Kuz'mina EA, Lipatov GY, Adrianovskiy VI
… +3 more, Zlygosteva NV, Russkikh KY, Kochneva NI
Med Tr Prom Ekol
· 2016 · PMID 30351777
The authors suggested scientific and methodic approaches based on hygienic and medical prophylactic technologies to define carcinogenically dangerous occupations with unacceptable level of occupational carcinogenous risk...The authors suggested scientific and methodic approaches based on hygienic and medical prophylactic technologies to define carcinogenically dangerous occupations with unacceptable level of occupational carcinogenous risk, to control oncogenesis predictors in these occupations, to diagnose early stages of oncologic diseases, to specify medical and prophylactic measures -aimed to decrease oncologic morbidity.
Roslyi OF, Fedoruk AA, Ruzakov VO
… +4 more, Roslaya NA, Bazarova EL, Slyshkina TV, Tartakovskaya LY
Med Tr Prom Ekol
· 2016 · PMID 30351776
In copper alloys production, workers engaged into the process are exposed to occupational hazards with leading one being high-dispersed dust of complex chemical composition. The workers of main occupations demonstrate in...In copper alloys production, workers engaged into the process are exposed to occupational hazards with leading one being high-dispersed dust of complex chemical composition. The workers of main occupations demonstrate increased prevalence of respiratory diseases, digestive diseases, peripheral nervous system disorders - that necessitates implementation of complex measures both in improvement of work conditions and in medical prophylaxis.
Bazarova EL, Roslyi OF, Tartakovskaya LY
… +5 more, Roslaya NA, Plotko EG, Fedoruk AA, Osherov IS, Porfir'eva OV
Med Tr Prom Ekol
· 2016 · PMID 30351775
The authors suggest to supplement a method evaluating individual occupational risk with tree blocks of occupational and non-occupational risk factors: index of sanitary legislation requirements fulfilment according to ex...The authors suggest to supplement a method evaluating individual occupational risk with tree blocks of occupational and non-occupational risk factors: index of sanitary legislation requirements fulfilment according to experts evaluation; lifestyle index with individual biologic and behavioral risk factors consideration; index of social well-being, considering social economic and social psychologic risk factors at workplace.
Gurvich VB, Kornilkov AS, Privalova LI
… +2 more, Lavrent'ev AN, Yarushin SV
Med Tr Prom Ekol
· 2016 · PMID 30351774
The study results stressed considerable contribution of technogenic environmental pollution in cities with developed copper industry into individual health risk of Sverdlovsk region population.The study results stressed considerable contribution of technogenic environmental pollution in cities with developed copper industry into individual health risk of Sverdlovsk region population.
Gorbacheva TT, Kasikov AG, Neradovskiy YN
… +1 more, Cherepanova TA
Med Tr Prom Ekol
· 2016 · PMID 30351756
Identification covered a source of dust deposits in snow on stationary monitoring sites near the largest in Europe copper-nickel enterprise <<Kolskaya GMK>>. Retrospective analysis demonstrated that considerable decrease...Identification covered a source of dust deposits in snow on stationary monitoring sites near the largest in Europe copper-nickel enterprise <<Kolskaya GMK>>. Retrospective analysis demonstrated that considerable decrease in aerotechnogenic load resulted in disappeared technogenic phase of the dust releases, but revealed influence of neighbouring heating power station using fuel oil.
Ulanova TS, Nurislamova T, Popova NA
… +1 more, Maltseva OA
Med Tr Prom Ekol
· 2016 · PMID 30351755
To evaluate occupational hazards for workers engaged into mechanical rubber production, the authors determined contents of acrylonitrile in serum and expired air, during occupational exposure and in reference group. Find...To evaluate occupational hazards for workers engaged into mechanical rubber production, the authors determined contents of acrylonitrile in serum and expired air, during occupational exposure and in reference group. Findings are that depending on occupation, age and length of service, acrylonitrile contamination level of expired air has intermittent effect. Main occupations workers are exposed to continuous inhalation of acrylonitrile vapors, with its average concentration of 0.01-0.015 mg/m3 in air of workplace. Acrylonitrile concentration in expired air of this group ranged from 0.0001-0.0009 mg/M3 - that is reliably (p <0.05) higher (5.5 times) than in expired air of the reference group members. Serum levels of acrylonitrile did not differ significantly between the main group and the reference group members.
Luzhetskyi KP, Ustinova OY, Shtina IE
… +3 more, Vekovshinina SA, Ivashova YA, Tsinker MY
Med Tr Prom Ekol
· 2016 · PMID 30351754
Clinical, laboratory and ultrasound examination covered features of lipid metabolism disorders in 137 adults and 170 children, neighbouring storage of ore-processing and extraction waste, in conditions of chronic exposur...Clinical, laboratory and ultrasound examination covered features of lipid metabolism disorders in 137 adults and 170 children, neighbouring storage of ore-processing and extraction waste, in conditions of chronic exposure to metals from various sources (ambient air, water, foods). Findings are that children with higher serum levels of cadmium and arsenic (1.4-2.0 times vs. the reference group) demonstrated 2.2 times more frequent endocrine diseases, up to 2.7 times more frequent obesity related diseases, if compared to the reference group (OR = 2.74; DI = 1.05-7.14; p < 0.05). Chronic noncarcinogenous risk for endocrine system was characterized by jeopardy index (THI) 3.78 - unacceptable risk. With unacceptable risk due'to multi-source exposure to lead, cadmium and arsenic, the findings are: dysfunction of hypothalamus-pituitary-thyroid link, with activated free radical oxidation and accumulation of perioxidation products, depletion of antioxidant defence resources, disorders of neuromediator processes and lipid metabolism, with obesity formation (ICD: E67.8-66.0), mostly related to negative influence of arsenic (r = 0.37-0.59; p = 0.004-0.05).
Occupational activity with night shifts and length of service over 5 years is characterized by prevalent sympathetic influence on cardiac activity, vagosympathetic interaction index (LF/HF) is considerably higher than in...Occupational activity with night shifts and length of service over 5 years is characterized by prevalent sympathetic influence on cardiac activity, vagosympathetic interaction index (LF/HF) is considerably higher than in workers with lower length of service and 1.5 times exceeding upper normal value. VLF indicator exceeds physiologic normal value due to increased activity of ergotropic and humoral metabolic mechanisms of cardiac rhythm regulation. Sympathetic regulation activity level (LF parameter) is also reliably higher than in workers with lower length of service (p = 0.024). Parasympathetic regulation activity level (HF parameter) is below normal value - that indicates decreased influence of parasympathetic vegetative system on cardiac activity (depression of defence mechanisms). Comparative analysis of vegetative regulation spectrum at rest, in accordance with length of service, demonstrated the most marked changes in workers with length of service over 5 years: lower total spectral capacity (TP, msz), lower share of high-frequency waves (HF, %), increase of average vagosympathetic interaction index (LF/HF) and higher share of very low waves (VLF, %) in the spectrum structure. Ihe data prove intensified ergotropic, humoral, sympathetic influences on cardiac activity and, as a result, higher risk of dysmetabolic processes and cardiovascular diseases.
Based on complex of parameters characterizing social economic level, innovation activity and morbidity among able-bodied population, the authors suggested a typology of RF regions different in potential, urgency and risk...Based on complex of parameters characterizing social economic level, innovation activity and morbidity among able-bodied population, the authors suggested a typology of RF regions different in potential, urgency and risk value of modernization. Claster analysis helped to identify 4 types of territories - moderately modernizing regions with high modernization potential (12 RF subjects), well modernizing regions with moderate modernization potential (26 RF subjects), moderately modernizing regions with moderate modernization potential (28 RF subjects), poorly modernizing regions with low modernization potential (5 RF subjects). Findings are that special attention is required not only by RF subjects with the workers' low health level and poorly modernization processes, but also highly modernized regions with the workers' health problems can result from risky character of modernization. The article is prepared with financial support from RGNF (project N 16-16-59007).
The authors demonstrate that work conditions for main occupations of sylvinite ore-dressing production (drying machine operator, granulation operator, drying and granulation dosage department operator, centrifuge operato...The authors demonstrate that work conditions for main occupations of sylvinite ore-dressing production (drying machine operator, granulation operator, drying and granulation dosage department operator, centrifuge operator, filtration operator, transporting machine operator in drying and granulation department, mill operator) are characterized by combined exposure to chemical and physical occupational hazards: formaldehyde, highly dispersed dust (PM,0), industrial noise, increased microclimate parameters. The work conditions are considered as hazardous (class 3.1, 3.2, 3.3). Findings are reliable increase of MDA level with lower general antioxidant defence in serum, when compared to the reference group. Increased homocysteine, lipoprotein with significant decreased nitrogen oxide production are seen. These processes can result in disordered structure and endothelial function of vessels, with higher prevalence of arterial hypertension. Values of MDA, antioxidant activity, homocysteine, lipoprotein (a), nitrogen oxide are justified as markers for early diagnosis of occupationally related arterial hypertension.
Ivashova YA, Ustinova OY, Luzhets KP
… +3 more, Vlasova EM, Belitskaya VE, Nurislamova TV
Med Tr Prom Ekol
· 2016 · PMID 30351750
Complex study of thyroid gland covered workers engaged into mechanical rubber production, under exposure to complex of occupational factors. Chemical analytic study revealed 5.5 times excess of acrylonitrile content of e...Complex study of thyroid gland covered workers engaged into mechanical rubber production, under exposure to complex of occupational factors. Chemical analytic study revealed 5.5 times excess of acrylonitrile content of expired air in examinees of the study group if compared to the reference group. Ultrasound examination data demonstrate structural changes in thyroid gland in 72% of the workers (diffuse changes and nodular masses). As early dysadaptation markers, findings are 1.3-1.7 times increased antibodies to TPO and higher TSH level. These disorders can indicate autoimmune processes in thyroid tissue and strain of compensatory adaptational mechanisms of pituitary-thyroid regulation.
Workers of titanium and magnesium production, under occupational exposure to complex of chemical (chlorine, hydrochloride, sulfur dioxide) and physical factors (industrial noise, work hardiness), have arterial hypertensi...Workers of titanium and magnesium production, under occupational exposure to complex of chemical (chlorine, hydrochloride, sulfur dioxide) and physical factors (industrial noise, work hardiness), have arterial hypertension as occupationally related disease, when length of service over 15 years (EF = 71,5%), and nasopharyngitis for length of service over 10 years (EF = 65%). Arterial hypertension risk is mostly associated with increased industrial noise level (F = 1621; R2 0.95; p < 0,001; noise 70,1 dB). Mathematic modelling of nasopharyngitis development probability demonstrated dependence of concentration of chlorine, hydrochloride, sulfur dioxide, chlorine and hydrochloride combination (F = 37-281; R2 = 0,37-0,73; p < 0.001; chlorine 0,63 mg/m3). Complex of parameters (leucocytosis, eosinophilia, increased IgA level), activated cellular immunity (increased CD 16+56+, CD3+CD25+) and absolute phagocytosis characterized nonspecific inflammatory reaction, immunity tension as a response to a complex of chemical factors of titanium and magnesium production. Markers of endoihelial dysfunction and cardiovascular risk (uric acid, VEGF, homocystein, LDLP) and stress marker (cortisol) demonstrate potential effect of occupational factors on vascular wall, metabolic processes and central nervous system, with involvement of <pituitary - hypothalamus - adrenals? axis. Changes of these parameters in workers with long length of service indicate risk of occupationally related disease on preclinical stage.
The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between...The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between occupational exposure to noise over 83 dB and hypertension and its predictors - increased activity of serum lipoprotein and homocystein. The studies determined an indicator of the workers' increased sensitivity to arterial hypertension development and to changes in parameters of disordered vascular tone regulation (increased activity of serum lipoprotein and homocystein) under exposure to noise - CT genotype of MTHFR gene. Workers with CT genotype of MTHFR gene, according to epidemiologic analysis, demonstrated increase in relative risk of vascular tone regulation disorders (hypertension predictor). Additional probability ofvascular tone regulation disorders under exposure to noise of 83 dB in sylvinitedressing workers with increased individual sensitivity is estimated at 3%.
Zaitseva NV, Ustinova OY, Zvezdin VN
… +2 more, Zemlyanova MA, Akaf'eva TI
Med Tr Prom Ekol
· 2016 · PMID 30351747
Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907)...Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907) but strong correlation (r = 0.52-0.93). Findings are that sorlie metals (nickel, copper, zinc, lead) contents of subcutaneous interstitial fluid have reliable differences in contents of serum and subcutaneous interstitial fluid., but these metals have strong correlations between their contents in the biologic media (r=0.43-0.72). Chances are that subcutaneous interstitial fluid is a promising medium for biomonitoring of dose load in metallurgic industry workers and enables to increase efficiency of measures reducing risk of occupational hazards influence on the worker's health.
The authors present analysis of <<Method of special evaluation of work conditions>> by RF Labor Ministry. Thorough consideration covers preparatory stage of special evaluation of work conditions and stage of identificati...The authors present analysis of <<Method of special evaluation of work conditions>> by RF Labor Ministry. Thorough consideration covers preparatory stage of special evaluation of work conditions and stage of identification of hazards. Drawbacks of the methods are revealed, improvement ways are suggested.
The authors presented results of hygienic evaluation of ambient air quality in area influenced by oil extraction wells, primary oil processing devices, squeeze stations and other oil extraction objects, using criteria -...The authors presented results of hygienic evaluation of ambient air quality in area influenced by oil extraction wells, primary oil processing devices, squeeze stations and other oil extraction objects, using criteria - adherence to hygienic requirements and allowable risk levels for public health. Findings are that due to substantial technologic, organizational changes and innovations in oil extraction industry chamicals content of air at MAC levels and allowable levels of inhalation risk in acute and chronic exposure for majority of the objects studied are reached on considerably shorter distances from industrial area, than it is preset by actual sanitary rules and regulations. Levels of hygienic safety at the objects indicate possible revision of sanitary classification toward reducing the size of approximate sanitary protective zones.
The authors defined occupational risk level and relations of health disorders in workers engaged into processing of titanium-containing and rare-elements materials with forecasting risk changes in accordance with length...The authors defined occupational risk level and relations of health disorders in workers engaged into processing of titanium-containing and rare-elements materials with forecasting risk changes in accordance with length of service and its realization evaluation. Work conditions are characterized by exposure to chemicals (sulphur dioxide, nitrogen oxide, chlorine and hydrochloride, vanadium compounds), noise, general vibration, heating, work hardiness - and are evaluated as hazardous, jeopardy degree 3 and 4. Results of a priori assessment of occupational risk define it as high. Modelling of health risk evolution outlines that after 15 years of service (by 35 years of age) the share of cardiovascular disease will approach 65% in total workers' health risk. Prevalence of arterial hypertension in the studied group by 15 years of service equals 44,5% (p = 0,04), in the reference group no reliable prevalence of arterial hypertension with length of service was seen. Realization of health risk due to chemicals manifested with higher prevalence of upper respiratory tract diseases that were significantly more frequent (p = 0,037) among the studied group (62,23%), than in the reference group (38,30%). The authors determined length of service criteria and health disorders, that outline priority contribution into the health risk, to specify a system of preventive measures for risk minimization.
Luzhetskiy KP, Kleyn SV, Vekovshinina SA
… +1 more, Tsinker MY
Med Tr Prom Ekol
· 2016 · PMID 30351727
The authors evaluated negative effects of cadmium and arsenic compounds on health of population residing near storage of extraction and processing waste of ore mining and processing enterprise. Hygienic analysis covered...The authors evaluated negative effects of cadmium and arsenic compounds on health of population residing near storage of extraction and processing waste of ore mining and processing enterprise. Hygienic analysis covered quality of ambient air, drinkable water and foods, evaluation of risk factors of lipid metabolism disorders. Clinical and laboratory examination involved 137 children and 99 adults in chronic multi-environmental (ambient air, water, foods) exposure to metals (cadmium and arsenic, HI 1.21-1.29), diagnosed endocrine diseases including lipid metabolism disorders (excessive nutrition and obesity, E67.8-66.0) in adults 1.4 times more, and in children in 1.7-2.2 times more than in the reference group. Direct probable statistically significant cause-effect relationship was established between lipid metabolism disorders and serum levels of cadmium and arsenic (R² = 0,36-0,95; 71,07≤ F ≤2597,94; p< 0,001). In multi-environmental exposure to cadmium and arsenic, reduced index of lipid metabolic disorders risk in adult population exceeds upper limit of low risk level (0,05) at 33 years of age, of high risk level (0,35) - at 58 years of age and very high (0,6) - at 63 years of age.
Nosov AE, Vlasova EM, Ponomareva TA
… +1 more, Agafonov AV
Med Tr Prom Ekol
· 2016 · PMID 30351726
Myocardium revascularization in coronary heart disease patients is one of the most important treatment modalities. Considerable improvement of somatic state after surgery for IHD is seen in 82-83% of patients in average,...Myocardium revascularization in coronary heart disease patients is one of the most important treatment modalities. Considerable improvement of somatic state after surgery for IHD is seen in 82-83% of patients in average, whereas only hardly more than a half return to occupational activity without decrease in preoperative level of qualification and performance. In occupational therapy and industrial medicine clinic with FBSI <<Federal Scientific Center for Medical and Preventive Health Risk Management technologies>>, examination covered 68 workers of Perm' area enterprises, derected for occupational fitness study after coronary artery bypass grafting and 100 workers at various terms after myocardium infarction, with verified IHD. Risk factors evaluation demonstrated that after coronary artery bypass grafting 75% of patients are motivated to maintain healthy lifestyle and compliance to treatment over 5 years; positive changes in a year according to functional study were seen in 75% of cases; level of blood pressure in office 127.8±9.4 mm Hg; dyslipidemia, hypercholesterolemia remain in 11.7% of cases. At first stage, criteria of permit-to-work are: decrease in functional class of chronic cardiac failure to 0-II degrees from initial one; absence of exertional stenocardia or exertional stenocardia less than II degree, absence of ventricular arrhythmias of high grade.
The study was aimed to evaluate level of morbidity with transitory disablement among workers in 11 municipal districts of Perm' area with high intensity of planned modernization processes. Findings are that industrial ci...The study was aimed to evaluate level of morbidity with transitory disablement among workers in 11 municipal districts of Perm' area with high intensity of planned modernization processes. Findings are that industrial cities being "locomotives> of social economic modernization (Perm, Solikamsk, Berezniki) demonstrate higher level of workers' health, than the territories with weak integration into modernization processes (Kudymkar, Gremyachensk and Kizelovsk municipal districts). More marked differences were seen in values of disablement due to cardiovascular diseases, traumatism, poisoning and other external causes, locomotory diseases. Measures on preservation and improvement of workers' health were proved to be a part of strategic programs of social econimic modernization of certain territories and the region as a whole.