Shanghai Kou Qiang Yi Xue = Shanghai Journal Of Stomatology[JOURNAL]
Sun
200 papers
[Evaluation of autologous fat grafting in improving post-treatment skin fibrosis in 20 patients with oral cancer].
Wang Y, Qian Z, Li-Li LL … +1 more , Wang MY
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275663
PURPOSE: To evaluate the clinical effect of autologous fat grafting for treating cervical skin fibrosis in patients with oral cancer after neck dissection with or without radiotherapy. METHODS: A total of 20 patients who...
PURPOSE: To evaluate the clinical effect of autologous fat grafting for treating cervical skin fibrosis in patients with oral cancer after neck dissection with or without radiotherapy. METHODS: A total of 20 patients who underwent oral cancer resection and neck dissection in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from October 2022 to July 2023 were enrolled, 7 patients were treated with radiotherapy after neck dissection and 13 patients were treated with neck dissection. According to the degree of face-neck depression, the range of fibrosis and the function of neck and shoulder, corresponding volume of autologous fat was used to fill the depression. Three months after treatment, the improvement of cervical skin fibrosis was evaluated in terms of scar improvement, shoulder and neck function, and quality of life. SPSS 26.0 software package was used for statistical analysis of the data. RESULTS: The interval between the treatment of oral cancer and fat filling was 11-72 months, and the dose of fat grafting was 15-45 mL. There were no complications such as local induration, infection and necrosis in all patients. Three months after treatment, the results of Constant-Murley Score(CMS), neck fibrosis symptom(VAS), patient observer scar assessment scale(PSAS, OSAS) and FACE-Q quality of life score were better than those before treatment, and the differences were statistically significant(P＜0.05). CONCLUSIONS: Autologous fat grafting can significantly improve the fibrosis of the neck skin after neck dissection with or without radiotherapy, and improve shoulder and neck dysfunction caused by surgery and radiotherapy. This method is worthy of clinical used because of the low rate of complication.
[Genetic analysis and multidisciplinary treatment of a pedigree affected with autosomal dominant hypocalcified amelogenesis imperfecta].
Cui MJ, Chai L, Zhai QL … +4 more , Wang ZL, Xu T, Chen JY, Liu C
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275662
PURPOSE: To investigate the pathogenic gene of one Chinese family with autosomal dominant hypocalcified amelogenesis imperfecta and to report multidisciplinary treatment process for two patients from this family, so as t...
PURPOSE: To investigate the pathogenic gene of one Chinese family with autosomal dominant hypocalcified amelogenesis imperfecta and to report multidisciplinary treatment process for two patients from this family, so as to provide guidance for genetic counseling and clinical treatment of hereditary amelogenesis imperfecta. METHODS: The clinical data and peripheral blood of the family members were collected. Whole-exome sequencing was performed, and candidate variants were filtered out by data analysis. The identified variant was confirmed by Sanger sequencing and protein three-dimensional structure prediction. RESULTS: Affected members of this hereditary family exhibited yellow-brown discoloration of the dental crowns, rough tooth surfaces, and enamel erosion, consistent with hypocalcified amelogenesis imperfecta. A nonsense mutation c.1363C＞T(p.Gln455*) in exon 5 of the FAM83H gene was identified in the proband, her mother, and her sister; this mutation was predicted to cause a truncation of the FAM83H protein. This variant was not found in unaffected family members. After receiving multidisciplinary treatment based on orthodontics, the proband and her sister restored oral function and aesthetics. CONCLUSIONS: The nonsense variant of FAM83H caused hypocalcified amelogenesis imperfecta in this study is detected for the first time in a Chinese family. The results further validate the pathogenic variant involved in FAM83H leading to amelogenesis imperfecta. Patients with amelogenesis imperfecta can restore oral function and aesthetics through various orthodontic and restorative treatments.
[Changes of saliva flow velocity, total protein and their relationship with dental plaque before and after orthodontic treatment].
Lei J, Zhu KK, DU FY
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275661
PURPOSE: To analyze the relationship between the changes of saliva flow velocity, total protein and dental plaque before and after orthodontic treatment. METHODS: The clinical data of 80 patients who received orthodontic...
PURPOSE: To analyze the relationship between the changes of saliva flow velocity, total protein and dental plaque before and after orthodontic treatment. METHODS: The clinical data of 80 patients who received orthodontic treatment in Huaibei Miners General Hospital from May 2021 to February 2024 were retrospectively analyzed.Six months after treatment, the patients were divided into low-level group (n=39) and high-level group (n=41) according to the median plaque index. The clinical data of the high-level group and the low-level group were compared to analyze the influencing factors of high dental plaque index in orthodontic patients. The predictive value of △saliva flow velocity(before treatment -after 6 months of treatment), △total protein and their combination on high dental plaque index in orthodontic patients was analyzed.SPSS 25.0 software package was used for statistical analysis of the data. RESULTS: Six months after treatment, the saliva flow velocity and total protein level of orthodontic patients were significantly lower than before treatment (P＜0.05). The soft scale index, △saliva flow velocity and △total protein level in high-level group were significantly higher than those in low-level group (P＜0.05). Logistic regression analysis showed that △saliva flow velocity(OR=4.604, 95%CI: 2.024-10.474) and △ total protein(OR=3.554, 95%CI: 1.562-8.084) were the influencing factors of high dental plaque index (P＜0.05).The area under the curve (AUC) of △ saliva flow velocity, △total protein and their combination in predicting high dental plaque index in orthodontic patients were 0.803, 0.799 and 0.905 (P＜0.05), respectively, and the AUC value of the combination was higher(P＜0.05). CONCLUSIONS: △Saliva flow velocity and △total protein can be used to predict high dental plaque index after orthodontic treatment, and their combination has higher predictive value.
[Analysis of the aesthetic effect and influencing factors of digital guided implant prosthesis in the treatment of dentition defect].
Lin Y, Liu Q, Zhang JH … +2 more , Chang XR, Hou D
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275660
PURPOSE: To explore the aesthetic effects and influencing factors of digital guided oral implant restoration in the treatment of dentition defect. METHODS: A total of 168 patients with dentition defect who underwent digi...
PURPOSE: To explore the aesthetic effects and influencing factors of digital guided oral implant restoration in the treatment of dentition defect. METHODS: A total of 168 patients with dentition defect who underwent digital guided dental implant restoration from May 2020 to June 2022 were selected as the experimental group, while 84 patients with dentition defect who underwent routine restoration were selected as the control group. The planting accuracy(neck distance deviation, apical distance deviation, depth deviation and angle deviation), PES score and WES score were compared. The experimental group was divided into good group (n=139) and poor group (n=29) according to the repair effect. Logistic regression analysis was used to analyze the risk factors affecting the therapeutic effect of digital-guided oral implant prosthesis in patients with denture defects, and based on the risk factors, a risk nomogram prediction model for adverse therapeutic effect in patients with denture defects was constructed. Receiver operating characteristic (ROC) curve was drawn to analyze the nomogram to predict the AUC value, sensitivity and specificity of patients with dentition defect. SPSS 22.0 software package was used for statistical analysis. RESULTS: The neck distance deviation, root tip distance deviation, depth deviation and angle deviation in the experimental group were significantly lower than those in the control group(P＜0.05). The PES scores and WES scores of the experimental group were significantly higher than those of the control group 6 months after treatment (P＜0.05). There was no significant difference in gender, age, implant, cause of tooth loss, history of hypertension, drinking history, implant diameter, implant length and bone increment surgery between good and poor groups(P＞0.05). There were significant differences in bone mineral density(BMD), diabetes mellitus, smoking history, probe depth and gingival sulcus bleeding index(P＜0.05). Logistic regression analysis showed that grade Ⅲ-Ⅳ bone mineral density(BMD), diabetes history, smoking history, gingival crevicular bleeding index ≥2 were the risk factors affecting the treatment effect of digital guided oral implant repair in patients with dental defect(P＜0.05). ROC curve analysis showed that AUC of nomogram prediction model, bone mineral density of missing teeth, diabetes mellitus, smoking history and gingival sulcus bleeding index in predicting adverse treatment effect of patients with dentition defect were 0.846, 0.725, 0.487, 0.731 and 0.702; the sensitivity was 44.70%, 53.20%, 59.60% and 66.00%,the specificity was 90.20%, 92.20%, 85.60% and 76.50%, respectively. CONCLUSIONS: Digital-guided oral implant restoration has a relatively ideal effect in the treatment of dentition defects, which is conducive to improving implant accuracy and aesthetics. However, bone mineral density(BMD), diabetes history, smoking history and gingival crevicular bleeding index will affect the therapeutic effect. The prediction model based on these risk factors has a higher predictive efficacy in evaluating the therapeutic effect.
[Application effect of A-PRF and CGF combined with nano-hydroxyapatite in external maxillary sinus lift implantation].
Liu BY, Yu XD, Li CM … +1 more , Shang WH
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275659
PURPOSE: To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF) and concentrated growth factor(CGF) combined with nano-hydroxyapatite in external maxillary sinus lift implantation. METHODS: A total of...
PURPOSE: To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF) and concentrated growth factor(CGF) combined with nano-hydroxyapatite in external maxillary sinus lift implantation. METHODS: A total of 68 patients who underwent external maxillary sinus lift implantation from April 2023 to March 2024 at Taikang Xianlin Gulou Hospital were selected. They were randomly assigned to the control group(n=34, using Bio-Oss large particle bone graft material) and combined group(n=34, using A-PRF and CGF combined with nano-hydroxyapatite). Postoperative symptoms, bone levels, wound healing status, stability coefficient, mucosal healing, and complications were compared between the two groups. SPSS 27.0 software package was used for statistical analysis of the data. RESULTS: At 1 month and 3 months after operation, the conscious symptom score in combination group was significantly lower than that in the control group (P＜0.05), bone mineral density, bone increment and bone height at 6 months after operation were significantly lower than those in the control group; ISQ value, keratinized gingiva width and thickness were significantly higher than those in the control group (P＜0.05). The primary healing rate I in combination group was higher than that in the control group, and the healing time was lower than that in the control group(P＜0.05). There was no significant difference in the occurrence of adverse events between the combined and control groups(P＞0.05). CONCLUSIONS: The combination of A-PRF and CGF with nano-hydroxyapatite significantly improves bone quality, enhances implant stability, and accelerates postoperative recovery in external maxillary sinus lift implantation.
[Application of 3D CT reconstruction in the prognostic evaluation of orthodontic treatment for skeletal Class Ⅱ malocclusion].
Liu Y, Ding LL
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275658
PURPOSE: To explore the clinical value of 3D computed tomography (CT) reconstruction in the prognostic evaluation of orthodontic treatment for patients with skeletal Class Ⅱ malocclusion. METHODS: A total of 48 patients...
PURPOSE: To explore the clinical value of 3D computed tomography (CT) reconstruction in the prognostic evaluation of orthodontic treatment for patients with skeletal Class Ⅱ malocclusion. METHODS: A total of 48 patients with skeletal Class Ⅱ malocclusion who received orthodontic treatment at the Department of Stomatology, Baoji People's Hospital from January 2022 to January 2023 were selected. All patients underwent CBCT scans 1 week before treatment (T0), 1 month after treatment(T1) and 6 months after treatment(T2). 3D Slicer software was used for modeling, and Geomagic Qualify software was utilized for fitting alignment and measuring the three-dimensional movement distances of various landmarks on the maxilla and mandible. The coordinates of the landmarks at T1 and T2 were compared and analyzed. Pearson correlation analysis was used to determine the correlation between significant relapse landmarks. SPSS 19.0 software package was used for statistical analysis of the data. RESULTS: One month and six months post-treatment, changes in the horizontal coordinate of landmark Rgo and changes in the anteroposterior coordinates of landmarks A, RP, B, Pog, Gn, Me, Rgo and Lgo, as well as changes in the vertical coordinate of Gn were statistically significant(P＜0.05). Correlation analysis revealed a positive correlation between the horizontal movement distance of landmark Rgo from T1 to T0 and the relapse distance(r=0.293, P=0.043). There was a positive correlation between the anteroposterior movement distance of landmark A from T1 to T0 and the relapse distance(r=0.418, P=0.003), a positive correlation between the movement distance of RP from T1 to T0 and the relapse distance (r=0.470, P=0.001), a negative correlation between the movement distance of B from T1 to T0 and the relapse distance(r=-0.523, P=0.000), and a negative correlation between the movement distance of Pog from T1 to T0 and the relapse distance(r=-0.391, P=0.006). CONCLUSIONS: Three-dimensional CT reconstruction can provide precise three-dimensional quantitative analysis for the prognostic assessment post-orthognathic surgery in patients with skeletal Class Ⅱ malocclusion. It helps identify landmarks with a high risk of relapse, thus providing more targeted postoperative treatment and monitoring strategies for clinical practice.
[Relationship between maxillary anterior dental arch crowding and alveolar bone morphology, dental arch and alveolar arch morphology in adult females].
Shu CL, Jiang Y, Cai J
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275657
PURPOSE: CBCT was used to measure and analyze the relationship between dental crowding degree and basal bone morphology, dental arch and alveolar arch morphology in adult female maxillary anterior teeth. METHODS: A retro...
PURPOSE: CBCT was used to measure and analyze the relationship between dental crowding degree and basal bone morphology, dental arch and alveolar arch morphology in adult female maxillary anterior teeth. METHODS: A retrospective analysis was conducted on the medical records of 122 adult female patients with maxillary anterior dental arch crowding who received orthodontic treatment at Qingdao Haici Hospital, Affiliated to Qingdao University, from December 2019 to December 2022. The patients were divided into two groups based on the degree of dental arch crowding: group I(mild crowding,maxillary dentition crowding degree ≤ 4 mm, n=62) and group II(moderate to severe crowding,maxillary dentition crowding degree 4-8 mm, n=60). The lengths and widths of the alveolar bones, dental arches and alveolar arches were compared between the two groups. The correlation between dental arch crowding and alveolar bone morphology, dental arch and alveolar arch morphology was analyzed. SPSS 26.0 software package was used for statistical analysis of the data. RESULTS: In group I (mild crowding), the maxillary basal bone length, mandibular basal bone length, maxillary basal bone width at the root apex and root bifurcation,mandibular basal bone width at the root apex and root bifurcation were significantly higher than group II(P＜0.05). The maxillary dental arch length, mandibular dental arch length, maxillary dental arch width,mandibular dental arch width on the mesial and distal sides were significantly higher in group I than group II(P＜0.05). The maxillary alveolar arch length and mandibular alveolar arch length in group I were significantly higher than group II (P＜0.05). There was no significant difference in maxillary alveolar arch width and mandibular alveolar arch width between the two groups(P＞0.05). The crowding degree of the dental arch was negatively correlated with the length of the maxillary and mandibular bases, the width of the maxillary and mandibular bases at the root bifurcation,and the width of the proximal maxillary and mandibular arches(P＜0.05). The length of the maxillary base bone(OR=0.283, 95% CI: 0.128-0.625), the width of the maxillary base bone at the root bifurcation (OR=0.182, 95%CI: 0.083-0.402), the width of the proximal maxillary arch (OR=0.347, 95%CI: 0.158-0.766) and the width of the mandibular arch(OR=0.304, 95% CI: 0.137-0.669) were the influencing factors of dental congestion in the aesthetic area of adult female maxillary anterior teeth(P＜0.05). CONCLUSIONS: The reduction of basal bone, dental arch and alveolar arch are associated with crowded dentition in the maxillary anterior aesthetic zone of adult females.
[Construction and application of organoid radiological model of patient-derived salivary gland malignant tumors].
Xu F, Meng J, Chen L … +2 more , Chen YY, Wang SP
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275656
PURPOSE: To construct a brachytherapentic model of patient-derived salivary gland malignant tumor organoids, and evaluate the impact of 125I radioactive seeds intervention on the activity of different organoids, and expl...
PURPOSE: To construct a brachytherapentic model of patient-derived salivary gland malignant tumor organoids, and evaluate the impact of 125I radioactive seeds intervention on the activity of different organoids, and explore the feasibility of using this model to guide clinical personalized treatment of salivary gland malignant tumors. METHODS: Biopsy specimens from patients with malignant salivary gland tumors including mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma(ACC) and acinic cell carcinoma (AciCC) from Xuzhou Central Hospital were collected, and 3D culture method was used to construct the organoid model. The expression levels of immunohistochemical indicators in salivary gland malignant tumor tissue samples and organoid samples were detected. Brachytherapentic model was constructed and the effect of different doses of 125I seeds on organoid activity were detected using 3D cell viability assay. The activity curves were plotted and the IC50 values were calculated. The data were analyzed by GraphPad Prism 9.0 software. RESULTS: H-E staining results and immunohistochemical staining results identified homology between organoids and specimen tumors. The mean IC50 values of 125I seeds on 5 cases of salivary gland malignant tumor organoids (1 case of ACC, 2 cases of AciCC and 2 cases of MEC) were 8 508, 6 053, 5 203, 10 379 and 7 743 cGy, respectively. AciCC has a higher sensitivity to 125I seeds, and the sensitivity of 125I seeds varied among individuals of the same type of tumor. CONCLUSIONS: An in vitro tumor organoid culture platform has been established for specimens from patients with salivary gland malignant tumors, and its morphological, histological structure, and molecular marker expression are consistent with the characteristics of tumor cells in the original specimens. Intervention results indicated that the model has significant individualized differences, providing a theoretical basis and methodological reference for the effectiveness of 125I seeds in some patients with local, recurrent, advanced, poorly differentiated, or unresectable tumours. This model has the advantages of low cost, short modeling time, and high throughput detection. It can predict the patient's post-treatment response in vitro, guide risk assessment of malignant tumors in clinical practice, and establish personalized and precise treatment plans.
[Finite element simulation of distally moving mandibular molars by sequence with clear aligner].
Kang FJ, Cui YC, Wang SQ … +3 more , Wu YM, Yu L, Zhu XC
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275655
PURPOSE: To construct a finite element model of the mandibular molars distalization with clear aligner, and to explore the characteristics of dentition movement and aligner deformation. METHODS: The models of mandible, t...
PURPOSE: To construct a finite element model of the mandibular molars distalization with clear aligner, and to explore the characteristics of dentition movement and aligner deformation. METHODS: The models of mandible, teeth, periodontal membrane and clear aligne were constructed using CBCT and oral scan data, and were divided into 8 groups according to the starting position of the second and first molar teeth. Working condition 1-4: the distance between the second molar and the first molar was 0, 1, 2, 3 mm, respectively. Working condition 5-8: the second molar had moved far to the target position of 3.2 mm, and the distance between the first molar and the second premolar was 0, 1, 2 and 3 mm, respectively. "Two-step method" was used to simulate the loading of the clear aligner and set the distance of the step to 0.2 mm, the characteristics of dental displacement and appliance shape change in each working condition were analyzed. RESULTS: Under each working condition, the molar with pseudo-remote displacement showed tilt movement of the crown to the far, and the other teeth showed reverse tilt movement. As the initial position of the pseudo-distant molar changed to the distal, the distal movement of the pseudo-distant molar increased. In working condition 4, the maximum displacement of the second molar was 0.11 mm, and in working condition 8, the maximum displacement of the first molar was 0.10 mm. The change trend of the Von Mises equivalent stress value of the periodontal membrane of the pretended distalization teeth was similar to that of the displacement. CONCLUSIONS: Clear aligner can complete distal movement of molar teeth, but the amount of movement cannot reach the expected value. As the initial position of the molars changed to the distal, the distance displacement will increase.
[Experimental study of GBE50 on facial nerve after being crushed in rabbits].
Lu HB, Zhang BB, Yu H … +3 more , Wang YE, Wu SJ, Wang QX
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275654
PURPOSE: To compare the regeneration and repair effects of GBE50 and mecobalamin on facial nerve crush injury. METHODS: Forty healthy Japan giant ear rabbits were randomly divided into 4 groups,namely GBE50 treatment gro...
PURPOSE: To compare the regeneration and repair effects of GBE50 and mecobalamin on facial nerve crush injury. METHODS: Forty healthy Japan giant ear rabbits were randomly divided into 4 groups,namely GBE50 treatment group, mecobalamin treatment group, normal control group and model control group. Each group contained 10 rabbits. Superior buccal branch of facial nerve cursh injured models were established for 2 treatment groups and model control group, while facial incision was made without crush injuries of facial nerve for normal control group. The treatment group was given GBE50 and mecobalamin respectively, while the control group was only given 1 mL of normal saline, respectively. After 28 days of treatment, rabbits' facial injured beard and orbicularis oris muscle movements were observed, neuroelectrophysiological tests, histomorphological observation, and image analysis were performed, facial nerve regeneration and functional recovery were detected. The data were analyzed by SPSS 22.0 software package. RESULTS: In the model control group, the beard and orbicularis oris muscle movement recovery of rabbits were the worst, but GBE50 treatment group showed better recovery than mecobalamin treatment group. The action potential latency in GBE50 group was lower than the mecobalamin group, and significantly lower than the control group(P＜0.05). The action potential amplitude of GBE50 group was higher than that of mecobalamin group, and significantly higher than the control group(P＜0.05). Image analysis result of never myelinated axons area and axon counts of GBE50 group was higher than that of mecobalamin group, and significantly higher than control group (P＜0.05). CONCLUSIONS: GBE50 is superior to mecobalamin in efficacy and speed of facial nerve repair, and it is expected to become another therapeutic drug for rapid and effective treatment of facial nerve injury in clinical practice.
[Gene expression profiling analysis of stress-sensitive genes and their potential functions in myoblasts].
Zheng Y, Yu SY, Yan X … +3 more , Li JP, Zhang Q, Yuan X
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275653
PURPOSE: To screen the stress-sensitive genes in myoblasts and reveal the potential target genes and their regulatory mechanisms of facial muscle remodeling induced by functional orthopaedic force. METHODS: The procedure...
PURPOSE: To screen the stress-sensitive genes in myoblasts and reveal the potential target genes and their regulatory mechanisms of facial muscle remodeling induced by functional orthopaedic force. METHODS: The procedure involved the use of gene microarray technology to identify the differentially expressed genes(DEGs) in myoblasts. DEGs were then categorized by Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses. Furthermore, real-time quantitative PCR(qRT-PCR) was used to verify the DEGs. Western blot, transmission electron microscopy(TEM), and confocal laser scanning microscope(CLSM) were employed to detect the effect of stress on autophagy in myoblasts. The data were analyzed by SPSS 17.0 software package. RESULTS: A total of 1 410 DEGs were identified in stretched myoblasts, with 788 up-regulated and 622 down-regulated genes. GO enrichment analysis indicated that DEGs were primarily involved in signal transduction, biopolymer metabolic process, and protein metabolic process. KEGG analysis revealed that DEGs were primarily associated with ECM-receptor interaction, pathway in cancer, MAPK signaling pathway, focal adhesion and lysosome. Both TEM and CLSM showed that stress could promote the formation of autophagosomes, and Western blot demonstrated that stress could promote the expression of autophagy-related molecules Beclin-1 and LC3-II. Rapamycin could enhance all the above processes, while 3-MA could inhibit them. CONCLUSIONS: Autophagy may play an important role in the regulation of myoblast fate induced by cyclic tensile stress.
[Effect of gingipain extracts on anxiety-like behavior in mice].
Zhao XR, Jiang YT, Jiang YT … +3 more , Xu LN, He ZY, Zhou W
Shanghai Kou Qiang Yi Xue · 2025 Feb · PMID 40275652
PURPOSE: To observe the effect of gingipain extracts on anxiety-like behavior in mice. METHODS: Gingipain extracts were derived from Porphyromonas gingivalis(P. gingivalis) ATCC33277 by sonication and ultra-speed centrif...
PURPOSE: To observe the effect of gingipain extracts on anxiety-like behavior in mice. METHODS: Gingipain extracts were derived from Porphyromonas gingivalis(P. gingivalis) ATCC33277 by sonication and ultra-speed centrifugation and identified by Western blot and enzyme activity assay. Gingipains infection models were established by intraperitoneal injection of gingipain extracts with/without iodoacetamide (IAM). Enzyme activity assays were used to detect the activity of arginine-gingipain (Rgp) and lysine-gingipain (Kgp) in plasma of mice. Open field experiments and elevated zero maze experiments were used to detect anxiety-like behavior in mice. Immunofluorescence staining of brain tissue slices was used to observe changes in astrocytes of the brain. GraphPad Prism software was used for statistical analysis. RESULTS: The gingipain extracts were collected from P. gingivalis ATCC33277 and they showed Rgp and Kgp activity. The activity of Rgp and Kgp could be detected in mice plasma after intraperitoneal injection of gingipain extracts. Compared with the control group, there were no significant changes in the autonomous activity ability of the gingipain group mice. In the open field experiment, the central area staying time of the gingipain groups was significantly reduced(P＜0.05). In the elevated zero maze experiment, the open area frequency of the gingipain groups was obviously shortened(P＜0.05). Anxiety-like behavior was significantly enhanced. Immunofluorescence staining showed that gingipain extracts could significantly activate astrocytes in the hippocampus of mice. The above results could be significantly alleviated by gingipain inhibitor IAM. CONCLUSIONS: Gingipain extracts could induce anxiety-like behavior in mice, which may be related to neuroinflammation due to activation of astrocytes.
[Practice and thoughts of standardized training of oral and maxillofacial surgery specialists].
Yu ZL, Ma SR, Pan L … +4 more , Zhang T, Yang XW, Shang ZJ, Jia J
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007304
The standardized training of oral and maxillofacial surgery specialists is an important part of post-graduation education in oral and maxillofacial surgery, and has been transferred from the initial local pilot to the fu...
The standardized training of oral and maxillofacial surgery specialists is an important part of post-graduation education in oral and maxillofacial surgery, and has been transferred from the initial local pilot to the full implementation stage. Hospital of Stomatology, Wuhan University is the first batch of national oral and maxillofacial surgery training bases in China, with a total of 25 students enrolled since 2018. The author is one of the first batch of oral and maxillofacial surgery trainees and instructors in China. In the practice of standardized training of oral and maxillofacial surgeons, we gradually found some problems, and conducted extensive discussions and in-depth thinking. It is hoped that this article will be helpful to improve the training system of oral and maxillofacial surgery specialists in China.
[Application of 4R crisis management theory in the protection of oral mucositis in patients with autologous hematopoietic stem cell transplantation].
Zou Q, Chen MH
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007303
PURPOSE: To investigate the clinical value of nursing care plans employing 4R crisis management model for prevention of oral mucositis in patients with autologous hematopoietic stem cell transplantation. METHODS: Accordi...
PURPOSE: To investigate the clinical value of nursing care plans employing 4R crisis management model for prevention of oral mucositis in patients with autologous hematopoietic stem cell transplantation. METHODS: According to different intervention time points, totally 40 transplantation patients from May 2019 to December 2020 were selected as the control group, while 68 transplantation patients from January 2021 to January 2023 were selected as the experimental group. Compared to the control group, patients in the experimental group adopted more comprehensive risk management measures and applied 4R crisis theory. The preventive and therapeutic outcomes were compared in the aspects of oral mucosal inflammation incidence, grade, time to resume orally fed diet and inpatient stay of two groups of patient. SPSS 27.0 software package was used for statistical analysis. RESULTS: Oral mucositis occurred in 76.5% of patients in the experimental group, which was significantly lower than the control group (100%) (P＜0.05). Severe oral mucositis (grades Ⅲ and Ⅳ) were 11.8% in the experimental group, which was significantly lower than the control group(65.0%). The clinical nursing satisfaction of the experimental group was significantly higher than that of the control group(P＜0.001). There was no significant difference in hospital duration or oral refeeding time between the two groups(P＞0.05). CONCLUSIONS: The application of 4R crisis management strategy can substantially decrease oral mucositis occurrences and severity, thereby enhancing the effectiveness of oral care management for autologous hematopoietic stem cell transplantation patients, reducing patient discomfort, accelerating recovery time and improving quality of life . The strategy has promising clinical potential of application.
[Clinical research of mandibular embedded third molars extraction by root dislocation first method resulting in external root absorption of adjacent teeth].
Dilihumaer K, Dilidaer T, Gu L … +2 more , Kadiliya T, Wang L
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007302
PURPOSE: To evaluate the impact of impacted lower third molar(ILTM) extraction by root dislocation first method on bone formation in the distal middle of the second molar(M2M), pulp status and external root resorption (E...
PURPOSE: To evaluate the impact of impacted lower third molar(ILTM) extraction by root dislocation first method on bone formation in the distal middle of the second molar(M2M), pulp status and external root resorption (ERR). METHODS: A total of 64 patients who underwent ILTM extraction in the First Affiliated Hospital of Xinjiang Medical University from January 2023 to October 2023 were selected. Among them, 32 patients underwent root first removal of ILTM (experimental group), and 32 patients underwent crown first removal of ILTM (control group). Preoperative and postoperative M2M mobility, pulp status, ERR situation, and postoperative visual analog scale for pain were recorded. Cone-beam CT was performed at 3 and 6 months after operation to measure bone defect depth of M2M, bone height of M2M, percentage of bone height, and bone ash degree. SPSS 26.0 software package was used for data analysis. RESULTS: The VAS pain score of the experimental group on the third postoperative day was significantly lower than that of the control group (P＜0.05), while there was no significant difference in surgical time, M2M pulp vitality, and mobility between the two groups(P＞0.05); the amount of bone resection in the experimental group was significantly less than that in the control group (P＜0.05). The immediate postoperative near-midfacial and distal tongue-side probing depth (PD) in the experimental group was significantly lower than that in the control group(P＜0.05). At 3 and 6 months postoperatively, the experimental group exhibited significantly lower bone defect depth, bone height, bone height percentage, and bone gray level compared to the control group across different degrees of external root resorption (ERR) (P＜0.05). There were statistically significant differences in bone defect depth, bone height, bone height percentage, and bone gray level between the two groups with different types of impaction(P＜0.05), while no statistically significant difference was found in impaction depth and ERR severity comparison (P＞0.05). None of the patients experienced complications such as infection or nerve injury postoperatively. CONCLUSIONS: The root dislocation method for ILTM extraction has certain guiding effects on the distal bone formation of M2M, and it has an effect on the improvement of periodontal health and postoperative reaction of M2M.
[Clinical study on the treatment of Class Ⅱ and ClassⅠmalocclusion in adolescents with mandibular recession using invisible orthodontic appliances without brackets].
Yu J, Wang HM, Zhu XM … +1 more , Fan ZL
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007301
PURPOSE: To explore the application value of invisible orthodontic appliance without brackets in the correction of ClassⅡand ClassⅠmalocclusion in adolescents with mandibular recession. METHODS: A retrospective collectio...
PURPOSE: To explore the application value of invisible orthodontic appliance without brackets in the correction of ClassⅡand ClassⅠmalocclusion in adolescents with mandibular recession. METHODS: A retrospective collection of clinical data was conducted on 114 adolescent patients with ClassⅡand ClassⅠmalocclusion of mandibular retrusion admitted to Hubei Hospital of Traditional Chinese Medicine from February 2020 to October 2022. They were divided into two groups based on different orthodontic methods, with 57 cases in each group. The control group was treated with Twin block appliances, while the experimental group was treated with invisible appliances without brackets. Both groups of patients were corrected for 12 months. The treatment effects of the two groups were evaluated, and the levels of inflammatory factors [alkaline phosphatase (ALP), matrix metalloproteinase-8 (MMP-8), interleukin-1β (IL-1β)] in gingival crevicular fluid before and after treatment, X-ray cephalometric indicators(SNB angle, ANB angle, Go-Gn, Ar-Go), temporomandibular joint parameters (anterior joint space, posterior joint space, superior joint space, fossa height) and upper airway conditions [nasopharyngeal volume (V-nasopharynx), velopharyngeal volume(V-velopharynx), glossopharyngeal volume (V-glossopharynx)], and the subjective perception scores of wearing orthodontic appliance were compared between the two groups. SPSS 28.0 software package was used for data analysis. RESULTS: There was no significant difference in the orthodontic outcome of the experimental group compared to the control group (P＞0.05). After correction, the levels of IL-1β, MMP-8 and ALP in the gingival crevicular fluid were significantly lower in the experimental group compared to the control group(P＜0.05), but there was no significant difference(P＞0.05) between the two groups in terms of SNB angle, ANB angle, Go Gan, Ar Go, anterior and posterior joint spaces, supraarticular space, and joint socket height. After correction, there was no significant difference(P＞0.05) between the two groups in V-glossopharynx, V-palatopharynx, and V-nasopharynx. The experimental group had significantly higher scores in terms of comfort, compliance, and aesthetics when wearing invisible orthodontic appliances without brackets compared to the control group(P＜0.05). CONCLUSIONS: The treatment effect of Twin-block appliance and non-bracket invisible appliance is comparable for Class Ⅱ division Ⅰ malocclusion in adolescents with mandibular retrognathia. Both can improve the morphology of the mandible and dentition, expand the upper airway, but non-bracket invisible appliance can further reduce inflammation and improve patients' comfort.
[Prevalence of temporomandibular joint disc displacement in patients malocclusion].
Zhou GL, Yuan LJ, Li HR … +2 more , Shi WT, Fang B
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007300
PURPOSE: To investigate the prevalence characteristics of temporomandibular joint disc displacement in patients with malocclusion and influencing factors of disc displacement, and to provide reference for orthodontic tre...
PURPOSE: To investigate the prevalence characteristics of temporomandibular joint disc displacement in patients with malocclusion and influencing factors of disc displacement, and to provide reference for orthodontic treatment. METHODS: A total of 1 157 consecutive orthodontic cases admitted to the Department of Orthodontics at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2012 to December 2021 were selected retrospectively. Based on temporomandibular joint MRI, the prevalence of disc displacement in orthodontic cases was investigated. The influencical factors of gender, age and skeletal classification on disc displacement was analyzed. SPSS 25.0 software package was used for data analysis. RESULTS: Among 1 157 orthodontic cases, there were 672 cases(58.08%) of disc displacement, and 334 cases(28.87%) had anterior disc displacement. The prevalence of disc displacement in female was significantly higher than that in male. The prevalence of disc displacement in skeletal Class Ⅱ malocclusion was significantly higher than that in skeletal Class Ⅲ malocclusion. In orthodontic cases aged between 10 and 18, the prevalence of disc displacement increased with age. CONCLUSIONS: There is a high proportion of abnormal articular disc position in patients with malocclusion. Age, gender(female) and skeletal Class Ⅱ malocclusion have higher correlation with temporomandibular joint disc displacement.
[Study on the effects of improved shield technique in the aesthetic zone for single tooth implantation in the maxillary anterior region].
Hu ZY, Niu W, Chen DY … +2 more , Zou JY, Xie H
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007299
PURPOSE: To explore the effects of improved shield technique in the aesthetic zone for single tooth implantation in the maxillary anterior region. METHODS: Eighty-four patients(84 teeth) who underwent single tooth implan...
PURPOSE: To explore the effects of improved shield technique in the aesthetic zone for single tooth implantation in the maxillary anterior region. METHODS: Eighty-four patients(84 teeth) who underwent single tooth implantation in the maxillary anterior region from January 2020 to January 2023 were selected,randomly divided into the control group and experimental group using digital table method, each with 42 patients(42 teeth). The success rate of implant in 2 groups was recorded, and periodontal index, pink esthetic score (PES), bone absorption and implant stability quotient (ISQ) preoperatively and 6 months after surgery were compared. The incidence of adverse reactions (redness, bleeding, pain and site infection) was recorded. SPSS 26.0 software package was used for statistical analysis of the data. RESULTS: The success rate of implantation in both groups was 100%. Six postoperative pericrescent indexes of the experimental group were significantly lower than that of the control group, PES and ISQ scores of the experimental group were significantly higher than that of the control group one year after surgery, bone absorption volume was significantly lower than that of the control group and the incidence of adverse reactions was significantly decreased(P＜0.05). CONCLUSIONS: The improved shield technique in the aesthetic zone can enhance the esthetic index and implant stability in the anterior region, and reduce bone resorption volume.
[Comparison of the effect of resin restoration and CAD/CAM all-porcelain veneer restoration on anterior tooth space].
Zhang GQ, Wang WG
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007298
PURPOSE: To compare the aesthetic effects of resin restoration and CAD/CAM all-porcelain veneer restoration on anterior tooth space. METHODS: The medical records of 185 patients (333 teeth) with anterior space restoratio...
PURPOSE: To compare the aesthetic effects of resin restoration and CAD/CAM all-porcelain veneer restoration on anterior tooth space. METHODS: The medical records of 185 patients (333 teeth) with anterior space restoration from February 2023 to January 2024 were retrospectively analyzed. The patients were divided into control group(n=92, 170 teeth) and experimental group(n=93, 163 teeth) according the restoration methods. The control group was repaired with resin,while the experimental group was repaired with CAD/CAM all-porcelain veneer. The clinical effect, masticatory function, periodontal health status, aesthetic effect and complications were compared between the two groups. SPSS 25.0 software package was used for statistical analysis of the data. RESULTS: The total effective rate of the experimental group was significantly higher than that of the control group (P＜0.05). After 1 month of treatment, the masticatory function scores of 2 groups were significantly increased (P＜0.05), and the experimental group was higher than the control group (P＜0.05). The gingival index (GI) score and plaque index (PI) score of the experimental group were significantly lower than those of the control group (P＜0.05), but there was no significant difference in probing depth (PD) between the two groups (P＞0.05). The abutment sensitivity and pulp status, the color matching degree with neighboring teeth, the edge color of prosthesis and the grade distribution of prosthesis integrity in the experimental group were significantly better than these of the control group (P＜0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). CONCLUSIONS: Compared with resin repair, CAD/CAM porcelain veneer has better effect on anterior tooth space repair, which can improve patients' chewing function and periodontal health, enhance aesthetic effect, and reduce the risk of complications.
[Analysis of periodontal health status and influencing factors of elderly people in Jiading District of Shanghai].
Tang YH, Zhu Q, Wu Z … +1 more , Ran X
Shanghai Kou Qiang Yi Xue · 2024 Dec · PMID 40007297
PURPOSE: To investigate the periodontal health status and influencing factors of the elderly aged 65-74 years in Jiading District of Shanghai, and to provide data support for periodontal prevention and health care for th...
PURPOSE: To investigate the periodontal health status and influencing factors of the elderly aged 65-74 years in Jiading District of Shanghai, and to provide data support for periodontal prevention and health care for the elderly in Jiading District. METHODS: A total of 961 elderly people aged 65-74 years old in Jiading District were selected by multi-stage, stratified, equal size and random sampling method, and oral examination and questionnaire survey were conducted. SPSS 22.0 software package was used for descriptive statistics and multivariate logistic regression analysis. RESULTS: Among 961 elderly people, the detection rate of periodontal pockets, bleeding on gingival probing, dental calculus and debris were 58.9%, 85.3%, 90.5% and 88%, respectively. The mean number of missing teeth was 6.25±5.94. The average number of gingival index, calculus index and debris index were 1.82±0.706, 1.26±0.632, 1.17±0.620, respectively. The results of univariate analysis showed that gender, education level, smoking, diabetes, cardiovascular disease, oral hygiene habits (frequency of brushing teeth and frequency of cleaning teeth) were risk factors for periodontitis in the elderly in Jiading District. Multivariate logistic regression analysis showed that smoking, diabetes and oral hygiene habits (tooth cleaning frequency) were independent risk factors for periodontitis in the elderly in Jiading District. CONCLUSIONS: The periodontal health status of the elderly aged 65-74 years in Jiading District is poor, and comprehensive prevention and treatment from various aspects and links should be carried out.
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