Archives Of Clinical Neuropsychology[JOURNAL]
Sun
200 papers
The Effect of Youth Concussion History on Preseason Reaction Time Performance on a Computerized Neuropsychological Test Battery.
Osherow EK, Mingils SM, Gorgens KA
Arch Clin Neuropsychol · 2025 Nov · PMID 40795876 · Publisher ↗
This study examined reaction time (RT) as a measure to detect lasting cognitive changes in youth athletes with a concussion history. Eighty-two high school athletes were included (20 with a history of one concussion [HC1...
This study examined reaction time (RT) as a measure to detect lasting cognitive changes in youth athletes with a concussion history. Eighty-two high school athletes were included (20 with a history of one concussion [HC1], 10 with two or more [HC2+], and 52 with no history of concussion [NHC]). Athletes completed the Automated Neuropsychological Assessment Metrics core battery. Performance (in milliseconds) on Simple Reaction Time (SRT) and Repeated Simple Reaction Time (RSRT) subtests were compared across groups using repeated measures ANOVA. Differences in change in RT were assessed with a one-way ANOVA and the relationship between SRT and RT was analyzed using hierarchical regression. Results showed significant group differences in RSRT, with the NHC group as the fastest and the HC2+ group the slowest. While 80.5% of athletes quickened their RT from SRT to RSRT, the HC2+ group showed significantly less change than the NHC group. The NHC and HC1 groups both showed a negative relationship between initial SRT and subsequent change in RT on the RSRT, but the HC2+ group exhibited a positive relationship, suggesting a potential deficit in dynamic performance. These findings demonstrate that RSRT may be more sensitive than SRT alone in detecting lasting cognitive differences among youth athletes with a concussion history. Specifically, athletes with multiple concussions demonstrated slower overall RTs and failed to benefit from practice on repeated assessment. Repeated testing of RT may be necessary to detect more subtle deficits and to potentially decrease the risk of long-term impairments and future injuries.
A Normative Study of the Trail Making Test-Black and White in the Korean Population.
Suh J, Baek MJ, Kang Y … +1 more , Kim S
Arch Clin Neuropsychol · 2025 Nov · PMID 40794897 · Publisher ↗
OBJECTIVE: Although the Trail Making Test (TMT) is widely used to identify cognitive dysfunction, it has limited utility in cross-cultural contexts due to the use of the English alphabet in a subset of the test. The TMT-...
OBJECTIVE: Although the Trail Making Test (TMT) is widely used to identify cognitive dysfunction, it has limited utility in cross-cultural contexts due to the use of the English alphabet in a subset of the test. The TMT-Black and White (TMT-B&W) is a newly developed version of the TMT that uses only black and white circles to overcome performance biases among non-English-speaking and illiterate older individuals. The objective of this study was to provide initial normative data for the TMT-B&W from the Korean population and investigate the influence of age, sex, and education level on the time taken to complete the test. METHODS: We recruited 1012 participants (430 men and 582 women) aged 19 to 90 in the community settings including a Welfare Center for the Elderly. TMT-B&W tests were conducted, and the time to completion of the test was measured. Scaled scores (M = 10, SD = 3) were calculated and multiple regression analyses were conducted to establish regression based normative T-scores (M = 50, SD = 10) for the TMT-B&W part A and B. RESULTS: Age, education level, and sex significantly predicted TMT-B&W Part A and Part B performance. The regression models explained 52.6% of the variance for Part A and 69.6% for Part B. Demographically adjusted T-scores were developed, providing standardized normative data for clinical interpretation. CONCLUSION: This study provided normative data for the TMT-B&W in the Korean population. This new version of the TMT has the potential to be employed in cross-cultural contexts without language barriers, although further validation across diverse populations is needed.
Investigation of the Effect of Repetitive Transcranial Magnetic Stimulation Method on Psychological Symptoms.
Bal F
Arch Clin Neuropsychol · 2025 Nov · PMID 40719759 · Publisher ↗
The aim of this study was to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on psychological symptoms. In order to examine the effects of the rTMS method on psychological symptoms, the stud...
The aim of this study was to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on psychological symptoms. In order to examine the effects of the rTMS method on psychological symptoms, the study employs a three-group design comprising pretest, posttest, and follow-up measurements. It can be characterized as a 3 × 3 factorial design, encompassing comparisons at three distinct time points. The research was conducted at a private psychiatric facility. The study sample comprises individuals who sought treatment at the psychiatric center during the 2023-2024 period. The total number of participants included in the study was 60. The participants were aged between 18 and 60. The research data were collected using a six-item `Personal Information Form' which requested descriptive information and included the Symptom Checklist-90-Revised for the purpose of general mental status assessment. The repetitive transcranial magnetic stimulation procedure was conducted at a psychiatric clinic. To ensure the efficacy of the treatment, pre-treatment clinical interviews were conducted. The sessions were conducted daily, five times per week, for a period of 4 to 6 weeks. The data obtained from the research were subjected to analysis using Statistical Package for the Social Sciences 25. As a result of the study, repetitive transcranial magnetic stimulation was found to have a significant effect on psychological symptoms. However, it was found to have no significant effect on anxiety, psychoticism and hostility scores in participants who did not use psychotherapy and medication. Further studies are needed to replicate these results in other populations.
A Pilot Study of the Effect of Repeated Practice in Virtual Reality on Everyday Action Performance in Real Life.
Divers R, Tassoni MB, Hackett K … +6 more , McKniff M, Yamaguchi T, Ham L, Matchanova A, Calamia M, Giovannetti T
Arch Clin Neuropsychol · 2025 Nov · PMID 40719755 · Full text
INTRODUCTION: In a prior case study of moderate dementia due to Alzheimer's disease, repeated performance of everyday tasks in a virtual environment demonstrated transfer of improvement in real world cooking tasks. The p...
INTRODUCTION: In a prior case study of moderate dementia due to Alzheimer's disease, repeated performance of everyday tasks in a virtual environment demonstrated transfer of improvement in real world cooking tasks. The present pilot study sought to replicate and extend these findings by employing similar virtual training for improving real everyday task performance in older adults with various levels of cognitive and functional impairment. METHODS: Older participants (N = 6; age range = 66-93; six women, two men) with self-reported cognitive/functional decline underwent daily virtual reality (VR) training sessions on one of two different everyday tasks (i.e., Breakfast or Lunch) for 1 week. Baseline and post-training (within 48 hours of the last day of training and at 1 month post training) testing was done with real objects for both trained and comparable untrained tasks. Reliable change indices for each training outcome (i.e., task accomplishment, time to completion, time per step, overt errors, micro-errors) were calculated for each follow up. RESULTS: Significant improvement in the speed at which task steps were accomplished, time to completion, task accomplishment, or errors were noted in five of the six participants. The one participant who did not show improvement on the trained task showed significant declines on only the untrained task. CONCLUSIONS: Our results demonstrate the feasibility of training in a virtual environment, with transfer of improvement to real tasks, suggesting the potential of VR training for precluding functional disability in older adults with various levels of cognitive/functional impairment.
Correction to: Mini-SEA: Validity and Normative Data for the French-Quebec Population Aged 50 Years and Above.
Arch Clin Neuropsychol · 2025 Aug · PMID 40719642 · Full text
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Screening for Neurocognitive Deficits in Pediatrics-the Clinical Utility of the Pediatric Perceived Cognitive Functioning item bank.
de Vries M, Marchal JP, Maurice-Stam H … +6 more , Mulder B, Grootenhuis M, Aarsen FK, Rietman AB, Luijten MAJ, Oostrom KJ
Arch Clin Neuropsychol · 2025 Nov · PMID 40693874 · Full text
OBJECTIVE: Efficient screening for neurocognitive dysfunction is pivotal for timely intervention in at-risk populations in pediatrics. The Pediatric Perceived Cognitive Functioning (PedsPCF) item bank was developed for t...
OBJECTIVE: Efficient screening for neurocognitive dysfunction is pivotal for timely intervention in at-risk populations in pediatrics. The Pediatric Perceived Cognitive Functioning (PedsPCF) item bank was developed for this purpose. We aimed to explore the relationship between, and the discriminative value of PedsPCF scores with neurocognitive outcomes and the behavior rating inventory of executive function parent report (BRIEF) in a pediatric population. METHODS: The PedsPCF parent- and self-report versions were added to neurocognitive testing batteries that were administered in clinical care or research in two Dutch academic pediatric hospitals. Most test batteries were individually tailored, resulting in a wide variety of measures. We determined Pearson correlations between the PedsPCF and neurocognitive test outcomes categorized into five neurocognitive domains as proposed in the Diagnostic and Statistical Manual of Mental Disorders-5, and the BRIEF-parent. Moreover, we assessed the discriminative values of PedsPCF deficit scores (M - 1 SD) for neurocognitive domain deficits (M - 1 SD) and the BRIEF-parent. RESULTS: The PedsPCF was completed by 104 children and 106 parents. The parent-PedsPCF correlated with three neurocognitive domains and the BRIEF-parent but did not indicate deficits in any of the neurocognitive domains. The self-report PedsPCF correlated with a deficit in complex attention and the BRIEF-parent, and could indicate a deficit in complex attention only. CONCLUSIONS: Although the PedsPCF correlated with neurocognitive test outcomes, the discriminative value of the total score was limited. The short and freely available PedsPCF appears to add a useful subjective dimension to neurocognitive testing rather than a replacement of neurocognitive assessment.
Get Your Brain in the Game: Using Machine Learning to Predict Recovery Timelines Following Sports-Related Concussion.
Thomas GA, Arnett PA
Arch Clin Neuropsychol · 2025 Nov · PMID 40685569 · Publisher ↗
OBJECTIVE: This exploratory proof-of-concept study aimed to develop predictive models for return-to-play (RTP) timelines following sports-related concussion using machine learning techniques. METHODS: Using data availabl...
OBJECTIVE: This exploratory proof-of-concept study aimed to develop predictive models for return-to-play (RTP) timelines following sports-related concussion using machine learning techniques. METHODS: Using data available through Federal Interagency Traumatic Brain Injury Research Informatics System (FITBIR) and the Concussion Assessment, Research and Education (CARE) Consortium, the sample included 971 college athletes with available RTP data. Data were split into training, testing, and validation sets. Random forest (RF) regression modeling was used to predict number of days to RTP based on individual factors, injury data, and symptom and cognitive performance data collected 24-48 hr post-concussion. Recursive feature elimination (RFE) was used to identify the features that were most strongly associated with RTP. We also conducted RF classification modeling with recovery type (typical [≤ 28 days] vs. prolonged [> 28 days]) as the outcome of interest. RESULTS: RFE revealed optimal performance with 31 features, most of which were related to post-concussion symptomatology and cognitive performance. The RF regression model showed modest performance, accounting for 21% and 17% of the variance in testing and validation sets, respectively. The RF classification models also showed good performance across different levels of dataset balancing. The strongest classification model showed an accuracy of 89.04% with an F1 score of 0.56 on the testing set. On the validation set, the model showed 85.52% accuracy with an F1 score of 0.40. Receiver operator characteristics showed an AUC of 0.85. CONCLUSIONS: Overall, these findings support the use of machine learning models in concussion management - particularly with predicting recovery timelines.
Linking Personality Traits to Disability Progression in Multiple Sclerosis: A Longitudinal Analysis.
de Alcântara IJ, Voruz P, Allali G … +2 more , Lalive PH, Péron JA
Arch Clin Neuropsychol · 2025 Nov · PMID 40663498 · Full text
OBJECTIVE: Living with a chronic disease often involves facing many personal changes. In multiple sclerosis (MS), these changes can occur in both physical and psychological domains. Interestingly, psychological factors,...
OBJECTIVE: Living with a chronic disease often involves facing many personal changes. In multiple sclerosis (MS), these changes can occur in both physical and psychological domains. Interestingly, psychological factors, including personality traits, have been suggested as potential contributors to disability progression in MS. However, longitudinal studies exploring these associations are scarce. The objective of this study is to highlight and understand long-term associations between personality and disability progression in MS using advanced statistical methods that provide a robust approach to analyzing repeated measures. METHODS: Twenty-eight people with a confirmed diagnosis of MS (Mage = 47.5 years; 19 women) were included in this longitudinal study. Personality was assessed using the NEO-Personality Inventory-3 and disability with the Expanded Disability Status Scale at two time points (mean interval of 4.2 years). Finally, Generalized Estimating Equations were performed. RESULTS: Persons who displayed an increase in Neuroticism, notably in its Anxiety facet, as well as a decrease in Extraversion, particularly in its Warmth and Gregariousness facets, showed more disability increase. CONCLUSION: These findings underscore the importance of considering personality dynamics in the management of MS and advocate for a more individualized, person-centered approach to care and research.
Statement of the Editors of the Archives of Clinical Neuropsychology regarding the March 2025 Minnesota Conference Guidelines.
Lee GP
Arch Clin Neuropsychol · 2025 Aug · PMID 40654148 · Publisher ↗
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Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.
Cabello Fernandez C, Didone V, Slama H … +6 more , Dupuis G, Fery P, Delrue G, Lesoinne A, Collette F, Willems S
Arch Clin Neuropsychol · 2025 Nov · PMID 40645608 · Full text
OBJECTIVE: A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study...
OBJECTIVE: A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study aimed to characterize individuals with Long COVID reporting cognitive issues. METHOD: One hundred twenty-three patients underwent a comprehensive neuropsychological evaluation resulting from the baseline of an RCT study (COVCOG), along with questionnaires assessing cognitive complaints, fatigue, sleep difficulties, quality of life, psychological distress, and impact on daily activities. Latent Profile Analyses on cognitive scores were conducted to investigate the presence of different patient profiles. Robust analyses of variance and Pearson's chi-square examined the profiles' effects on demographic variables and questionnaire scores. RESULTS: Patients had had predominantly mild to moderate infections (87.8%) and were assessed an average of 20.9 (±8.6) months post-infection. Neuropsychological assessment showed cognitive impairment in at least one domain in 72% of the patients, mainly in attention and executive functions. Over 80% reported sleep problems and fatigue, 97% concentration problems, and some 80% memory and word-finding problems. The self-report questionnaires also revealed significant complaints. Three profiles emerged (all ps < .001). Profiles 1 and 2 both experienced widespread cognitive issues; Profile 1 patients expressed more complaints about cognitive functioning and daily fatigue (all ps < .045). Patients in Profile 3 were more frequently men (all ps < .049) with a specific impairment of verbal long-term memory and fewer complaints. CONCLUSIONS: The study identifies three different profiles of individuals with Long COVID, highlighting the need for comprehensive evaluations including neuropsychological, psychological, somatic, and functional aspects to implement effective, tailored interventions. Clinicaltrials.gov: NCT05167266.
Bridging Gaps in Sundown Syndrome Research: a Scoping Review and Roadmap for Future Multimodal Approaches.
Xu Q, Lin FV, Liu Y … +1 more , Zhao G
Arch Clin Neuropsychol · 2025 Nov · PMID 40608498 · Full text
OBJECTIVE: Sundown syndrome (SS), or sundowning, is a neuropsychiatric phenomenon marked by the worsening of symptoms in the late afternoon or evening, primarily in individuals with dementia. By systematically examining...
OBJECTIVE: Sundown syndrome (SS), or sundowning, is a neuropsychiatric phenomenon marked by the worsening of symptoms in the late afternoon or evening, primarily in individuals with dementia. By systematically examining previous studies, this scoping review aims to (1) bridge traditional questionnaire-based assessment methods with advanced sensor-based tools and (2) propose a multimodal framework to guide future research in enhancing risk identification, diagnosis, monitoring, and treatment across key symptom categories. METHOD: We conducted a comprehensive review of Web of Science, PubMed, Medline, APA PsycInfo, and IEEE Xplore to identify studies on SS. Following established scoping review guidelines, 13 review papers and 41 empirical studies were selected and analyzed based on traditional questionnaire-based observation and/or sensor-based measurement methods. RESULTS: We identified key limitations in traditional assessment methods and classified SS symptoms into five domains: psychomotor symptoms, cognitive and perceptual disturbances, mood and affective symptoms, psychosis, and disruptions in activities of daily living and instrumental activities of daily living. Building on these insights, we proposed a multimodal platform integrating sensor technologies to enhance risk identification, diagnosis, continuous monitoring, and treatment. CONCLUSIONS: This study advances the understanding of SS by synthesizing prior research, refining symptom domains, and proposing a roadmap for future investigation and intervention. The integration of multimodal sensor technologies holds the potential to reduce caregiver burden, enhance patient care, and enable more effective management of SS and other behavioral disturbances in older adults.
Translation and Validation of the Persian Version of the Communication and Language Assessment Questionnaire for Persons with Multiple Sclerosis (P-CLAMS).
Fatemeh A, Shima R, Maryam A … +3 more , Fatemeh H, Hamide G, Sarah EW
Arch Clin Neuropsychol · 2025 Nov · PMID 40583788 · Full text
OBJECTIVE: Persons with multiple sclerosis (MS) can experience communication changes, which can significantly impact their quality of life. To explore and help address these challenges, patient-reported outcome measures...
OBJECTIVE: Persons with multiple sclerosis (MS) can experience communication changes, which can significantly impact their quality of life. To explore and help address these challenges, patient-reported outcome measures (P-CLAMS) can be valuable tools in both research and clinical practice. They can help track symptom progression, support patient-centered care, assess the effectiveness of service delivery, and complement clinical assessments. This study aimed to translate and validate the Persian version of the Communication and Language Assessment Questionnaire for Persons with Multiple Sclerosis (P-CLAMS). METHOD: The adaptation and translation of the questionnaire occurred in two phases: (1) translation and cultural adaptation and (2) validity and reliability. The final version of the P-CLAMS consists of 11 items with one component factor (communication/language). RESULTS: Significant differences were observed in construct and criterion validity measures. Confirmatory factor analysis indicated that the P-CLAMS is a unidimensional measure for assessing communication difficulties in MS. The internal consistency was high (α = 0.92), and test/retest reliability was acceptable (ICC = 0.89). Additionally, the P-CLAMS effectively discriminated between people with MS (PwMS) and healthy controls. CONCLUSION: The psychometric evaluation demonstrated that the Persian version of the CLAMS (P-CLAMS) has good validity and reliability. The P-CLAMS can be a valuable tool for clinicians and researchers to assess communication changes in PwMS and evaluate intervention effectiveness.
A Case Study of a Multilingual Individual with Primary Progressive Aphasia: Diagnostic Considerations and Implications for Language Representation.
Kelly BE, Shehab AAS
Arch Clin Neuropsychol · 2025 Aug · PMID 40581733 · Publisher ↗
OBJECTIVE: This study reports a case of primary progressive aphasia (PPA) in a multilingual Haitian American individual. Earlier literature has suggested that cases of PPA in multilingual individuals are relatively rare....
OBJECTIVE: This study reports a case of primary progressive aphasia (PPA) in a multilingual Haitian American individual. Earlier literature has suggested that cases of PPA in multilingual individuals are relatively rare. Several factors complicate the assessment of language dysfunction and diagnosis of PPA in multilingualism, including age of language acquisition, degree of proficiency, language representation in the bilingual brain, and limited availability/validity of tests/norms for bilinguals. METHOD: This is a 69-year-old right-handed trilingual (French/English/Haitian Creole) Haitian American female with 16 years of education. Difficulties with word finding and speech production emerged two years prior to evaluation. Language was assessed with select subtests of the Boston Diagnostic Aphasia Examination (BDAE-3), Boston Naming Test (BNT), and Verbal Fluency. Positron emission tomography-computed tomography imaging displayed large areas of hypometabolism in the left and right frontal, temporal, and parietal lobes, with the left areas being more greatly impacted. RESULTS: Neuropsychological testing showed impairments in visual and auditory naming, verbal fluencies, sentence repetition, and word reading. Reading comprehension and repetition of single words were relatively spared. There were deficits in learning/memory, visuospatial functioning, and processing speed. Speech was dysfluent with occasional agrammatism and mild dysarthria. CONCLUSIONS: Overlapping characteristics of both logopenic and non-fluent/agrammatic variants of PPA were evident. Patient's neuroimaging findings and clinical presentation suggest an advanced PPA syndrome. Cognitive/brain reserve and a globalized language representation, theorized in bilingual individuals, could be considered as contributors to the trajectory of her deficits. This case study contributes to the growing literature on PPA in diverse populations and multilingual individuals.
Development of a Neuropsychological Service Pathway for School-Age Neonatal Follow Up: a Feasibility Pilot.
Williams TS, Taylor MM, Green RR … +3 more , Lyon R, Bondi BC, Désiré N
Arch Clin Neuropsychol · 2025 Nov · PMID 40580052 · Publisher ↗
OBJECTIVE: Neuropsychological care benefits children with neonatal brain conditions by monitoring brain health and directing supports to optimize learning and psychosocial growth. Conventional assessments often are time...
OBJECTIVE: Neuropsychological care benefits children with neonatal brain conditions by monitoring brain health and directing supports to optimize learning and psychosocial growth. Conventional assessments often are time and resource intensive; innovative, precise, and efficient assessment models are needed. This study examined 1) feasibility and acceptability of a tiered assessment protocol and 2) preliminary predictive validity of screening measures. METHOD: Children aged 4-18 years and their caregivers were referred for neuropsychological evaluation. A tiered protocol was co-designed with family advisors and included 3 steps: 1) invitation to consultation, including psychoeducation; 2) screening measures of cognition, learning, and well-being; and 3) virtual 1:1 consultation with a neuropsychologist/fellow. Collaborative caregiver-clinician discussion led to a) in-person testing, b) deferred assessment, or c) discharge. A portion (22%) of cases were reviewed independently to assess inter-clinician reliability. Caregiver feedback was gathered via survey. Multiple linear regression models assessed relationships between screening measures and 1) consultation outcome, and 2) child full scale intellectual IQ scores (FSIQ). RESULTS: Of 104 families invited to participate, 98 (94%) responded: 9 (9.2%) declined services and 85 (86.7%) completed screening measures and consultation. After consultation, 50 (59%) proceeded to in-person testing, 17 (20%) deferred assessment, and 18 (21%) were discharged. Inter-clinician agreement on consultation outcome was strong (90%). Caregiver feedback reflected protocol feasibility and acceptability; comments described helpfulness of monitoring, and timeliness of process. Screening measures predicted outcomes of consultation and child FSIQ. CONCLUSIONS: Results illustrate importance of evaluating neuropsychological pathways with precision, efficiency and caregiver-partners in mind.
Neuropsychological Integration, a Sense of Relationship, and the Self as Unified Experience.
Johnstone B, Smith E, Cohen D
Arch Clin Neuropsychol · 2025 Nov · PMID 40577230 · Publisher ↗
INTRODUCTION: Although the neuropsychological foundations of the self have been poorly understood to date, a neuropsychological model has recently been proposed that suggests that the self is best conceptualized as a "un...
INTRODUCTION: Although the neuropsychological foundations of the self have been poorly understood to date, a neuropsychological model has recently been proposed that suggests that the self is best conceptualized as a "unified experience" that is created when all neuropsychological processes are integrated in the right hemisphere association area to produce a sense of relationship between them (i.e., that they are occurring to the same entity at the same time, place, and context). This model was recently validated by a factor analysis of the Cambridge Depersonalization Scale that identified empirically distinct factors for dis-integrated neurological inputs (i.e., sensations) and dis-integrated neurological outputs (i.e., affect, behavior, cognition). However, further validation and expansion of the model are needed. METHODS: This article reviews and reinterprets previous neuropsychological studies of the self to validate the model. RESULTS: Review of this neuropsychological model of the self and supporting research suggest that this integrative neuropsychological process of relationship be conceptualized and assessed in terms of: (a) the specific neuropsychological processes that are integrated (i.e., affect, behavior, cognition, sensations); (b) the quantitative degree of experienced relationship (i.e., high to low); and (c) the center of experience/point of reference from which this integration occurs (i.e., body/brain; external). CONCLUSIONS: It is suggested that this model be used to provide a universal framework to explain diverse neurologic, psychiatric, and delusional misidentification disorders of the self, socially based character traits (i.e., experiences of relationship to other individuals), and other selfless experiences (e.g., transcendence, flow states). Clinical and research applications are discussed.
Seizures and Functional Deficits across Mendelian Disorders of Epigenetic Machinery: Differential Effects as a Function of Epigenetic Modifications.
Ng R
Arch Clin Neuropsychol · 2025 Nov · PMID 40511852 · Publisher ↗
Intellectual disability is common in a large proportion of Mendelian disorders of epigenetic machinery (MDEMs), underscoring the strong association between epigenetic dysregulation with the developmental disorder. Howeve...
Intellectual disability is common in a large proportion of Mendelian disorders of epigenetic machinery (MDEMs), underscoring the strong association between epigenetic dysregulation with the developmental disorder. However, the epigenetic factors/mechanisms that drive differences in neurodevelopmental presentation and severity remain unclear. This preliminary study aimed to identify neurobehavioral differences across MDEMs involving genes related to chromatin writer, writer/readers (WR), and chromatin remodeler/readers (CRR) in efforts to determine the effect of epigenetic function (chromatin modification) on severity of neurological dysfunction. Simon Searchlight data repository was accessed for this study. We included data from a total of 71 participants with a MDEM, 15 with a disorder involving chromatin writer, 22 of WR, and 34 of CRR. Caregivers provided genetic records to afford molecular confirmation of the MDEM, and completed a Vineland Adaptive Behavior Scale and a survey regarding diagnostic/seizure history. Results showed that participants with MDEMs of CRR yielded lower adaptive functioning scores across all skill areas relative to the Writer group, with the exception of receptive communication. Higher proportion of the CRR group are nonverbal, cannot ambulate independently, and require emergent seizure treatment (rescue drugs, emergency room admissions) as compared to the Writer group. Those with disorder involving WR did not significantly differ across measures from either groups. Findings highlight severity in neurological dysfunction, including seizure risk, can vary as a function of the disrupted epigenetic machinery. Results underscore the need for systematic research to identify epigenetic processes involved in the pathogenesis of neurodevelopmental disorders.
Subjective Cognitive Complaints in Mild Traumatic Brain Injury: Association with Cognitive Test Performance and Protective Psychological Factors.
Mäki K, Nybo T, Hietanen M … +3 more , Huovinen A, Marinkovic I, Melkas S
Arch Clin Neuropsychol · 2025 Nov · PMID 40511851 · Full text
OBJECTIVE: To examine subjective cognitive complaints (SCC) in patients with mild traumatic brain injury (mTBI), and to explore the associations between SCC, cognitive test performance and protective psychological factor...
OBJECTIVE: To examine subjective cognitive complaints (SCC) in patients with mild traumatic brain injury (mTBI), and to explore the associations between SCC, cognitive test performance and protective psychological factors. METHOD: A sample of patients with mTBI (n = 99) or orthopedic injury (OI; n = 34) prospectively recruited and assessed 3 months post-injury. All participants underwent a neuropsychological test battery and completed self-report measures on SCC, psychological resilience, perceived social support, depressive symptoms, fatigue, and pain. RESULTS: 27.3% of the patients with mTBI and 17.6% of the OI controls endorsed at least some SCC. The two groups did not differ significantly in their SCC endorsement. Within the mTBI group, patients with and without SCC did not differ significantly in their cognitive test performance in majority of the cognitive domains examined. Patients with SCC reported lower psychological resilience (p = .005) and perceived social support (p = .009) than the non-SCC group. CONCLUSIONS: This study provides support for the notion that SCC following mTBI are not consistently related to cognitive test performance deficits and further suggests SCC may associate with perceived social support and psychological resilience. These findings highlight the importance of considering psychological factors in the clinical assessment and intervention planning of patients presenting with SCC after mTBI.
Healthcare Self-Management, Executive Functioning, and Social Determinants of Health in Young Adults with Pediatric-Onset Disabilities: a Pilot Study.
Petranovich CL, Drenth E, Sarmiento C … +10 more , Lantagne A, Graber S, Simpson T, Connery AK, Miele A, Wilson P, Dichiaro M, Apkon S, Kirkwood MW, Peterson RL
Arch Clin Neuropsychol · 2025 Nov · PMID 40497433 · Publisher ↗
OBJECTIVE: We examined the associations of executive functioning and social determinants of health with medical self-management skills in transition-age adults (TAA) with pediatric-onset disabilities. METHOD: This cross-...
OBJECTIVE: We examined the associations of executive functioning and social determinants of health with medical self-management skills in transition-age adults (TAA) with pediatric-onset disabilities. METHOD: This cross-sectional pilot study included 47 young adults between the ages of 18-28 and their informants (e.g., parents, partners, siblings). Participants were followed by pediatric rehabilitation clinics for acquired brain injury (ABI = 16), neuromuscular disorders (NMD = 22), or spina bifida (SB = 9). Informants completed the Behavior Rating Inventory of Executive Functions - Adult Version, from which we reported the General Executive Composite. To assess medical self-management, young adult participants completed the Transition Readiness Assessment Questionnaire (TRAQ). RESULTS: Using generalized linear regression with the TRAQ as the dependent measure, better informant-rated executive functioning skills were associated with more favorable ratings of healthcare self-management with a large effect size (β = -0.62, p < .001). With a small effect size, there was also a main effect of participant race and ethnicity (β = 0.27, p = .049). Marginalized identities, specifically identification as of Indigenous and Black races, were associated with poorer ratings of healthcare self-management skills. CONCLUSIONS: Lower executive functioning skills and some marginalized identities are linked to poorer healthcare self-management in this sample of TAA with pediatric-onset disabilities. These findings highlight the value of neuropsychologists in identifying cognitive challenges and implementing targeted interventions in the context of social determinants of health.
Cognitive and Emotional Health in Long COVID: a Cross-Sectional Study in Brazil.
Ribeiro-Carvalho A, Prado MF, Marcelo GG … +3 more , Viveiros L, de Andrade Fernandes M, Nórte CE
Arch Clin Neuropsychol · 2025 Nov · PMID 40485056 · Publisher ↗
OBJECTIVE: Long COVID is characterized by persistent symptoms following a COVID-19 infection, including cognitive and emotional impairment. Brazil has one of the highest rates of COVID-19 infections globally, but there a...
OBJECTIVE: Long COVID is characterized by persistent symptoms following a COVID-19 infection, including cognitive and emotional impairment. Brazil has one of the highest rates of COVID-19 infections globally, but there are still few studies assessing the long-term impact of the disease on mental health in this population. In the present study, we evaluated cognition and emotional symptoms in patients with cognitive complaints after COVID infection in Rio de Janeiro, Brazil. METHOD: Cognitive and emotional assessments were performed individually (n = 114) using the Cognitive Screening (TRIACOG) and the Depression, Anxiety, and Stress Scale-21 (DASS-21) in participants with long COVID. Of the total subjects, 78% were women, with a mean age of 50.4 ± 16 years. A total of 72.6% received treatment at home, whereas 28% were hospitalized during the acute phase of the infection. RESULTS: Our data revealed a high prevalence of cognitive and emotional impairment. Approximately 66.7% exhibited symptoms suggestive of depression, 55.9% anxiety disorder, and 65.7% stress. Notably, executive functions and memory were the most affected cognitive domains. Intriguingly, the time from infection onset to assessment did not appear to influence cognitive performance, suggesting that cognitive impairment associated with COVID-19 may persist as a long-term comorbidity. Furthermore, hospitalization did not affect cognitive or DASS-21 scores. CONCLUSIONS: These findings underscore the importance of investigating the long-term impacts of COVID-19 on mental health. Assessing emotional and cognitive functions after COVID-19 is crucial for developing therapeutic responses, both on an individual level and from a public health perspective.
Can Research Findings be Used in Clinical Neuropsychology? Analysis of Randomized Controlled Trials of Working Memory Intervention for Children.
Blause SD, Léonard F, Willems S … +1 more , Tirelli E
Arch Clin Neuropsychol · 2025 Oct · PMID 40485054 · Publisher ↗
OBJECTIVE: Working memory difficulties are prevalent in children with cognitive disorders, affecting their academic performance and quality of life. To offer optimal care, neuropsychologists rely on evidence-based practi...
OBJECTIVE: Working memory difficulties are prevalent in children with cognitive disorders, affecting their academic performance and quality of life. To offer optimal care, neuropsychologists rely on evidence-based practice principles, particularly drawing from relevant research data. Randomized controlled trials (RCTs) are the gold standard for assessing intervention effectiveness, but for these studies to be reliable and clinically applicable, they must meet specific quality standards. This article aims to assess the quality of RCTs published on working memory interventions in children. METHODS: Two investigators independently evaluated the quality of a sample of 30 RCTs on the revalidation of working memory in children with the help of the CONSORT SPI grid (completeness of reporting) and the RoB 2 tool (risk of bias). RESULTS: In our sample, only an average of 11.9 out of 45 CONSORT items were fully reported per article. Key elements like intervention descriptions, outcome definitions, and the blinding process were inadequately reported in over 80% of articles. According to the RoB 2 classification, 36 RCTs were deemed high risk for bias, 10 had some concerns, and 1 was rated as low risk. CONCLUSIONS: The analyzed RCTs on cognitive rehabilitation in children reveal considerable transparency issues and high bias risks, limiting their clinical reliability. Researchers need to enhance the quality and clarity of their studies to better support clinical neuropsychologists.
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