Searches
/
International Journal For Vitamin And Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition[JOURNAL]
International Journal For Vitamin And Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition[JOURNAL]
Sun
200 papers
Vitamin K2 Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease Through Mitochondrial Dysfunction Modulation via Gut Microbiota.
Wang W, Li J, Mu L … +7 more , Bai Y, Zhu M, Zhao Y, Hu S, Wang J, Shao P, Su X
Int J Vitam Nutr Res · 2025 Oct · PMID 41201220 · Publisher ↗
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. Meanwhile, the development of MASLD is related to dysbiosis of the gut microbiota (...
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. Meanwhile, the development of MASLD is related to dysbiosis of the gut microbiota (GM). Our previous studies have shown that Vitamin K2 (VK2) has considerable potential to ameliorate mitochondrial dysfunction in mice fed a high-fat diet (HFD); however, the mechanism through which VK2 improves mitochondrial function and mitigates MASLD remains unclear. OBJECTIVE: This study aimed to elucidate the mechanism through which VK2 modulates MASLD. METHODS: A total of 80 C57BL/6J mice (4-5 weeks old) were fed a HFD for 16 weeks to establish the MASLD animal model. Additionally, VK2 was administered at a dose of 120 mg/kg/day for the last 8 weeks; 30 mice were fed a normal diet for the entire 24-week period. Mice were randomly divided into groups according to different experimental protocols. Hematoxylin and Eosin (H&E) staining, Oil Red O staining, and Cluster of Differentiation 11b (CD11b) immunofluorescence staining were used to detect liver histology and inflammatory cell infiltration in the mouse liver tissues. Moreover, 16S rRNA gene sequencing, antibiotic treatment, and fecal microbiota transplantation (FMT) were employed to investigate the microbiota-mediated anti-MASLD effects of VK2. Adeno-associated virus 9 (AAV9) was used to elucidate the mechanism through which VK2 regulates MASLD severity. RESULTS: VK2 significantly reduced hepatic lipid (triacylglycerol (TG) and total cholesterol (TC)) levels, as well as serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in HFD-fed mice ( < 0.05). VK2 also significantly suppressed inflammatory responses ( < 0.05), oxidative stress ( < 0.05), and improved mitochondrial dysfunction ( < 0.05) in a GM-dependent manner. Furthermore, VK2 restored the balance in the intestinal microbiota primarily through regulating spp. abundance, and markedly alleviated MASLD via a GM-dependent manner. VK2 notably upregulated the expression of SIRT3 signaling pathway proteins ( < 0.05), thereby reducing MASLD-associated mitochondrial dysfunction ( < 0.05). CONCLUSIONS: VK2 exerts promising therapeutic effects mainly through enhancing intestinal abundance and ameliorating mitochondrial dysfunction.
L. as a Potential Alternative Therapy to Improve the Management of Diabetes: An Overview on Phytochemical Insights, Mechanisms, and Therapeutic Applications.
Siam NH, Eti NAT, Mim AA … +6 more , Hossen MD, Tabassum T, Sarker P, Tasnim T, Parvin I, Chowdhury JA
Int J Vitam Nutr Res · 2025 Aug · PMID 40919694 · Publisher ↗
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and associated with severe complications, including cardiovascular diseases, neuropathy, nephropathy, and retinopathy. Alth...
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and associated with severe complications, including cardiovascular diseases, neuropathy, nephropathy, and retinopathy. Although synthetic antidiabetic drugs are available, the side effects and limited long-term effectiveness of these medications highlight the urgent need for safer, more potent alternative therapies. L., a traditional medicinal plant rich in flavonoids, terpenoids, and bilobalide, has attracted attention for its potential role in diabetes management. This review critically evaluates the antidiabetic potential of by analyzing evidence from , , and clinical studies. Moreover, this review highlights the pharmacological actions of and its key bioactive compounds, focusing on their mechanisms of action, including the activation of adenosine monophosphate-activated protein kinase (AMPK), the translocation of glucose transporter type 4 (GLUT4), and the inhibition of protein tyrosine phosphatases. The review also discusses the therapeutic implications of supplementation and identifies gaps in clinical validation, optimal dosing, and safety profiling. Preclinical studies have demonstrated that improves glycemic control by enhancing glucose uptake, regulating insulin secretion, inhibiting α-glucosidase activity, and exerting antioxidant and anti-inflammatory effects. Additionally, clinical trials suggest that supplementation with can reduce oxidative stress, improve lipid profiles, and mitigate diabetes-related complications. However, despite these promising outcomes, inconsistencies remain in present study designs, dosages, and patient populations, which question the validity of results. Furthermore, studies related to the antidiabetic effect and underlying mechanisms of , such as modulation of AMPK pathways and GLUT4 expression, also remain inadequate and warrant further systematic investigation. may still be considered a complementary treatment approach in managing diabetes due to its broad pharmacological activities and favorable safety profile. However, well-designed, large-scale clinical trials are crucial for establishing standardized dosing regimens, confirming long-term safety, and fully elucidating the mechanisms of action. Integrating into therapeutic strategies could offer a natural, and effective adjunct for enhancing glycemic control and reducing diabetes-related complications.
Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
Du F, Alhaskawi A, Zou X … +2 more , Zhou W, Lu H
Int J Vitam Nutr Res · 2025 Aug · PMID 40919693 · Publisher ↗
The vitamin B complex, a group of water-soluble vitamins, is essential for various metabolic and cellular processes and critical for achieving optimal surgical outcomes in plastic and cosmetic procedures. This review exa...
The vitamin B complex, a group of water-soluble vitamins, is essential for various metabolic and cellular processes and critical for achieving optimal surgical outcomes in plastic and cosmetic procedures. This review examines the mechanistic contributions of this complex at the cellular level, including any roles in mitochondrial bioenergetics, redox balance, gene regulation, and cellular repair mechanisms. Niacinamide, as a precursor to NAD⁺, enhances mitochondrial efficiency and facilitates energy production, supporting tissue regeneration. Pyridoxine functions as a cofactor in neurotransmitter biosynthesis and amino acid metabolism, contributing to nerve recovery post-surgery. Furthermore, cobalamin is crucial for maintaining the myelin sheath and facilitating axonal repair, thereby ensuring neuronal integrity and minimizing nerve damage. Additionally, pantothenic acid, through its role in coenzyme A synthesis, regulates fatty acid metabolism and accelerates cellular repair, aiding in wound healing. Biotin is fundamental for keratin synthesis and follicular cell proliferation, promoting skin integrity and hair regeneration, which are vital in aesthetic and reconstructive treatments. Meanwhile, thiamine ensures a sufficient energy supply for neuronal recovery and cellular resilience through modulating carbohydrate metabolism. Thus, by integrating these cellular mechanisms, the vitamin B complex enhances tissue repair, minimizes inflammation, and improves both aesthetic and functional outcomes. Advances in precision supplementation, innovative drug delivery methods, and regenerative medicine continue to expand the therapeutic potential of B vitamins in plastic and reconstructive surgery. This comprehensive overview underscores the clinical significance of these vitamins in optimizing surgical recovery and promoting long-term tissue health.
Inflammatory-Driven Vitamin A Transport Dysfunction in Ulcerative Colitis.
Zhou Z, Miao J, Jing Y … +11 more , Shi X, Liu Y, Wei X, Feng Z, Li H, Tu Q, Zhang H, Yi Q, Yang M, Li X, Cao X
Int J Vitam Nutr Res · 2025 Sep · PMID 40919692 · Publisher ↗
BACKGROUND: Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in...
BACKGROUND: Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in both pediatric and adult patients with ulcerative colitis (UC). The association between serum vitamin A levels and serum RBP4 levels, as well as the underlying mechanism involved inimpaired vitamin A transport during inflammation in UC patients, has yet to been investigated. METHODS: A validation cohort comprising 103 UC patients and 22 controls was analyzed. Serum RBP4 levels were measured using anenzyme-linked immunosorbent assay (ELISA), and correlations with vitamin A levels and disease severity wereassessed. A dextran sulfate sodium (DSS)-induced colitis mouse model was used to valuatehepatic RBP4 expression and inflammatory changes. Primary hepatocytes from C57BL/6 mice were exposed to inflammatory cytokines to assess the impact of these cytokines on RBP4 expression. RESULTS: Serum vitamin A ( < 0.001) and RBP4 levels ( < 0.001) were significantly lower in UC patients compared to controls, exhibiting a pronounced decreasing trend as disease severity increased (vitamin A: < 0.001; RBP4: < 0.001), while vitamin A levels increased after effective treatment ( < 0.001). Hepatic expression was reduced in the DSS-induced colitis model and negatively correlated with , , and . CONCLUSIONS: Serum RBP4 levels are decreased in UC patients and negatively correlate with disease severity, possibly due to proinflammatory cytokine-induced suppression which might contribute to inflammation-driven vitamin A transport dysfunction.
The Generalized Association Between Niacin Intake and Cardiovascular Events in US Adults Living With Chronic Kidney Disease.
Zhang D, Wu H, Gong S … +4 more , Zhou G, Liu Y, Li Y, Yang X
Int J Vitam Nutr Res · 2025 Jul · PMID 40919691 · Publisher ↗
BACKGROUND: The effects of dietary niacin on the risk of cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD) remain unclear. METHODS: CKD patients with estimated glomerular filtration...
BACKGROUND: The effects of dietary niacin on the risk of cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD) remain unclear. METHODS: CKD patients with estimated glomerular filtration rates (eGFRs) 20-59 mL/min/1.73 m or urinary albumin/creatinine ratio ≥30 mg/g were identified in the National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2018. Age, gender, race, education level, marital status, body mass index, blood pressure, and smoking and drinking history were considered as confounders. RESULTS: The present study encompassed 3815 CKD patients eligible for inclusion based on the study criteria. Participants with a niacin intake of >27.7 mg/d (quartile 4) had a lower prevalent CVD risk than those with an intake of ≤14.67 mg (quartile 1) (odds ratio (OR), 0.710, 95% CI: 0.560-0.900; for trend = 0.004). In the follow-up with a median of 7.0 years, 323 from CVD. After adjustment, a higher niacin intake (>27.7 mg) reduced CVD mortality compared to a lower intake (≤14.67 mg) (hazard ratio (HR), 0.610, 95% CI: 0.480-0.770; for trend <0.001). Adding dietary niacin to clinical variables increased the C-index from 0.746 to 0.749 for CVD prevalence and from 0.659 to 0.682 for mortality. The net reclassification improvement increased by 9.0% and 13.1% for CVD and mortality, respectively, and the integrated discrimination improvement increased by 0.3% and 1%, respectively. CONCLUSIONS: Higher dietary niacin intake may reduce CVD and its mortality in individuals with CKD.
Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis.
Zhang R, Wei X, Xu Y … +5 more , Han C, Cai X, Wu Y, Geng Y, Liu C
Int J Vitam Nutr Res · 2025 Aug · PMID 40919690 · Publisher ↗
BACKGROUND: Dietary interventions have exhibited promise in restoring microbial balance in chronic kidney disease. A low-protein calorie-restricted diet can reduce kidney injury in diabetic rodents. However, whether the...
BACKGROUND: Dietary interventions have exhibited promise in restoring microbial balance in chronic kidney disease. A low-protein calorie-restricted diet can reduce kidney injury in diabetic rodents. However, whether the renoprotective effects of this dietary intervention in murine diabetic kidney disease models are linked to gut microbiota modulation remains to be determined. METHODS: Diabetic mice (induced by high-fat diet and streptozotocin) were randomized into four groups (n = 8/group): normal protein (20% protein), caloric restriction (30% restriction), low-protein (13% protein), and low-protein calorie-restricted (13% protein + 30% restriction). After a 5-week intervention, blood and urine samples were collected for relevant analyses, fecal samples for gut microbiota analysis, and kidney tissues for histological, immunohistochemical, and Western immunoblotting assays. RESULTS: The low-protein calorie-restricted diet significantly improved glycemic control (fasting blood glucose: < 0.01), ameliorated dyslipidemia (all < 0.01), and mitigated kidney damage in diabetic mice. Additionally, the low-protein calorie-restricted diet ameliorated gut microbiota dysbiosis, significantly suppressing the increase in Firmicutes/Bacteroidetes ratio ( = 0.02) and decreasing serum trimethylamine oxide levels (67.51 ± 1.47 ng/mL vs. 56.58 ± 5.75 ng/mL; < 0.01). Compared to the normal protein group, the low-protein calorie-restricted group exhibited significant reductions in serum tumor necrosis factor-α (TNF-α) levels (20.75 ± 7.83 μmol/L vs. 5.37 ± 2.45 μmol/L; < 0.01) and apoptosis-associated speck-like protein containing a CARD (ASC), NOD-like receptor family pyrin domain containing 3 (NLRP3), and interleukin-1β (IL-1β) expression in kidney tissue (all < 0.01). CONCLUSIONS: The low-protein calorie-restricted diet exerts renoprotective effects in mice with diabetic kidney disease, possibly by modulating the gut-kidney axis to reduce circulating trimethylamine oxide levels, suggesting a potential link to NLRP3 inflammasome suppression in kidney tissue.
The Association Between a Body Shape Index and Testosterone Among U.S. Adult Males: National Health and Nutrition Examination Survey (2011-2016).
Gao F, Deng C, Luo P
Int J Vitam Nutr Res · 2025 Jul · PMID 40919689 · Publisher ↗
BACKGROUND: Obesity, a prevalent global health issue, is associated with testosterone deficiency (TD). A body shape index (ABSI) provides a more precise assessment of obesity and visceral fat, but its relationship with t...
BACKGROUND: Obesity, a prevalent global health issue, is associated with testosterone deficiency (TD). A body shape index (ABSI) provides a more precise assessment of obesity and visceral fat, but its relationship with testosterone remains unclear. This study aimed to explore the association between ABSI and testosterone levels leading to TD. METHODS: Data from 5256 adult males participating in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016 were collected to analyze of the association between ABSI and TD. The data underwent analysis using multivariate linear regression, logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and interaction testing. The predictive ability of ABSI based on weight, height, and waist circumference, as well as body mass index (BMI) based on weight and height, alongside a multiplicative combination of both metrics, BMI × ABSI, and optimal proportional combination O for assessing TD risk, was valuated using receiver operating characteristic (ROC) curves. RESULTS: Following adjustment for all confounding factors, ABSI exhibited a negative linear correlation with testosterone (β = -6.99, 95% confidence interval (CI): -8.25 to -5.73; < 0.001) and a positive association with TD risk (odds ratio (OR) = 1.06, 95% CI: 1.04-1.08; < 0.001). Notably, these associations remained consistent in the subgroup analysis. Additionally, age and hypertension demonstrated significant interactions between ABSI and TD ( < 0.05). Moreover, combining metrics, such as BMI × ABSI and O, proved to be more reliable predictors of TD compared to BMI or ABSI alone. CONCLUSIONS: This study identified a negative linear correlation between ABSI and total testosterone levels in adult American males, as well as a positive linear correlation with TD prevalence. ABSI represents a valuable addition to BMI for assessing obesity and the association between obesity and TD.
Dietary Selenium Intake and All-Cause Mortality in Diabetic Kidney Disease: A Dose-Response Relationship Based on the NHANES Observational Study.
Wang X, Wang D, Su S
Int J Vitam Nutr Res · 2025 Jul · PMID 40613401 · Publisher ↗
OBJECTIVE: Substantial experimental evidence has demonstrated that selenium, an essential micronutrient with pleiotropic physiological effects, also promotes dual antioxidant and anti-inflammatory effects. Meanwhile, the...
OBJECTIVE: Substantial experimental evidence has demonstrated that selenium, an essential micronutrient with pleiotropic physiological effects, also promotes dual antioxidant and anti-inflammatory effects. Meanwhile, the epidemiological association between dietary selenium consumption and mortality risk in diabetic kidney disease (DKD) remains underexplored. This investigation demonstrated a significant association between selenium intake and all-cause mortality among adult populations with DKD. METHODS: This study analyzed data from 2183 individuals diagnosed with DKD, obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2014. The mortality rate was determined through linkage to the National Death Index until December 31, 2015. The hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards regression models. Kaplan-Meier survival curves were generated to examine the association between survival probabilities and selenium intake. RESULTS: A total of 1063 mortalities were recorded over an average follow-up period of 8 years. All-cause mortality decreased with higher selenium intake levels. Adjusted for demographic variables, dietary habits, lifestyle factors, glucose regulation, and significant comorbidities, higher selenium intake was associated with improved all-cause mortality among DKD patients (adjusted HR = 0.705, 95% CI: 0.551-0.901). A significant overall association was observed between selenium intake and all-cause mortality risk, as evidenced by restricted cubic spline (RCS) analysis ( < 0.001; = 0.397). CONCLUSION: Higher dietary selenium intake was significantly associated with lower risk of all-cause mortality after multivariable adjustment for confounders among individuals with DKD.
Mean Corpuscular Volume and Risk of Autism Spectrum Disorder.
Fideli ÜS, Scher AI, Young WW … +3 more , Olsen CH, Susi A, Hisle-Gorman E
Int J Vitam Nutr Res · 2025 Jun · PMID 40613400 · Publisher ↗
BACKGROUND: Autism spectrum disorder (ASD) can be diagnosed as early as 18 months old, but more reliably after two years. Notably, no laboratory test exists to identify mothers at higher risk of having a child who will l...
BACKGROUND: Autism spectrum disorder (ASD) can be diagnosed as early as 18 months old, but more reliably after two years. Notably, no laboratory test exists to identify mothers at higher risk of having a child who will later be diagnosed with ASD or to identify at-risk infants before the manifestation of symptoms. One frequently described risk factor for neurodevelopmental disorders is vitamin B12 and folate deficiency, which results in macrocytic anemias. METHODS: We evaluated whether increased mean corpuscular volume (MCV), an indicator of macrocytic anemias in the mother or child, is associated with increased odds of a subsequent ASD diagnosis. Maternal mean MCV (mMCV) was calculated from any value in the year before birth, and the mMCV for the child was calculated from any MCV value from birth until the end of the follow-up time. Odds ratios with 95% confidence intervals were estimated from logistic regression models. RESULTS: A total of 3798 mothers (984 cases-ASD/2814 controls) and 9633 children (3206 cases-ASD/6427 controls) had at least one MCV value. The mMCV for the mother one year before birth was not associated with a later diagnosis of ASD in their children. In children, compared to the reference group (mMCV 76 femtoliters (fL)), an mMCV of 81 fL, 84 fL, and 91 fL was increased odds of ASD of 26%, 38%, and 32%, respectively. CONCLUSION: The MCV can be a potential inexpensive biomarker to identify a subset of children at risk of ASD or other developmental disorders; this exploratory study can inform larger studies to determine the clinical utility of MCV.
Lowering Sodium Intake: Reduction and Substitution for Cardiovascular Health.
Hu N, McLean R
Int J Vitam Nutr Res · 2025 Jun · PMID 40613399 · Publisher ↗
Clinical and epidemiological evidence supports sodium reduction as an effective strategy to lower blood pressure and reduce the risk of stroke, cardiovascular disease, and overall mortality. High sodium (salt) intake is...
Clinical and epidemiological evidence supports sodium reduction as an effective strategy to lower blood pressure and reduce the risk of stroke, cardiovascular disease, and overall mortality. High sodium (salt) intake is a well-established contributor to elevated blood pressure and adverse cardiovascular outcomes. The World Health Organization (WHO) recommends that adults should consume less than 5 g of table salt per day; however, the global average intake is estimated at around 10.78 g/day. The primary sources of dietary sodium vary by region: in high-income countries, the majority of salt intake comes from processed foods and meals prepared outside the home, while in many low-and middle-income countries, sodium is mainly added during home cooking or comes from condiments such as soy sauce and fish sauce. This review discusses the effects of high dietary sodium on blood pressure and vascular health, along with global consumption trends, regional disparities, and key nutritional sources. In addition to reducing sodium, adopting a salt-sensitive, whole-diet approach, such as increasing fruit and vegetable intake to boost potassium, can further protect cardiovascular health. Potassium-enriched, low-sodium salt substitutes are increasingly used in food production. Emerging strategies, including flavor enhancers, bitter blockers, spatial salt distribution, and microencapsulation, also help enhance saltiness perception while lowering sodium content. The review also summarizes national guidelines and those by the WHO, highlights selected country strategies, and calls for coordinated global and national efforts to reduce sodium intake and improve cardiovascular health worldwide.
Nutritional Support for Prevention and Treatment of Pressure Injuries in Adults: An Integrative Narrative Literature Review.
Cangelosi G, Sacchini F, Palomares SM … +7 more , Sguanci M, Biondini F, Mancin S, Amendola A, Ferrara G, Caggianelli G, Petrelli F
Int J Vitam Nutr Res · 2025 Jun · PMID 40613398 · Publisher ↗
INTRODUCTION AND OBJECTIVES: Pressure injuries (PIs) are a significant issue for international healthcare systems. Particularly common among older adults with reduced mobility, PIs represent a considerable socio-healthca...
INTRODUCTION AND OBJECTIVES: Pressure injuries (PIs) are a significant issue for international healthcare systems. Particularly common among older adults with reduced mobility, PIs represent a considerable socio-healthcare burden, which deeply impacts the psychological well-being of patients. Malnutrition is one of the main risk factors for the development of PIs, as malnutrition hinders healing and increases the risk of complications. For these reasons, implementing appropriate nutritional interventions, often underestimated in clinical practice, is crucial to manage PIs effectively. This study primarily aimed to identify and synthesize the best scientific evidence on nutritional interventions to prevent, facilitate, or improve the healing of PIs in an adult population. Additionally, both qualitative and quantitative outcomes were analyzed. METHODS: A narrative literature review was conducted using the PubMed-Medline, Scopus, and Google Scholar databases to potentially include potential studies. The scientific validity of the study was ensured using the Scale for the Assessment of Narrative Review Articles (SANRA) and the pre-registration of the OSF database was performed using the PICOS method, which is employed in numerous studies of this type. Randomized controlled trials (RCTs) published within the last 10 years and in English were included. RESULTS: Out of the 1507 records identified, 8 RCTs were included, published between May 2014 and May 2023. One study focused on patient education and self-care in nutrition related to PIs, while the remaining seven focused on intensive nutritional interventions or the administration of dietary supplements to treat PIs directly. Positive therapeutic effects were observed using collagen peptides, vitamin C, and arginine. Furthermore, the topical application of fish oil showed a protective effect. CONCLUSIONS: This study found that targeted nutritional interventions have a direct positive impact on PIs and an indirect effect on care, reducing complications and the duration of intensive care and healing times for PIs. Future systematic studies are recommended to broaden the understanding of the studied care framework.
Overall and Progression-Free Survival of Patients With Malignant Neoplasm Following Intravenous Vitamin C: A Systematic Review and Meta-Analysis.
Qu J, Yao M, Yu S … +12 more , Wang Y, Lu S, Wang B, He J, Wang S, Zhao Y, Wang X, Tao X, Liu X, Rao Y, Li Y, Rao B
Int J Vitam Nutr Res · 2025 Jul · PMID 40613397 · Publisher ↗
BACKGROUND: This study aimed to determine whether administering intravenous vitamin C in patients with malignant neoplasm is associated with increased survival outcomes compared to no intravenous vitamin C administration...
BACKGROUND: This study aimed to determine whether administering intravenous vitamin C in patients with malignant neoplasm is associated with increased survival outcomes compared to no intravenous vitamin C administration. METHODS: The primary search was conducted using MEDLINE (via PubMed), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception to October 13, 2024. Results were collected from randomized clinical trials and cohort studies that compared intravenous vitamin C and blank controls or placebo in patients with malignant neoplasm. Two reviewers independently assessed the data extraction process and the risk of bias, while the certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. A frequentist framework was used as the primary analysis approach. RESULTS: A total of 8 studies with 2722 adult participants were included. The vitamin C dose ranged from 2.5 g/d to 1.5 g/kg of body weight per day, with the treatment duration ranging from 9 days to 1 year. The primary outcome was overall survival, with progression-free survival as a secondary measure. Intravenous vitamin C was associated with a significantly longer median overall survival (pooled estimated median survival ratio: 1.83; 95% confidence interval: 1.40-2.40; < 0.001; moderate certainty), and a trend towards improved progression-free survival (pooled estimated median survival ratio: 1.80; 95% confidence interval: 0.95-3.41; = 0.073). Subgroup analyses of overall survival showed higher median survival ratios with vitamin C doses <1 g/kg ( ≥1 g/kg), in non-Chinese regions (vs. Chinese regions), with non-chemotherapy combinations ( chemotherapy combinations), and in cohort studies ( randomized controlled trials). CONCLUSIONS: The administration of intravenous vitamin C to adults with malignant neoplasm was associated with a longer median overall survival compared to no vitamin C administration. The current evidence indicates a moderate degree of certainty for considering intravenous vitamin C as a standard of care in managing malignant neoplasms. The PROSPERO Registration: CRD42024600634, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024600634.
Research Advances in Hydration Status and Kidney, Liver, and Cardiovascular Health, and Tailored Water Intake Recommendations for Chinese Children.
Li M, Wu B, Guan M … +4 more , He H, Liu J, Huang D, Hu Y
Int J Vitam Nutr Res · 2025 May · PMID 40613396 · Publisher ↗
Suboptimal hydration status has increasingly been recognized as a risk factor for the progression of chronic diseases. A nationwide survey conducted in China found that 82% of children aged 6 to 17 years failed to meet t...
Suboptimal hydration status has increasingly been recognized as a risk factor for the progression of chronic diseases. A nationwide survey conducted in China found that 82% of children aged 6 to 17 years failed to meet the recommended daily total water intake of 1600-2500 mL. On average, boys consumed 1603 ± 731 mL per day, while girls consumed 1487 ± 661 mL per day, placing them at a higher risk of dehydration. Worldwide studies have suggested associations between dehydration and chronic kidney disease, steatotic liver disease, and cardiovascular diseases in adults. However, there is a lack of evidence concerning hydration status and target organ damage in the pediatric population. Only a limited number of studies have suggested that suboptimal hydration status is associated with transient renal impairment, an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD), and decreased ventricular structure and function in children. This article reviews the association between hydration status and target organ damage in both adult and pediatric populations and summarizes tailored water intake recommendations for Chinese children. We aim to advance research on hydration status and kidney, liver, and cardiovascular health, especially in the pediatric population.
Global Burden of Diseases Associated With Iron Deficiency: GBD 2021.
Huang S, Li H, Zhang L … +2 more , Chen H, Gao C
Int J Vitam Nutr Res · 2025 May · PMID 40613395 · Publisher ↗
BACKGROUND: Iron deficiency is a major global public health concern associated with various adverse outcomes. METHODS: This study utilized the Global Burden of Disease Study 2021 (GBD 2021) to analyze the contemporary bu...
BACKGROUND: Iron deficiency is a major global public health concern associated with various adverse outcomes. METHODS: This study utilized the Global Burden of Disease Study 2021 (GBD 2021) to analyze the contemporary burden of iron deficiency-associated diseases. We conducted an epidemiological analysis using Bayesian age-period-cohort methods for forecasting, decomposition analysis to assess the impact of aging, population growth, and epidemiological shifts, and slope/concentration indices to assess health inequalities. RESULTS: Between 1990 and 2021, disability-adjusted life years (DALYs) due to iron deficiency increased (2021: 34,519,623, 95% uncertainty interval [UI]: 23,607,706.06-48,762,323.14), despite a decline in age-standardized rates (ASR) (451.58 per 100,000; 95% UI: 308.48-639.42) with an estimated annual percentage change of -0.87 (95% confidence interval [CI]: -0.91 to -0.83). The burden was highest in low socio-demographic index regions, with 13,893,312.7 DALYs (95% UI: 9,567,547.98-19,440,905.71), an ASR of 735.34 per 100,000 (95% UI: 506.01-1027.57), and an annual percentage change (EAPC) of -1.36 (95% CI: -1.41 to -1.32). Deaths totaled 18,628.31 (95% UI: 9082.46-27,243.01), with a mortality rate of 1.77 per 100,000 (95% UI: 0.86-2.60), primarily from maternal health disorders and dietary iron deficiency. Population growth and epidemiological shifts were key contributors to the disease burden. CONCLUSIONS: These findings highlight the persistent global burden of iron deficiency and the need for targeted interventions, particularly in low socio-demographic index regions.
The Effect of the L-Carnitine Supplementation on Obesity Indices: An Umbrella Meta-Analysis.
Hamedi-Kalajahi F, Zarezadeh M, Malekahmadi M … +4 more , Jamilian P, Jamilian P, Molani-Gol R, Ostadrahimi A
Int J Vitam Nutr Res · 2025 Apr · PMID 40298161 · Publisher ↗
AIMS: Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However,...
AIMS: Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However, given the inconclusive results from recent meta-analyses on L-carnitine, we conducted an umbrella meta-analysis of placebo-controlled and controlled trials to evaluate the effect of L-carnitine on anthropometric indices. METHODS: Data synthesis: A comprehensive search approach using the relevant keywords was performed in PubMed, Web of Science, Scopus databases, and Google Scholar up to March 2023. Meta-analyses published in English that provided quantitative statistical analyses regarding the effects of L-carnitine on body weight, waist circumference (WC), and body mass index (BMI) were included. A random-effects model and subgroup analysis were performed based on the L-carnitine dosage and study population. RESULTS: A total of 16,352 participants were included. Intervention durations ranged from 8 to 30 weeks, with L-carnitine dosages ranging between 150 and 4000 mg/day. The pooled results of the eight included meta-analyses indicated that L-carnitine supplementation can significantly decrease weight (effect size (ES) = -1.11; 95% confidence intervals (CIs): -1.90, -0.33, = 0.005; I = 90.6%, < 0.001), BMI (ES = -0.33; 95% CI: -0.61, -0.04, = 0.026; I = 89.8%, < 0.001), and WC (ES = -1.34; 95% CI: -1.83, -0.85, < 0.001; I = 00.0%, = 0.442). CONCLUSION: The findings of this umbrella meta-analysis support that supplementation of L-carnitine supplementation can successfully manage weight, BMI, and WC reduction. Therefore, L-carnitine might help treat obesity. PROSPERO Registration Number: CRD42022307951.
To Bio or not to Bio? Organic Food Consumption in Switzerland.
Müller I, Suter F, Rohrmann S … +1 more , Pestoni G
Int J Vitam Nutr Res · 2025 Apr · PMID 40298160 · Publisher ↗
BACKGROUND: Our study aimed to gain from a comprehensive understanding of organic food consumption in Switzerland. METHODS: Data from the Swiss National Nutrition Survey menuCH (2014-2015, n = 2057, 18 to 75 years old)an...
BACKGROUND: Our study aimed to gain from a comprehensive understanding of organic food consumption in Switzerland. METHODS: Data from the Swiss National Nutrition Survey menuCH (2014-2015, n = 2057, 18 to 75 years old)and a cross-sectional, population-based survey were used. Dietary information was collected using two non-consecutive 24-hour dietary recalls (24HDRs). Organic foods were classified using information about food descriptors and labels. Participants were classified as organic food consumers if they had consumed organic foods in at least one 24HDR. Binomial logistic regression models were used to identify factors associated with organic food consumption. RESULTS: This study determined that 27.8% of the Swiss population consumed organic food. However, only 3.6% of all food consumed within this group of organic food consumers was organic. Food products of plant origin tended to be consumed more frequently as organic than were those of animal origin, except for eggs and dairy products. Organic food consumption was positively associated with female sex (odds ratio (OR) = 2.18, 95% confidence interval (CI) 1.69, 2.80), high educational degree (OR = 1.28, 95% CI 1.02, 1.61), and high alternate healthy eating index (OR = 5.45, 95% CI 3.70, 8.02), and negatively associated with young age (OR = 0.56, 95% CI 0.40, 0.78), French-speaking living area (OR = 0.73, 95% CI 0.56, 0.93), non-Swiss nationality (OR = 0.74, 95% CI 0.56, 0.98), large household size (OR = 0.59 95% CI 0.38, 0.89), and obesity (OR = 0.53, 95% CI 0.36, 0.77). CONCLUSION: The present study provides a better understanding of the distribution of organic food consumption within the Swiss population and which subgroups consume particularly little organically produced food. CLINICAL TRIAL REGISTRATION: Clinical Trial Registration: ISRCTN 16778734; https://www.isrctn.com/search?q=menuch.
YDJ-03 and YDJ-6 Alleviate Metabolic Syndrome in Mice.
Chen S, Shi M, Chen X … +2 more , Le Q, He J
Int J Vitam Nutr Res · 2025 Apr · PMID 40298159 · Publisher ↗
BACKGROUND: Probiotics are increasingly recognized for promoting beneficial effects on intestinal health. However, most probiotic strains have been insufficiently researched, underscoring the need for further studies to...
BACKGROUND: Probiotics are increasingly recognized for promoting beneficial effects on intestinal health. However, most probiotic strains have been insufficiently researched, underscoring the need for further studies to fully understand their potential health benefits, especially in metabolic conditions. Therefore, this study aimed to explore the role and possible mechanism of YDJ-03 (YDJ-03) and YDJ-6 (YDJ-6) in metabolic syndrome (MetS) and hyperuricemia. METHODS: Twelve mice per group were fed a high-fat, high-fructose, high-cholesterol (HFFC) diet for 90 days. Mice in both the YDJ-03 and YDJ-6 groups were administered a dose of 1.2 × 10 colony-forming units (CFU) intragastrically per mouse for 28 days before being injected with hypoxanthine (400 mg/kg) to induce hyperuricemia. Blood lipids (triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)), liver injury markers (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), oxidative stress indicators (malondialdehyde (MDA) and superoxide dismutase (SOD)), and renal injury markers (uric acid (UA) and creatinine (CREA)) levels were analyzed after the conclusion of the study. RESULTS: In contrast to the model group, the YDJ-03 group exhibited a marked decrease in liver TGs ( = 0.033), MDA ( = 0.0041), serum UA ( = 0.0071) and CREA ( = 0.0072). The mRNA levels of renal toll-like receptor 2 () ( = 0.0018), tumor necrosis factor receptor-associated factor 6 () ( = 0.0013), and nuclear factor kappa B subunit 1 () ( = 0.032) were downregulated, accompanied by marked attenuation of inflammatory cell infiltration in renal tissues and alleviation of glomerular epithelial cell swelling. Furthermore, YDJ-6 treatment promoted significant downward adjustments in hepatic TG ( = 0.0055), serum TG ( = 0.0082), and LDL-C ( = 0.0233) levels. YDJ-6 treatment also decreased serum ALT ( = 0.0458) and AST ( = 0.029) concentrations, downregulated the gene expression levels of inflammation-related adhesion G protein-coupled receptor E1 () ( = 0.033) and prostaglandin-endoperoxide synthase 2 () ( = 0.0077), and effectively ameliorated hepatocellular lipid deposition and ballooning degeneration with hepatocyte necrosis. CONCLUSIONS: YDJ-03 may exert nephroprotective effects by regulating the TLR2-mediated NF-κB pathway, and YDJ-6 can effectively reduce hepatic fat deposition and inflammation to alleviate liver injury.
Prognostic Value of the Magnesium Depletion Score for Mortality Outcomes Among NAFLD Patients.
Ding Y, Xu W, Feng Y … +2 more , Shi B, Wang W
Int J Vitam Nutr Res · 2025 Apr · PMID 40298158 · Publisher ↗
BACKGROUND: The magnesium depletion score (MDS), a novel clinical score, incorporates alcohol consumption, kidney disease, use of diuretics and proton pump inhibitors (PPIs) to assess magnesium levels. However, the progn...
BACKGROUND: The magnesium depletion score (MDS), a novel clinical score, incorporates alcohol consumption, kidney disease, use of diuretics and proton pump inhibitors (PPIs) to assess magnesium levels. However, the prognostic significance of the MDS individuals with nonalcoholic fatty liver disease (NAFLD) remains uncertain. This research aimed to explore the relationship between the MDS and mortality outcomes in NAFLD patients, including all-cause mortality, cancer mortality, and cardiovascular disease (CVD) mortality. METHOD: Data acquired on 16,394 NAFLD patients from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018 were analyzed in this cohort study. Mortality outcomes were assessed using the linked National Death Index, which included all-cause mortality, cancer mortality, and CVD mortality. Cox proportional hazards models were used to determine the hazard ratios (HRs) for mortality outcomes related to the MDS. Subgroup analyses were also performed to explore the potential modifying influences of different demographic and clinical characteristics. RESULT: An elevated MDS was associated with significantly higher risks of all-cause mortality (HR 1.22; 95% CI, 1.15-1.30), cancer mortality (HR 1.15; 95% CI, 1.03-1.28), and CVD mortality (HR 1.33; 95% CI, 1.18-1.51). While these associations remained consistent in many subgroups, factors such as gender, education level, and alcohol consumption influenced the link between the MDS and mortality. CONCLUSION: The MDS is as an innovative and feasible prognostic indicator for mortality among NAFLD patients. Incorporating the MDS into clinical practice could improve risk stratification and inform targeted interventions aimed at diminishing the risk of mortality linked to magnesium deficiency within this group.
Is Potassium Hydroxide Safe as a Source of Nutrient in Food Supplements? An Expert Opinion.
Zovi A, Ferrara F
Int J Vitam Nutr Res · 2025 Apr · PMID 40298157 · Publisher ↗
Diet and nutrition have recently become a primary focus of public health worldwide. Food supplements (FSs), used to integrate common diets, are a highly marketed category of food products. This has positioned healthcare...
Diet and nutrition have recently become a primary focus of public health worldwide. Food supplements (FSs), used to integrate common diets, are a highly marketed category of food products. This has positioned healthcare professionals (e.g., pharmacists) to have critical roles in their distribution and monitoring. Following a serious case of intoxication due to ingestion of potassium hydroxide (KOH) as a nutrient source in a FS, a technical analysis was carried out to assess the admissible levels of vitamins and minerals in such products. KOH, known for its high potential hydrogen (pH) and caustic properties, poses safety risks if not properly diluted. The EU Regulation 1169/2011 regulates the provision of food information to consumers and establishes minimum significant quantities for nutrients in all food products, including K, which must not exceed certain levels to ensure safety. The use of KOH as a unique K source has been shown to create high alkalinity, posing potential risks when dissolved in water for human consumption. Safer alternative forms of K are available for FS. This underscores the need for continuous regulatory oversight and involvement of public decision makers to ensure consumer safety, given the broad variability in FS formulations and their increasing market share.
Influence of Health Education on Nutrition and Lifestyle Habits in the Spanish Population: A Descriptive Cross-Sectional Study.
Sandri E, Amigo-Bravo M, Werner LU
Int J Vitam Nutr Res · 2025 Mar · PMID 40298156 · Publisher ↗
BACKGROUND: This study aimed to investigate how education centering around nutrition can influence diet quality and health-related behavior in the Spanish population. METHODS: A descriptive cross-sectional study was perf...
BACKGROUND: This study aimed to investigate how education centering around nutrition can influence diet quality and health-related behavior in the Spanish population. METHODS: A descriptive cross-sectional study was performed, and the validated NutSo-HH (Nutritional and Social Healthy Habits) questionnaire was administered. The overall sample was 1087 Spanish adults, 48.11% of whom had studied or were studying a degree in health sciences, compared to 51.89% who had no studies or were studying another subject. Differences between groups were assessed using statistical analyses. RESULTS: The results indicated that people with higher nutrition education exhibited an increased consumption of vegetables (3.64 3.50), cereals (3.09 2.70), legumes (2.19 2.10) and water (3.47 3.34) (all < 0.001) and a lower consumption of red meat (1.60 1.73) ( < 0.001). No statistically significant differences were observed in the consumption of the remaining analyzed food products. People with health literacy reported better self-perceived health (3.94 3.76) ( < 0.001) and had a lower body mass index (BMI) (23.68 kg/m 24.75 kg/m) ( < 0.001) than those without health literacy. No significant differences were observed in the time spent in sports practice and sedentary lifestyle or in variables related to eating disorders. CONCLUSIONS: This study concluded that although health science education showed some benefits in eating habits and perceptions of well-being, did not significantly influence all aspects of nutritional habits and lifestyles. Further studies with a more holistic approach could provide a more complete picture of the influence of health education on overall well-being.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe