Photodiagnosis And Photodynamic Therapy[JOURNAL]
Sun
200 papers
Does the use of laser therapy enhance healing and reduce the size of periapical lesions? A systematic review and meta-analysis.
Creazzo G, Salmon B, Almeida J … +5 more , Faria-E-Silva AL, Lopes-Olhê FC, Souza-Gabriel AE, Sousa-Neto MD, Candemil AP
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42001923 · Publisher ↗
INTRODUCTION AND OBJECTIVE: Laser therapy has been proposed as an adjunct to conventional endodontic treatment due to its potential photobiomodulatory and antimicrobial effects on apical periodontitis. This systematic re...
INTRODUCTION AND OBJECTIVE: Laser therapy has been proposed as an adjunct to conventional endodontic treatment due to its potential photobiomodulatory and antimicrobial effects on apical periodontitis. This systematic review and meta-analysis aimed to evaluate whether adjunctive laser therapy enhances the healing of periapical lesions. STUDY SELECTION AND SOURCES: A comprehensive literature search was conducted in PubMed, Embase, Scopus, and Web of Science. Randomized and non-randomized studies assessing periapical lesion healing using the Periapical Index (PAI) and comparing conventional endodontic treatment with and without adjunctive laser therapy were included. Meta-analysis was performed using a random-effects model, risk of bias was assessed with RoB 2.0 and ROBINS-I and the evidence certainty was rated using GRADE. RESULTS: Six studies met the inclusion criteria. All included studies reported significant reductions in PAI in both experimental and control groups. However, meta-analysis demonstrated no significant difference between adjunctive laser therapy and conventional endodontic treatment (mean difference = 0.17; 95% CI: -0.14 to 0.47; p = 0.28), with moderate heterogeneity (I² = 52%). All randomized controlled trials were judged as presenting some concerns of bias, the single non-randomized clinical study was judged to have a critical risk of bias and the certainty of evidence was rated as low CONCLUSIONS: Current evidence does not consistently demonstrate a significant additional benefit of adjunctive laser therapy over conventional endodontic treatment in terms of radiographic healing of periapical lesions assessed by PAI. CLINICAL SIGNIFICANCE: Conventional endodontic treatment is sufficient for periapical healing, and routine adjunctive laser use may not be justified.
Definitive bronchoscopic photodynamic therapy for low-grade endobronchial mucoepidermoid carcinoma adjacent to the carina.
Yu Z, Cui L, Jimu A … +1 more , Yu P
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42001922 · Publisher ↗
Pulmonary mucoepidermoid carcinoma (PMEC) is a rare salivary gland-type primary lung malignancy arising from the tracheobronchial submucosal glands. Although surgery remains a standard curative option, carefully selected...
Pulmonary mucoepidermoid carcinoma (PMEC) is a rare salivary gland-type primary lung malignancy arising from the tracheobronchial submucosal glands. Although surgery remains a standard curative option, carefully selected low-grade and localized endobronchial lesions may also be amenable to definitive bronchoscopic treatment. We report a 40-year-old man with compensated liver cirrhosis (preserved liver function) who presented with a 1-year history of cough. Chest computed tomography revealed an endobronchial lesion (∼10 mm) in the left main bronchus approximately 1 cm distal to the carina. 18F-FDG PET/CT showed no nodal or distant metastasis. Pathology confirmed low-grade PMEC (Ki-67 ∼5%), and MAML2 break-apart fluorescence in situ hybridization (FISH) was positive (split signals in 23% of analyzed nuclei). After multidisciplinary discussion, an initial airway-preserving definitive bronchoscopic strategy was selected because the lesion was small, low-grade, and apparently confined to the bronchial lumen, with surgery reserved as a salvage option if local control could not be achieved. The visible tumor was removed by endoscopic electrosnare resection, followed by one treatment course of photodynamic therapy using a hematoporphyrin derivative photosensitizer (Hiporfin, 2 mg/kg, Chongqing Milelonge Biopharmaceutical Co., Ltd., China) and 630-nm laser irradiation (120 J/cm, 3-cm cylindrical diffuser; Guilin Xingda Photoelectric Medical Instrument Co., Ltd., China) at 48 h and 72 h to treat the implantation base and adjacent at-risk mucosa. Complete endobronchial clearance was achieved with preservation of airway anatomy. Follow-up bronchoscopy and chest imaging at 1, 3, 9, 24, and 36 months demonstrated sustained complete response without recurrence or metastasis; site-directed mucosal biopsies at each visit showed no tumor cells. This case adds to the limited literature supporting bronchoscopic PDT as a potential initial local treatment option in carefully selected patients with localized low-grade endobronchial PMEC, particularly when airway preservation is desirable.
Comparing myopia control efficacy and corneal power changes in children wearing corneal refractive therapy (CRT) and vision shaping treatment (VST) orthokeratology lenses with smaller back optic zone diameters.
Li N, Jiang W, Wang N … +4 more , Cai Z, Du B, Lin W, Wei R
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42001921 · Publisher ↗
PURPOSE: To compare axial length (AL) elongation and relative corneal refractive power (RCRP) changes in children wearing corneal refractive therapy (CRT) and vision shaping treatment (VST) lenses with smaller back optic...
PURPOSE: To compare axial length (AL) elongation and relative corneal refractive power (RCRP) changes in children wearing corneal refractive therapy (CRT) and vision shaping treatment (VST) lenses with smaller back optical zone diameters (BOZD). METHODS: This retrospective study included136 eyes from children aged 8-11 years, having myopia of -0.50 to -3.00 D, which were fitted with two types of orthokeratology (OK) lenses: 5.0 mm-BOZD CRT and 5.6 mm-BOZD VST. The analysis detected AL at baseline, 6 months, and 12 months. The treatment zone size (TZS), treatment zone decentration (TZD) and RCRP parameters were obtained through analyzing the corneal topography maps obtained at baseline and after 1 year. RESULTS: The AL increase in the 5.6 mm-BOZD VST group was significantly slower than the 5.0 mm-BOZD CRT group (6 months: 0.09 ± 0.08 mm vs. 0.15 ± 0.10 mm; 12 months: 0.16 ± 0.14 mm vs. 0.31 ± 0.18 mm; both P < 0.001). The 5.6 mm-BOZD VST group showed a smaller 3/4X value (indicating the distance from which the RCRP profile first reaches its three-quarter peak) and a higher summed RCRP value within the pupillary region compared to the 5.0 mm-BOZD CRT group (both P < 0.05). However, the maximum RCRP value, TZS, and TZD were similar between the two groups. CONCLUSIONS: 5.6 mm-BOZD VST lenses provided superior myopia control efficacy compared to 5.0 mm-BOZD CRT lenses in 8-11-year-old children with low myopia, mainly through inducing a steeper RCRP profile and a greater RCRP sum value within the pupillary area.
Association between systemic inflammation and obesity-myopia comorbidity in adolescents: A cross-sectional analysis.
Li M, Deng H, Chen D … +4 more , Tao Z, Xu Z, Hu G, Lv Z
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42000095 · Publisher ↗
OBJECTIVE: This study aimed to investigate the association between systemic inflammation and the comorbidity of obesity and myopia among adolescents, focusing on the Systemic Immune-Inflammation Index (SII) and Systemic...
OBJECTIVE: This study aimed to investigate the association between systemic inflammation and the comorbidity of obesity and myopia among adolescents, focusing on the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as markers of inflammation. METHODS: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2008. The associations between SII and SIRI and obesity-myopia comorbidity were evaluated using multivariable logistic regression, restricted cubic spline (RCS) modeling, and subgroup analyses. RESULTS: A total of 8043 adolescents were included in this study. Multivariable logistic regression analysis indicated a significant positive association between both SII and SIRI, analyzed as continuous and quartile-based variables, and the likelihood of obesity-myopia comorbidity (p < 0.05). A dose-response relationship was observed, with the highest quartile of SII (Q4) associated with an odds ratio (OR) of 2.78 and the highest quartile of SIRI associated with an OR of 2.12. RCS analysis indicated significant nonlinear associations (SII: p < 0.001; SIRI: p = 0.001), suggesting that inflammation is positively associated with myopia after exceeding a critical threshold. Subgroup analysis demonstrated that these associations were statistically significant among adolescents with mild to moderate myopia, but not among those with high myopia. However, due to the non‑significant interaction term, these subgroup results should be considered exploratory analyses of this study. CONCLUSIONS: The findings of this study indicate a nonlinear dose-dependent association between systemic inflammatory markers (SII and SIRI) and the comorbidity of obesity and myopia in adolescents. This association was particularly evident in adolescents with mild to moderate myopia. However, due to the cross‑sectional design and the exploratory nature of the subgroup analyses, causality cannot be established, and further research is needed for validation.
Efficacy of PDD-guided tumor excision combined with photodynamic therapy in high-risk basal cell carcinoma.
Hu X, Ye Z, Li Y … +7 more , Yang N, Zhao C, Zhang J, Wang Y, Tan L, Yang Y, Lu Y
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42000094 · Publisher ↗
BACKGROUND: Basal cell carcinoma (BCC) is the most common non-pigmented cutaneous malignancy. Photodynamic diagnosis (PDD) can distinguish tumor tissues from normal tissues by visible fluorescence. Photodynamic therapy (...
BACKGROUND: Basal cell carcinoma (BCC) is the most common non-pigmented cutaneous malignancy. Photodynamic diagnosis (PDD) can distinguish tumor tissues from normal tissues by visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with BCC. METHODS: A retrospective cohort study was conducted on 19 patients diagnosed with high-risk BCC, who were grouped based on the actual treatment they had received in clinical practice: the PDD group (n = 9) and the non-PDD group (n = 10). Patients were not randomized. The PDD group were treated with PDD-guided tumor excision, and the non-PDD group were treated with wide local excision (WLE). Both groups underwent frozen section analysis, and PDT was performed intraoperatively or postoperatively as an adjunctive therapy to target potential subclinical residual tumor cells. Clinical outcomes were analyzed, including efficacy, aesthetic outcome, patient satisfaction, and quality of life. RESULTS: The negative rate of tumor margins in PDD group was 95.3%, compared to 75.5% in the non-PDD group. PDD group needed fewer times of frozen section analysis and observed better cosmetic outcomes and superior patient satisfaction. CONCLUSIONS: PDD can reveal tumor margins in high-risk BCC to guide the extent of surgical resection. The combination of PDD-guided tumor resection with PDT demonstrates high safety and efficacy in the treatment of BCC, particularly in managing potential subclinical residual disease. However, this still needs to be verified in studies with larger sample sizes and longer follow-up periods.
Broad-spectrum abnormal localized photosensitivity syndrome: a case report and literature review.
Numpaisarn M, Pemcharoen J, Fassihi H … +1 more , Boontaveeyuwat E
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 42000093 · Publisher ↗
Broad-spectrum abnormal localized photosensitivity syndrome (BALPS) is a rare photodermatosis characterized by recurrent cutaneous eruptions occurring at fixed body sites following ultraviolet (UV) radiation exposure. Th...
Broad-spectrum abnormal localized photosensitivity syndrome (BALPS) is a rare photodermatosis characterized by recurrent cutaneous eruptions occurring at fixed body sites following ultraviolet (UV) radiation exposure. This report presents a case of skin phototype III in a 30-year-old woman who presented with a 7-year history of recurrent erythematous to violaceous, edematous plaques occurring exclusively on both buttocks during beach holidays. The eruptions were associated with burning and pruritus, occasionally progressing into vesicles or blisters. Each episode resolved within 1-2 weeks but resulted in post-inflammatory hyperpigmentation that persisted for several months. Phototesting demonstrated a reduced minimal erythemal dose (MED) to UVA and narrowband UVB on previously affected areas but normal responses to broadband UVA, broadband UVB, and visible light (VIS) on unaffected skin. Photoprovocation testing of the affected buttocks confirmed photosensitivity, with a positive UVA response on day 3. These findings align with BALPS. Therefore, photoinvestigations are useful for confirming BALPS, and both physical photoprotection and selective sunscreen are necessary for disease management.
Investigation of chromene-porphyrin derivatives for use in photodynamic therapy and photodynamic antimicrobial chemotherapy.
Vukeya TS, Mack J, Nyokong T
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41997555 · Publisher ↗
This work focuses on the photophysical and photochemical properties of chromene-porphyrin derivatives (containing Zn, Ga and In as central metals) and their use as photosensitizers in photodynamic therapy (PDT) and photo...
This work focuses on the photophysical and photochemical properties of chromene-porphyrin derivatives (containing Zn, Ga and In as central metals) and their use as photosensitizers in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) in the presence and absence of carbon quantum dots (CQDs). PDT is being developed as an alternative non-invasive treatment option for cancer. PACT has been used to combat the growing challenge of antimicrobial resistance to the currently used anti-biotics. The biological activities were tested against the triple negative breast cancer cells against MDA-MB-231 (using PDT) and Escherichia coli (using PACT). Resazurin assay was used to monitor the toxicity of the complexes. The porphyrins were stacked ontoCQDs in order to enhance their water solubility and also improve their bio-availability. In general, the porphyrins did not show dark toxicity. Zinc tetrakis-(4‑bromo-chromene) porphyrin (ZnTBCP) and indium tetrakis-(4‑bromo-chromene) porphyrin (InTBCP) had good activities in PDT and PACT respectively, with cell viabilities as low as 23.43% (PDT) and 31.38% (PACT) at the highest concentrations. The results suggest that ZnTBCP and InBCTP are good candidates for use as photosensitizers. CQDs reduced the dark toxicity of the porphyrins.
Sequential multimodal therapy for senile-onset Coats disease.
Gui C, Liu H, Gao Y … +1 more , Peng Q
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41997554 · Publisher ↗
We report a rare case of senile-onset Coats disease presenting with severe macular exudation and subretinal fluid in a 70-year-old male who experienced progressive vision loss. Multimodal imaging excluded other exudative...
We report a rare case of senile-onset Coats disease presenting with severe macular exudation and subretinal fluid in a 70-year-old male who experienced progressive vision loss. Multimodal imaging excluded other exudative maculopathies and confirmed the diagnosis, guiding a personalized sequential therapeutic strategy. Initial intravitreal dexamethasone induction facilitated rapid reduction of subretinal fluid and inflammation, permitting targeted high-frequency fractionated laser photocoagulation of telangiectatic retinal vessels. Follow-up intravitreal aflibercept injections were administered to stabilize vascular permeability and maintain retinal dryness. Over 12 months, structural and functional outcomes were monitored with fundus photography, optical coherence tomography, and angiographic imaging. Best-corrected visual acuity improved from counting fingers at 20 cm to 0.15, while imaging demonstrated sustained resolution of macular edema, marked reduction of lipid exudation, and stable retinal architecture without active leakage. This case highlights the potential contribution of inflammatory processes in the pathogenesis of senile-onset Coats disease and suggests that an imaging-guided, multimodal approach combining corticosteroid induction, precise laser ablation, and anti-vascular endothelial growth factor therapy can achieve durable anatomical and functional stabilization in elderly patients with advanced exudative disease.
Beyond imine-linked COFs: Does framework stability and characterization depth influence the reliability of photodynamic therapeutic conclusions?
Shi JL, Tang W
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41997553 · Publisher ↗
Abstract loading — click title to view on PubMed.
Photodynamic therapy for pulmonary mucoepidermoid carcinoma: a case report.
Hong Q, Yang L, Zou H … +1 more , Wang H
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41974298 · Publisher ↗
SIGNIFICANCE: Pulmonary mucoepidermoid carcinoma (PMEC) is a rare salivary glandtype tumor with no standard treatment. While photodynamic therapy (PDT) shows promise in early-stage central lung cancers, its role in PMEC...
SIGNIFICANCE: Pulmonary mucoepidermoid carcinoma (PMEC) is a rare salivary glandtype tumor with no standard treatment. While photodynamic therapy (PDT) shows promise in early-stage central lung cancers, its role in PMEC remains underexplored. APPROACH: We report a case of a 46-year-old male with low-grade PMEC of the left main bronchus. After initial bronchoscopic electrosnare resection, recurrence occurred 2 years later. The patient was treated with PDT, consisting of three consecutive daily sessions over three days using a 630 nm light source (0.9 W). Each treatment included two light exposures, with a total irradiation time of 600 seconds (540 J) for the first two sessions and 300 seconds (270 J) for the final session. RESULTS: PDT resulted in complete tumor response, with no residual tumor cells on histology. Follow-up over 38 months confirmed no recurrence. CONCLUSIONS: This case demonstrates PDT as a minimally invasive therapy for early stage PMEC, warranting further investigation.
Safety analysis of repeated low-level red light therapy on cone mosaic and microvasculature by adaptive optics scanning laser ophthalmoscopy.
Yue Y, Zhang N, Liu KY … +6 more , Zhong YY, Wang H, Liu SL, Wan WJ, Zhang YL, Deng WL
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41974297 · Publisher ↗
PURPOSE: Despite the growing use of repeated low-level red light (RLRL) therapy for myopic children, its safety remains controversial. This study aimed to analyze macular cone morphology and retinal microvascular hemodyn...
PURPOSE: Despite the growing use of repeated low-level red light (RLRL) therapy for myopic children, its safety remains controversial. This study aimed to analyze macular cone morphology and retinal microvascular hemodynamics using adaptive optics scanning laser ophthalmoscopy (AOSLO) to evaluate retinal microstructural impacts. DESIGN: Cross-sectional study. METHODS: Three groups were recruited: Myopia-RLRL (20 eyes; ≥8 months treatment), Myopia-Untreated (32 eyes), and Non-Myopic (14 eyes). RLRL therapy was administered using a 650 nm laser at 0.29 mW, twice daily for 3 min per session. AOSLO was used to assess cone morphology (density, spacing, regularity, dispersion) and retinal microvasculature parameters (vessel diameter, lumen diameter, blood flow velocity). RESULTS: Cone density was higher in the Non-Myopic group (45,649 ± 5092/mm²) compared to the Myopia-Untreated group (40,202 ± 7365/mm², P = 0.013), with no significant difference versus the Myopia-RLRL group (41,274 ± 6228/mm², P = 0.627). Cone spacing was enlarged in myopic groups relative to non-myopic (P < 0.05). Cone dispersion was lower in the Myopia-RLRL group (16.47 ± 2.43%) than in the Myopia-Untreated (17.36 ± 2.14%, P = 0.030) and Non-Myopic (17.80 ± 2.25%, P = 0.024) groups. No significant intergroup differences were found in cone regularity or microvasculature. Cone density positively correlated with spherical equivalent refraction (r = 0.541) and negatively with axial length (r=-0.594; both P < 0.001). CONCLUSIONS: After 8 months of RLRL therapy, there was no significant loss of cone density or issues with retinal microvasculature. Assessment of retinal arteriole and venule diameters and flow velocity also showed no significant differences. The reduced cone dispersion in the RLRL group suggests potential photobiomodulation effects on photoreceptor organization, indicating the therapy's safety and potential benefits.
Photodynamic diagnosis using 5-aminolevulinic acid for detecting residual ovarian cancer within post-chemotherapy scarring: A case report.
Nakamoto K, Matoba Y, Uyama T … +6 more , Tomono K, Teraoka Y, Oomori Y, Yamazaki T, Banno K, Yamaguchi K
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41966508 · Publisher ↗
INTRODUCTION: 5-aminolevulinic acid (5-ALA) photodynamic diagnosis (PDD) facilitates intraoperative identification of malignant lesions. While established in bladder and brain tumors, its utility in advanced ovarian canc...
INTRODUCTION: 5-aminolevulinic acid (5-ALA) photodynamic diagnosis (PDD) facilitates intraoperative identification of malignant lesions. While established in bladder and brain tumors, its utility in advanced ovarian cancer remains limited, particularly for identifying residual disease within post-chemotherapy scarring during interval debulking surgery (IDS). We report a case where 5-ALA PDD identified occult tumors during both diagnostic laparoscopy and IDS. CASE PRESENTATION: A 74-year-old woman with stage IVB high-grade serous ovarian carcinoma underwent diagnostic laparoscopy followed by three cycles of neoadjuvant chemotherapy (NAC). During subsequent IDS, 5-ALA PDD was employed alongside standard white light imaging. PDD identified peritoneal disseminations that were invisible under white light. Notably, PDD successfully detected viable malignant foci within fibrotic, scar-like lesions modified by NAC, which were otherwise indistinguishable. Although suboptimal debulking was performed due to unresectable nodules near the pancreas, histopathological analysis confirmed malignancy in 100% of PDD-positive sites. No 5-ALA-related adverse events occurred. CONCLUSION: 5-ALA PDD may enhance the accuracy of cytoreduction in advanced ovarian cancer by facilitating the detection of residual viable tumors within post-chemotherapy scarring. This technique offers significant diagnostic value in the NAC-IDS setting where conventional inspection is often limited.
Parameter-efficient contrastive language-image pre-training (CLIP) adaptation for few-shot anomaly detection in ultra-widefield fundus images.
Liao G, Xu H, Ai H … +7 more , Wang T, Huang Y, Han L, Zhuang Y, Chen K, Zhang M, Lin J
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41966507 · Publisher ↗
Fundus diseases are among the leading causes of visual impairment and blindness, many of which could be prevented through early intervention. Ultra-widefield fundus (UWF) imaging, offering a wide field of view and enabli...
Fundus diseases are among the leading causes of visual impairment and blindness, many of which could be prevented through early intervention. Ultra-widefield fundus (UWF) imaging, offering a wide field of view and enabling non-mydriatic acquisition, has emerged as an ideal modality for screening; however, the volume of cases far exceeds the diagnostic capacity of ophthalmologists, necessitating an automated diagnostic system. Nevertheless, existing deep learning algorithms often encounter challenges including high computational costs, large data requirements, and performance degradation on out-of-distribution data. Domain-adaptive fine-tuning of existing multimodal large models offers a promising pathway to address these limitations. Here, we developed an anomaly detection framework for UWF images based on CLIP. First, we proposed a dual-pathway detection mechanism for accurate anomaly detection. Second, a lightweight hybrid low-rank adapter is designed for parameter-efficient fine-tuning to bridge the domain gap between natural images and fundus images. Moreover, to address the scarcity and variability of abnormal samples, we developed an anomaly synthesis algorithm based on Poisson-blending to broaden and generalize the anomaly paradigm. With only 32 pairs of training samples, the framework achieved efficient and robust anomaly detection. The framework was evaluated on 8 independent cross-source datasets (29,739 images covering >50 anomaly patterns), yielding an average AUC of 85.93% and a peak AUC of 94.54%. Owing to its low computational and data requirements, this framework provides a practical and scalable solution for fundus disease screening and shows strong potential for clinical translation. Code and details are available through https://github.com/JohnLeo-XJTU/AnomalyUWF.
Fractionated electrocoagulation combined with delayed photodynamic therapy for treating giant perianal condyloma acuminatum: A case report.
Zhang Q, Fu X, Chen K … +1 more , Wang M
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41966506 · Publisher ↗
Giant perianal condyloma acuminatum poses significant clinical challenges due to its extensive lesions and high recurrence rates. Traditional treatments, like surgical excision, frequently result in considerable tissue d...
Giant perianal condyloma acuminatum poses significant clinical challenges due to its extensive lesions and high recurrence rates. Traditional treatments, like surgical excision, frequently result in considerable tissue damage and impaired anal function. This paper presents a case of a patient with a giant perianal mass successfully treated with an innovative combined approach involving staged electrocautery followed by delayed photodynamic therapy, leading to complete lesion clearance. This method offers an effective treatment paradigm for giant perianal condyloma acuminatum.
Clinical outcomes of ray tracing-guided LASIK for myopic astigmatism correction.
Wang Y, Pan J, Seow SY … +6 more , Jiao Z, Wang J, Zhang Y, Guo Z, Bian M, Fang X
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41966505 · Publisher ↗
PURPOSE: To evaluate real world clinical outcomes of Ray Tracing-Guided LASIK for the correction of various degrees of myopic astigmatism. METHODS: A retrospective analysis of patients who underwent Ray Tracing-Guided LA...
PURPOSE: To evaluate real world clinical outcomes of Ray Tracing-Guided LASIK for the correction of various degrees of myopic astigmatism. METHODS: A retrospective analysis of patients who underwent Ray Tracing-Guided LASIK. The safety, efficacy, stability, and predictability of the surgery were also analyzed. Vector analysis was used to assess astigmatism outcomes at 3 months postoperatively. Subgroup analysis was performed for different degrees of astigmatism to explore the ablation designs for each group. RESULTS: A total of 309 patients (586 eyes) were included in this study. At 3 months postoperatively, 586 eyes (100.0%) achieved uncorrected distance visual acuity (UDVA) of 20/25 or better, and 579 eyes (98.81%) achieved a UDVA of 20/20 or better. No eye lost two or more lines of UDVA compared to preoperatively. Refractive outcomes showed manifest refraction spherical equivalent (MRSE) within ±0.5D in 466 eyes (79.52%) and within ±1.0D in 578 eyes (98.63%). For eyes with astigmatism <1.0DC, the correction index (CI) was 1.33±0.61 and index of success (IOS) was 0.85±0.75, indicating overcorrection. The Angle of Error (AofE) was within ±15° in 74.89% of eyes with <1.0D cylinder, 99.23% with 1.0-2.0D, and 100% with ≥2.0D As the astigmatism cylinder increased, CI and IOS values decreased. CONCLUSIONS: Ray Tracing-Guided LASIK demonstrated safety, efficacy, predictability and stability for correcting myopic astigmatism. Ablation profile and treatment should be adjusted for patients with low and high astigmatism. However, overcorrection or undercorrection of various degrees of myopic astigmatism may also occur if the sightmap measurements are significantly different from the manifest refraction.
Artificial intelligence for epiretinal membrane detection using ultrawidefield scanning laser ophthalmoscopy.
Zhu H, Gu S, Huang L … +10 more , Yuan Q, Yu W, Bao T, Cui S, Lin J, Yang J, Li Q, Ye Z, Luo J, Ling S
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41966504 · Publisher ↗
BACKGROUND: There is currently no validated artificial intelligence (AI) model for detecting epiretinal membrane (ERM) using ultrawidefield scanning laser ophthalmoscopy (UWF-SLO). To address this gap, we aimed to develo...
BACKGROUND: There is currently no validated artificial intelligence (AI) model for detecting epiretinal membrane (ERM) using ultrawidefield scanning laser ophthalmoscopy (UWF-SLO). To address this gap, we aimed to develop and validate a dedicated deep learning (DL) model for automated ERM detection on UWF-SLO images. METHODS: In this retrospective study, an optimized Inception-v3 model was developed using 920 original UWF-SLO images. We systematically compared models trained on two distinct fields of view: the macular and posterior pole regions. The models were evaluated on an internal testing set and an independent, multicentre external validation set. Their performance was benchmarked against that of three ophthalmologists with different levels of expertise. Furthermore, an AI-assisted reader study was conducted in which the same ophthalmologists re-evaluated the images using model-generated heatmaps. RESULTS: The macula AI model achieved a specificity of 93.1%, a sensitivity of 84.0%, and an AUC of 0.943, while the posterior pole AI model achieved corresponding values of 88.6%, 86.0%, and 0.931, respectively. Both models maintained good performance in the external validation set, achieving AUCs of 0.937 and 0.949, respectively. In the reader study, AI assistance improved the average diagnostic accuracy of the three ophthalmologists from 75.4 to 83.3%, with the greatest improvement observed in the resident ophthalmologist. CONCLUSIONS: We present the first well-validated DL model for ERM detection on UWF-SLO images. The model performed well in both internal and external validation and could be used to support the clinical screening and detection of ERMs.
Comments on "Randomized comparative study of 5-Fluorouracil 4 %, tirbanibulin, and photodynamic therapy for relapsing actinic keratoses".
Lamba P
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41962615 · Publisher ↗
Abstract loading — click title to view on PubMed.
Anterior segment, static and dynamic pupillography changes in patients with primary open-angle glaucoma using different types of topical antiglaucomatous agents.
Birgul R, Uzakgider NK
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41941919 · Publisher ↗
INTRODUCTION: Glaucoma is a major cause of avoidable blindness and the most common type is primary open angle glaucoma (POAG). Topical antiglaucomatous agents are the mainstay of treatment. There are many studies on the...
INTRODUCTION: Glaucoma is a major cause of avoidable blindness and the most common type is primary open angle glaucoma (POAG). Topical antiglaucomatous agents are the mainstay of treatment. There are many studies on the ocular effects of antiglaucomatous agents and these results may contradict each other. The aim of our study was to investigate the effects of topical antiglaucomatous agents on the anterior segment and pupil in patients with POAG. MATERIALS AND METHODS: The right eye of the patients using dorzolamide+timolol, brimonidine, latanoprost and the right eye of the control group were included in the study. Anterior segment and pupillography measurements were performed using Scheimpflug imaging technique with the Sirius device. Central corneal thickness (CCT), corneal volume (CV), anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV), first non-contact tear break up time (NCTBUT), mean NCTBUT, meibography, scotopic, mesopic, photopic pupil sizes and dynamic pupil sizes at 0, 1, 2, 4, 6, 8 and 10 s(s) were measured. RESULTS: The dorzolamide+timolol (n = 54), brimonidine (n = 50), and latanoprost (n = 51) groups were compared with the control group (n = 57). There was no statistically significant difference between the groups in terms of age, gender, CCT, CV, ACV, 0 and 1 s dynamic pupillography measurements. There were statistically significant differences between the groups in terms of ACD, ACA, first NCTBUT, mean NCTBUT, meibography, scotopic, mesopic, photopic pupil sizes and dynamic pupillography values at 2, 4, 6, 8 and 10 s. CONCLUSION: This study demonstrated that the most commonly used antiglaucomatous agents increased ACD and ACA but did not affect other anterior segment structures, such as CCT, CV, or ACV. On the ocular surface, antiglaucomatous agents had significant negative effects. Meibography revealed adverse effects on the eyelids. Both first and mean NCTBUT were shortened. In pupillography, both static and dynamic pupil diameters were significantly smaller than those in the control group.
Prognostic factors influencing the cure rate of 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) of High-grade squamous intraepithelial lesions (HSIL): A retrospective cohort study.
Chen Y, Liu L, Chen Y … +2 more , Wang Y, Yan Y
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41941918 · Publisher ↗
BACKGROUND: High-grade squamous intraepithelial lesions (HSIL) are key cervical cancer precursors. While effective, traditional treatments may impair fertility. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) offers...
BACKGROUND: High-grade squamous intraepithelial lesions (HSIL) are key cervical cancer precursors. While effective, traditional treatments may impair fertility. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) offers a minimally invasive alternative, yet prognostic factors remain unclear. This study evaluated 12-month cure rates and identified predictors of response. METHODS: This retrospective cohort included 174 HSIL patients treated with ALA-PDT and followed for ≥12 months. Data on age, lesion type (CIN2 vs. CIN3), HPV status, prior treatments (including CO₂ laser pretreatment), and concomitant vaginitis were collected. Cure was defined as normal ThinPrep cytology, negative HPV, and histologic regression. Logistic regression and ROC analysis identified predictors. RESULTS: ALA-PDT achieved 88.5% cure rate. CIN3 lesions (OR=0.175, P = 0.012) and prior CO₂ laser ablation (OR=19.024, P = 0.005) were independent predictors. CIN3 patients showed lower HPV clearance. The positive prognostic value of CO₂ laser pretreatment is likely attributable to enhanced drug penetration after lesion debulking, while standardized management of concomitant vaginitis may optimize therapeutic outcomes by reducing local inflammation. Combining lesion type and treatment history improved predictive accuracy (AUC=0.772). CONCLUSION: ALA-PDT is effective for HSIL. CIN3 and prior CO₂ laser ablation are key prognostic factors. Optimizing pretreatment strategies and managing vaginitis may further improve cure rates.
Comprehensive quantitative analysis of structural and vascular alterations in retinal and choroidal layers in patients treated with hydroxychloroquine.
Doguizi S, Tekin K, Yavrum F … +2 more , Aydemir E, Sekeroglu MA
Photodiagnosis Photodyn Ther · 2026 Jun · PMID 41936978 · Publisher ↗
PURPOSE: To quantitatively assess retinal and choroidal thicknesses, as well as microvascular alterations, using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA) i...
PURPOSE: To quantitatively assess retinal and choroidal thicknesses, as well as microvascular alterations, using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA) in hydroxychloroquine (HCQ) users. METHODS: Eighty-one eyes of 81 patients receiving HCQ for rheumatoid arthritis or Sjögren's syndrome were included. Patients were categorized as high-risk (treatment ≥5 years) or low-risk (treatment <5 years) users. SD-OCT, OCTA, and visual fields were obtained. Outer retinal layer and choroidal thicknesses, retinal vascular densities, and choriocapillaris flow areas were assessed, and their correlations with cumulative HCQ dose and treatment duration were analyzed. RESULTS: Outer nuclear layer (ONL), outer plexiform layer (OPL), and retinal pigment epithelium (RPE) thicknesses in several macular regions were significantly lower in long-term than in short-term HCQ users (p < 0.05). Choroidal thickness and choriocapillaris flow area were also significantly reduced in long-term users (p < 0.05). Additionally, deep capillary plexus (DCP) vascular density was lower at several locations in the long-term group. HCQ treatment duration and cumulative dose showed significant negative correlations with DCP vascular density, choriocapillaris flow area, choroidal thickness, and ONL thickness (p < 0.05 for each). CONCLUSIONS: Long-term HCQ use was associated with thinning of the ONL, OPL, RPE, and choroid, accompanied by reduced DCP vascular density and choriocapillaris flow area. These structural and microvascular parameters correlated negatively with treatment duration and cumulative HCQ dose, suggesting subclinical alterations related to cumulative HCQ exposure.
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