Colloids And Surfaces. B, Biointerfaces[JOURNAL]
Sun
200 papers
ROS-responsive bio-hybrid probiotics for synergistic acute lung injury therapy.
Deng Y, Jia PP, Zuo N … +9 more , Huang GT, Yang ZH, Li YY, Wang ZQ, Li DX, Yang MQ, Dong ZX, Gao Y, Qian K
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42314510 · Publisher ↗
Acute lung injury (ALI) features uncontrolled inflammation and oxidative stress that drive rapid deterioration and high mortality. While probiotics offer a promising vehicle for localized therapeutic delivery, their appl...
Acute lung injury (ALI) features uncontrolled inflammation and oxidative stress that drive rapid deterioration and high mortality. While probiotics offer a promising vehicle for localized therapeutic delivery, their application in ALI is hindered by limited immunomodulatory activity and insufficient retention within inflamed lung tissue. Here, we report a dual-functional engineered Lactobacillus paracasei that couples cytokine-based immune regulation with microenvironment-responsive antioxidation. Through synthetic biology, the strain was programmed to secrete interleukin-4 (IL-4). A subsequent material-assisted surface modification enhanced the bacterium's ROS scavenging capability and facilitated improved therapeutic effects in inflamed lung tissue. In vitro, the engineered strain markedly suppressed TNF-α and IL-6 production and reduced intracellular ROS. In LPS- and Pseudomonas aeruginosa - induced ALI mouse models, treatment significantly attenuated lung inflammation, alleviated histopathological injury, and decreased the lung wet/dry ratio, with therapeutic benefits accumulating over time. Metabolomic profiling further revealed that the intervention reshaped the pulmonary microenvironment, notably elevating host-beneficial metabolites such as indole-3-butyric acid. Collectively, this work establishes a synergistic probiotic strategy integrating synthetic biology and responsive materials engineering to achieve targeted delivery, immune modulation, and oxidative stress relief. The engineered probiotic demonstrates potent therapeutic efficacy in ALI and represents a versatile platform for managing inflammation-associated respiratory diseases.
Hybrid BSA-PEO nanofibers as a stable biointerface for electrochemical cortisol immunosensing.
Marterior AA, Kolodzinska K, Wojtas M … +3 more , Sznitko L, Cabaj J, Baluta S
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42308886 · Publisher ↗
The long-term stability of antibody immobilization remains one of the key limitations of electrochemical cortisol immunosensors. Herein, a hybrid bovine serum albumin-poly(ethylene oxide) (BSA-PEO) electrospun nanofiber...
The long-term stability of antibody immobilization remains one of the key limitations of electrochemical cortisol immunosensors. Herein, a hybrid bovine serum albumin-poly(ethylene oxide) (BSA-PEO) electrospun nanofiber matrix was employed as a stable and biocompatible platform for antibody immobilization and electrochemical cortisol detection. The nanofibrous biointerface was deposited directly onto Platinum (Pt) and gold (Au) electrodes, followed by anti-cortisol antibody immobilization and blocking. Structural and electrochemical characterization confirmed the formation of a homogeneous and highly functionalized sensing layer. The resulting immunosensors exhibited linear responses in the ranges of 0.1-15 μM (Pt) and 0.01-200 μM (Au), with the gold-based platform achieving a detection limit of 0.01 μM. High selectivity toward cortisol and satisfactory recoveries in human serum were obtained for both systems. Notably, the nanofiber matrix effectively preserved antibody activity and sensor performance, providing signal retention of 92.0% and 97.9% after 14 days for platinum- and gold-based immunosensors, respectively. These findings highlight the critical role of biointerface design in electrochemical immunosensing and demonstrate the potential of BSA-PEO nanofibers as stable immobilization matrices for cortisol monitoring in point-of-care and wearable applications.
Peptide-copper co-assembled metalloenzyme mimics with superior laccase-like activity for efficient aflatoxin B₁ degradation.
Li X, Lei Q, Han Q … +6 more , Li J, Zhang X, Zhu J, Sun D, Li J, Li P
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42308885 · Publisher ↗
Aflatoxin B₁ (AFB₁), a potent natural carcinogen, poses a severe and widespread threat to global food safety and public health. To address this challenge, the rational design of robust artificial catalysts for efficient...
Aflatoxin B₁ (AFB₁), a potent natural carcinogen, poses a severe and widespread threat to global food safety and public health. To address this challenge, the rational design of robust artificial catalysts for efficient AFB₁ degradation represents a promising strategy. Inspired by the multicopper active center of natural laccase, we herein fabricated high-performance metalloenzyme mimics via a biomimetic interfacial co-assembly strategy for efficient AFB degradation. De novo designed peptides, incorporating histidine and cysteine as cooperative metal-binding motifs within a self-assembling LK peptide framework, underwent coordinative co-assembly with Cu²⁺ ions. Driven by synergistic metal-ligand interactions-primarily the imidazole groups of histidine and thiol groups of cysteine-the assembly process enabled the formation of well-defined, copper-enriched catalytic interfaces that accurately recapitulated the geometric architecture and electronic structure of laccase's active center, yielding peptide-copper colloidal nanoassemblies with remarkable laccase-mimicking activity. In comparison with natural laccase, the optimized metalloenzyme mimic displayed superior catalytic efficiency, as well as enhanced pH tolerance and thermal stability, enabling complete degradation of AFB₁ within 90 min under optimal conditions. The transformation products of AFB₁ showed markedly reduced cytotoxicity relative to parent mycotoxin. Importantly, the metalloenzyme mimic exhibited excellent practical performance, efficiently degrading AFB₁ in contaminated grain and nut samples and reducing residual concentrations to meet the strict safety limits set by the European Union. This work not only provides a potent biocatalyst for mycotoxin remediation but also elucidates a fundamental co-assembly pathway for engineering functional colloidal materials with tailored catalytic interfaces, offering broad implications for designing bio-inspired solutions in environmental and food chemistry.
Liposome formulation of a myristoylated antimicrobial peptide derived from Chionodracine: preparation, physico-chemical characterization and biological activity.
Toma F, Volpe A, Pandolfi F … +10 more , Massaro F, Porcelli F, Buonocore F, Taddei AR, Squitieri D, Bugli F, Ceccacci F, Borocci S, Clemente M, Bombelli C
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42308884 · Publisher ↗
Second-generation antimicrobial lipopeptides are considered very promising tools to combat the spread of systemic fungal infections caused by fungi multidrug resistance and biofilm-associated infections. The present work...
Second-generation antimicrobial lipopeptides are considered very promising tools to combat the spread of systemic fungal infections caused by fungi multidrug resistance and biofilm-associated infections. The present work reports a study on the lipopeptide Myr-B, derived from myristoylation of the natural antimicrobial peptide Chionodracine. The aim was to exploit its therapeutic potential by developing a suitable procedure for its encapsulation in liposomes, with a view to overcoming its in vivo instability and tendency to aggregation. A systematic investigation allowed to select two optimal liposome formulations, based on dimyristoylphosphatidylcholine, having chains of the same length of the lipopetide, and cholesterol and/or cholesteryl-hemisuccinate. Thin-film hydration and lipid-cake preparation methods were explored, and chemical-physical characterization was integrated with molecular dynamics simulations. The lipid-cake method proved to be the optimal approach, yielding monodisperse, stable liposomes with high encapsulation efficiency. Encapsulation in both liposome formulations markedly enhanced antifungal activity, lowering minimum inhibitory concentrations more than ten-fold against Candida albicans and approximately four-fold against Candida tropicalis compared to free Myr-B. LIVE/DEAD imaging also confirmed a strong reduction in biofilm formation. Liposomes displayed minimal haemolysis, low cytotoxicity toward human fibroblasts, and good in vivo tolerability in Galleria mellonella. Notably, specific interactions between cholesteryl-hemisuccinate and the peptide involved a peculiar liposome structure and a slower release from the liposome. Overall, both Myr-B-loaded liposomes produced by the lipid cake protocol significantly potentiates MYR-B efficacy while maintaining a favourable safety profile. These formulations are not universally applicable to all lipopeptides; however, the underlying criteria presented in this work are.
Plant-derived extracellular vesicles for cancer therapy: Biological features, therapeutic mechanisms and pharmaceutical applications.
Wei Z, Yang J, Wei Y … +4 more , Li S, Tao J, Qi J, Zhuang J
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42308883 · Publisher ↗
Plant-derived extracellular vesicles (PDEVs) are nanoscale particles isolated from plant tissues that carry proteins, lipids, nucleic acids and secondary metabolites, and function as mediators of intercellular communicat...
Plant-derived extracellular vesicles (PDEVs) are nanoscale particles isolated from plant tissues that carry proteins, lipids, nucleic acids and secondary metabolites, and function as mediators of intercellular communication. PDEVs have been increasingly investigated in both basic research and translational medicine. Owing to their intrinsic anticancer activity, favorable biocompatibility, and capacity for cargo association/loading and delivery, PDEVs are being explored as nanotherapeutics and drug delivery systems for cancer treatment. This review summarizes the biological features of PDEVs, their mechanisms of action in cancer therapy, and current strategies for engineering multifunctional PDEV-based therapeutic platforms. Finally, the review discusses their potential as drug delivery platforms and analyzes current strategies, advantages, and challenges related to clinical translation. This review aims to advance understanding of PDEV biology and support their future clinical development.
Magnetothermally responsive fibrin hydrogel for localized neuromodulation.
Kuznetsova E, Shchori GS, Maierovicz T … +4 more , Shalom S, Shine O, Begmatova D, Rosenfeld D
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42308882 · Publisher ↗
Magnetic biointerfaces have emerged as powerful tools in neuroscience, enabling significant advances in both neural regeneration and neuromodulation. Magnetothermal neuromodulation using magnetic nanoparticles (MNPs) res...
Magnetic biointerfaces have emerged as powerful tools in neuroscience, enabling significant advances in both neural regeneration and neuromodulation. Magnetothermal neuromodulation using magnetic nanoparticles (MNPs) responsive to alternating magnetic fields (AMFs), offers a remote means of localized thermal stimulation of thermosensitive ion channels, which subsequently modulate neural activity, but clinical translation is limited by poor spatial control and off-target nanoparticle distribution. Here, we introduce a magnetically responsive fibrin hydrogel that spatially confines polyethylene glycol-functionalized iron oxide nanoparticles and enables localized magnetothermal stimulation in three-dimensional (3D) neural constructs. Incorporation of MNPs (3-10 mg/mL) yielded hybrid hydrogels with tunable morphology, mechanical properties, and degradation kinetics while generating temperature increases under AMFs. The magnetic fibrin hydrogel supported dorsal root ganglion explant viability (>95%) and promoted neurite outgrowth within a 3D matrix. When adhered to spinal cord tissue ex vivo, the hydrogels produced localized and concentration-dependent heating, demonstrating efficient heat transfer to neural tissue. These results establish fibrin-based magnetic hydrogels as a biocompatible platform for spatially controlled magnetothermal neuromodulation and suggest their potential as implantable interfaces for minimally invasive bioelectronic therapies.
pH-responsive in situ hydrogelation behavior of a dipotassium glycyrrhizinate-propylene glycol alginate micro-hydrogel for oral sustained release of kaempferol.
Huang X, Du M, Feng K … +4 more , Ye B, Wu X, Jia D, Wang H
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42302545 · Publisher ↗
Kaempferol (Kae), a natural flavonoid with considerable pharmacological potential, is severely limited in oral application due to its poor aqueous solubility and instability under acidic gastrointestinal conditions. Here...
Kaempferol (Kae), a natural flavonoid with considerable pharmacological potential, is severely limited in oral application due to its poor aqueous solubility and instability under acidic gastrointestinal conditions. Here, a dipotassium glycyrrhizinate (DG)-propylene glycol alginate (PGA) micro-hydrogel with pH-responsive in situ hydrogelation behavior was developed for the oral sustained release of Kae. Specifically, Kae was first encapsulated within ultra-small nanomicelles formed by DG, enhancing molecular dispersion and dissolution behavior with high encapsulation efficiency. The obtained nanomicelles were subsequently coated with PGA to construct a pH-responsive micro-hydrogel. This outer micro-hydrogel layer endowed the system with in situ gelling capability, allowing it to remain fluid before administration while rapidly transforming into a cohesive gel network upon exposure to the acidic gastric environment. Molecular dynamics simulation and fluorescence imaging further confirmed the rapid pH-triggered in situ gelation and gastric retention behavior of the (K@D)@PM. In vitro release studies demonstrated effective protection of Kae under gastric conditions with negligible cumulative release. Simultaneously, pharmacokinetic evaluation revealed delayed absorption and significantly enhanced oral exposure, as indicated by the increased T, MRT, and AUC. Overall, these findings demonstrate that (K@D)@PM is a promising oral drug delivery platform for hydrophobic flavonoids, offering improved gastric protection, sustained release, and enhanced oral bioavailability.
Layer‑by‑layer biointerface engineering of biopolymer-nanoparticle hybrid coatings for durable antifouling and antibiofilm performance.
Ghasemi H, Kamrani E, Homaei A … +2 more , Zarei M, Fernandes P
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42296943 · Publisher ↗
The layer-by-layer (LbL) assembly method using nanomaterials and naturally derived cationic and anionic polysaccharides is an actively researched field, driven to meet the demand for eco-friendly antifouling coatings and...
The layer-by-layer (LbL) assembly method using nanomaterials and naturally derived cationic and anionic polysaccharides is an actively researched field, driven to meet the demand for eco-friendly antifouling coatings and to improve current available alternatives. In this work, we present a strategy involving the activation of a polyethylene substrate to construct a four-layered coating consisting of an alginate-iron oxide nanoparticle hybrid (layer 1), bacterial cellulose (layer 2), an alginate-zinc sulfide nanoparticle hybrid (layer 3), and a protease extracted from Penaeus vannamei shrimp waste immobilized on graphene oxide nanosheets (layer 4). This assembly was deposited onto the polyethylene substrate using a polyethyleneimine adhesive sublayer via LbL self-assembly. The time required to deposit the layers in the optimal pH was measured using a design of experiments approach, which was based on atomic force microscopy and contact angle measurements. Our results indicate that layers 1 and 4 maintained their antifouling performance over time, due to the stability and low solubility of iron oxide nanoparticles and graphene oxide nanosheets. Moreover, we show that enhanced contact among each constructed layer progressively improved antifouling efficacy against bacterial adhesion (Escherichia coli and Staphylococcus aureus) and microalgal attachment (Nannochloropsis oculata). Our findings unequivocally indicate that the substantial water-binding capacity of biopolymers such as alginate and cellulose enables the fabrication of highly impermeable multilayer coatings when hybridized with nanoparticles. Overall, this study provides a straightforward and scalable approach for preparing antifouling and antimicrobial coatings from natural materials, aimed at significantly reducing biofilm growth and fouling in medical and marine applications.
Tumor cell membrane-camouflaged biomimetic liposomes for targeted delivery of phytosphingosine with enhanced anti-lung cancer activity.
Fang L, Deng R, Yu S … +4 more , Xue R, Ma Z, Xia L, Li J
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42296942 · Publisher ↗
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for over 80% of cases. Conventional chemotherapy is severely limited by insufficient tumor t...
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for over 80% of cases. Conventional chemotherapy is severely limited by insufficient tumor targeting, severe off-target systemic toxicity, and poor bioavailability of hydrophobic antitumor agents, which greatly compromise therapeutic efficacy and patient quality of life. Phytosphingosine (PHS), a natural sphingolipid with potent antitumor activity via cell cycle regulation and apoptosis induction, is hindered by low water solubility and dose-dependent systemic toxicity, restricting its clinical translation. To address these critical obstacles, we fabricated a biomimetic liposomal nanosystem (PHS-LPs@CCM) by camouflaging PHS-loaded liposomes with homologous NCI-H1299 lung cancer cell membranes. The resulting nanoparticles exhibited favorable colloidal stability, uniform size distribution, and excellent hemocompatibility, with the membrane coating retaining native surface adhesion molecules for specific homotypic recognition. This bioinspired design markedly enhanced cellular internalization in NCI-H1299 cells compared with uncoated liposomes. In vitro functional studies demonstrated that PHS-LPs@CCM induced significant G0/G1 phase arrest and ROS-dependent mitochondrial apoptosis, while effectively suppressing cell migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT) process. This biomimetic colloidal platform offers a promising strategy to improve the delivery, efficacy, and safety of hydrophobic antitumor drugs, providing valuable implications for the design of biointerfacial functional nanocarriers for targeted cancer therapy.
Programmable nanocarriers with reversible ligand shielding and acid-triggered burst release for sequential tumor penetration and intracellular drug delivery.
Liu S, Wei W, Zhu W … +4 more , Xue C, Sun J, Zhang C, Ye W
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42296941 · Publisher ↗
The treatment of solid tumors with nanomedicines faces two major challenges: poor penetration of nanomedicines into deep tumor tissues and slow intracellular drug release, leading to suboptimal therapeutic efficacy. To a...
The treatment of solid tumors with nanomedicines faces two major challenges: poor penetration of nanomedicines into deep tumor tissues and slow intracellular drug release, leading to suboptimal therapeutic efficacy. To address these issues, this study designed and constructed a programmable folate-reversibly shielded acid self-amplifying nanomedicine (sDPFP NMs) featuring reversible ligand shielding and acid-triggered burst release. This carrier utilizes hydrophobically modified dextran (sDex) as the hydrophobic core and polyethylene glycol (PEG) as the hydrophilic shell, with a hypoxia-responsive azobenzene linker connecting the PEG layer to achieve reversible shielding of the folate ligand. Through hypoxia-regulated reversible ligand shielding, enhanced penetration of the nanomedicine into solid tumors was achieved. The self-amplifying degradation of sDex under acidic conditions triggered rapid burst release of doxorubicin within tumor cells. Results demonstrated that sDPFP NMs exhibit excellent tumor penetration and outstanding anti-tumor efficacy, effectively overcoming the bottlenecks of tumor penetration and intracellular delivery, thus providing a new strategy for solid tumor therapy.
An artificial model of ATP-binding cassette mediated transport.
Sarangi NK, Lyons R, Roantree M … +1 more , Keyes TE
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42296940 · Publisher ↗
Active drug efflux is a critical bottleneck in multidrug-resistance (MDR) in cancers, bacterial infections and in neurological disease. Preclinical acellular permeation assays do not predict efflux (active) transport, an...
Active drug efflux is a critical bottleneck in multidrug-resistance (MDR) in cancers, bacterial infections and in neurological disease. Preclinical acellular permeation assays do not predict efflux (active) transport, and cell-based assays may be confounded by the complexity and heterogeneity of cells which can make efflux data analysis challenging. We report here a cell-free platform as a model for functional multidrug resistance (MDR) efflux pump that mimics the inner membrane of Escherichia coli (E. coli). The system comprises a PE:PG:CL (67:23.2:9.8 mol%) lipid bilayer reconstituted with ABC (ATP-Binding Cassette) transporter BmrA, that is suspended over gold and PDMS microcavity pore arrays. Using real-time electrochemical impedance spectroscopy, adsorption and intercalation of six antibiotics-doxorubicin, daunorubicin, epirubicin, moxifloxacin, lomefloxacin, and vancomycin-were detected in E. coli bilayers with and without reconstituted BmrA, each producing a characteristic decrease in membrane admittance. Upon activation of BmrA with Mg/ATP, all six drugs displayed ATP-dependent efflux, manifested as increases in membrane admittance. The extent of drug-membrane adsorption and active transport was quantified by fitting the impedance responses to kinetic association-dissociation models. Transporter mediated efflux was then validated using a direct assay format, by tracking the metal-enhanced fluorescence (MEF) of intrinsic doxorubicin fluorescence in real time. Inhibition studies revealed that verapamil suppressed ATP-dependent transport for all tested drugs except epirubicin. These results establish the microcavity-supported lipid bilayer (MSLB) platform as a robust, biomimetic, and label-free system capable of resolving active versus passive drug transport across biomembranes. The approach offers a powerful tool for mechanistic interrogation of ABC transporters and may accelerate the discovery of antibiotics and efflux pump inhibitors.
Development of a gene-activated scaffold using niosomes and minicircle DNA as a novel non-viral delivery platform to enhance cartilage repair.
López-Seijas J, Iglesias-Fente A, Intini C … +3 more , Dobricic M, O'Brien FJ, Rey-Rico A
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42287831 · Publisher ↗
Gene therapy combined with advanced biomaterial-based delivery systems represents a powerful strategy to enhance chondrogenic differentiation of mesenchymal stem cells (MSCs), enabling the development of next-generation...
Gene therapy combined with advanced biomaterial-based delivery systems represents a powerful strategy to enhance chondrogenic differentiation of mesenchymal stem cells (MSCs), enabling the development of next-generation regenerative therapies for cartilage repair. In this context, gene-activated biomaterials provide a versatile tool for spatially and temporally regulating cell fate within three-dimensional (3D) microenvironments. Here, we combine collagen type I/type II-hyaluronic acid (CI/CII-HyA) scaffold with a novel non-viral gene delivery platform based on niosomes (DP20CQ) to deliver the master chondrogenic transcription factor SOX9 using either parental (PP) or minicircle (MC) plasmids, thereby promoting chondrogenesis in MSCs. After 28 days under chondrogenic conditions, DP20CQ-based scaffolds promoted a more favourable chondrogenic-to-hypertrophic profile than gene-free or Lipofectamine (LPF)-based scaffolds while preserving metabolic activity. Sustained SOX9 overexpression was evidenced in both PP and MC niosome-based systems at the gene and protein levels. Similarly, both systems showed an upregulation of key chondrogenic markers, including aggrecan (ACAN) and collagen type II (COLII), together with the concomitant downregulation of fibrocartilage (collagen type I, COLI) and hypertrophic (collagen type X, COLX) markers, with DP20CQ/MC exhibiting the highest expression ratios. Taken together, these findings demonstrate that DP20CQ-activated biomaterials enable efficient and sustained genetic regulation in MSCs within a 3D microenvironment, promoting the formation of hyaline-like cartilage while suppressing hypertrophic differentiation. This strategy constitutes a versatile gene-activated biomaterial platform with promising potential for cartilage regeneration.
Electroactive nanostructured polypyrrole coatings with on-demand drug release for immunomodulation of neural electrode interfaces.
Chen A, You Y, Zhang D … +5 more , Yang J, Tang J, Wang Z, Ning C, Zhang H
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42287830 · Publisher ↗
Neural electrodes are central to a wide range of neuroprosthetic and neuromodulation technologies. However, persistent macrophage-driven inflammation often leads to fibrotic encapsulation and elevated electrical impedanc...
Neural electrodes are central to a wide range of neuroprosthetic and neuromodulation technologies. However, persistent macrophage-driven inflammation often leads to fibrotic encapsulation and elevated electrical impedance, severely limiting stimulation efficiency and device longevity. Here, we reported an electroactive, electrically controlled drug-releasing neural electrode coating based on nanostructured polypyrrole (NPPy), enabling on-demand and sustained immunomodulation at neural interfaces. The nanostructured coating exhibited a high drug-loading capacity and released dexamethasone in a time-dependent manner under electrical stimulation. Electrically triggered drug release effectively suppressed lipopolysaccharide-induced macrophage M1 polarization, significantly reducing pro-inflammatory cytokine secretion, nitric oxide production, and inflammatory gene expression. Using cochlear implants as a representative peripheral neural electrode system, a transwell co-culture model demonstrated that macrophage-mediated inflammatory injury severely impairs spiral ganglion neuron survival and neurite extension, whereas electrically released dexamethasone markedly preserved neuronal viability and promoted neurite outgrowth. By coupling electrical stimulation with on-demand immunomodulatory drug delivery, this work established a generalizable electroactive coating strategy for dynamic regulation of neural electrode interfaces, offering a promising route to enhance the long-term stability and functional performance of implantable neural electrodes.
Study on the inhibition of liver cancer progression by lenvatinib nanoparticles combined with hyaluronic acid/gelatin scaffold.
Zhu L, Chen H, Guo Q … +8 more , Ren C, Shi P, Wang Q, Hu Y, Fan Z, Xu Y, Lin D, Chen H
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42287829 · Publisher ↗
Hepatocellular carcinoma (HCC) remains a leading cause of malignancy-related mortality worldwide, primarily due to the high incidence of postoperative recurrence and the absence of standardized adjuvant therapeutic proto...
Hepatocellular carcinoma (HCC) remains a leading cause of malignancy-related mortality worldwide, primarily due to the high incidence of postoperative recurrence and the absence of standardized adjuvant therapeutic protocols. While lenvatinib (LT) is established as a first-line targeted therapy for advanced HCC, its clinical efficacy is frequently compromised by poor aqueous solubility and significant systemic adverse effects. To bridge this therapeutic gap, we developed a dual-functional nano-delivery platform, designated as Gel@LTNPS, which integrates rapid localized hemostasis with sustained, targeted antitumor activity for postoperative wound management. In this study, pH-sensitive nanoparticles (LTNPS) were successfully fabricated using the amphiphilic copolymer PAE-PEG-NH via ultrasonic emulsification, achieving a high drug loading (DL) rate of 38.9% and an encapsulation efficiency (EE) of 73.9%. These nanoparticles were subsequently incorporated into a gelatin/hyaluronic acid (Gel-HA) hydrogel scaffold through covalent cross-linking. Physicochemical analysis demonstrated that LTNPS exhibit highly sensitive pH-dependent release kinetics, with 67.3% of LT released at a pH of 5.5 (simulating the acidic tumor microenvironment) compared to only 18.3% at physiological pH 7.4 within 96 h. The optimized Gel@LTNPS formulation (containing 15% gelatin) exhibited superior swelling properties, a controlled biodegradation profile of 21 days, and a robust compressive strength of 0.13 MPa, satisfying the mechanical prerequisites for surgical applications. Functional evaluations in mouse tail-bleeding models confirmed that Gel@LTNPS significantly expedited the coagulation process and minimized blood loss, demonstrating hemostatic performance equivalent to clinical-grade gelatin. Furthermore, in vitro and in vivo assays against H22 HCC models revealed that the platform effectively suppressed tumor cell viability and inhibited proliferation, as evidenced by a marked reduction in proliferating cell nuclear antigen (PCNA) expression. Crucially, the platform exhibited an excellent biosafety profile, with no observable systemic toxicity or histopathological damage to major organs. Collectively, this study offers a sophisticated strategy for the postoperative management of HCC by combining localized wound care with microenvironment-responsive chemotherapy, presenting significant potential for clinical translation.
MAO/SA composite coating on magnesium alloy: Corrosion resistance improvement and time-programmed Ca/Mg release for bone repair.
Zhang J, Sun N, Liu W … +10 more , Lu S, Jiang L, Zhang J, Zhang B, Lin Z, Wang T, Li L, Qiu M, Yang K, Yang H
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42287828 · Publisher ↗
Magnesium (Mg) alloys are attractive as orthopedic implants because of their favorable biofunctions, mechanical properties, and biodegradability. However, their clinical applications are hindered by their rapid degradati...
Magnesium (Mg) alloys are attractive as orthopedic implants because of their favorable biofunctions, mechanical properties, and biodegradability. However, their clinical applications are hindered by their rapid degradation rate in physiological environments, leading to inadequate functional and mechanical behavior of implants across different stages of bone repair. Here, Mg alloys were firstly modified by micro-arc oxidation (MAO), and then sealed with Ca-crosslinked sodium alginate (SA) hydrogel coatings through different immersion cycles, constructing the MAO/SA composite coatings to further improve the corrosion resistance and simultaneously supply Ca alongside Mg. It was found that the coatings prepared with three immersion cycles showed markedly improved corrosion resistance, concomitant with a thicker, more uniform, and defect-scarce surface layer. Increasing immersion cycles also enhanced surface hydrophilicity and supported favorable in vitro cellular responses, including improved cell attachment and osteogenic differentiation. Results of in vivo implantation in rat femoral condyles demonstrated desirable biocompatibility, superior bone-implant integration and better new bone formation for MAO/SA-treated samples. In addition, the heterostructure of the MAO/SA-Mg composite enabled a time-programmed ratio of Ca/Mg release profile, which may facilitate a stage-adaptive immune niche for bone repair. The MAO/SA-modified Mg alloys are considered as promising candidates for orthopedic applications.
Colloidal virus-like nanoparticles for targeted delivery of doxorubicin to non-small cell lung cancer using a cell-internalizing peptide.
Tan JS, Lee RFS, Ho KL … +3 more , Mariatulqabtiah AR, Asilah AT, Tan WS
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42287827 · Publisher ↗
Non-small cell lung cancer (NSCLC) is among the deadliest cancers globally. While chemotherapy is the most common treatment for NSCLC, its non-specific distribution to normal cells often leads to severe side effects. To...
Non-small cell lung cancer (NSCLC) is among the deadliest cancers globally. While chemotherapy is the most common treatment for NSCLC, its non-specific distribution to normal cells often leads to severe side effects. To overcome this limitation, cell internalizing peptides (CIPs) present a promising strategy for delivering chemotherapeutics directly to NSCLC cells, potentially improving patients' quality of life. In the present study, a novel CIP with the sequence IAQGASTPNQLR that internalized NSCLC was isolated from a phage-displayed peptide library using subtraction biopanning. This peptide demonstrated preferential internalization into lung adenocarcinoma cells via an active endocytosis pathway. Nanoglue and chemical crosslinkers were used to display the CIP on the surface of colloidal virus-like particles (VLPs) loaded with doxorubicin (Dox). These Dox-loaded VLPs were delivered specifically to lung adenocarcinoma cells by the CIP, significantly reducing non-specific toxicity to normal lung fibroblast cells. The present study highlights the potential of colloidal VLPs displaying the CIP for targeted delivery of chemotherapeutic agents to NSCLC cells.
Corrigendum to "Cu-doped HA coating with osteogenic and antimicrobial properties on porous tantalum" [Colloids Surf. B: Biointerfaces 259 (2026) 115371].
Qiang Y, Qi X, Liu W … +3 more , Wu S, Li X, Li M
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42285822 · Publisher ↗
Abstract loading — click title to view on PubMed.
Artificial intelligence-guided MOF immobilization of Leloir glycosyltransferases for enhanced catalytic efficiency.
Chang M, Ji Y, Sun Q … +3 more , Qiao M, Zheng J, Zhang X
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42284962 · Publisher ↗
Leloir glycosyltransferases (LGTs) are key enzymes in glycan assembly, prone to flocculation and inactivation during practical application. Unlike many other commercially available enzymes, conventional immobilization st...
Leloir glycosyltransferases (LGTs) are key enzymes in glycan assembly, prone to flocculation and inactivation during practical application. Unlike many other commercially available enzymes, conventional immobilization strategies often lead to the inactivation of LGTs. This study proposes the use of structurally tunable metal organic frameworks (MOFs) as immobilization carriers. To overcome the complexity of screening diverse MOF parameters, we developed an integrated molecular dynamics simulations (MD)-machine learning (ML) strategy that revealed hydrophilic ZIF-90 as the optimal carrier. We further optimized the synthesis conditions for immobilized LGTs, achieving efficient enzyme loading and high catalytic performance. Using KfoC and PmHS2 as representative model enzymes, both immobilized enzymes retained over 98% of their activities. Notably, PmHS2@ZIF-90 exhibited up to 37.2-fold and 8.0-fold activity enhancements relative to the free enzyme under alkaline and elevated-temperature conditions, respectively, demonstrating exceptional stability and tolerance. Meanwhile, the synthesized PmHS2@ZIF-90 was successfully applied in the synthesis of heparosan polysaccharide. This rational immobilization platform substantially surpasses conventional empirical strategies and offers a broadly applicable framework for the customized immobilization of LGTs in carbohydrate biomanufacturing.
Magnolol nanoparticles combat MRSA by disrupting TCA cycle and arginine metabolism to induce oxidative stress.
Xu H, Hao M, He Q … +5 more , Kuang H, Tie S, Guo Q, Li J, Chen L
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42284961 · Publisher ↗
Plant-derived bioactive compounds are promising antimicrobial candidates due to their diverse bioactivities and low propensity for inducing bacterial resistance. However, the clinical translation of magnolol (MG) is hind...
Plant-derived bioactive compounds are promising antimicrobial candidates due to their diverse bioactivities and low propensity for inducing bacterial resistance. However, the clinical translation of magnolol (MG) is hindered by its poor aqueous solubility, low bioavailability, and non-negligible cytotoxicity. Here, core-shell magnolol nanoparticles (MGs) were developed via self-assembly of MG, polyvinylpyrrolidone (PVP), and bovine serum albumin (BSA). This formulation significantly improved aqueous stability and sustained release, enhanced drug-bacteria interactions, while concomitantly reducing toxicity. In vitro, MGs exhibited enhanced antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) values of 15.625 µg/mL and 31.25 µg/mL, approximately half of the values observed for free MG. In vivo studies further demonstrated superior therapeutic efficacy with improved biocompatibility. Mechanistically, MGs disrupted the tricarboxylic acid (TCA) cycle and arginine metabolism, promoted reactive oxygen species (ROS) accumulation, depleted superoxide dismutase (SOD) activity, and induced oxidative stress-mediated bacterial death. These findings highlight MGs as a promising strategy for treating drug-resistant infections through bacterial metabolic modulation.
Target-anchoring nanofibers with retention-enhanced drug delivery for synergistic chemo-photothermal therapy of ovarian cancer.
He J, Cao X, Zhang H … +7 more , Qian L, Xu Y, Li T, Cheng L, Sun D, Zhou Q, Yao Q
Colloids Surf B Biointerfaces · 2026 Jun · PMID 42284960 · Publisher ↗
In patients with advanced ovarian cancer, a formidable "drug barrier" formed by interstitial pressure and postsurgical adhesions severely limits the tumor accumulation of intravenously administered chemotherapeutics, lea...
In patients with advanced ovarian cancer, a formidable "drug barrier" formed by interstitial pressure and postsurgical adhesions severely limits the tumor accumulation of intravenously administered chemotherapeutics, leading to sub-therapeutic tumor exposure and inevitable chemoresistance. Injectable short-fiber systems represent a promising localized platform to circumvent the drug barrier; however, their application is limited by poor intratumoral retention of the nanofibers, passive drug release, and a lack of targeting affinity. Here, we present an injectable target-anchoring short nanofiber (TASF) system designed to overcome these multifactorial barriers. TASF integrates a 3D interlocking network for mechanical anchoring, a polydopamine coating for chemical adhesion, folate ligands for tumor-targeted affinity, and an NIR-responsive component for controlled activation. After intratumoral administration, TASF remains stably anchored and is activated by NIR irradiation, triggering rapid drug release and localized photothermal therapy. This design ensures potent chemo-photothermal action is confined to tumor tissues. In ovarian cancer models, NIR-activated TASF treatment downregulates resistance-related protein expression and leads to robust tumor growth suppression. Importantly, the synergistic action of robust adhesion, targeting affinity, and NIR-controlled activation minimizes off-target effects, thereby enhancing the safety profile. This work provides a promising local delivery strategy to circumvent interstitial pressure and stromal barriers that limit drug penetration in solid tumor therapy, offering potential insights for future localized treatment of ovarian cancer.
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