their Applications.
Izhar SK, Rizvi SF, Afaq U … +2 more , Fatima F, Siddiqui S
Recent Pat Biotechnol · 2024 · PMID 38817008 · Publisher ↗
Actinomycetes are present in various terrestrial and aquatic habitats, predominantly in the soil rhizosphere, encompassing marine and freshwater ecosystems. These microorganisms exhibit characteristics that resemble both...
Actinomycetes are present in various terrestrial and aquatic habitats, predominantly in the soil rhizosphere, encompassing marine and freshwater ecosystems. These microorganisms exhibit characteristics that resemble both bacteria and fungi. Numerous actinomycetes exhibit a mycelial existence and undergo significant morphological transformations. These bacteria are widely recognized as biotechnologically significant microorganisms utilized for the production of secondary metabolites. In all, over 45% of all bioactive microbial metabolites are produced by actinomycetes, which are responsible for producing around 10,000 of them. The majority of actinomycetes exhibit substantial saprophytic characteristics in their natural environment, enabling them to effectively decompose a diverse range of plant and animal waste materials during the process of decomposition. Additionally, these organisms possess a sophisticated secondary metabolic system, which enables them to synthesize almost two-thirds of all naturally occurring antibiotics. Moreover, they can create a diverse array of chemical compounds with medical or agricultural applications, including anticancer, antiparasitic, and antibacterial agents. This review aims to provide an overview of the prominent biotechnological domains in which actinobacteria and their metabolites demonstrate noteworthy applicability. The graphical abstract provides a preview of the primary sections covered in this review. This paper presents a comprehensive examination of the biotechnological applications and metabolites of actinobacteria, highlighting their potential for patent innovations.
Actinobacteria: Smart Micro-Factories for The Health Sector.
Roohi, Bano N
Recent Pat Biotechnol · 2025 · PMID 38756090 · Publisher ↗
Antibiotics are considered "wonder drugs" due to the fact that they are the most extensively utilised medication in the world. They are used to cure a broad spectrum of diseases and lethal infections. A variety of bacter...
Antibiotics are considered "wonder drugs" due to the fact that they are the most extensively utilised medication in the world. They are used to cure a broad spectrum of diseases and lethal infections. A variety of bacteria and fungi produce antibiotics as a result of secondary metabolism; however, their production is dominated by a special class of bacteria, namely Actinobacteria. Actinobacteria are gram-positive bacteria with high G+C content and unparalleled antibiotic-producing ability. They produce numerous polyenes, tetracyclines, β-lactams, macrolides, and peptides. Actinobacteria are ubiquitous in nature and are isolated from various sources, such as marine and terrestrial endophytes of plants and air. They are studied for their relative antibiotic-producing ability along with the mechanism that the antibiotics follow to annihilate the pathogenic agents that include bacteria, fungi, protozoans, helminths, etc. Actinobacteria isolated from endophytes of medicinal plants have amassed significant attention as they interfere with the metabolism of medicinal plants and acquire enormous benefits from it in the form of conspicuous novel antibiotic-producing ability. Actinobacteria is not only an antibiotic but also a rich source of anticancer compounds that are widely used owing to its remarkable tumorigenic potential. Today, amongst Actinobacteria, class Streptomyces subjugates the area of antibiotic production, producing 70% of all known antibiotics. The uniqueness of bioactive Actinobacteria has turned the attention of scientists worldwide in order to explore its potentiality as effective "micronanofactories". This study provides a brief overview of the production of antibiotics from Actinobacteria inhabiting patent environments and the methods involved in the screening of antibiotics.
Prospects of Plant Derived Bioactive Compounds as Nanoparticles for Biotechnological Applications.
Bano N, Izhar SK, Gupta A … +2 more , Zaheer MR, Roohi
Recent Pat Biotechnol · 2025 · PMID 38644720 · Publisher ↗
Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles prod...
Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agriculture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases. Herein, we review the production of bioactive compounds from leaves, roots, seeds, flowers and stems. We further summarize the different methods for obtaining plant extracts and the green technologies for the synthesis of nanoparticles of plant derived bioactive compounds. Biotechnological aspects of these synthesized nanoparticles are also added here as highlights of this review. Overall, plant derived nanoparticles provide an alternative to conventional approaches for drug delivery as well and present exciting opportunities for future research on novel areas. We explore patent applications for novel plant-derived nanoparticle technologies, highlighting their potential in various fields.
Decarbonizing the Transport of Microalgae-based Products -The Role of E-mobility.
Dias RR, Depra MC, Carvalho VCR … +3 more , de Menezes CR, Zepka LQ, Jacob-Lopes E
Recent Pat Biotechnol · 2025 · PMID 38629373 · Publisher ↗
BACKGROUND: The decarbonization of road transport is a precondition for achieving carbon neutrality. Battery-electric vehicle technology, driven by several patents, can make this a reality. In this bias, the objective of...
BACKGROUND: The decarbonization of road transport is a precondition for achieving carbon neutrality. Battery-electric vehicle technology, driven by several patents, can make this a reality. In this bias, the objective of the article is to shed light on the ongoing debate about the potentially important role of the adoption of electric vehicles in the transport of microalgae-based products to help them advance to a cleaner life cycle. METHODS: Five routes, including unimodal and multimodal conditions, were defined to assess the carbon emissions of the transport system and, more specifically, of road transport. The headquarters of market-leading microalgae manufacturers were selected as the origin of the routes and, as the destination, regions that sustain them. RESULTS: The results reveal the supremacy of road transport of microalgae-based products using electric vehicles powered by nuclear, hydroelectric, and wind, followed by biomass and photovoltaic energy. They also show that the positive impact of wind, water, and photovoltaic energy on the climate, added to the lower battery charging costs and the greater opportunity to generate revenue from the sale of carbon credits, make their trade-offs. CONCLUSION: The exquisite results of this study convey key messages to decision-makers and stakeholders about the role of electromobility in building a zero-carbon delivery route.
The Anti-ulcer Potential of Assisted Bio-fermented Product of Waste Peel in Wistar Albino Rats.
Singh M, Singh S, Puri D … +4 more , Sawhney SK, Kumar N, Yasir M, Nainwal P
Recent Pat Biotechnol · 2024 · PMID 38566382 · Publisher ↗
BACKGROUND: There are patents available related to fermented food and beverages which enhance to human health. (Mosambi) has a high content of flavonoids and exhibits antioxidant activity, which could stimulate the dige...
BACKGROUND: There are patents available related to fermented food and beverages which enhance to human health. (Mosambi) has a high content of flavonoids and exhibits antioxidant activity, which could stimulate the digestive system and be useful for gastroprotective activity. It supports digestion by neutralizing the acidic digestive juices and reducing gastric acidity. OBJECTIVE: This study explored the potential of using waste peel extract from to prevent ulcers. The study specifically sought to assess the anti-ulcer properties of fermented and non-fermented extracts and compare them. Further, the study looked at the potential benefits of treating or preventing ulcers with waste peels and whether fermentation affected the efficacy of the treatment. METHODS: Thirty female Wistar albino rats were equally distributed into five different groups. Group 1 received distilled water (20 ml/kg/b.w); Group 2 received indomethacin (mg/kg/b.w); Group 3 received omeprazole (20 mg/kg/b.w); Group 4 received aqueous extract of Mosambi peel (400 mg/kg/b.w) and Group 5 received fermented product of extract of Mosambi peel (400 mg/kg/b.w). RESULTS: Findings explored that, compared to non-fermented citrus fruit juice, biofermented exhibited less gastric volume (1.58 ± 0.10 ml vs. 1.8 ± 0.14 ml), reduced MDA levels (355.23 ± 100.70 μmol/mg protein vs. 454.49 ± 155.88 μmol/mg protein), and low ulcer index (0.49 ± 0.07 vs. 0.72 ± 0.14). CONCLUSION: The results suggest that the bio-fermented product of peel has better anti-ulcer potential against peptic ulcer induced by indomethacin in Wistar albino rats compared to non-fermented.
Exploring and in Hydroponic System and Compare its Chemical Constituents with Soil-Based Method: A Prospective in Agriculture.
Debnath S, Sharma A
Recent Pat Biotechnol · 2024 · PMID 38528667 · Publisher ↗
BACKGROUND: The forthcoming problems will be of food, and soil due to environmental alteration, growing populations, pollution, and exhaustion of natural resources among other factors. Hydroponic farming has the capacity...
BACKGROUND: The forthcoming problems will be of food, and soil due to environmental alteration, growing populations, pollution, and exhaustion of natural resources among other factors. Hydroponic farming has the capacity to alleviate the intimidation of these con-cerned issues in the agricultural system. Hydroponics is recommended as an alternative way to enhance product yield compared to conventional agriculture. OBJECTIVE: The present study aimed to determine the different growth parameters and constituents of soil-grown and hydroponically grown and for the first time, which could be a patentable in future. METHODS: In this study, extraction was carried out by maceration method using methanol as a solvent whereas, growth parameters were performed by the leaves number, plant height, and leaf area. Chlorophyll content was also performed in both sources. Further, a comparison of chemical constituents from different sources was analyzed by GC-MS. RESULTS: The bioactive components in hydroponically grown were found more as compared to soil-grown . The GC-MS analysis revealed the presence of various compounds in the methanolic extract of plant materials. CONCLUSION: Hence, hydroponics could be an alternative in agriculture and this system is now accepted globally. This method provides diverse perspectives for farmers to harvest high-yield, better quality, and enhanced bioactive compounds.
An Outline of the Immunogenic Potential of Progressing SARSCoV- 2 Vaccine Technologies among Children and Adolescents.
Ghanem H, Ghanem S, AlMutawa E
Recent Pat Biotechnol · 2024 · PMID 38528666 · Publisher ↗
BACKGROUND: SARS-CoV-2, a highly dynamic beta-coronavirus, can afflict all age groups. Notably, over 16100 mortalities have been recorded among children as yet. In this regard, many vaccine projects are operational to as...
BACKGROUND: SARS-CoV-2, a highly dynamic beta-coronavirus, can afflict all age groups. Notably, over 16100 mortalities have been recorded among children as yet. In this regard, many vaccine projects are operational to assess immuno-potency among young cohorts. A bulk of reports have evidenced the efficacy of these immunization technologies in the elderly population, though the impact is yet to be determined among children. OBJECTIVES: This review is envisioned to outline the current efficacy of contributing vaccine technologies and examine the dose-dependent impact of immunization regimens in lowering the risks of SARS-CoV-2 infections among children and adolescents. Furthermore, the current review exclusively estimated the vaccine impact at current doses. METHODS: A total of 52 research papers extracted from PubMed, Pubmed Central, Science Direct, Research Gate, Google Scholar and Semantic Scholar were screened along with an emphasis on patents. Inclusion criteria involved all published reports directly or indirectly linked to the contributing vaccine candidates that are operational among the young cohort. Unrelated research papers were excluded from the study. Key search terminologies included information on vaccine identifiers, such as name, type and clinical trial ID, and successively restricted to children and adolscents age groups. RESULTS: Several vaccine designs, such as mRNA-based vaccinations, viral vector vaccines, DNA vaccines, inactivated vaccines, recombinant vaccines, and protein-based immunizations, are being examined at various stages of clinical trials to gauge the effects on children and adolescents. With reference to the published reports, the mRNA 1273 (1610 GMT; 6-10 yrs, 1401 GMT; 12-15 yrs), BNT162b2 (1407 GMT; 6 months- <2 yrs, 1535 GMT; 2-4 yrs, 4583 GMT; 5-11 yrs, 1239.5 GMT; 12-15 yrs) and Ad5 nCoV (1037.5 GMT; 6-17 yrs) offered relatively high neutralization titers with sharp seroconversion rates compared to MVC-COV1901 (648.5 GMT; 12-17 yrs) and ZyCoV-D (133.49 GMT; 12-17 yrs), which produced modest immune responses. CONCLUSION: Currently, the WHO is analyzing emerging evidence to issue an emergency use list of vaccines for vaccinating children and adolescents.
Botanical Extracts and Compounds of Plants and Methods of Use: US20190125818A1 - The United States Patent Evaluation.
Dos Santos TB, Dos Santos Gomes D, Dos Santos Neto AG … +2 more , do Amorim Costa Gaspar LM, Droppa-Almeida D
Recent Pat Biotechnol · 2024 · PMID 38282444 · Publisher ↗
BACKGROUND: Bacterial infections are increasingly difficult to combat, which makes them a threat to public health on a global level. is considered one of the main causes of infections in hospitals, as it has a variety o...
BACKGROUND: Bacterial infections are increasingly difficult to combat, which makes them a threat to public health on a global level. is considered one of the main causes of infections in hospitals, as it has a variety of virulence factors, as well as is able to produce bacterial biofilms, which, consequently, bring numerous damages to public health as a result of increased resistance to conventional antibiotics and a longer hospital stay. Therefore, the use of compounds extracted from medicinal plants is a potential pharmaceutically acceptable target, as they do not have toxicity and the potential to disrupt biofilms produced by already evidenced, thus revealing their relevance to our study. OBJECTIVE: The objective of this work was to perform a critical analysis of a patent with natural extracts against bacterial biofilms found in the United States Patent and Trademark Office (USPTO) database, to map the possible bioactive compounds that may serve as potential future antimicrobial drugs. METHODS: A technological survey was carried out to verify existing patents using natural extracts with anti-biofilm potential. For this, it was searched with the keywords: Botanical extracts AND biofilms; which were performed in the United States Patent and Trademark Office (USPTO) database. Thus, the selected patent used a non-aqueous extract partitioned and vacuum-contracted, subsequently lyophilized for assays with antimicrobial potential. Because of this, a patent was analyzed regarding its chemistry, and biological activity, followed by a critical analysis of the technology proposed in the invention. RESULTS: When using the keywords Botanical extracts AND biofilms in the USPTO, it was possible to find twenty-two inventions; however, only four patents in the USPTO were in agreement with the proposal of the natural extract having antimicrobial activity and an anti-biofilm potential, of which two belonged to the same applicant with similar proposals. The key point of this invention was to enable the compounds of the plant and its methods of obtaining the extract to present a significant antimicrobial action associated or not with antibiotics, promoting the development of new therapies against bacterial infections capable of disrupting biofilms. The invention developed a methodology for extracting , in which pentacyclic triterpene compounds were found mostly in its leaves. Whereas for the extraction, the crude methanol extracts called extracts 224 from the ground leaves were made by maceration, filtered, combined, concentrated under pressure in rotary evaporators, and lyophilized. After that, they were resuspended in water and partitioned in succession with hexane, ethyl acetate, and butanol. The most active refined partition was the 224C extract with the solvent ethyl acetate, which was subjected to further fractionation using silica column chromatography. Resulting in the most refined extract, which was 224C-F2, capable of acting directly on the quorum sensing of bacteria, mainly , blocking the translation of RNAIII, including a series of exotoxins. Regarding the antimicrobial capacity against , it presented Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of 1.56 μg/mL and > 100 μg/mL, respectively. CONCLUSION: Given the analyzed patent, it was possible to verify the importance of alternatives to reduce the impact of bacterial biofilms, which causes damage to industries in general and to health. From this, the invention analyzed has a promising proposal with antimicrobial potential focusing on the great impact of bacterial biofilms. Therefore, natural extracts with antibiofilmic potential can help to minimize the economic losses caused to health due to these multidrug-resistant microorganisms with different virulence mechanisms.
Intellectual Property Rights: Protection of Biotechnological Inventions in India.
Gomase V, Kemkar K, Potnis V
Recent Pat Biotechnol · 2024 · PMID 38282443 · Publisher ↗
The current Intellectual Property Rights (IPR) framework supports the commercialization of seed improvement, monoculture, and the patent protection of novel plant varieties, microorganisms, and genetically modified anima...
The current Intellectual Property Rights (IPR) framework supports the commercialization of seed improvement, monoculture, and the patent protection of novel plant varieties, microorganisms, and genetically modified animals. As a consequence, our rich biogenetic diversity is irreversibly dissipating. However, we need to figure out how to create a methodology for elective choices that will achieve harmony between the official Intellectual Property (IP) structure and maintainable biodiversity components. The majority of the biotechnology sector's programmes in India are managed by the Department of Biotechnology. It is under the Ministry of Science and Technology. Its goals are to provide services in the fields of study, infrastructure, human resource development, biotechnology popularisation, industry promotion, and establishment of centres of excellence. Implementation of practise biosafety regulations for genetically modified organisms, recombinant DNA products, and programmes is based on biotechnology for the good of society. This creates an information network for India's bioinformatics mission in the local, national, and worldwide scientific community.
Fundamental Uses of Peptides as a New Model in Both Treatment and Diagnosis.
Okasha H
Recent Pat Biotechnol · 2024 · PMID 38282442 · Publisher ↗
An amino acid short chain is known as a peptide. Peptide bonds are the connections that hold the amino acids of a peptide together in a particular order. Characteristically, the shorter length of peptides helps to identi...
An amino acid short chain is known as a peptide. Peptide bonds are the connections that hold the amino acids of a peptide together in a particular order. Characteristically, the shorter length of peptides helps to identify them from proteins. Different ways are used to classify peptides, including chain length, source of peptides, or their biological functions. The fact that peptides serve several purposes suggests that there is a foundation for improvement in peptide production and structure to enhance action. In addition, many patents on peptides for therapeutic and diagnostic approaches have been obtained. This review aims to give an overview of peptides used recently in treatment and diagnosis.
A Review on Romiplostim Mechanism of Action and the Expressive Approach in .
Hashemzaei M, Ghoshoon MB, Jamshidi M … +2 more , Moradbeygi F, Hashemzehi A
Recent Pat Biotechnol · 2024 · PMID 38282441 · Publisher ↗
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder determined by immune-mediated platelet demolition and reduction of platelet production. Romiplostim is a new thrombopoiesis motivating peptibody that binds...
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder determined by immune-mediated platelet demolition and reduction of platelet production. Romiplostim is a new thrombopoiesis motivating peptibody that binds and stimulates the human thrombopoietin receptor the patent of which was registered in 2008. It is used to treat thrombocytopenia in patients with chronic immune thrombocytopenic purpura. Romiplostim is a 60 kDa peptibody designed to inhibit cross-reacting immune responses. It consists of four high-affinity TPO-receptor binding domains for the Mpl receptor and one human IgG1 Fc domain. is a good host for the fabrication of recombinant proteins such as romiplostim. The expression of a gene intended in is dependent on many factors such as a protein's inherent ability to fold, mRNA's secondary structure, its solubility, its toxicity preferential codon use, and its need for post-translational modification (PTM). This review focuses on the structure, function, mechanism of action, and expressive approach to romiplostim in .
Edible Vaccines: A Patent-Driven Exploration of Immunization Technologies.
Kashyap S, Kamboj R, Kamboj S … +2 more , Guarve K, Kamboj S
Recent Pat Biotechnol · 2025 · PMID 38279742 · Publisher ↗
Vaccines are biological preparations that improve immunity to particular diseases. Particularly for poor developing nations, edible vaccines show significant potential as a financially advantageous, simple to administer,...
Vaccines are biological preparations that improve immunity to particular diseases. Particularly for poor developing nations, edible vaccines show significant potential as a financially advantageous, simple to administer, straightforward to store, fail-safe, and socially and culturally acceptable vaccine delivery system. A vaccine incorporates the gene-encoding bacterial or viral disease-causing agent in plants without losing its immunogenic property. Potatoes, tomatoes, rice, soybeans, and bananas are the primary plants for edible vaccines. It activates the systemic and mucosal immunity responses against a foreign disease-causing organism. It offers exciting possibilities to reduce diseases like hepatitis B, rabies, HIV/AIDS (human immunodeficiency virus infection and acquired immune deficiency syndrome), etc. These vaccines provide many benefits, like being convenient to administer, efficiently storing, and readily acceptable drug delivery systems for patients of different age groups. So, an edible vaccine may be the most convenient vaccine to improve immunity. However, there are a lot of technical and regulatory challenges to overcome in the way of edible vaccine technology. Though all seem surmountable, various technical obstacles and regulatory and non-scientific challenges need to be overcome. Moreover, edible vaccine patents represent a cutting-edge area of biotechnology, where the integration of genetic material into edible substances holds great promise for revolutionizing vaccination methods. These patents aim to harness the potential of plants and other edibles to stimulate immune responses, offering a potential alternative to traditional injectable vaccines. This review states the technologies, host plants, current status, recent patents, the future of this new preventive modality, and different regulatory issues concerning edible vaccines.
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