Zhonghua Er Bi Yan Hou Ke Za Zhi[JOURNAL]
Sun
200 papers
[Microsurgery of temporal bone].
Wang ZM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 May · PMID 15338859
Abstract loading — click title to view on PubMed.
[Analysis of risk factors in the prediction of distant metastases of head and neck squamous cell carcinomas].
Li XM, Di B, Shang YD … +3 more , Zhou YQ, Ma HM, Cheng JM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283298
OBJECTIVE: To investigate the risk factors related with distant metastases (DM) from head and neck squamous cell carcinomas (HNSCC). METHODS: A retrospective study was carried out to review the histopathological data fro...
OBJECTIVE: To investigate the risk factors related with distant metastases (DM) from head and neck squamous cell carcinomas (HNSCC). METHODS: A retrospective study was carried out to review the histopathological data from 532 HNSCC patients treated in Bethune International Peace Hospital from February 1978 to February 1998. The incidence and the risk factor for DM were evaluated in a model that included the following factors: sex, age, clinical staging, T and N staging, site of primary tumor, depth of primary tumor infiltration, histological grade of primary tumor, presence of cervical lymph node metastasis, number of positive neck nodes and levels involved, and presence of extracapsular nodal spread. Univariate chi2 test and multivariate stepwise logistic regression model were used for the analysis. Statistical analysis of overall survival was performed using Kaplan-Meier method. RESULTS: Sixty cases (11.3%) presented distant metastases in 532 patients of head and neck squamous cell carcinomas. In a univariate analysis, it was confirmed that the following variables correlated to DM, i.e., clinical staging (P = 0.0126), T classification (P = 0.0082), site of primary tumor (P = 0.0011), depth of primary tumor infiltration (P = 0.0005) , presence of cervical metastasis (P = 0.0057), number of positive neck nodes (P = 0.0149) and levels involved (P = 0.0034), presence of extracapsular nodal spread (P = 0.0118). In a multivariate analysis, the most significant risk factors for DM were the site of primary tumor and the depth of primary tumor infiltration. Kaplan-Meier analysis showed that overall survival rates of 60 HNSCC patients who presented distant metastases were 51.7% at 1 year, 13.3% at 3 years, 6.5% at 5 years, respectively. CONCLUSION: The site of primary tumor and the depth of primary tumor infiltration are the key risk factors in determining the development of DM in HNSCC patients. Patients with laryngeal and hypopharyngeal carcinomas and patients with primary tumor infiltrating muscular, bone or cartilage level have the highest risk of developing DM.
[The surgical treatment and reconstructive methods in management of hypopharyngeal cancer].
Tang PZ, Zhang ZM, Qi YF … +4 more , Xu ZG, Wu XX, Wu YH, He YD
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283297
OBJECTIVE: To study the surgical treatment and the long-term effect of different reconstructive methods in surgical treatment of hypopharyngeal cancer. METHODS: A retrospective review of 303 (265 males, 38 females, ages...
OBJECTIVE: To study the surgical treatment and the long-term effect of different reconstructive methods in surgical treatment of hypopharyngeal cancer. METHODS: A retrospective review of 303 (265 males, 38 females, ages ranging from 32 to 77 years) cases with hypopharyngeal cancer that were treated with surgical treatment from 1965 to 1998 were accomplished. Of the 303 cases, 130 cases were treated with different reconstructive methods and 173 cases without reconstruction. Of the 130 (stage II, 5; III, 16; IV, 109) cases, 94 were originated from pyriform sinus, 18 from posterior pharyngeal wall and 18 from postcricoid. Fifteen patients were reconstructed with free jejunum. Eighty-one patients were performed total pharyngo-larygo-oesophagectomy and gastric pull-up. Ten patients were treated with vascularized colon. Twenty patients were reconstructed with pectorals major myocutaneous flap. Four patients were reconstructed with other methods. Of the 173 (stage I, 7; II, 12; III, 51; IV, 103) cases, 160 were originated from pyriform sinus, 8 from posterior pharyngeal wall and 5 from postcricoid. RESULTS: The overall 3 and 5 years survival rate of 130 patients with reconstruction were 43.2%, 36.4% respectively. The overall 5 years survival rate of 173 patients with no reconstruction was 47.7%. The overall rate of regular swallowing was over 80%. The mortality rate in period of surgery of gastric pull-up and pectorals major myocutaneous flap were 8.6% and 15% respectively. No patients with free jejunum and vascularized colon died. The overall complication rate in nineties was lower than before 1990 (chi2 = 13.457, P = 0.004). The highest complication rate occurred in patients with pectorals major myocutaneous flap. In contrast to other reconstruction methods, the rate of success of swallowing was higher in patients with free jejunum. CONCLUSIONS: In selected patients these reconstruction techniques enable functional rehabilitation of swallowing. Even high survival rate was obtained after extended partial pharyngolaryngectomy.
[The clinical value of quantitative analysis of plasma Epstein-Barr virus DNA in patients with nasopharyngeal carcinoma].
Yuan H, Yang BB, Xu ZF
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283296
OBJECTIVE: To elucidate the clinical value of quantitative analysis of plasma cell-free EBV-DNA in patients with nasopharyngeal carcinoma (NPC) . METHODS: Using fluorescence quantitative polymerase chain reaction (FQ-PCR...
OBJECTIVE: To elucidate the clinical value of quantitative analysis of plasma cell-free EBV-DNA in patients with nasopharyngeal carcinoma (NPC) . METHODS: Using fluorescence quantitative polymerase chain reaction (FQ-PCR), the copies of EBV-DNA in 66 plasma samples of pre- and post-treated NPC patients were examined, and compared with 30 normal controls. The relationships between the copies of free EBV-DNA and tumor stage, metastases load, as well as short-term therapeutic response were analyzed. RESULTS: The positive percentage and copies of plasma EBV-DNA of NPC patients (66.7%, Median 522.0) were significantly higher than those of normal controls (10.0%, Median 0). Among the pre-treated patients, plasma EBV-DNA copies in stage III-IV patients (Median 3130.0) were higher than those were in stage I-II (Median 400.0), and the copies of N2-3 patients (Median 3250.0) were higher than those were in N0-1 patients (Median 400.0). And then the level of post-treated patients (Median 0) was lower than that of pre-treated patients (Median 522.0). Depending on the evaluation of therapeutic response, post-treated patients could be classified as two different categories, patients whose tumor regressed satisfyingly and those with remaining lesions. It was found that EBV-DNA copies of the former (Median 0) were lower than those of the latter (Median 2083.0). CONCLUSIONS: FQ-PCR determination of plasma EBV-DNA may become a promising marker to monitor the course of this disease.
[The expression and significance of bcl-2 and bax in each phase of the cell cycle in laryngeal carcinoma].
Chen WL, Guo XF, Quan CS … +1 more , Luan XY
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283295
OBJECTIVE: To detect the expression of bcl-2 and bax in each phase of cell cycle in laryngeal carcinoma, and explore the relationship between the expression of bcl-2 and bax in each phase of the cell cycle and the occurr...
OBJECTIVE: To detect the expression of bcl-2 and bax in each phase of cell cycle in laryngeal carcinoma, and explore the relationship between the expression of bcl-2 and bax in each phase of the cell cycle and the occurrence, development and prognosis in the carcinoma of larynx. METHODS: The immunohistochemical method, TUNEL technique and flowcytometry (FCM) parameter analyses were combined to detect the apoptosis and the expression of bcl-2 and bax in each phase of the cell cycle in 15 polyps of vocal cord and 387 laryngeal carcinomas. RESULTS: Total bcl-2 expression and bcl-2 expression in G0G1 stage in laryngeal carcinoma was significantly higher than that in polyp of vocal cord. In contrast, the total bax expression and the bax expression in each phase of cell cycle in laryngeal carcinoma were all lower than that in polyp of vocal cord. The total apoptosis index in laryngeal carcinoma was obviously lower than that in polyp of vocal cord, and this phenomenon was mainly caused by the decrease of the apoptosis in G0G1 phase. The bcl-2, bax expression and the apoptosis wasn't notably related to clinical stage, clinical type and T grade. In poor-differentiated squamous carcinoma, the bcl-2 expression in S and G2M phase was obviously higher than that in well-differentiated and the moderate-differentiated squamous carcinoma. The total apoptosis index, the apoptosis in S phase and the apoptosis in G2M phase were obviously enhanced both in the group of recurrence and in the patients who died in 5 years after the operation, in the same samples, the significant increasing of bcl-2 expression in S and G2M phase was detected. CONCLUSIONS: The significant decreasing of the apoptosis in G0G1 phase caused by high expression of bcl-2 was an important affair in the initial stage of laryngeal carcinoma. Accompanying the significant increasing of the total apoptosis index, the apoptosis in S phase and the apoptosis in G2M phase could be regard as an indicator that the cancer of larynx was malignant with poor prognosis and need adjuvant therapy. The decreasing of bax expression may play a role in the occurrence of laryngeal carcinoma.
[Promoter hypermethylation of DNA repair gene O6-methylguanine DNA methyltransferase in laryngeal squamous cell carcinoma].
Zhang S, Kong WJ, Liu Z
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283294
OBJECTIVE: O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein. It plays a important role in the repair of DNA damage caused by the exposure to methylating agents. Hypermethylation of CpG islands in the...
OBJECTIVE: O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein. It plays a important role in the repair of DNA damage caused by the exposure to methylating agents. Hypermethylation of CpG islands in the promoter regions result in MGMT genes loss of transcription. This study explored the hypermethylation of CpG islands in the promoter regions of MGMT genes in laryngeal squamous cell carcinoma. METHODS: Methylation-specific PCR and semiquantify RT-PCR were used to study the promoter methylation of the MGMT gene and loss of transcription in laryngeal carcinoma tissues, tissues adjacent to the tumor and normal laryngeal tissues. RESULTS: Among the 46 laryngeal carcinoma, MGMT gene hypermethylation was present in 16 cases (34.8%). MGMT hypermethylation was not detected in all tissues adjacent to the tumors and 5 normal tissues. There is no statistical significant difference of promoter hypermethylation among the samples of different histological grade (chi2 = 3.130, P = 0.077) or samples from patients with different TNM stages (chi2 = 3.957, P = 0.138). No expression of MGMT mRNA was found in all hypermethylated laryngeal carcinoma tissues. Expression of MGMT mRNA was detected in all unmethylated laryngeal carcinoma tissues, tissues adjacent to the tumors and 5 normal tissues. Expression of MGMT mRNA in unmethylated laryngeal carcinoma tissues is higher than tissues adjacent to the tumors (t = 30.540, P < 0.01) and normal tissues (t = 31.882, P < 0.01). There is no statistical significant difference of MGMT mRNA expression between tissues adjacent to the tumors and normal tissues (t = 0.419, P = 0.677). CONCLUSION: MGMT gene promoter hypermethylation is associated with loss of its transcription.
[An improved animal model of autoimmune inner ear disease].
Chai L, Gao Y, Gu ZY … +1 more , Ni DF
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283293
OBJECTIVE: To establish an experimental autoimmune inner ear disease model, which could exhibit high reproducibility and be adopted for detailed immunological analysis. METHODS: Extraction of guinea pig inner ear antigen...
OBJECTIVE: To establish an experimental autoimmune inner ear disease model, which could exhibit high reproducibility and be adopted for detailed immunological analysis. METHODS: Extraction of guinea pig inner ear antigens (IEAg). The inbred mice were given a single subcutaneous injection of diluted solution of pertussis and an emulsion containing equal parts of CFA and IEAg. The ABR threshold shifts were evaluated. The antibody level to IEAg in serum was detected by ELISA. Inner ear specimen were examined by light microscopy with hematoxylin and eosin staining. The infiltrated cells within cochlea were clarified with immunohistochemical techniques. RESULTS: The ABR thresholds of IEAg-sensitized animals were elevated significantly. Histological changes in cochlea were significant. Inflammatory cell infiltration was clearly observed in the cochlea of the animals following sensitization with IEAg. Degeneration of the spiral ganglion cells, which characterizes a decrease in cell numbers, and formation of endolymphatic hydrops were often seen too. Serum anti-IEAg levels after inoculation were significantly increased in the IEAg sensitised groups. Most of the infiltrated lymphocytes in scala tympani were CD4+ T cells. CONCLUSIONS: The experimental autoimmune inner ear disease can be induced by a single inoculation of IEAg-CFA emulsion and pertussis in inbred C57BL/6 mice.
[Expression and distribution of Fas and Fas-L in the nasal polyps].
Jin H, Zhao CY, Xu XY … +2 more , Sun YN, Li XD
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283292
OBJECTIVES: To confirm the expression and distribution of Fas and Fas-L in the nasal polyps and to illustrate the role of the Fas/Fas-L system in the pathogenesis of human nasal polyps. METHODS: Investigating the transcr...
OBJECTIVES: To confirm the expression and distribution of Fas and Fas-L in the nasal polyps and to illustrate the role of the Fas/Fas-L system in the pathogenesis of human nasal polyps. METHODS: Investigating the transcripts of the Fas/Fas-L gene in 30 human nasal polyp tissues and 30 nasal turbinate mucosa specimens using reverse transcription-polymerase chain reaction. Localization of Fas/Fas-L was performed with immunohistochemistry. RESULTS: The transcripts of the Fas/Fas-L gene were detected at similar levels in both polyps and nasal mucosa. There was a significant overexpression of Fas-L protein on nasal polyps (epithelium: 25 +/- 21, glands: 19 +/- 14) compared to nasal mucosa (epithelium: 14 +/- 13, glands: 12 +/- 10), (t = 1.66, P < 0.01), while Fas was overexpressed on nasal mucosa (epithelium: 17 +/- 11, glands: 17 +/- 13) compared to nasal polyps (epithelium: 13 +/- 10, glands: 11 +/- 9), (t = 1.98, P < 0.01). Fas-L positive cells were localized on the epithelial layers of cystically dilated glands and the down-growing epithelium of nasal polyps. Fas positive cells were localized on the cilia of the epithelial of nasal mucosa and mainly on the infiltrative cells. CONCLUSION: Fas/Fas-L may play an important role on the pathogenesis of human nasal polyps, including cystic degeneration of submucosal glands, apoptosis and conferring of immune privilege to nasal polyp formation.
[Effect of endoscopic sinus surgery on asthmatic patients with chronic sinusitis and nasal polyps].
Hong SL, Huang JJ, Yang YC … +5 more , Kang HY, Wang YQ, Sun R, Qian D, Dong XQ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283291
OBJECTIVES: To explore the effect of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis and asthma. METHODS: Forty-two patients with asthma who underwent ESS and control group were investigated. Inter...
OBJECTIVES: To explore the effect of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis and asthma. METHODS: Forty-two patients with asthma who underwent ESS and control group were investigated. Interleukin-4 (IL-4), interferon-gamma (IFN-gamma), soluble interleukin-2 receptor (sIL-2R) and soluble CD23 (sCD23) levels in culture supernatant of peripheral blood mononuclear cell (PBMC) were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Of these 42 patients 32 (76%), their asthma was relieved greatly after ESS comparing with that before ESS. 14 of 21 patients (67%) taken regular medication for asthma before ESS reported that less medicine was used after operation. CONCLUSION: This study demonstrates that ESS has a favorable effect on asthma in patients with symptomatic chronic sinusitis.
[Imaging-navigated endoscopic sinus surgery].
Ge WT, Zhou B, Han DM … +2 more , Zhang L, Zhang YJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283290
OBJECTIVE: To evaluate the advantages and disadvantages of different type of image-guidance system in endoscopic sinus surgery. METHODS: Fifty-three endoscopic sinus surgery were performed under different type of image-g...
OBJECTIVE: To evaluate the advantages and disadvantages of different type of image-guidance system in endoscopic sinus surgery. METHODS: Fifty-three endoscopic sinus surgery were performed under different type of image-guidance system, there were 24 chronic sinusitis with or without nasal polyp, 4 juvenile nasopharyngeal angiofibroma, 8 pituitary adenoma, 9 ethmoid ossifying fibroma, 2 nasopharyngeal mixed tumor, 1 nasal leiomyoma, 3 fungal sinusitis, and 2 inverting papilloma. RESULTS: In all cases, the preoperative time was 15-30 minutes, the registration rate were 1.3-2.0, the localization accuracy was within 1 mm. Compared with the traditional endoscopic sinus surgery, the operating time was similar, without obvious difference. No complication occurred. CONCLUSION: All types of image-guidance system could work well with endoscopic system, each of them had its own shortages. Every type of image-guidance system could identify the borders and critical anatomical structures in the corresponding CT data, especially in cases in which anatomical landmarks were no longer present, with anatomical variation, intranasal and anterior skull base tumor. Combined with endoscopic surgery, the image-guided endoscopic surgery provided accurate tumor resection while preserving normal tissue, increased surgical effectiveness, decreased overall surgical complications. It is believed that the image-guidance system is a useful tool for endoscopic sinus surgery.
[Clinical analysis of 58 cases intraoperative image-guidance in nasal endoscopic surgery].
Qiu JH, Chen FQ, Qiao-Li … +2 more , Huang H, Gao XJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283289
OBJECTIVE: To evaluate the availability and our experience of intraoperative image-guidance in endoscopic nasal surgery. METHODS: Fifty-eight cases of endoscopic nasal surgery with intraoperative image-guidance were retr...
OBJECTIVE: To evaluate the availability and our experience of intraoperative image-guidance in endoscopic nasal surgery. METHODS: Fifty-eight cases of endoscopic nasal surgery with intraoperative image-guidance were retrospectively reviewed, including 39 cases of chronic sinusitis with or without nasal polyp; 3 cases of necrotizing maxillary sinusitis; 6 cases of sphenoid sinus cyst; 2 cases of nasopharyngeal angiofibroma; 1 case of cranio-nasal meningioma; 1 case of traumatic cerebrospinal rhinorrhea; 1 case of traumatic optic nerve lesion. All patients were operated on with Brain Lab operation imaging navigation system and nasal endoscope. RESULTS: The preoperative preparatory time would take 10-20 minutes, including coordination, head holder localization, conventional instrument registration. In our cases, the localization accuracy between 3-D image landmarks of navigation system and actual anatomical landmarks was less than 1.5 mm. The optic nerve and other anatomical points could be orientated accurately in intraoperative procedures. No complication occurred. CONCLUSIONS: Nasal endoscope combined with image-guidance systems provides accurate anatomical localization of nasal cavity, sinuses and anterior skull base with enlarged operation field. It is possible for surgeons to observe the surrounding important anatomical structures during endoscopic nasal surgery. It could increase the effectiveness and decrease surgical complications, especially in complicated cases.
[The current development of rhinology in China: still a lot of work to be done].
Han DM
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Mar · PMID 15283288
Abstract loading — click title to view on PubMed.
[Evaluation of the clinical studies of prevention and treatment of sudden deafness in China].
Guo W, Yang SM, Yang WY … +1 more , Gu R
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283287
OBJECTIVE: To summarize and evaluate the current situation on sudden deafness in China by retrospective review of the articles appeared in Chinese journals in the past 3 years. METHODS: The terms of sudden deafness and t...
OBJECTIVE: To summarize and evaluate the current situation on sudden deafness in China by retrospective review of the articles appeared in Chinese journals in the past 3 years. METHODS: The terms of sudden deafness and therapy were used to search all of the articles on the therapy of sudden deafness through the Chinese bio-medicine literature data base and Chinese journal net from 2000 - 2002. All of the articles were analyzed according to the standards of evidence-based medicine. RESULTS: One hundred and seventy-six articles were collected. 126 were on the curative effect of medicine, of which 26 (20.6%) based on the diagnosis and therapy standards settled by the otolaryngology branch of Chinese medical association in 1996, 89 (70.6%) were controlled clinical trials and 36 (28.5%) were randomized controlled trials. Most of the articles mentioned the 5 items diagnosis based and not detailed weather hypertension, diabetes and hyperlipemia were excluded. CONCLUSIONS: There are many articles on the therapy of sudden deafness. However, the inconsistent understanding of the prognosis and evaluation and unstuck trial design limited the therapy, research and the standards of literature on sudden deafness to progress further.
[Surgical treatment of advanced thyroid carcinoma with aero-digestive invasion].
Ge JH, Zhao RL, Hu JL … +1 more , Zhou WA
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283286
OBJECTIVE: To study the surgical management of the advanced thyroid carcinoma with aero-digestive invasion. METHODS: To analyze 18 cases of advanced thyroid carcinoma which had aerodigestive invasion retrospectively, the...
OBJECTIVE: To study the surgical management of the advanced thyroid carcinoma with aero-digestive invasion. METHODS: To analyze 18 cases of advanced thyroid carcinoma which had aerodigestive invasion retrospectively, the patients were treated from 1988 to 1998. RESULTS: The rate of aerodigestive invasion occur was 3.5% (18/516), The inner cavity invaded rate was 2.7% (14/516). The most invaded organ was trachea; The others were esophagus and larynx, pharynx; Two and/or more organs invaded rates were 44. 4% (8/18). The cases that survived 1, 3, 5 and 10 year were 17, 14, 9 and 6. The 5 years survival rates of the differentiated thyroid cancer (61.5%) were more higher than the undifferentiated thyroid cancer (20.0%), but there were no statistical difference between them (P > 0.05) and the same in clinical stage (P > 0.05). CONCLUSIONS: Intraluminal extension is a more serious problem in which usually extensive resection of the aerodigestive tract is required. Effective surgical treatment combined with postoperative auxiliary management for this kind of patients may achieve a good long term results.
[Clinical analysis of 71 cases of multiple primary cancers in head and neck squamous carcinomas].
Zhou YQ, Li XM, Gao CM … +4 more , Zhao QL, Li GS, Cheng JM, Shang YD
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283285
OBJECTIVE: To study the location, treatment, life status of multiple primary cancers (MPCs) in head and neck squamous cell carcinomas. METHODS: The clinical data of 71 head and neck squamous carcinoma patients with MPCs...
OBJECTIVE: To study the location, treatment, life status of multiple primary cancers (MPCs) in head and neck squamous cell carcinomas. METHODS: The clinical data of 71 head and neck squamous carcinoma patients with MPCs were retrospectively analyzed. RESULTS: MPCs were seen in head and neck regions in 27 cases and in remote organs in 42 cases, two of which were triplicate primary cancers. Four cases were synchronous MPCs, including one patient with synchronous triplicate primary cancer. Other 67 cases were heterochronous MPCs, including one patient with heterochronous triplicate primary cancer. Of 67 heterochronous MPCs, the time interval between index tumor presentation and diagnosis of MPCs was eight months to twelve years. MPCs occurred in seventy percent index oral cavity squamous cancers, which were located in head and neck regions, and in sixty-two percent index hypopharynx cancers and seventy-nine percent index laryngeal cancers, which were located in remote organs. The incidence of MPCs in esophagus and lung was higher than that in other remote organs. Among the various MPCs in this serials, the incidence of the disease appeared to be the highest in esophagus, accounting for twenty-four percent of all cases. The total three- and five-year survival rates were 32.4% and 22.5%, respectively. Of all MPCs patients, the three-year survival rate for patients who received different therapies for their MPCs was obviously higher than that of untreated patients (P < 0.01, Chi-square test). CONCLUSIONS: Esophageal carcinoma is the most common second primary cancer among the various MPCs of the head and neck squamous carcinomas. Oral cavity cancers tend to have more MPCs in the head and neck regions, and laryngeal and hypopharyngeal cancers are easily to be associated with MPCs in the remote organs. Regular follow-up and early diagnosis with effective treatment can help to improve the survival of MPC patients in head and neck squamous cell carcinomas.
[Quality of life, personality, coping style in the patients with advanced laryngeal cancer].
Fang WQ, Chen XY, Guan CH … +2 more , Chen JF, Wang JB
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283284
OBJECTIVE: To evaluate the relationship between the life quality of advanced laryngeal squamous cell cancer patients and their personality, coping style and other psychological factors. METHODS: The life quality were mea...
OBJECTIVE: To evaluate the relationship between the life quality of advanced laryngeal squamous cell cancer patients and their personality, coping style and other psychological factors. METHODS: The life quality were measured for 2 sub-groups of advanced laryngeal cancer patients and the normal control group. The Eysenck personality questionnaire (EPQ), coping style questionnaires (CSQ) and University of Washington-quality of life (UW-QOL) were used for life quality evaluation. The 2 sub-groups of the patients on the worse speech, job and ability (group I), the better speech, job and ability (group II), and normal control. RESULTS: (1) UW-QOL score: the total, activity, recreation, job and speech scores of group II were significantly higher than those of group I (P < 0.01). Group II was better than group I in appearance (P < 0.05). (2) EPQ score: the P and N scores in group II were lower than that in group I (P < 0.05). The E scores in group II were significantly higher than that in group I (P < 0.01). (3) CSQ score: the problem-saving factor and help-seeking factor in group II were more significantly lower than that in group I (P < 0.01). The self-blaming factor in group II were higher than that in group I (P < 0.05). (4) There was positive correlation between total scores of QOL and the problem-saving factor, help-seeking factor of CSQ, the E scores of EPQ (P < 0.05), there was negative correlation between total scores of QOL and the P scores, the N scores of EPQ (P < 0.05). CONCLUSIONS: The advanced laryngeal cancer patients of group II have better life quality, and their personalities showed more extroversive, stable feeling, adaptable, mature coping styles. The above characteristics may have good effects on the prognosis of advanced laryngeal cancer.
[Immune responses against cancers in cervical lymph nodes of laryngeal carcinoma].
Zhang JW, Xu J, Zhao XS … +1 more , Jia SS
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283283
OBJECTIVE: Densities of dendritic cells (DC) and hyperplastic follicular response in cervical lymph nodes were performed to prove their roles in immune responses against cancers. METHODS: Paraffin blocks were prepared fo...
OBJECTIVE: Densities of dendritic cells (DC) and hyperplastic follicular response in cervical lymph nodes were performed to prove their roles in immune responses against cancers. METHODS: Paraffin blocks were prepared for staining with monoclonal antibodies against CD45RO, CD20 and S-100 proteins,in 157 lymph nodes obtained from elective cervical lymphadenectomy in 47 cases of laryngeal squamous cell carcinomas. RESULTS: Quantitative analysis showed that the patients who survived longer than 5 years had significant higher number of follicles and higher extent of infiltration by DCs in the lymph nodes than those who less than 5 years (P < 0.001). According to negative or positive lymph node metastasis, there were statistically significant differences between two groups (P < 0.001). The patients who possessed T cell increase type follicular reaction had significant higher five-year survival rate ( P < 0.01) and lower lymph node metastasis rate (P < 0.05) than those who possessed T cell decrease type reaction. CONCLUSION: DCs and hyperplastic follicular response may be more directly involved in the host immune reaction against tumor. The classification of follicular reaction, the densities of DCs and follicular reaction, can serve as important indicators in assessing prognosis of laryngeal carcinomas.
[Treating defective damage of facial nerve with great auricular nerve grafting covered by pediculated fascial tube].
Jiang LX, Zhang SF, Yu XE … +1 more , Jiao YL
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283282
OBJECTIVE: To study the curative effect of grafting great auricular nerve with pediculated fascial tube in defective damage of facial nerve. METHODS: All the 7 patients in this study were treated by grafting great auricu...
OBJECTIVE: To study the curative effect of grafting great auricular nerve with pediculated fascial tube in defective damage of facial nerve. METHODS: All the 7 patients in this study were treated by grafting great auricular nerve covered by pediculated fascial tube near facial nerve trunk. RESULTS: Four cases with otogenic facial paralysis had grade III - IV recovery of facial nerve function from two to two and half years after the nerve grafting operation. Three patients post-traumatic facial paralysis had grade III recovery of facial nerve function 2 years after the nerve grafting operation. CONCLUSIONS: The grafting of pediculated fascial tube surrounded great auricular nerve can provide a biological environment with better blood supply for the plerosis and regeneration of nerve and can accelerate the functional recovery of nerves after the nerve grafting.
[Effect of ventilation tube insertion on otitis media with effusion in cleft palate children].
Liu L, Sun YG, Ma L … +2 more , Zhao W, Wu R
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283281
OBJECTIVE: To explore the effect of eardrum tubing in the repair of cleft palate on alleviating the otitis media with effusion (OME) and hearing loss in cleft palate patients. METHODS: Nineteen ears of 19 cleft palate ch...
OBJECTIVE: To explore the effect of eardrum tubing in the repair of cleft palate on alleviating the otitis media with effusion (OME) and hearing loss in cleft palate patients. METHODS: Nineteen ears of 19 cleft palate children with OME and hearing loss were treated with the ventilation tube insertion in the repair of the cleft palates, while the untreated opposite ears were selected as the control group. All patients were followed up from 2 weeks to 18 months postoperatively and their middle ear condition and hearing thresholds were reevaluated by otoscopy and pure-tone audiometry. RESULTS: Significant differences were found in the incidences of hearing loss between pre and postoperative patients in treated ears, and there are no differences in the untreated ears. Postoperative hearing thresholds become lower than that before the operation and no serious complications were found in the treated ears. CONCLUSIONS: The ventilation tube insertion in medial ear is safe and effective to restore the hearing impaired by OME in the cleft palate patients. It can be used as a regular management for OME and hearing loss in cleft palate children.
[Expression of transforming growth factor-beta1 and c-fos and p27 in human middle ear cholesteatoma].
Jiang CW, Zhan HM, Wang WH … +4 more , Zhang L, Jin SZ, Yang YB, Zhang ZJ
Zhonghua Er Bi Yan Hou Ke Za Zhi · 2004 Apr · PMID 15283280
OBJECTIVES: To analyze the expression of transforming growth factor-beta1 (TGF-beta1), cyclin dependent kinase inhibitor (p27) and c-fos in human middle ear cholesteatomas and to investigate the correlation between their...
OBJECTIVES: To analyze the expression of transforming growth factor-beta1 (TGF-beta1), cyclin dependent kinase inhibitor (p27) and c-fos in human middle ear cholesteatomas and to investigate the correlation between their expression and the ability of erosion of cholesteatoma. METHODS: Immunohistochemical staining (SP method) of 31 cholesteatomas and 11 external ear canal skin samples from patients and 10 external ear canal skin samples from healthful men which were taken intraoperatively, was performed for c-fos, TGF-beta1 and p27 positivity. The signals representing the expression of c-fos, TGF-beta1 and p27 were observed under microscope and scanned into a computer by an image scanner. The gray-scale of positive signals were quantitated by image processing computer. RESULTS: The percentage of positive expression of TGF-beta1 and c-fos in cholesteatoma were 87.1% and 83.9%, respectively. Their expression tended to be increased greatly compared with which in the skins of the control groups. Positive p27 signals were not observed in cholesteatomas and external ear skin tissues. It showed statistically significant correlation between expression of c-fos and the ability of erosion of cholesteatoma. There was correlation between the express ion of TGF-beta1 and the ability of erosion of cholesteatoma too. But there was no correlation between the expression of c-fos and TGF-beta1. CONCLUSION: The expression of c-fos in cholesteatoma was significally higher compared with which in the skin of external auditory of cholesteatoma patients and healthful men, which indicate that c-fos plays an important role in the hyperproliferative of cholesteatoma. The expression of TGF-beta1 was significant higher in cholesteatoma, which indicate that cytokines such as TGF-beta1 play a great role in the etiology of cholesteatoma.
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