Recent Patents On Biotechnology[JOURNAL]
Sun
200 papers
Patented Keratinolytic Enzymes for Industrial Application: An Overview.
Anna S, Veronika L, Svetlana T … +1 more , Alexander O
Recent Pat Biotechnol · 2023 · PMID 36515026 · Publisher ↗
Proteases that perform keratin hydrolysis (keratinases) have great potential in biotechnology. After investigation, the next step to an industrial application is protecting intellectual property by patenting. There are m...
Proteases that perform keratin hydrolysis (keratinases) have great potential in biotechnology. After investigation, the next step to an industrial application is protecting intellectual property by patenting. There are many fields of discovered keratinase implementation dictated by features of the molecule and its producer. This article provides an overview of existing patents on keratinases. Among the patents found using terms related to 'keratinase', only those that contain data on the structure and features of the enzyme to provide a sufficient overview of the current situation are covered. It includes information on publication timelines of patents, as well as their origin; features of cultivation process and producers, such as fermentation type and pathogenicity; and features of enzymes, such as their classes, pH, and temperature optima. This article summarizes information about proprietary keratinases and reflects trends and dependencies in their production and application development. It is also the first review of existing patents on keratinases, which emphasizes the uniqueness and novelty of this article.
The Patent Landscape of Polyhydroxyalkanoates Production by Algae and Cyanobacteria.
Procópio DP, Cardoso LOB, Borrego BB … +5 more , Gracioso LH, Oller Nascimento CA, Perpetuo EA, Stevani CV, Freire RS
Recent Pat Biotechnol · 2023 · PMID 36503455 · Publisher ↗
BACKGROUND: As global awareness regarding climate change and environmental pollution outcomes arise, eco-friendly and negative emission technologies emerge. METHODS: In this scenario, polyhydroxyalkanoate (PHA)-accumulat...
BACKGROUND: As global awareness regarding climate change and environmental pollution outcomes arise, eco-friendly and negative emission technologies emerge. METHODS: In this scenario, polyhydroxyalkanoate (PHA)-accumulating microorganisms play an important role in the transition from the petrochemical-based non-biodegradable polymer to renewable, eco-friendly, and biocompatible materials. More specifically, CO can be converted to biopolymers through photosynthesis by cyanobacteria and algae, posing as a promising technology for renewable material, CO, and petroleum-dependence mitigations. However, although many microorganisms can accumulate PHA intracellularly, limitations persist, such as the elevated cost and limited market availability. RESULTS: Herein is presented a patent-based mapping on technological trends of PHAs production, including its production by microalgae and cyanobacteria using the Questel Orbit Intelligence software (version 1.9.8) in complement with the Espacenet Patent Search database. CONCLUSION: The inquiry on PHAs retrieved 34,243 patents filed since 1912, whereas 156 are related to their specific production by photosynthetic microorganisms, evidencing a prospective market for intellectual property.
Technological and Scientific Prospection on Pigments Produced by Microorganisms.
de Souza TLS, de Souza CO, Umsza-Guez MA
Recent Pat Biotechnol · 2023 · PMID 36321241 · Publisher ↗
BACKGROUND: Interest in natural pigments has grown due to the negative aspects caused by synthetic options, which trigger damage to the body and the environment. Research with natural pigments produced by microorganisms...
BACKGROUND: Interest in natural pigments has grown due to the negative aspects caused by synthetic options, which trigger damage to the body and the environment. Research with natural pigments produced by microorganisms becomes viable in relation to other pigments extracted from animals or plants, as microorganisms have advantages in terms of versatility and productivity. Thus, production technologies are protected by patents. METHODS: To evaluate the evolution of research and technological development on producing natural pigments by different microorganisms through scientific and technological prospection. Scientific prospecting was done by searching articles published from 2010 to 2020 in the Scopus, Science Direct, and Web of Science databases. Technological prospecting was carried out with patents obtained from the European Patent Office (ESPACENET) database. RESULTS: The searches were based on the keywords "pigment" and "dye" crossed with microalgae, fungi, bacteria and yeast. A total of 2.811 articles and 451 patents were selected. Scientific prospecting has shown interest in alternative cultivation media, and among the microorganisms that produce pigments, fungi and microalgae are the most studied. CONCLUSION: Technological prospecting showed that 375 (83%) recovered patent documents refer to the protection of pigment extraction and production techniques and that the largest patent holders are private companies, followed by Chinese universities.
Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review.
Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS … +1 more , Roselino MN
Recent Pat Biotechnol · 2023 · PMID 36305126 · Publisher ↗
BACKGROUND: The use of Lactobacillus probiotics may confer beneficial effects on an individual's health, such as the ability to act against fungi of the genus Candida. There are about 200 species of those yeasts, and the...
BACKGROUND: The use of Lactobacillus probiotics may confer beneficial effects on an individual's health, such as the ability to act against fungi of the genus Candida. There are about 200 species of those yeasts, and they can develop candidiasis infections, which affect about 75% of adult women. OBJECTIVE: This study aimed to raise articles that investigated the potential action of several Lactobacillus strains in front of Candida species. METHODS: For this review, 15 articles published between 2015 and 2020 were studied. RESULTS: The results showed the Lactobacillus species L. paracasei, L. acidophilus, L. helveticus, L. rhamnosus, L. reuteri, and L. gasseri have the potential action to inhibit the growth and quantity of colony-forming units of Candida species in vitro studies. Further, they can reduce the rate of candidiasis recurrence and increase the cure rate, mainly when associated with traditional pharmacotherapy, as observed in vivo studies. CONCLUSION: The time of use and the strain of Lactobacillus probiotics can also be determining factors for the efficiency in the treatment against Candida species, suggesting that a long time of use of Lactobacillus probiotics is directly associated with a better result.
Basic Guidelines for Bacteriophage Isolation and Characterization.
Samir S
Recent Pat Biotechnol · 2023 · PMID 36263478 · Publisher ↗
The world is on the cusp of a post-antibiotic period. A century ago, before the advent of antibiotics, bacteriophage therapy was the treatment of choice for bacterial infections. Although bacteriophages have yet to be ap...
The world is on the cusp of a post-antibiotic period. A century ago, before the advent of antibiotics, bacteriophage therapy was the treatment of choice for bacterial infections. Although bacteriophages have yet to be approved as a treatment in Western medicine, researchers and clinicians have begun to anticipate phage therapy. Bacteriophages are viruses that depend on bacterial cell metabolism to multiply. They offer a promising alternative to the use of antibiotics and an excellent antibacterial option for combating multidrug resistance in bacteria. However, not every phage is suitable for phage therapy. In particular, prophages should not be used because they can lysogenize host cells instead of lysing them. To offer adequate therapeutic options for patients suffering from various infectious diseases, a wide selection of different phages is needed. While there is no evidence of direct toxicity induced by phage particles, it is crucial to study mammalian cell-phage interactions. This requires phage preparations to be free of bacterial cells, toxins and other compounds to avoid skewing host responses. Negative staining of purified viruses and electron microscopy remain the gold standard in the identification of bacteriophages. Interestingly, genomics has greatly changed our understanding of phage biology. Bacteriophage genome sequencing is essential to obtain a complete understanding of the bacteriophages' biology and to obtain confirmation of their lifestyle. Full genetic sequencing of bacteriophage will enable a better understanding of the phage-encoded proteins and biomolecules (especially phage lytic enzymes) involved in the process of bacterial cell lysis and death. Mass spectrometry can be used for the identification of phage structural proteins. The use of lytic phages as biocontrol agents requires the most appropriate and standard methods to ensure application safety. This review pursues recent research and methods in molecular biology for the isolation and characterization of phages to facilitate follow-up and implementation of work for other researchers. Patents related to this topic have been mentioned in the text.
A Biotechnological Review on Patents Applied to Rubella Diagnosis.
da Silva JO, Dos Santos M, Silva AAM … +9 more , Ferreira AVF, Nogueira LM, Gandra IB, Junior SJEC, Machado JM, Gonçalves AAM, Giunchetti RC, Campos-da-Paz M, Galdino AS
Recent Pat Biotechnol · 2023 · PMID 36056838 · Publisher ↗
BACKGROUND: Rubella, caused by the Rubella virus (RV), is considered a mild self-limited illness. However, RV has teratogenic potential. Laboratory investigation plays an important role in both diagnosis and surveillance...
BACKGROUND: Rubella, caused by the Rubella virus (RV), is considered a mild self-limited illness. However, RV has teratogenic potential. Laboratory investigation plays an important role in both diagnosis and surveillance of the disease. The main methods for diagnosing Rubella are serological assays for the detection of specific IgM and molecular assays for detecting viral RNA. However, some laboratories perform IgG avidity testing, virus isolation and analysis of genetic sequence as tools to help Rubella eradication. The importance of the diagnosis of Rubella involves the appropriate treatment of the disease, because the Rubella clinical symptoms may be similar to those of other diseases, and the population monitoring to avoid new emergent cases. This study addresses different methods of diagnosing Rubella and contributes as a source of knowledge to assist health systems in controlling the disease. OBJECTIVE: The main objective of this study was to review the available patents regarding Rubella diagnosis published in intellectual property databases, and provides an overview of the technologies available for the diagnosis of Rubella. METHOD: The search strategy was based on the keywords searched separately or together using a Boolean operator either in the patent title or abstract the time interval was restricted to patents filed or granted from January 2009 until February 2022. The database used was Google Patents. RESULTS: This study analyzed 24 patent documents regarding strategies for the diagnosis of Rubella. Of these, 15 patents disclose strategies for detecting Rubella antibodies, 7 patents the detection of Rubella virus nucleic acid, and 2 patents the production of antibodies applied in Rubella diagnosis. CONCLUSION: Rubella is still a public health problem in some countries, mainly those in development, especially due to congenital Rubella syndrome, which can cause malformation or fetal death. However, its diagnosis is challenging, due to similarity of symptoms with other diseases, and for this reason, laboratory diagnosis is essential. Studies like this encourage researchers and governments to invest in research to continue the development of new products, using different areas of biotechnology, to solve society's problems, especially diseases that have an impact on global health, such as Rubella.
Evaluating the Cytotoxicity of Monolayered and Multilayered Carbon Nanotubes on Three Different Human Cell Lines.
Nezhad AM, Farshad O, Morowvat MH
Recent Pat Biotechnol · 2023 · PMID 35996262 · Publisher ↗
BACKGROUND: Nanotechnology and nanobiotechnology have emerged as novel technologies for the production and application of nanoscale materials in different pharmaceutical, medical, and biological fields. Besides, there ar...
BACKGROUND: Nanotechnology and nanobiotechnology have emerged as novel technologies for the production and application of nanoscale materials in different pharmaceutical, medical, and biological fields. Besides, there are a bunch of recently published patents in this field. Although Carbon Nanotubes (CNTs) have various advantages and can be applied for a wide variety of purposes, their toxicity on humans is a matter of concern. OBJECTIVE: This study aimed to evaluate six different types of CNTs, including pristine, carboxylated, and hydroxylated single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs) on three human cell lines. METHODS: MTT assay was employed to assess the cytotoxicity of six types of CNTs, including pristine, carboxylated, and hydroxylated forms of SWCNTs and MWCNTs on three different human cell lines. RESULTS: The findings of the MTT assay showed that the six different types of CNTs (100- 600 μg/mL) exhibited different levels of cytotoxicity on the three human cell lines. The observed trend presented dose-dependent cytotoxicity on the three studied cell lines, including pulmonary, skin, and gastrointestinal cell lines. SWCNT-COOH and MWCNTs accounted for the lowest cell viability in the three human cell lines. CONCLUSION: In conclusion, researchers and industrial workers are recommended to be cautious while working with different types of CNT because all their toxicity dimensions have not been determined yet.
Bioactive Polysaccharides from Microalgae: A Close Look at the Biomedical Applications.
Depra MC, Dias RR, Maroneze MM … +4 more , Nascimento TC, Severo IA, Zepka LQ, Jacob-Lopes E
Recent Pat Biotechnol · 2023 · PMID 35993463 · Publisher ↗
There is a current tendency towards bioactive natural products that can be used in different areas such as food, pharmaceutical, and biomedical. In the last decades, polysaccharides have attracted increasing interest bec...
There is a current tendency towards bioactive natural products that can be used in different areas such as food, pharmaceutical, and biomedical. In the last decades, polysaccharides have attracted increasing interest because of their potent nontoxic effects, therapeutic properties, and diversified range of applications. Polysaccharides are complex and heterogeneous macromolecules constituted of different monosaccharides and, in some cases, of glucuronic acid and sulphate groups. Polysaccharides with biological activity can be derived from plants, animals and microorganisms, especially microalgae. Microalgae are considered one of the most promising sources of these compounds that have already proved to have several important biological properties. In this sense, our objective is to elucidate the use of bioactive polysaccharides from microalgae in biomedical applications, emphasizing the biological activity of these compounds. Furthermore, the microalgal biomass production systems and polysaccharides extraction methods were presented and discussed.
Cypermethrin Toxicity-induced Infertility: An Assessment of Longitudinal Transfer of Protective Potentials of Date Fruit Extracts in Wister Rats.
Ubah SA, Agbonu OA, Columbus PK … +7 more , Abah KO, Chibuogwu IC, Bankole AS, Enem SI, Ejiofor CE, Akefe IO, Ajayi IE
Recent Pat Biotechnol · 2023 · PMID 35980049 · Publisher ↗
BACKGROUND: There is a potential for longitudinal and horizontal transfer of the cytotoxic effects of cypermethrin, and evidence suggests that date fruit extracts can ameliorate these cytotoxic effects. Thus, the current...
BACKGROUND: There is a potential for longitudinal and horizontal transfer of the cytotoxic effects of cypermethrin, and evidence suggests that date fruit extracts can ameliorate these cytotoxic effects. Thus, the current study evaluated female Wister rats' fertility and pup parameters after mating males treated with cypermethrin and date fruit (Phoenix dactylifera) extract. METHODS: Adult Wistar rats (n = 74; 140 - 207 g) were used to conduct this experiment in two phases: The first phase was a single dose toxicity study (n = 18), while the second phase (n = 56) evaluated female Wister rats' reproductive and pup development parameters after mating with male Wistar rats exposed to date fruit extract and cypermethrin. Male rats were distributed randomly into four groups (n = 7 per group) and administered distilled water (Group I); 60 mg/kg cypermethrin (Group II) to simulate infertility; 250 mg/kg date fruit extract alone (Group III); and date fruit extracts plus 60 mg/kg cypermethrin (Group IV). Treated males were then mated with healthy female rats at a ratio of 1:1. Successfully mated females were appraised for conception and pregnancy rates, gestation length, litter size, and weights at birth, and on days 5, 10, 15, and 21 post-partum, an anogenital distance at day-20, sex ratio, and age of pup when hair growth was evident. RESULTS: Significant differences (p < 0.05) were observed in litter size and male anogenital distance but not in reproductive performance. Also, the study demonstrated that date fruit extract skewed the sex ratio of offspring to more female than male pups when female Wister rats were mated with males that received date fruit extracts alone or cypermethrin and date fruit extracts. The body weight gain did not differ significantly between the control and cypermethrin-treated groups. CONCLUSION: This evidence suggested a longitudinal transfer of the protective effects of date fruit extracts following a weekly exposure of male rats to cypermethrin at 60 mg/kg.
Artificial Intelligence in Accelerating Drug Discovery and Development.
Tripathi A, Misra K, Dhanuka R … +1 more , Singh JP
Recent Pat Biotechnol · 2023 · PMID 35927896 · Publisher ↗
Drug discovery and development are critical processes that enable the treatment of wide variety of health-related problems. These are time-consuming, tedious, complicated, and costly processes. Numerous difficulties aris...
Drug discovery and development are critical processes that enable the treatment of wide variety of health-related problems. These are time-consuming, tedious, complicated, and costly processes. Numerous difficulties arise throughout the entire process of drug discovery, from design to testing. Corona Virus Disease 2019 (COVID-19) has recently posed a significant threat to global public health. SARS-Cov-2 and its variants are rapidly spreading in humans due to their high transmission rate. To effectively treat COVID-19, potential drugs and vaccines must be developed quickly. The advancement of artificial intelligence has shifted the focus of drug development away from traditional methods and toward bioinformatics tools. Computer-aided drug design techniques have demonstrated tremendous utility in dealing with massive amounts of biological data and developing efficient algorithms. Artificial intelligence enables more effective approaches to complex problems associated with drug discovery and development through the use of machine learning. Artificial intelligence-based technologies improve the pharmaceutical industry's ability to discover effective drugs. This review summarizes significant challenges encountered during the drug discovery and development processes, as well as the applications of artificial intelligence-based methods to overcome those obstacles in order to provide effective solutions to health problems. This may provide additional insight into the mechanism of action, resulting in the development of vaccines and potent substitutes for repurposed drugs that can be used to treat not only COVID-19 but also other ailments.
Current Status and Medicinal Prominence of (Ratanjot): A Critically Endangered Plant of Trans-Himalayan Region.
Devi S, Sharma P, Sharma R … +1 more , Thakur M
Recent Pat Biotechnol · 2023 · PMID 35850652 · Publisher ↗
Trans-Himalayan region has been a major component of the India's opulent medicinal plant heritage that encompasses numerous critically endangered plant species. Arnebia euchroma (Royle ex Benth.) Johnston (common name: R...
Trans-Himalayan region has been a major component of the India's opulent medicinal plant heritage that encompasses numerous critically endangered plant species. Arnebia euchroma (Royle ex Benth.) Johnston (common name: Ratanjot), a Trans- Himalayan native, is amongst them, and it belongs to the family Boraginaceae. Ratanjot has long been used as a colourant in food and cosmetics besides a major ingredient of traditional remedies prescribed for curing mild constipation, dermatitis, frostbite, and eczema like health disorders. Though principally harvested for its roots, almost all the parts of this plant have been used in pharmaceutical products, food, dyes and beverages since prehistoric times. Its roots are a rich source of naphthoquinone pigment(s) mainly shikonin, acetylshikonin and deoxyshikonin, accountable for its medicinal value as antimicrobial, wound healing, anti-inflammatory, anticancer, and antioxidant agent(s). Considering the medicinal importance and critically endangered status of this taxon, the need of the hour is to conserve and propagate it for supplying sufficient raw materials for its commercial exploitation.
Plant Extracts and Phytochemicals, a Promising Strategy Against Oral Lichen Planus: A Review on Clinical Trials.
Gupta S, Nath LR, Mangalathillam S
Recent Pat Biotechnol · 2023 · PMID 35850651 · Publisher ↗
BACKGROUND: Oral lichen planus (OLP) is an autoimmune disease that distress keratinized cells of the oral epithelium. Topical corticosteroids and other potential therapies like immunosuppressives, hydroxychloroquine, aza...
BACKGROUND: Oral lichen planus (OLP) is an autoimmune disease that distress keratinized cells of the oral epithelium. Topical corticosteroids and other potential therapies like immunosuppressives, hydroxychloroquine, azathioprine, mycophenolate, dapsone, retinoids, biologic agents are used for the management of OLP. However, their effectiveness, best dose, duration of treatment and safety remain mostly unidentified. Moreover, recurrence of disease and dose-related side effects are the other issues. OBJECTIVE: The primary objective of the review is to explore the existing clinical trials for the efficacy of phytochemicals in treating OLP in comparison to corticosteroids. A comprehensive information about their mode of action is also discussed. METHODS: We have discussed different clinical trials conducted on various phytochemicals and plant extracts/formulations like curcumin, lycopene, quercetin, glycyrrhizin, purslane, raspberry, aloe vera gel and aloe vera mouthwash for the treatment of OLP. RESULTS: The current therapy for the management of OLP has numerous adverse effects and requires a long-term treatment. Phytochemicals can be a very good alternative in overcoming these side effects and reducing the course of treatment. CONCLUSION: Herbal extracts and their formulations can be an effective alternative to the current therapy due to their proven therapeutic effects, reduced side effects, long-term applicability, prevention of recurrence as well as progression into cancer.
Effect of Captopril and BQ123 Endothelin-1 Antagonist on Experimentally Induced Hyperlipidemic Nephropathy in Rats.
Jaiswal A, Semwal BC, Singh S
Recent Pat Biotechnol · 2023 · PMID 35770402 · Publisher ↗
BACKGROUND: Kidney disease is a universal public health problem, and epidemiological studies demonstrated that the incidences of chronic kidney disease are increasing day by day. However, the efficiency of currently avai...
BACKGROUND: Kidney disease is a universal public health problem, and epidemiological studies demonstrated that the incidences of chronic kidney disease are increasing day by day. However, the efficiency of currently available drugs on the progression of nephropathy is limited. Therefore, the current research was designed to evaluate the therapeutic efficacy of captopril and BQ123 against hyperlipidemia-induced nephropathy in rats. OBJECTIVE: The objective of this study was to examine the implication of Endothelin-1 in experimentally induced hyperlipidemic nephropathy in rats. METHODS: Animals were divided into various groups, and the administration of a high-fat diet for six weeks induced hyperlipidemia. After confirmation of hyperlipidemia, treatment was started for the next 14 days. At the end of the experimental period, the animals were sacrificed, and various biochemical parameters and histopathological studies were performed. RESULTS: Treatment of both the agents in combination effectively decreased BUN levels, serum creatinine, serum nitrite, and proinflammatory markers and ameliorated the pathological injuries to kidneys. CONCLUSION: Furthermore, both treatments also inhibited oxidative stress and restored the hyperlipidemia-induced reduction in the level of antioxidant enzymes.
Ethnomedical Applications and Conservation Status of Leguminosae- Caesalpinioideae Plants in Uttar Pradesh, India.
Pandey S, Singh L, Srivastava RP … +4 more , Kushwaha AK, Dixit P, Saxena G, Chaudhary LB
Recent Pat Biotechnol · 2023 · PMID 35747965 · Publisher ↗
BACKGROUND: This review highlights the folklore, ethnomedicinal uses and conservation status of Caesalpinioideae in Uttar Pradesh (India). AIMS: It aims at compiling available data on traditional medicine, biological act...
BACKGROUND: This review highlights the folklore, ethnomedicinal uses and conservation status of Caesalpinioideae in Uttar Pradesh (India). AIMS: It aims at compiling available data on traditional medicine, biological activity, phytochemical information and assessing the regional red list status of Caesalpinioideae in Uttar Pradesh. The information provided would help in formulating new drugs and medicines and addressing global conservation issues of such medicinally exploited species. METHODS: The current study included an extensive and systematic review of available literature, the study of previous collections of herbarium specimens, random interviews with locals and tribals, field surveys, and GeoCAT tool-based assessment during 2016-2020. The study reports that the majority of species of Caesalpinioideae are used for curing digestive problems (about 20 species) and skin diseases (19 species). RESULTS: Almost all the species have antimicrobial and antioxidant properties. These pharmacological activities can be attributed to the presence of various types of anthraquinones in plants. CONCLUSION: The regional conservation status reveals that eight species qualified for the status of regionally threatened category while two species fall under the near threatened category.
Impact of COVID-19 on Brain and Psychological Health, its Possible Mechanisms, and Coping Strategies.
Simnani FZ, Singh D, Choudhury A … +1 more , Akhtar A
Recent Pat Biotechnol · 2023 · PMID 35718956 · Publisher ↗
COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind the angiotensin-converting enz...
COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind the angiotensin-converting enzyme (ACE) receptor. The receptor is mainly present peripherally and to some extent in the brain. Different psychological and neurodegenerative disorders can arise due to the peripheral origin of destruction. These triggers could be inflammatory pathways releasing pro-inflammatory cytokines reaching the brain and causing neuroinflammation. In continuation with traditional viruses, SARS-CoV-2 too might lead to brain diseases like meningitis, encephalitis, etc. Besides, several peripheral hormonal changes like cortisol can influence neurochemical alterations, thereby inflicting mood-related activities and psychological phenomena. In this regard, health care workers, frontline line warriors and relatives of COVID-19 patients can be the secondary victims; however, patients with COVID-19 remain the primary ones prone to neurological health problems. Several strategies like socialization, engagement, physical activity, etc., are well-opted measures to get relief from and check psychiatric disturbances. The worth of this review can be attributed to the understanding of brain-related mechanisms of COVID-19 in the context of its mechanism of action to create the pathology pertaining to brain disorder, precisely psychological devastation. Likewise, its epidemiological relevance has concisely been mentioned. Furthermore, different categories and classes of people prone to psychological deterioration are briefly elaborated on. Lastly, some coping strategies and approaches have been discussed to minimize or combat mental health problems.
Physicochemical Properties and Biological Activities of Koseret ( Hochst. Var. Koseret) Seed and Leaf Oil Extracts.
Shiferaw M, Yusuf Z, Desta M
Recent Pat Biotechnol · 2023 · PMID 35718955 · Publisher ↗
BACKGROUND: Lippia adoensis Hoechst var. adoensis (wild variety) and variety koseret (cultivated variety) have been used as traditional medicine, condiments, and endemic to Ethiopia. OBJECTIVE: This study aimed to assess...
BACKGROUND: Lippia adoensis Hoechst var. adoensis (wild variety) and variety koseret (cultivated variety) have been used as traditional medicine, condiments, and endemic to Ethiopia. OBJECTIVE: This study aimed to assess the physicochemical properties and biological activities of oil extracts from seed and leaves of koseret (L. adoensis var. koseret). METHODOLOGY: Soxhlet apparatus was used for oil extraction using hexane as a solvent. The oil quality assessment was based on oil yield, acid value, percent free fatty acid, and peroxide value, while the biological activities were investigated based on antioxidant and antimicrobial activities. The antimicrobial experiment was arranged as 2 x1x4 in a completely randomized factorial design with three replications. RESULTS: The result indicated that significantly higher oil yield (2.25%), acid value (2.66%) and free fatty acid (1.34%) were recorded for seed oil using the solvent extraction method. Leaf oil was recorded to have significantly higher values of DPPH (2,2- diphenyl-1- picrylhydrazyl), ascorbic acid and total carotenoid contents, but a lower value of hydrogen peroxide scavenging activity indicated that leaf oil presented higher antioxidant activity than seed oil in koseret. The koseret leaf oil demonstrated stronger antibacterial activity with a maximum zone of inhibition (14.50±0.21 mm), minimum inhibitory concentration (MIC, 0.25 μg/ml) and corresponding minimum bactericidal concentration (MBC, 0.25 μg/ml) against S. aureus. Furthermore, leaf oil has also presented stronger antifungal activity with a maximum zone of inhibition (14.83 mm), MIC (0.25 μg/ml), and minimum fungicidal concentration (MFC, 0.50 μg/ml) against Aspergillus versicolor. CONCLUSION: It can be concluded from the results of this study that leaf oil extract has demonstrated better biological activities, including both antioxidant and antimicrobial potentials, than seed oil in koseret.
WITHDRAWN: Moderna’s COVID 19 Patent Under the Magnifying Glass.
Storz U
Recent Pat Biotechnol · 2022 Jun · PMID 35713124 · Publisher ↗
UNLABELLED: Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn. Bentham Science apologizes to the readers of the journal for any...
UNLABELLED: Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Using Bacteria and Fungi as Plant Biostimulants for Sustainable Agricultural Production Systems.
Shahrajabian MH, Cheng Q, Sun W
Recent Pat Biotechnol · 2023 · PMID 35570523 · Publisher ↗
Different compounds with bioactive constituents can be applied as biostimulants to increase plant growth and development under both normal and stressful conditions. Biostimulant utilization can be considered a sustainabl...
Different compounds with bioactive constituents can be applied as biostimulants to increase plant growth and development under both normal and stressful conditions. Biostimulant utilization can be considered a sustainable and beneficial nutritional crop management, and may decrease the negative impacts of excessive chemical fertilization. Google scholar, Science Direct, CAB Direct, Springer Link, Scopus, Web of Science, Taylor and Francis, and Wiley Online Library have been checked. The search was done to all manuscript sections according to the terms "Glomus intraradices", "Trichoderma atroviride", "Trichoderma reesei", "Heteroconium chaetospira", "Arthrobacter spp.", "Acintobacter spp.", "Enterobacer spp.", "Pseudomonas spp.", "Ochrobactrum spp.", "Bacilus spp.", "Rhodococcus spp.", "Biostimulants", and "Plant growth promotion". On the basis of the initial check, Titles and Abstracts were reviewed based on online literature, and then articles were read carefully. Within the framework of sustainable crop management, this review article aimed to provide an overview of the application of the most common fungi and bacteria as plant biostimulants on various crops.
Antidiabetic Agents from Fungi with Special Reference to α-Glucosidase Inhibitors.
Deshmukh SK, Gupta MK, Agrawal S
Recent Pat Biotechnol · 2023 · PMID 35549858 · Publisher ↗
The enzyme α-glucosidases (EC 3.2.1.20) catalyzes the hydrolysis of α-1,4- glucopyranoside bond in oligosaccharides and disaccharides, and thus plays an essential role in regulating glucose content and the level of postp...
The enzyme α-glucosidases (EC 3.2.1.20) catalyzes the hydrolysis of α-1,4- glucopyranoside bond in oligosaccharides and disaccharides, and thus plays an essential role in regulating glucose content and the level of postprandial hyperglycemia. The inhibition of α-glucosidases is considered a viable strategy to develop new and effective antidiabetic drugs. Many patents like ZA201905405B; US9073897B2 have been published on α- glucosidase inhibitors. In recent years, several classes of fungal metabolites possessing a varying degree of α-glucosidases inhibitory activity have been reported. The primary chemical classes include xanthone, phenanthrene, terpenoid, coumarin, isocoumarin, naphthalene, piperazine, and polyketides. Few of the identified inhibitors exhibited severalfold better activities than well-known α-glucosidases inhibitor acarbose and can be used as a lead to develop new antidiabetic drugs. The present review highlights the recent development in the identification of α-glucosidases inhibitors from various fungal sources. Their chemical class, structures, and inhibitory activity in terms of IC or MIC are discussed here.
Review on : An Emerging Multidrug- resistant Opportunistic Pathogen.
Majumdar R, Karthikeyan H, Senthilnathan V … +1 more , Sugumar S
Recent Pat Biotechnol · 2022 · PMID 35549857 · Publisher ↗
Stenotrophomonas maltophilia is an opportunistic pathogen that results in nosocomial infections in immunocompromised individuals. These bacteria colonize on the surface of medical devices and therapeutic equipment like u...
Stenotrophomonas maltophilia is an opportunistic pathogen that results in nosocomial infections in immunocompromised individuals. These bacteria colonize on the surface of medical devices and therapeutic equipment like urinary catheters, endoscopes, and ventilators, causing respiratory and urinary tract infections. The low outer membrane permeability of multidrug-resistance efflux systems and the two chromosomally encoded β- lactamases present in S. maltophilia are challenging for arsenal control. The cell-associated and extracellular virulence factors in S. maltophilia are involved in colonization and biofilm formation on the host surfaces. The spread of antibiotic-resistant genes in the pathogenic S. maltophilia attributes to bacterial resistance against a wide range of antibiotics, including penicillin, quinolones, and carbapenems. So far, tetracycline derivatives, fluoroquinolones, and trimethoprim-sulfamethoxazole (TMP-SMX) are considered promising antibiotics against S. maltophilia. Due to the adaptive nature of the intrinsically resistant mechanism towards the number of antibiotics and its ability to acquire new resistance via mutation and horizontal gene transfer, it is quite tricky for medicinal contribution against S. maltophilia. The current review summarizes the literary data on pathogenicity, quorum sensing, biofilm formation, virulence factors, and antibiotic resistance of S. maltophilia.
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